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Search results 201 to 300 out of 372 for Hal

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Type Details Score
Genotype
Symbol: Il36rn/Il36rn
Background: C.129(B6)-Il36rn
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Wang J
Year: 2015
Journal: Biochem Biophys Res Commun
Title: The NLRP3 inflammasome is dispensable for ER stress-induced pancreatic β-cell damage in Akita mice.
Volume: 466
Issue: 3
Pages: 300-5
Publication
First Author: Russell SE
Year: 2016
Journal: Mucosal Immunol
Title: IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation.
Volume: 9
Issue: 5
Pages: 1193-204
Publication
First Author: Kovach MA
Year: 2017
Journal: Mucosal Immunol
Title: IL-36γ is a crucial proximal component of protective type-1-mediated lung mucosal immunity in Gram-positive and -negative bacterial pneumonia.
Volume: 10
Issue: 5
Pages: 1320-1334
Strain
Attribute String: congenic, mutant strain, targeted mutation
Publication
First Author: Maroni L
Year: 2017
Journal: Am J Pathol
Title: Nlrp3 Activation Induces Il-18 Synthesis and Affects the Epithelial Barrier Function in Reactive Cholangiocytes.
Volume: 187
Issue: 2
Pages: 366-376
Publication
First Author: Shen J
Year: 2020
Journal: Cell Death Dis
Title: Membrane nanotubes facilitate the propagation of inflammatory injury in the heart upon overactivation of the β-adrenergic receptor.
Volume: 11
Issue: 11
Pages: 958
Strain
Attribute String: targeted mutation, mutant strain, congenic
Publication
First Author: Youm YH
Year: 2015
Journal: Nat Med
Title: The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
Volume: 21
Issue: 3
Pages: 263-9
Allele
Name: squamous cell carcinoma antigen recognized by T cells 3; targeted mutation 1.1, Hal E Broxmeyer
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Strain
Attribute String: targeted mutation, congenic, mutant strain
Strain
Attribute String: congenic, mutant strain, targeted mutation
Publication      
First Author: Hoffman H
Year: 2012
Journal: MGI Direct Data Submission
Title: Direct Data Submission 2012/03/01
Publication
First Author: Byun DJ
Year: 2024
Journal: Cell Commun Signal
Title: NLRP3 exacerbates EAE severity through ROS-dependent NET formation in the mouse brain.
Volume: 22
Issue: 1
Pages: 96
Genotype
Symbol: Il36rn/Il36rn Tg(KRT14-Il1f6)1Hblu/?
Background: involves: 129 * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Il1rl2/Il1rl2 Tg(KRT14-Il1f6)1Hblu/?
Background: involves: 129 * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Rag2/Rag2 Tg(KRT14-Il1f6)1Hblu/?
Background: involves: 129S/SvEv * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Il1r1/Il1r1 Tg(KRT14-Il1f6)1Hblu/?
Background: involves: 129S1/Sv * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Il1rap/Il1rap Tg(KRT14-Il1f6)1Hblu/?
Background: involves: 129S1/Sv * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Nlrp3/Nlrp3
Background: B6N.129-Nlrp3
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Jansen AH
Year: 2017
Journal: Glia
Title: Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific.
Volume: 65
Issue: 1
Pages: 50-61
Publication
First Author: Boguslavskyi A
Year: 2021
Journal: Circulation
Title: Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure, and Hypertension in Mice and Humans.
Volume: 143
Issue: 11
Pages: 1123-1138
Publication
First Author: Vigne S
Year: 2011
Journal: Blood
Title: IL-36R ligands are potent regulators of dendritic and T cells.
Volume: 118
Issue: 22
Pages: 5813-23
Publication  
First Author: Zhu X
Year: 2023
Journal: Front Immunol
Title: Loss of NLRP3 reduces oxidative stress and polarizes intratumor macrophages to attenuate immune attack on endometrial cancer.
Volume: 14
Pages: 1165602
Publication
First Author: Qu C
Year: 2015
Journal: FASEB J
Title: NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.
Volume: 29
Issue: 4
Pages: 1269-79
Publication
First Author: Chen X
Year: 2022
Journal: EMBO Rep
Title: Vitamin D receptor enhances NLRC4 inflammasome activation by promoting NAIPs-NLRC4 association.
Volume: 23
Issue: 9
Pages: e54611
Publication  
First Author: Peng Y
Year: 2022
Journal: Front Immunol
Title: NLRP3+ macrophages aggravate inflammatory cystitis in diabetes.
Volume: 13
Pages: 1057746
Publication
First Author: Lakhdari O
Year: 2019
Journal: Sci Rep
Title: Differential Immune Activation in Fetal Macrophage Populations.
