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Search results 201 to 278 out of 278 for Gss

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Type Details Score
GXD Expression
GXD Expression
Probe: MGI:3724961
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421612
Age: embryonic day 14.5
Image: MH1613; Specimen C1117
Note: Expression was weak in whisker follicle.
Specimen Label: MH1613; Specimen C1117
Detected: true
Specimen Num: 1
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Publication
20300111 | J:175212
First Author: Meixner A
Year: 2010
Journal: Cell Death Differ
Title: Jun and JunD-dependent functions in cell proliferation and stress response.
Volume: 17
Issue: 9
Pages: 1409-19
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Publication
39328932 | J:354587
First Author: Nedomova M
Year: 2024
Journal: iScience
Title: DDI2 protease controls embryonic development and inflammation via TCF11/NRF1.
Volume: 27
Issue: 10
Pages: 110893
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Publication
11471062 | J:70827
First Author: Ehringer MA
Year: 2001
Journal: Mamm Genome
Title: High-throughput sequence identification of gene coding variants within alcohol-related QTLs.
Volume: 12
Issue: 8
Pages: 657-63
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Publication
30938680 | J:274697
   
First Author: Celaya AM
Year: 2019
Journal: Elife
Title: Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss.
Volume: 8
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Publication
27689697 | J:235644
First Author: Wu Y
Year: 2016
Journal: PLoS Genet
Title: Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Volume: 12
Issue: 9
Pages: e1006355
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
15962001 | J:99842
First Author: Nazor KE
Year: 2005
Journal: EMBO J
Title: Immunodetection of disease-associated mutant PrP, which accelerates disease in GSS transgenic mice.
Volume: 24
Issue: 13
Pages: 2472-80
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Publication
29338055 | J:274039
First Author: Mercer RCC
Year: 2018
Journal: PLoS Pathog
Title: A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles.
Volume: 14
Issue: 1
Pages: e1006826
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Publication
10601325 | J:276393
First Author: Kwong M
Year: 1999
Journal: J Biol Chem
Title: The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts.
Volume: 274
Issue: 52
Pages: 37491-8
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Publication
39438588 | J:361613
First Author: Yu M
Year: 2025
Journal: Leukemia
Title: The BIM deletion polymorphism potentiates the survival of leukemia stem and progenitor cells and impairs response to targeted therapies.
Volume: 39
Issue: 1
Pages: 134-143
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Allele
Hmgcr<Gt(A005H04)Wrst> | MGI:4122667
 
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; gene trap A005H04, German Gene Trap Consortium
Allele Type: Gene trapped
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Interaction Term
MI:1078 | plantgdb
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Strain
MGI:5496909 | C3Fe.129-Hmgcr<Gt(A005H04)Wrst>/Ieg
Attribute String: congenic, gene trap, mutant strain
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DO Term
DOID:0112252 | congenital nonspherocytic hemolytic anemia 6
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Publication
39002785 | J:352034
 
