Type |
Details |
Score |
Allele |
Name: |
HCLS1 associated X-1; gene trap IST11510C1, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
HCLS1 associated X-1; gene trap IST12366F6, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
HCLS1 associated X-1; gene trap IST12400B1, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
HCLS1 binding protein 3; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
HCLS1 binding protein 3; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
HCLS1 associated X-1; gene trap IST13185G6, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
HCLS1 binding protein 3; gene trap IST13837D5, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
HCLS1 associated X-1; gene trap IST14233A1, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
HCLS1 associated X-1; gene trap IST14309E12, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hax1/Hax1 |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hax1/Hax1 |
Background: |
involves: BALB/c |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hs1bp3/Hs1bp3 |
Background: |
C57BL/6NJ-Hs1bp3/Mmjax |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Hirasaka K |
Year: |
2016 |
Journal: |
Biochem Biophys Res Commun |
Title: |
UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion. |
Volume: |
472 |
Issue: |
1 |
Pages: |
108-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1. |
Volume: |
12 |
Issue: |
1 |
Pages: |
1731 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hax1/Hax1 Bak1/Bak1 |
Background: |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Bax/Bax Hax1/Hax1 |
Background: |
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2016 |
Journal: |
Cell |
Title: |
Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating. |
Volume: |
165 |
Issue: |
2 |
Pages: |
434-448 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mixter PF |
Year: |
1995 |
Journal: |
J Immunol |
Title: |
Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin. |
Volume: |
154 |
Issue: |
5 |
Pages: |
2063-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Segade F |
Year: |
1995 |
Journal: |
J Immunol |
Title: |
Isolation of nine gene sequences induced by silica in murine macrophages. |
Volume: |
154 |
Issue: |
5 |
Pages: |
2384-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen SH |
Year: |
2020 |
Journal: |
Cells |
Title: |
TCTP is Essential for Cell Proliferation and Survival during CNS Development. |
Volume: |
9 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Continolo S |
Year: |
2005 |
Journal: |
Exp Cell Res |
Title: |
The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization. |
Volume: |
302 |
Issue: |
2 |
Pages: |
253-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee JH |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice. |
Volume: |
187 |
Issue: |
4 |
Pages: |
1807-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brunati AM |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase. |
Volume: |
274 |
Issue: |
11 |
Pages: |
7557-64 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Tyrosine-protein kinase Fgr belongs to the SRC family of the Tyr protein kinases. It is a non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration [, , ]. It contains a protein kinase domain, an SH2 domain and an SH3 domain. Fgr interacts with tyrosine phosphorylated SYK, FLT3 and HCLS1 via its SH2 domain [].This entry represents the SH2 domain of Fgr. |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoye ML |
Year: |
2022 |
Journal: |
Elife |
Title: |
Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model. |
Volume: |
11 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Beekman R |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Retroviral integration mutagenesis in mice and comparative analysis in human AML identify reduced PTP4A3 expression as a prognostic indicator. |
Volume: |
6 |
Issue: |
10 |
Pages: |
e26537 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baruzzi A |
Year: |
2010 |
Journal: |
FEBS Lett |
Title: |
c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration. |
Volume: |
584 |
Issue: |
1 |
Pages: |
15-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
McClive PJ |
Year: |
2003 |
Journal: |
Genesis |
Title: |
Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad. |
Volume: |
37 |
Issue: |
2 |
Pages: |
84-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Papin J |
Year: |
2004 |
Journal: |
Curr Opin Biotechnol |
Title: |
Bioinformatics and cellular signaling. |
Volume: |
15 |
Issue: |
1 |
Pages: |
78-81 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
517
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
517
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Mootha VK |
Year: |
2003 |
Journal: |
Cell |
Title: |
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. |
Volume: |
115 |
Issue: |
5 |
Pages: |
629-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|