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Search results 201 to 300 out of 376 for Hamp

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Type Details Score
Publication
First Author: Lee P
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Regulation of hepcidin transcription by interleukin-1 and interleukin-6.
Volume: 102
Issue: 6
Pages: 1906-10
Publication
First Author: Harrison-Findik DD
Year: 2009
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-alpha signaling.
Volume: 296
Issue: 1
Pages: G112-8
Publication  
First Author: Iacovelli J
Year: 2009
Journal: Brain Res
Title: Brain and retinal ferroportin 1 dysregulation in polycythaemia mice.
Volume: 1289
Pages: 85-95
Publication
First Author: Zhang Z
Year: 2014
Journal: PLoS One
Title: Bmp6 expression can be regulated independently of liver iron in mice.
Volume: 9
Issue: 1
Pages: e84906
Publication
First Author: Liu Q
Year: 2012
Journal: J Clin Invest
Title: Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis.
Volume: 122
Issue: 12
Pages: 4635-44
Publication
First Author: Anderson ER
Year: 2012
Journal: Mol Cell Biol
Title: The hypoxia-inducible factor-C/EBPα axis controls ethanol-mediated hepcidin repression.
Volume: 32
Issue: 19
Pages: 4068-77
Publication
First Author: Wang CY
Year: 2020
Journal: Blood
Title: Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3.
Volume: 135
Issue: 6
Pages: 453-456
Publication
First Author: Wang RH
Year: 2005
Journal: Cell Metab
Title: A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.
Volume: 2
Issue: 6
Pages: 399-409
Publication
First Author: De Domenico I
Year: 2010
Journal: J Clin Invest
Title: Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice.
Volume: 120
Issue: 7
Pages: 2395-405
Publication
First Author: Schwartz AJ
Year: 2019
Journal: J Clin Invest
Title: Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload.
Volume: 129
Issue: 1
Pages: 336-348
Publication
First Author: Rausa M
Year: 2015
Journal: PLoS One
Title: Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?
Volume: 10
Issue: 4
Pages: e0122696
Publication
First Author: Vujić Spasić M
Year: 2013
Journal: Biochim Biophys Acta
Title: Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload.
Volume: 1832
Issue: 1
Pages: 76-84
Publication
First Author: Willemetz A
Year: 2014
Journal: Blood
Title: Matriptase-2 is essential for hepcidin repression during fetal life and postnatal development in mice to maintain iron homeostasis.
Volume: 124
Issue: 3
Pages: 441-4
Publication
First Author: Sangkhae V
Year: 2022
Journal: Am J Hematol
Title: Erythroferrone contributes to iron mobilization for embryo erythropoiesis in iron-deficient mouse pregnancies.
Volume: 97
Issue: 10
Pages: 1348-1358
Publication
First Author: Huang H
Year: 2009
Journal: Blood
Title: Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli.
Volume: 113
Issue: 15
Pages: 3593-9
Publication
First Author: Andriopoulos B Jr
Year: 2009
Journal: Nat Genet
Title: BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism.
Volume: 41
Issue: 4
Pages: 482-7
Publication
First Author: Lee DH
Year: 2010
Journal: Blood
Title: Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis.
Volume: 115
Issue: 15
Pages: 3136-45
Publication
First Author: Yu Y
Year: 2020
Journal: Blood
Title: Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis.
Volume: 136
Issue: 6
Pages: 726-739
Publication  
First Author: Cao C
Year: 2022
Journal: Development
Title: Loss of the placental iron exporter ferroportin 1 causes embryonic demise in late-gestation mouse pregnancy.
Volume: 149
Issue: 23
Publication
First Author: Okabe Y
Year: 2008
Journal: Eur J Immunol
Title: IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation.
Volume: 38
Issue: 11
Pages: 3150-8
Publication
First Author: Arsenault PR
Year: 2016
Journal: Mol Cell Biol
Title: The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α.
Volume: 36
Issue: 18
Pages: 2328-43
Publication
First Author: Moroishi T
Year: 2011
Journal: Cell Metab
Title: The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.