First Author: Niibori-Nambu A
Year: 2024
Journal: Gene
Title: Integrin-α9 overexpression underlies the niche-independent maintenance of leukemia stem cells in acute myeloid leukemia.
Volume: 928
Pages: 148761
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Publication
9215686 | -
First Author: Dahl N
Year: 1997
Journal: Hum Mol Genet
Title: Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction.
Volume: 6
Issue: 7
Pages: 1147-52
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Protein Domain
IPR014042 | Glutathione_synthase_a-hlx
Type: Homologous_superfamily
Description: This superfamily represents an α-helical domain found in glutathione synthetase () (GSS), a homodimeric enzyme that catalyses the conversion of gamma-L-glutamyl-L-cysteine and glycine to phosphate and glutathione in the presence of ATP. This is the second step in glutathione biosynthesis, the first step being catalysed by gamma-glutamylcysteine synthetase []. In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, and increased rate of haemolysis and defective function of the central nervous system.
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Protein Domain
IPR005615 | Glutathione_synthase
Type: Family
Description: This entry represents glutathione synthetase () (GSH-S), a homodimeric enzyme that catalyses the conversion of gamma-L-glutamyl-L-cysteine and glycine to phosphate and glutathione in the presence of ATP. This is the second step in glutathione biosynthesis, the first step being catalysed by gamma-glutamylcysteine synthetase []. In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, and increased rate of haemolysis and defective function of the central nervous system [].
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Protein
P51855
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
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Protein
Q541E2
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: true
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Protein
Q3TWM2
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
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Protein
Q8R436
Organism: Mus musculus/domesticus
Length: 473  
Fragment?: true
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Protein
Q3UEE2
Organism: Mus musculus/domesticus
Length: 405  
Fragment?: false
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Publication
15981742 | -
First Author: Njålsson R
Year: 2005
Journal: Acta Paediatr
Title: Physiological and pathological aspects of GSH metabolism.
Volume: 94
Issue: 2
Pages: 132-7
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Protein
H3BKH4
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
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Protein Domain
IPR014049 | Glutathione_synthase_N_euk
Type: Homologous_superfamily
Description: This superfamily represents the N-terminal domain found in eukaryotic glutathione synthetase () (GSS), a homodimeric enzyme that catalyses the conversion of gamma-L-glutamyl-L-cysteine and glycine to phosphate and glutathione in the presence of ATP. This is the second step in glutathione biosynthesis, the first step being catalysed by gamma-glutamylcysteine synthetase []. In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, and increased rate of haemolysis and defective function of the central nervous system. The N-terminal domain has a 2-layer alpha/beta structure.
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Protein Domain
IPR004887 | GSH_synth_subst-bd
Type: Domain
Description: This entry represents the substrate-binding domain of glutathione synthetase () (GSS), a homodimeric enzyme that catalyses the conversion of gamma-L-glutamyl-L-cysteine and glycine to phosphate and glutathione in the presence of ATP. This is the second step in glutathione biosynthesis, the first step being catalysed by gamma-glutamylcysteine synthetase []. In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, and increased rate of haemolysis and defective function of the central nervous system. The substrate-binding domain has a 3-layer α/β/α structure [].
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Protein Domain
IPR014709 | Glutathione_synthase_C_euk
Type: Homologous_superfamily
Description: This superfamily represents the C-terminal domain found in eukaryotic glutathione synthetase () (GSS), a homodimeric enzyme that catalyses the conversion of gamma-L-glutamyl-L-cysteine and glycine to phosphate and glutathione in the presence of ATP. This is the second step in glutathione biosynthesis, the first step being catalysed by gamma-glutamylcysteine synthetase []. In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, and increased rate of haemolysis and defective function of the central nervous system.This domain has a 2-layer alpha/beta structure.
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Protein Domain
IPR037013 | GSH-S_sub-bd_sf
Type: Homologous_superfamily
Description: This superfamily represents the substrate-binding domain of glutathione synthetase () (GSS), a homodimeric enzyme that catalyses the conversion of gamma-L-glutamyl-L-cysteine and glycine to phosphate and glutathione in the presence of ATP. This is the second step in glutathione biosynthesis, the first step being catalysed by gamma-glutamylcysteine synthetase []. In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, and increased rate of haemolysis and defective function of the central nervous system. The substrate-binding domain has a 3-layer alpha/beta/alpha structure [].
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Protein
Q3TF63
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: false
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Protein
A2AQN9
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
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Publication
10369661 | -
First Author: Polekhina G
Year: 1999
Journal: EMBO J
Title: Molecular basis of glutathione synthetase deficiency and a rare gene permutation event.
Volume: 18
Issue: 12
Pages: 3204-13
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Protein
A2AQN7
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Publication
17531449 | J:123306
First Author: Nazor KE
Year: 2007
Journal: Biochim Biophys Acta
Title: Motor behavioral and neuropathological deficits in mice deficient for normal prion protein expression.
Volume: 1772
Issue: 6
Pages: 645-53
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Publication
10581259 | J:58820
First Author: Manson JC
Year: 1999
Journal: EMBO J
Title: A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy.
Volume: 18
Issue: 23
Pages: 6855-64
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Publication
22160704 | J:180145
First Author: Stöhr J
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Spontaneous generation of anchorless prions in transgenic mice.
Volume: 108
Issue: 52
Pages: 21223-8
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Publication
37355986 | J:338143
First Author: Andres-Alonso M
Year: 2023
Journal: Cell Rep
Title: Golgi satellites are essential for polysialylation of NCAM and expression of LTP at distal synapses.
Volume: 42
Issue: 7
Pages: 112692
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Publication
8698234 | J:136434
First Author: Telling GC
Year: 1996
Journal: Genes Dev
Title: Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice.
Volume: 10
Issue: 14
Pages: 1736-50
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Publication
19675240 | J:151934
First Author: Yang W
Year: 2009
Journal: J Neurosci
Title: A New Transgenic Mouse Model of Gerstmann-Straussler-Scheinker Syndrome Caused by the A117V Mutation of PRNP.
Volume: 29
Issue: 32
Pages: 10072-80
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Publication
22956830 | J:221701
First Author: Cortes CJ
Year: 2012
Journal: J Neurosci
Title: Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann-Sträussler-Scheinker disease.
Volume: 32
Issue: 36
Pages: 12396-405
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Publication
24398683 | J:209509
First Author: Zanusso G
Year: 2014
Journal: J Biol Chem
Title: Gerstmann-Sträussler-Scheinker disease and "anchorless prion protein" mice share prion conformational properties diverging from sporadic Creutzfeldt-Jakob disease.
Volume: 289
Issue: 8
Pages: 4870-81
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Publication
24086135 | J:214875
First Author: Asante EA
Year: 2013
Journal: PLoS Pathog
Title: Inherited prion disease A117V is not simply a proteinopathy but produces prions transmissible to transgenic mice expressing homologous prion protein.
Volume: 9
Issue: 9
Pages: e1003643
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Publication
21727894 | J:175896
First Author: Safar JG
Year: 2011
Journal: Lab Invest
Title: Conserved properties of human and bovine prion strains on transmission to guinea pigs.
Volume: 91
Issue: 9
Pages: 1326-36
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Publication
14747574 | J:88452
First Author: Tremblay P
Year: 2004
Journal: J Virol
Title: Mutant PrPSc conformers induced by a synthetic peptide and several prion strains.
Volume: 78
Issue: 4
Pages: 2088-99
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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