Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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|
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•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
278
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
293
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Einarson MB |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
Human enhancer of invasion-cluster, a coiled-coil protein required for passage through mitosis. |
Volume: |
24 |
Issue: |
9 |
Pages: |
3957-71 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Assembly of a robust microtubule-based mitotic spindle is essential foraccurate segregation of chromosomes to progeny []. Spindle assembly relies on the concerted action of centrosomes, spindle microtubules, molecular motors and non-motor spindle proteins []. A number of novel regulators of spindle assembly have been identified: one of these is HAUS, an 8-subunit protein complex that shares similarity with Drosophila Augmin [, ]. Plants also have a augmin complex consisting of eight subunits. Subunits AUG1 to AUG6 can be aligned with the human HAUS1 to HAUS6 proteins [].HAUS localises to interphase centrosomes and to mitotic spindle micro- tubules; its disruption induces microtubule-dependent fragmentation of centrosomes, and an increase in centrosome size. HAUS disruption results in the destabilisation of kinetochore microtubules and eventual formation of multipolar spindles. Such severe mitotic defects are alleviated by co-depletion of NuMA, indicating that both factors regulate opposing activities. HAUS disruption alters NuMA localisation, suggesting that mis-localised NuMA activity contributes to the observed spindle and centrosome defects. The Augmin complex (HAUS) is thus a critical, evolutionarily conserved multi-subunit protein complex that regulates centrosome and spindle integrity [].The HAUS (Homologous to AUgmin Subunits) individual subunits have been designated HAUS1 to HAUS8 []. HAUS augmin-like complex subunit 1 (also known as enhancer of invasion-cluster, HEI-C [], and coiled-coil domain-containing protein 5) is a coiled-coil protein required for passage through mitosis []. |
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•
•
•
•
•
|
Publication |
First Author: |
Hotta T |
Year: |
2012 |
Journal: |
Plant Cell |
Title: |
Characterization of the Arabidopsis augmin complex uncovers its critical function in the assembly of the acentrosomal spindle and phragmoplast microtubule arrays. |
Volume: |
24 |
Issue: |
4 |
Pages: |
1494-509 |
|
•
•
•
•
•
|
Publication |
First Author: |
Uehara R |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. |
Volume: |
106 |
Issue: |
17 |
Pages: |
6998-7003 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lawo S |
Year: |
2009 |
Journal: |
Curr Biol |
Title: |
HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. |
Volume: |
19 |
Issue: |
10 |
Pages: |
816-26 |
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•
•
•
•
•
|