Volume: 14
Issue: 3
Pages: 339-51
Publication
First Author: Yoon D
Year: 2006
Journal: J Biol Chem
Title: Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development.
Volume: 281
Issue: 35
Pages: 25703-11
Publication
First Author: Fisher AL
Year: 2021
Journal: Nat Commun
Title: Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy.
Volume: 12
Issue: 1
Pages: 4026
Publication
First Author: Bai X
Year: 2024
Journal: J Neuroinflammation
Title: Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice.
Volume: 21
Issue: 1
Pages: 15
Publication  
First Author: Suzuki T
Year: 2019
Journal: Development
Title: Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes.
Volume: 146
Issue: 4
Publication
First Author: Labialle S
Year: 2014
Journal: EMBO J
Title: The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation.
Volume: 33
Issue: 19
Pages: 2216-30
Publication
First Author: Shalom-Barak T
Year: 2012
Journal: Dev Biol
Title: Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.
Volume: 372
Issue: 1
Pages: 143-55
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Tang T
Year: 2010
Journal: Nat Biotechnol
Title: A mouse knockout library for secreted and transmembrane proteins.
Volume: 28
Issue: 7
Pages: 749-55
Publication      
First Author: Lexicon Genetics, Inc
Year: 2011
Journal: Database Download
Title: MGI download of Lexicon knockout data
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication  
First Author: Ouni M
Year: 2023
Journal: Mol Metab
Title: Differences in DNA methylation of HAMP in blood cells predicts the development of type 2 diabetes.
Volume: 75
Pages: 101774
Publication
First Author: Patel N
Year: 2014
Journal: Br J Haematol
Title: The transcription factor ATOH8 is regulated by erythropoietic activity and regulates HAMP transcription and cellular pSMAD1,5,8 levels.
Volume: 164
Issue: 4
Pages: 586-96
Allele
Name: hepcidin antimicrobial peptide; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
Allele
Name: hepcidin antimicrobial peptide; targeted mutation 1, Sophie Vaulont
Allele Type: Targeted
Attribute String: Null/knockout
Genotype
Symbol: Hamp/Hamp
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: hm
Has Mutant Allele: true
DO Term
Allele  
Name: hepcidin antimicrobial peptide; targeted mutation 1.1, Barbra J Sasu
Allele Type: Targeted
Allele  
Name: hepcidin antimicrobial peptide 2; targeted mutation 1.1, Barbra J Sasu
Allele Type: Targeted
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Genotype
Symbol: Hamp/Hamp2/Hamp/Hamp2
Background: involves: 129 * NTac:NIHBS
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Hamp/Hamp2/Hamp/Hamp2
Background: involves: 129 * NTac:NIHBS
Zygosity: hm
Has Mutant Allele: true
Allele
Name: transgene insertion 2181, Nancy C Andrews
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
Publication
First Author: Keipert S
Year: 2017
Journal: Cell Metab
Title: Long-Term Cold Adaptation Does Not Require FGF21 or UCP1.
Volume: 26
Issue: 2
Pages: 437-446.e5
Publication  
First Author: Xu P
Year: 2018
Journal: Front Physiol
Title: Diet-Induced Obesity Affects Muscle Regeneration After Murine Blunt Muscle Trauma-A Broad Spectrum Analysis.
Volume: 9
Pages: 674
Strain
Attribute String: transgenic, mutant strain, congenic
Publication
First Author: Guo W
Year: 2013
Journal: Aging Cell
Title: Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells.
Volume: 12
Issue: 2
Pages: 280-91
Publication
First Author: O'Neill TJ
Year: 2021
Journal: Sci Immunol
Title: TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease.
Volume: 6
Issue: 65
Pages: eabh2095
Publication
First Author: Roy CN
Year: 2007
Journal: Blood
Title: Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation.