Volume: 9
Issue: 1
Pages: 7677
Publication
First Author: Ioannou GN
Year: 2023
Journal: J Lipid Res
Title: Genetic deletion or pharmacologic inhibition of the Nlrp3 inflammasome did not ameliorate experimental NASH.
Volume: 64
Issue: 2
Pages: 100330
Publication
First Author: Lee HE
Year: 2019
Journal: Sci Rep
Title: Inhibition of NLRP3 inflammasome in tumor microenvironment leads to suppression of metastatic potential of cancer cells.
Volume: 9
Issue: 1
Pages: 12277
Publication
First Author: Toldo S
Year: 2015
Journal: Cardiovasc Res
Title: Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart.
Volume: 105
Issue: 2
Pages: 203-12
Publication
First Author: Inzaugarat ME
Year: 2019
Journal: Hepatology
Title: NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice.
Volume: 69
Issue: 2
Pages: 845-859
Publication
First Author: Colantuoni M
Year: 2023
Journal: Sci Transl Med
Title: Constitutive IL-1RA production by modified immune cells protects against IL-1-mediated inflammatory disorders.
Volume: 15
Issue: 698
Pages: eade3856
Publication  
First Author: Schuster-Gaul S
Year: 2020
Journal: JCI Insight
Title: ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model.
Volume: 5
Issue: 2
Publication  
First Author: Kunte SC
Year: 2023
Journal: Front Immunol
Title: No NLRP3 inflammasome activity in kidney epithelial cells, not even when the NLRP3-A350V Muckle-Wells variant is expressed in podocytes of diabetic mice.
Volume: 14
Pages: 1230050
Publication
First Author: Jiang Z
Year: 2017
Journal: J Invest Dermatol
Title: IL-36γ Induced by the TLR3-SLUG-VDR Axis Promotes Wound Healing via REG3A.
Volume: 137
Issue: 12
Pages: 2620-2629
Publication
First Author: Ershaid N
Year: 2019
Journal: Nat Commun
Title: NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis.
Volume: 10
Issue: 1
Pages: 4375
Publication
First Author: Palomo J
Year: 2018
Journal: PLoS One
Title: The severity of imiquimod-induced mouse skin inflammation is independent of endogenous IL-38 expression.
Volume: 13
Issue: 3
Pages: e0194667
Publication
First Author: Giannoudaki E
Year: 2019
Journal: Nat Commun
Title: Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction.
Volume: 10
Issue: 1
Pages: 4003
Publication
First Author: de Sá KSG
Year: 2024
Journal: PLoS Pathog
Title: Pulmonary inflammation and viral replication define distinct clinical outcomes in fatal cases of COVID-19.
Volume: 20
Issue: 6
Pages: e1012222
Genotype
Symbol: Il36rn/Il36rn<+> Tg(KRT14-Il1f6)1Hblu/?
Background: involves: 129 * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Il1rl2/Il1rl2<+> Tg(KRT14-Il1f6)1Hblu/?
Background: involves: 129 * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Nlrp3/Nlrp3<+>
Background: involves: 129
Zygosity: ht
Has Mutant Allele: true
Allele  
Name: histidine ammonia lyase; histidinemia
Allele Type: Spontaneous
Publication
First Author: Douglas T
Year: 2015
Journal: J Immunol
Title: The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice.
Volume: 195
Issue: 5
Pages: 2365-73
Publication
First Author: Vigne S
Year: 2012
Journal: Blood
Title: IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells.
Volume: 120
Issue: 17
Pages: 3478-87
Publication
First Author: Takaishi M
Year: 2018
Journal: J Invest Dermatol
Title: Regnase-1, an Immunomodulator, Limits the IL-36/IL-36R Autostimulatory Loop in Keratinocytes to Suppress Skin Inflammation.
Volume: 138
Issue: 6
Pages: 1439-1442
Publication
First Author: Wali JA
Year: 2014
Journal: PLoS One
Title: Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets.
Volume: 9
Issue: 11
Pages: e113128
Publication
First Author: Kui L
Year: 2024
Journal: Cell Mol Gastroenterol Hepatol
Title: BRP39 Regulates Neutrophil Recruitment in NLRP3 Inflammasome-Induced Liver Inflammation.
Volume: 17
Issue: 3
Pages: 481-497
Publication
First Author: Wree A
Year: 2018
Journal: Hepatology
Title: NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice.
Volume: 67
Issue: 2
Pages: 736-749
Publication  
First Author: Bozoyan L
Year: 2015
Journal: J Neuroinflammation
Title: Interleukin-36γ is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis.
Volume: 12
Pages: 173
Strain
Attribute String: mutant strain, targeted mutation, congenic
Publication  
First Author: Bourne JH
Year: 2023
Journal: Front Immunol
Title: Megakaryocyte NLRP3 hyperactivation induces mild anemia and potentiates inflammatory response in mice.
