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Search results 201 to 207 out of 207 for Gtf2a1

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0.017s

Type

Details

Score

Protein Domain

IPR022591 | TAF1_HAT_dom

Type:

Domain

Description:

Transcription initiation factor TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. The complex includes TATA binding protein (TBP) and various TBP-associated factors (TAFS). TFIID is a RNA polymerase II-specific TATA-binding protein-associated factor (TAF) that is essential for viability.This group represents a transcription initiation factor TFIID subunit 1 (TAF1, also known as cell cycle gene 1 protein) [, , ]. This is the largest subunit and the core scaffold of the complex, contains Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors including TP53, GTF2A1 and GTF2F1 [, ], and has acetyltransferase activity towards histones H3 and H4 []. It is essential for progression of the G1 phase of the cell cycle [].This entry represents the histone acetyltransferase domain (HAT, formerly known as DUF3591) that is found centrally in the protein TAF1 from eukaryotes. This region is highly conserved from yeast to human. X-ray determination of the crystal structure show it has a compact architecture that consists of a winged helix (WH) domain that folds on top of a triple barrel and a C-terminal α-helical region. The WH domain has intrinsic DNA-binding activity [, , , ].

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Protein

Q80UV9

Organism:	Mus musculus/domesticus
Length:	1891
Fragment?:	false

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Protein

S4R1B9

Organism:	Mus musculus/domesticus
Length:	1733
Fragment?:	false

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Protein

D3YZK4

Organism:	Mus musculus/domesticus
Length:	1902
Fragment?:	false

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Protein

B1Q2W7

Organism:	Mus musculus/domesticus
Length:	1893
Fragment?:	false

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Publication

11963920 | -

First Author:	Tora L
Year:	2002
Journal:	Genes Dev
Title:	A unified nomenclature for TATA box binding protein (TBP)-associated factors (TAFs) involved in RNA polymerase II transcription.
Volume:	16
Issue:	6
Pages:	673-5

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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