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Search results 201 to 287 out of 287 for Hcn1

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Type Details Score
Publication
30392798 | J:269413
First Author: Kalmbach BE
Year: 2018
Journal: Neuron
Title: h-Channels Contribute to Divergent Intrinsic Membrane Properties of Supragranular Pyramidal Neurons in Human versus Mouse Cerebral Cortex.
Volume: 100
Issue: 5
Pages: 1194-1208.e5
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Publication
25761792 | J:314574
 
First Author: Seo H
Year: 2015
Journal: Mol Brain
Title: Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.
Volume: 8
Pages: 13
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Publication
15479642 | J:93895
First Author: Ango F
Year: 2004
Journal: Cell
Title: Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment.
Volume: 119
Issue: 2
Pages: 257-72
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Publication
31398341 | J:285373
First Author: Orefice LL
Year: 2019
Journal: Cell
Title: Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models.
Volume: 178
Issue: 4
Pages: 867-886.e24
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Publication
25037921 | J:235635
First Author: Leone DP
Year: 2015
Journal: Cereb Cortex
Title: Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex.
Volume: 25
Issue: 10
Pages: 3406-19
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Publication
17482496 | J:122471
First Author: Hattori K
Year: 2007
Journal: Mol Genet Metab
Title: Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart.
Volume: 91
Issue: 3
Pages: 285-93
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Publication
30270038 | J:267411
First Author: Jiang Z
Year: 2018
Journal: Cell
Title: Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.
Volume: 175
Issue: 3
Pages: 652-664.e12
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Publication
29107716 | J:276621
 
First Author: Semmler J
Year: 2018
Journal: Pharmacol Res
Title: Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.
Volume: 128
Pages: 200-210
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Publication
27180262 | J:250657
 
First Author: Greulich F
Year: 2016
Journal: J Mol Cell Cardiol
Title: Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature.
Volume: 97
Pages: 140-9
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Publication
26494785 | J:226616
First Author: Araujo DJ
Year: 2015
Journal: Genes Dev
Title: FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.
Volume: 29
Issue: 20
Pages: 2081-96
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Publication
17473172 | J:121230
First Author: Hoogaars WM
Year: 2007
Journal: Genes Dev
Title: Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.
Volume: 21
Issue: 9
Pages: 1098-112
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Publication
35942939 | J:327434
   
First Author: Ramirez M
Year: 2022
Journal: Elife
Title: Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions.
Volume: 11
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Publication
21052544 | J:166679
 
First Author: Won J
Year: 2011
Journal: J Ophthalmol
Title: Mouse model resources for vision research.
Volume: 2011
Pages: 391384
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Publication
16985003 | J:119550
First Author: Harrell MD
Year: 2007
Journal: Physiol Genomics
Title: Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.
Volume: 28
Issue: 3
Pages: 273-83
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Publication
19554387 | J:156036
First Author: Schilling K
Year: 2009
Journal: Cerebellum
Title: The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex.
Volume: 8
Issue: 4
Pages: 477-89
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Publication
24154525 | J:205051
First Author: Miller JA
Year: 2013
Journal: Development
Title: Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Volume: 140
Issue: 22
Pages: 4633-44
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Publication
- | J:24194
     
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Hcn1<tm2Kndl> | MGI:2686951
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 1; targeted mutation 2, Eric R Kandel
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
23077068 | J:191246
First Author: Huang Z
Year: 2012
Journal: J Neurosci
Title: TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels.
Volume: 32
Issue: 42
Pages: 14835-48
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Publication
30406178 | J:269357
 