Volume: 14
Pages: 1226196
Publication  
First Author: Ma JH
Year: 2022
Journal: EBioMedicine
Title: Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model.
Volume: 82
Pages: 104184
Genotype
Symbol: Il1rap/Il1rap<+> Tg(KRT14-Il1f6)1Hblu/?
Background: involves: 129S1/Sv * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Nlrp3/Nlrp3<+> Tg(Zp3-cre)3Mrt/?
Background: involves: 129/Sv * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nlrp3/Nlrp3<+> Tg(CAG-cre/Esr1*)5Amc/?
Background: involves: 129/Sv * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Nlrp3/Nlrp3<+> Tg(CAG-cre/Esr1*)5Amc/?
Background: involves: 129/Sv * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nlrp3/Nlrp3<+> Tg(CAG-cre/Esr1*)5Amc/?
Background: involves: 129/Sv * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Nlrp3/Nlrp3<+> Tg(CAG-cre/Esr1*)5Amc/?
Background: involves: 129/Sv * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nlrp3/Nlrp3 Vsig4/Vsig4
Background: B6.Cg-Nlrp3 Vsig4
Zygosity: cx
Has Mutant Allele: true
Strain
Attribute String: mutant stock, spontaneous mutation
Genotype
Symbol: Hal/Hal
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Baedeker M
Year: 2002
Journal: Eur J Biochem
Title: Structures of two histidine ammonia-lyase modifications and implications for the catalytic mechanism.
Volume: 269
Issue: 6
Pages: 1790-7
Publication
First Author: Appert C
Year: 1994
Journal: Eur J Biochem
Title: Structural and catalytic properties of the four phenylalanine ammonia-lyase isoenzymes from parsley (Petroselinum crispum Nym.).
Volume: 225
Issue: 1
Pages: 491-9
Publication
First Author: Rachid S
Year: 2006
Journal: Chem Biol
Title: Molecular and biochemical studies of chondramide formation-highly cytotoxic natural products from Chondromyces crocatus Cm c5.
Volume: 13
Issue: 6
Pages: 667-81
Publication
First Author: Krug D
Year: 2009
Journal: Chembiochem
Title: Discovery of additional members of the tyrosine aminomutase enzyme family and the mutational analysis of CmdF.
Volume: 10
Issue: 4
Pages: 741-50
Publication
First Author: Poppe L
Year: 2001
Journal: Curr Opin Chem Biol
Title: Methylidene-imidazolone: a novel electrophile for substrate activation.
Volume: 5
Issue: 5
Pages: 512-24
Publication
First Author: Alunni S
Year: 2003
Journal: Arch Biochem Biophys
Title: Mechanisms of inhibition of phenylalanine ammonia-lyase by phenol inhibitors and phenol/glycine synergistic inhibitors.
Volume: 412
Issue: 2
Pages: 170-5
Protein Domain
Type: Family
Description: This family includes phenylalanine ammonia-lyase, (PAL; ), histidine ammonia-lyase, (HAL; ), and tyrosine aminomutase, () [, , ].PAL and HAL are members of the Lyase class I_like superfamily of enzymes that, catalyze similar beta-elimination reactions and are active as homotetramers. Both PAL and HAL contain a catalytic Ala-Ser-Gly triad that is post-translationally cyclised []. PAL is a key biosynthetic catalyst in phenylpropanoid assembly in plants and fungi, and is involved in the biosynthesis of a wide variety of secondary metabolites such as flavanoids, furanocoumarin phytoalexins and cell wall components. These compounds are important for normal growth and in responses to environmental stress. HAL catalyses the first step in histidine degradation, the removal of an ammonia group from histidine to produce urocanic acid. The core domain in PAL and HAL share about 30% sequence identity, with PAL containing an additional approximately 160 residues extending from the common fold []. Tyrosine 2,3-aminomutase has aminomutase activity and, to a much lesser extent, ammonia-lyase activity [].PAL is being explored as enzyme substitution therapy for Phenylketonuria (PKU), a disorder which involves an inability to metabolize phenylalanine. HAL failure in humans results in the disease histidinemia [, , , ].
Publication
First Author: Ngo VL
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: IL-36R signaling integrates innate and adaptive immune-mediated protection against enteropathogenic bacteria.
Volume: 117
Issue: 44
Pages: 27540-27548
Publication
First Author: Wang X
Year: 2015
Journal: Cancer Cell
Title: IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses.
Volume: 28
Issue: 3
Pages: 296-306
Publication
First Author: Kajiwara Y
Year: 2014
Journal: J Immunol
Title: A critical role for human caspase-4 in endotoxin sensitivity.
Volume: 193
Issue: 1
Pages: 335-43
Publication  
First Author: Huang Y
Year: 2018
Journal: EMBO Mol Med
Title: Tranilast directly targets NLRP3 to treat inflammasome-driven diseases.