Volume: 109
Issue: 9
Pages: 4038-44
Protein Domain
Type: Homologous_superfamily
Description: TorS is part of the trimethylamine-N-oxide (TMAO) reductase (Tor) pathway, which consists TorT, a periplasmic binding protein that binds TMAO; TorS, a sensor histidine kinase that forms a complex with TorT, and TorR, the response regulator. The Tor pathway is involved in regulating a cellular response to trimethylamine-N-oxide (TMAO), a terminal electron receptor in anaerobic respiration [, , , ]. TorS consists of a periplasmic sensor domain, as well as a HAMP domain, a histidine kinase domain, and a receiver domain [, ].
Protein Domain
Type: Domain
Description: TorS is part of the trimethylamine-N-oxide (TMAO) reductase (Tor) pathway, which consists TorT, a periplasmic binding protein that binds TMAO; TorS, a sensor histidine kinase that forms a complex with TorT, and TorR, the response regulator. The Tor pathway is involved in regulating a cellular response to trimethylamine-N-oxide (TMAO), a terminal electron receptor in anaerobic respiration [, , , ]. TorS consists of a periplasmic sensor domain, as well as a HAMP domain, a histidine kinase domain, and a receiver domain [, ].
Publication
First Author: Jeffery CJ
Year: 1993
Journal: Protein Sci
Title: Vibrio cholerae hlyB is a member of the chemotaxis receptor gene family.
Volume: 2
Issue: 9
Pages: 1532-5
Publication  
First Author: Ishchenko A
Year: 2017
Journal: Sci Rep
Title: New Insights on Signal Propagation by Sensory Rhodopsin II/Transducer Complex.
Volume: 7
Pages: 41811
Protein Domain
Type: Domain
Description: This entry represents a four-helix bundle that operates as a ubiquitous sensory module in prokaryotic signal-transduction, which is known as four-helix bundles methyl-accepting chemotaxis protein (4HB_MCP) domain. The 4HB_MCP is always found between two predicted transmembrane helices indicating that it detects only extracellular signals. In many cases the domain is associated with a cytoplasmic HAMP domain suggesting that most proteins carrying the bundle might share the mechanism of transmembrane signalling which is well-characterised in E coli chemoreceptors [].This domain is found in a group of methyl-accepting chemotaxis receptors that includes Vibrio cholerae HlyB [].
Protein Domain
Type: Domain
Description: Archaebacterial photoreceptors mediate phototaxis by regulating cell motility through two-component signaling cascades like those found in chemotaxis signaling chains of enteric bacteria. The photoreceptor sensory rhodopsin II from N. pharaonis (NpSRII) in complex with its cognate transducer NpHtrII serves as a system for transmembrane signal transfer. This entry is for the transmembrane domain of the transducer HtrII. Studies suggest that conformation changes of the NpSRII/NpHtrII complex may be crucial for the mechanism of signal propagation spanning the membrane domain and feeding into the HAMP domain []. Furthermore, HtrII in H. salinarum not only transmits the signal from the photoreceptor SRII but also operates as a chemoreceptor.
Publication
First Author: Baraquet C
Year: 2006
Journal: J Biol Chem
Title: TorT, a member of a new periplasmic binding protein family, triggers induction of the Tor respiratory system upon trimethylamine N-oxide electron-acceptor binding in Escherichia coli.
Volume: 281
Issue: 50
Pages: 38189-99
Publication
First Author: Jourlin C
Year: 1996
Journal: Mol Microbiol
Title: An unorthodox sensor protein (TorS) mediates the induction of the tor structural genes in response to trimethylamine N-oxide in Escherichia coli.
Volume: 20
Issue: 6
Pages: 1297-306
Publication
First Author: Moore JO
Year: 2009
Journal: Structure
Title: Structural analysis of sensor domains from the TMAO-responsive histidine kinase receptor TorS.
Volume: 17
Issue: 9
Pages: 1195-204
Publication
First Author: Sommer E
Year: 2013
Journal: PLoS One
Title: The sensory histidine kinases TorS and EvgS tend to form clusters in Escherichia coli cells.
Volume: 8
Issue: 10
Pages: e77708
Publication
First Author: Kurabayashi K
Year: 2015
Journal: J Bacteriol
Title: Identification of a second two-component signal transduction system that controls fosfomycin tolerance and glycerol-3-phosphate uptake.