First Author: Meseke M
Year: 2018
Journal: eNeuro
Title: Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin.
Volume: 5
Issue: 5
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Publication
- | J:167198
First Author: Chang B
Year: 2006
Journal: Invest Ophthalmol Vis Sci
Title: A New Mouse Model of Cone Photoreceptor Function Loss (cpfl6) Associated With the Targeted Hcn1 Gene Mutation
Volume: 47
Issue: 13
Pages: 2294
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GXD Expression
GXD Expression
Probe: MGI:4457195
Assay Type: Immunohistochemistry
Annotation Date: 2024-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3519628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7716876
Age: postnatal day 56
Image: 7B,D
Note: Expression co-localized with Hcn1 expression in stratum pyramidale.
Specimen Label: 7B,D
Detected: true
Specimen Num: 13
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DO Term
DOID:0111296 | generalized epilepsy with febrile seizures plus 10
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GXD Expression
GXD Expression
Probe: MGI:7716809
Assay Type: Immunohistochemistry
Annotation Date: 2024-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284527
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:7716872
Age: postnatal day 0
Image: 2E-1
Note: Expression in cells migrating from ventricular zone, more prominent for Hcn1 and Hcn2 than for Hcn4.
Specimen Label: 2E-1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5563341
Assay Type: Immunohistochemistry
Annotation Date: 2024-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284527
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:7716874
Age: postnatal day 0
Image: 2I-1
Note: Expression in cells migrating from ventricular zone, less prominent for Hcn4 than for Hcn1 and Hcn2.
Specimen Label: 2I-1
Detected: true
Specimen Num: 2
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Publication
11675786 | -
First Author: Stevens DR
Year: 2001
Journal: Nature
Title: Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli.
Volume: 413
Issue: 6856
Pages: 631-5
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Publication
15351778 | -
First Author: Gill CH
Year: 2004
Journal: Br J Pharmacol
Title: Characterization of the human HCN1 channel and its inhibition by capsazepine.
Volume: 143
Issue: 3
Pages: 411-21
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Publication
12089064 | -
First Author: Xue T
Year: 2002
Journal: Circ Res
Title: Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: insights into structure-function relationships and multimerization.
Volume: 90
Issue: 12
Pages: 1267-73
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DO Term
DOID:0080429 | developmental and epileptic encephalopathy 24
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Allele
Hcn1<M1Btlr> | MGI:6268766
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 1; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6268767 | C57BL/6J-Hcn1<M1Btlr>
Attribute String: mutant strain, chemically induced mutation, coisogenic
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Genotype
Genotype
Symbol: Hcn1/Hcn1
Background: C57BL/6J-Hcn1
Zygosity: hm
Has Mutant Allele: true
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GO Term
GO:0098855 | HCN channel complex
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Publication
25201528 | J:214796
First Author: Kupferman JV
Year: 2014
Journal: Cell
Title: Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment.
Volume: 158
Issue: 6
Pages: 1335-1347
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Publication
30877792 | J:274719
     
First Author: Zobeiri M
Year: 2019
Journal: Cereb Cortex
Title: The Hyperpolarization-Activated HCN4 Channel is Important for Proper Maintenance of Oscillatory Activity in the Thalamocortical System.
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Publication
30079889 | J:269821
   
First Author: Qiu J
Year: 2018
Journal: Elife
Title: Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females.
Volume: 7
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Publication
23305677 | J:198074
First Author: Bosch MA
Year: 2013
Journal: Mol Cell Endocrinol
Title: mRNA expression of ion channels in GnRH neurons: subtype-specific regulation by 17β-estradiol.
Volume: 367
Issue: 1-2
Pages: 85-97
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Publication
11459060 | -
First Author: Wainger BJ
Year: 2001
Journal: Nature
Title: Molecular mechanism of cAMP modulation of HCN pacemaker channels.
Volume: 411
Issue: 6839
Pages: 805-10
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Publication
12161074 | -
First Author: Biel M
Year: 2002
Journal: Trends Cardiovasc Med
Title: Cardiac HCN channels: structure, function, and modulation.
Volume: 12
Issue: 5
Pages: 206-12
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Publication
11248683 | -
First Author: Moosmang S
Year: 2001
Journal: Eur J Biochem
Title: Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues.
Volume: 268
Issue: 6
Pages: 1646-52
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Publication
18953682 | -
First Author: Wahl-Schott C
Year: 2009
Journal: Cell Mol Life Sci
Title: HCN channels: structure, cellular regulation and physiological function.
Volume: 66
Issue: 3
Pages: 470-94
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Publication
11102480 | -
First Author: Petrecca K
Year: 2000
Journal: J Neurosci
Title: Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin.
Volume: 20
Issue: 23
Pages: 8736-44
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Publication
12923176 | J:113938
First Author: Sampson LJ
Year: 2003
Journal: J Biol Chem
Title: Direct interaction between the actin-binding protein filamin-A and the inwardly rectifying potassium channel, Kir2.1.
Volume: 278
Issue: 43
Pages: 41988-97
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Protein Domain
IPR030169 | K/Na_HCN1
Type: Family
Description: This entry represents HCN1, which belongs to the hyperpolarisation-activated cyclic nucleotide-gated (HCN) channel family. HCN1 is expressed in the brain, spinal cord, dorsal root ganglion and heart muscle []. It contributes to the native pacemaker currents in heart and in neurons [, , ]. It may be involved in motor learning and hippocampal-dependent network oscillation in mice [, ]. It binds to filaminA, a putative cytoplasmic scaffold protein that binds actin and links transmembrane proteins, such as the K+ channels Kv4.2 and Kir2.1, to the actin cytoskeleton [, , ].The hyperpolarisation-activated cation current (termed I(f), I(h), or I(q)) plays a key role in the initiation and modulation of cardiac and neuronal pacemaker depolarisations. This current is carried by both K+ and Na+ through I(h) or I(f) channels, such as members of the hyperpolarisation-activated cyclic nucleotide-gated (HCN) family. HCN channels belong to the superfamilyof voltage-gated pore loop channels. The voltage-dependent opening ofthe HCN channels is directly regulated by the binding ofcAMP. In vertebrates, the HCN channel family comprises four members (HCN1-4) []. Whereas HCN3 seems to be specifically expressed in neurons, the other three channels (HCN1, 2, and 4) have been detected in both heart and brain [, ]. HCN channels contain six membrane-spanning helices (S1-S6), including a positively charged voltage-sensing S4 segment and an ion-conducting pore between S5 and S6. In the C terminus the channels carry a cyclic nucleotide-binding domain (CNBD) []. Binding of cAMP to the CNBD speeds up channel opening and shifts the voltage-dependence of activation to more positive voltages []. HCN channels exhibit weak selectivity for potassium over sodium ions.
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Publication
17601992 | J:126574
First Author: Sauerhöfer S
Year: 2007
Journal: Diabetes
Title: L-carnosine, a substrate of carnosinase-1, influences glucose metabolism.
Volume: 56
Issue: 10
Pages: 2425-32
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Publication
35002623 | J:321658
 