Volume: 10
Issue: 4
Publication
First Author: Bonar SL
Year: 2012
Journal: PLoS One
Title: Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice.
Volume: 7
Issue: 4
Pages: e35979
Publication
First Author: Erlich Z
Year: 2019
Journal: Nat Immunol
Title: Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model.
Volume: 20
Issue: 4
Pages: 397-406
Publication
First Author: Shim DW
Year: 2024
Journal: Exp Mol Med
Title: Deficiency of circadian clock gene Bmal1 exacerbates noncanonical inflammasome-mediated pyroptosis and lethality via Rev-erbα-C/EBPβ-SAA1 axis.
Volume: 56
Issue: 2
Pages: 370-382
Publication  
First Author: Wang P
Year: 2022
Journal: Front Immunol
Title: Persistent expression of NLRP3 in spinal microglia promotes development of lumbar disc degeneration.
Volume: 13
Pages: 1064303
Publication
First Author: Xiao J
Year: 2018
Journal: PLoS Biol
Title: Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice.
Volume: 16
Issue: 11
Pages: e3000047
Genotype
Symbol: Nlrp3/Nlrp3<+> Rag1/Rag1 Lyz2/Lyz2<+>
Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nlrp3/Nlrp3 Lyz2/Lyz2<+>
Background: involves: 129 * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nlrp3/Nlrp3<+> Lyz2/Lyz2<+>
Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nlrp3/Nlrp3<+> Lyz2/Lyz2<+>
Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Sart3/Sart3<+> Tg(Tek-cre)1Ywa/?
Background: involves: C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Protein
Organism: Mus musculus/domesticus
Length: 44  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 59  
Fragment?: false
Publication
First Author: Zhang Y
Year: 2013
Journal: Structure
Title: Structural insights into the intrinsic self-assembly of Par-3 N-terminal domain.
Volume: 21
Issue: 6
Pages: 997-1006
Protein Domain
Type: Domain
Description: This domain is found in eukaryotes and is about 150 amino acids in length. It has a conserved GILD sequence motif. Some proteins containing this domain are essential for cell polarity establishment and maintenance such as Par3 (partitioning defective), and some are involved in conversion of histidine into ammonia (a crucial step for forming histamine in humans) such as Histidine ammonia lyase (HAL). This N-terminal domain is found to mediate oligomerization critical for the membrane localization of Par-3. It is also found to possess a self-association capacity via a front-to-back mode in Par-3 and HAL proteins. However, unlike the Par-3 N-terminal domain which self-assembles into a left-handed helical filament, the HAL N-terminal domain does not tend to form a helical filament but rather self-assembles into circular oligomeric particles. This has been suggested to be likely due to the absence of equivalent charged residues that are essential for the longitudinal packing of the Par-3 N-terminal domain filament [].
Publication
First Author: Huang X
Year: 2019
Journal: Sci Adv
Title: VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages.
Volume: 5
Issue: 1
Pages: eaau7426
Publication  
First Author: Stackowicz J
Year: 2021
Journal: J Exp Med
Title: Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome.
Volume: 218
Issue: 10
Publication
First Author: Jiang H
Year: 2017
Journal: J Exp Med
Title: Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders.
Volume: 214
Issue: 11
Pages: 3219-3238
Publication  
First Author: Patrick GJ
Year: 2021
Journal: J Clin Invest
Title: Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease.
Volume: 131
Issue: 5
Publication
First Author: McGeough MD
Year: 2012
Journal: J Immunol
Title: Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models.
Volume: 189
Issue: 6
Pages: 2707-11
Publication
First Author: Lin AE
Year: 2024
Journal: Circulation
Title: Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation.
Volume: 149
Issue: 18
Pages: 1419-1434
Publication
First Author: Brydges SD
Year: 2013
Journal: J Clin Invest
Title: Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies.
Volume: 123
Issue: 11
Pages: 4695-705
Publication
First Author: Guo S
Year: 2015
Journal: PLoS Pathog
Title: The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant Hepatitis.
Volume: 11
Issue: 9
Pages: e1005155
Publication  
First Author: Guo J
Year: 2024
Journal: Mol Immunol
Title: MS4A6D Promotes carrageenan-induced footpad swelling in mice through enhancing macrophages-derived inflammation.
Volume: 169
Pages: 28-36
Publication
First Author: Marneros AG
Year: 2018
Journal: FASEB J
Title: Effects of chronically increased VEGF-A on the aging heart.
Volume: 32
Issue: 3
Pages: 1550-1565
Publication    
First Author: Malsy J
Year: 2020
Journal: Elife
Title: Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization.
Volume: 9
Publication
First Author: McGeough MD
Year: 2017
Journal: J Clin Invest
Title: TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies.
Volume: 127
Issue: 12
Pages: 4488-4497