Volume: 197
Issue: 5
Pages: 861-71
Publication
First Author: Moore JO
Year: 2012
Journal: Structure
Title: An asymmetry-to-symmetry switch in signal transmission by the histidine kinase receptor for TMAO.
Volume: 20
Issue: 4
Pages: 729-41
Publication
First Author: Roy CN
Year: 2004
Journal: Nat Genet
Title: An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice.
Volume: 36
Issue: 5
Pages: 481-5
Protein Domain
Type: Domain
Description: The GGDEF domain, which has been named after the conserved central sequence pattern GG[DE][DE]F is widespread in prokaryotes. It is typically present in multidomain proteins containing regulatory domains of signaling pathways or protein-protein or protein-ligand interaction modules, such as the response regulatory domain, the PAS/PAC domain, the HAMP domain, the GAF domain, the FHA domain or the TPR repeat. However a few single-domain proteins are also known. The GGDEF domain is involved in signal transduction and is likely to catalyze synthesis or hydrolysis of cyclic diguanylate (c-diGMP, bis(3',5')-cyclic diguanylic acid), an effector molecule that consists of two cGMP moieties bound head-to-tail [, , ].Structural studies of PleD from Caulobacter crescentus show that this domain forms a five-stranded beta sheet surrounded by helices, similar to the catalytic core of adenylate cyclase [].
Protein Domain
Type: Domain
Description: The nitrate and nitrite-sensing (NIT) domain is a (~250 aa) sensor domain found in various receptor components of signal transduction pathways from different bacterial lineages []. Proteins containing a NIT domain belong to one of four known classes of prokaryotic signal transduction proteins: intracellular transcription anti-termination regulators, sensor histidine kinases, methyl-accepting chemotaxis proteins, diguanylate cyclases/phosphodiesterases. NIT-containing receptors regulate cellular functions such as gene expression (transcription anti-terminators and histidine kinases), cell motility (chemotaxis receptors), and enzyme activity (diguanylate cyclases/phosphodiesterases), in response to changes in nitrate and/or nitrite concentrations. The NIT domain is found as both an extracellular and an intracellular sensor. The NIT domain can be found in combination with other signalling domains, such as ANTAR, HAMP (), MCP, Hemerythrins (), CHASE (), GGDEF (), PAS (), EAL (), HK (), GAF, REC and Hpt ().This entry represents a subgroup found exclusively in bacteria.
Protein Domain
Type: Domain
Description: The nitrate and nitrite-sensing (NIT) domain is a (~250 aa) sensor domain found in various receptor components of signal transduction pathways from different bacterial lineages []. The NIT domain is predicted to be all α-helical in structure []. Proteins containing a NIT domain belong to one of four known classes of prokaryotic signal transduction proteins: intracellular transcription anti-termination regulators, sensor histidine kinases, methyl-accepting chemotaxis proteins, diguanylate cyclases/phosphodiesterases. NIT-containing receptors regulate cellular functions such as gene expression (transcription anti-terminators and histidine kinases), cell motility (chemotaxis receptors), and enzyme activity (diguanylate cyclases/phosphodiesterases), in response to changes in nitrate and/or nitrite concentrations. The NIT domain is found as both an extracellular and an intracellular sensor. The NIT domain can be found in combination with other signalling domains, such as ANTAR, HAMP (), MCP, Hemerythrins (), CHASE (), GGDEF (), PAS (), EAL (), HK (), GAF, REC and Hpt ().
Publication
First Author: Shu CJ
Year: 2003
Journal: Trends Biochem Sci
Title: The NIT domain: a predicted nitrate-responsive module in bacterial sensory receptors.
Volume: 28
Issue: 3
Pages: 121-4
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684623
Stage: TS23
Assay Id: MGI:2676235
Age: embryonic day 15.5
Image: 4
Specimen Label: E15.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684623
Stage: TS23
Assay Id: MGI:2676235
Age: embryonic day 15.5
Image: 4
Specimen Label: E15.5
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:2676235
Age: embryonic day 17.5
Image: 4
Specimen Label: E17.5
Detected: false
Specimen Num: 3