First Author: Deng PY
Year: 2021
Journal: Front Mol Neurosci
Title: Hyperexcitability of Sensory Neurons in Fragile X Mouse Model.
Volume: 14
Pages: 796053
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Publication
28363781 | J:244073
 
First Author: Eroli F
Year: 2017
Journal: Neuroscience
Title: Hyperpolarization-activated current Ih in mouse trigeminal sensory neurons in a transgenic mouse model of familial hemiplegic migraine type-1.
Volume: 351
Pages: 47-64
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Publication
23516534 | J:200188
First Author: Bonin RP
Year: 2013
Journal: PLoS One
Title: Hyperpolarization-activated current (In) is reduced in hippocampal neurons from Gabra5-/- mice.
Volume: 8
Issue: 3
Pages: e58679
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Publication
29375299 | J:285697
 
First Author: Stieglitz MS
Year: 2017
Journal: Front Mol Neurosci
Title: Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice.
Volume: 10
Pages: 436
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Publication
29879376 | J:283930
First Author: Silbernagel N
Year: 2018
Journal: FASEB J
Title: The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function.
Volume: 32
Issue: 11
Pages: 6159-6173
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Publication
31410614 | J:298522
First Author: Ison JR
Year: 2019
Journal: J Assoc Res Otolaryngol
Title: Sound Localization in Preweanling Mice Was More Severely Affected by Deleting the Kcna1 Gene Compared to Deleting Kcna2, and a Curious Inverted-U Course of Development That Appeared to Exceed Adult Performance Was Observed in All Groups.
Volume: 20
Issue: 6
Pages: 565-577
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Publication
27670841 | J:303007
First Author: Oginsky MF
Year: 2017
Journal: J Cell Physiol
Title: Hyperexcitability of Mesencephalic Trigeminal Neurons and Reorganization of Ion Channel Expression in a Rett Syndrome Model.
Volume: 232
Issue: 5
Pages: 1151-1164
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Publication
36745683 | J:336290
First Author: Szegedi V
Year: 2023
Journal: PLoS Biol
Title: HCN channels at the cell soma ensure the rapid electrical reactivity of fast-spiking interneurons in human neocortex.
Volume: 21
Issue: 2
Pages: e3002001
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Publication
32269286 | J:331674
First Author: Lee SY
Year: 2020
Journal: Exp Mol Med
Title: PRMT7 deficiency causes dysregulation of the HCN channels in the CA1 pyramidal cells and impairment of social behaviors.
Volume: 52
Issue: 4
Pages: 604-614
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Publication
30459593 | J:288609
 
First Author: Shen H
Year: 2018
Journal: Front Aging Neurosci
Title: Age-Dependent Up-Regulation of HCN Channels in Spiral Ganglion Neurons Coincide With Hearing Loss in Mice.
Volume: 10
Pages: 353
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Publication
31290157 | J:302875
First Author: Lainez S
Year: 2019
Journal: J Physiol
Title: HCN3 ion channels: roles in sensory neuronal excitability and pain.
Volume: 597
Issue: 17
Pages: 4661-4675
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Protein
O88704
Organism: Mus musculus/domesticus
Length: 910  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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