|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 232 out of 232 for Hexim1

<< First    < Previous  |  Next >    Last >>
0.019s

Categories

Hits by Category

Hits by Strain

Type Details Score
Publication
23300697 | J:195728
First Author: Yoshikawa N
Year: 2012
Journal: PLoS One
Title: Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice.
Volume: 7
Issue: 12
Pages: e52522
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5817384
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1610525
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5817414
Age: embryonic day 17.5
Note: Authors report decreased expression.
Specimen Label: 4C FGF9 HEXIM1 1-312
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5817388
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610525
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5817416
Age: embryonic day 17.5
Note: Authors report no obvious difference in expression between the hearts of wild type and mutant mice.
Specimen Label: S3 HEXIM1 1-312
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5817380
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1916023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5817410
Age: embryonic day 15.5
Note: Expression in an abundance of coronary vessels in the epicardium. Markedly decreased vascularization of the myocardium.
Specimen Label: 4A section HEXIM1 1-312
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5817381
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3274823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5817412
Age: embryonic day 15.5
Note: Authors report decreased expression in ventricular myocardium.
Specimen Label: 4B VEGF HEXIM1 1-312
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5817380
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1916023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5817410
Age: embryonic day 15.5
Note: Expression in coronary arteries with a disorganized pattern of branching.
Specimen Label: 4A whole mount HEXIM1 1-312
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5817235
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5817417
Age: embryonic day 13.5
Note: Authors report a decrease in expression.
Specimen Label: S4B Ser1 Phosph RNAP II HEXIM1 1-312
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5817235
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5817419
Age: embryonic day 13.5
Note: Authors report a decrease in expression.
Specimen Label: S4B Ser1 Phosph RNAP II HEXIM1 1-312
Detected: true
Specimen Num: 2
•
•
•
•
•
Publication
14580347 | -
First Author: Yik JH
Year: 2003
Journal: Mol Cell
Title: Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA.
Volume: 12
Issue: 4
Pages: 971-82
•
•
•
•
•
Publication
15713661 | -
First Author: Yik JH
Year: 2005
Journal: J Biol Chem
Title: Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription.
Volume: 280
Issue: 16
Pages: 16368-76
•
•
•
•
•
Protein
Q3TVI4
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
•
•
•
•
•
Protein
A2AB65
Organism: Mus musculus/domesticus
Length: 52  
Fragment?: true
•
•
•
•
•
Protein
A2AB66
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: true
•
•
•
•
•
Protein
A2AB67
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
•
•
•
•
•
Protein Domain
IPR024876 | HEXIM2
Type: Family
Description: Hexamethylene bisacetamide-inducible proteins (HEXIMs) are transcriptional regulators that function as general RNA polymerase II transcription inhibitors. HEXIMs, aided by the 7SK snRNA, sequester positive transcriptional elongation factor b (P-TEFb) into a large inactive 7SK snRNP complex [, ]. This prevents P-TEFb from phosphorylating RNA polymerase II and blocks subsequent transcriptional elongation.Two HEXIM family members have been identified in mammals, termed HEXIM1 and HEXIM2, which exhibit distinct expression patterns []. In HEXIM1-knocked down cells, HEXIM2 can functionally and quantitatively compensate for the loss of HEXIM1 to maintain a constant level of the 7SK/HEXIM-bound P-TEFb [].
•
•
•
•
•
Publication
16109376 | J:101015
First Author: Jang MK
Year: 2005
Journal: Mol Cell
Title: The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.
Volume: 19
Issue: 4
Pages: 523-34
•
•
•
•
•
Protein
Q8BNZ8
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
•
•
•
•
•
Protein
Q8BS78
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: false
•
•
•
•
•
Protein Domain
IPR031354 | BRD4_CDT
Type: Domain
Description: This entry represents the short highly conserved C-terminal domain of certain bromodomain proteins, notably Brd4. The Brd4 CTD interacts with the cyclin T1 and Cdk9 subunits of positive transcription elongation factor b (pTEFb) complex. Brd4 displaces negative regulators, the HEXIM1 and 7SKsnRNA complex, from pTEFb, thereby transforming it into an active form that can phosphorylate RNA pol II [, ].
•
•
•
•
•
Protein Domain
IPR024872 | HEXIM
Type: Family
Description: Hexamethylene bisacetamide-inducible proteins (HEXIMs) are transcriptional regulators that function as general RNA polymerase II transcription inhibitors. HEXIMs, aided by the 7SK snRNA, sequester positive transcriptional elongation factor b (P-TEFb) into a large inactive 7SK snRNP complex [, ]. This prevents P-TEFb from phosphorylating RNA polymerase II and blocks subsequent transcriptional elongation.Two HEXIM family members have been identified in mammals, termed HEXIM1 and HEXIM2, which exhibit distinct expression patterns [].
•
•
•
•
•
Publication
21555454 | -
First Author: Rahman S
Year: 2011
Journal: Mol Cell Biol
Title: The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.
Volume: 31
Issue: 13
Pages: 2641-52
•
•
•
•
•
Publication
31183407 | J:338737
First Author: Sun Y
Year: 2019
Journal: Sci Adv
Title: Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease.
Volume: 5
Issue: 6
Pages: eaaw3593
•
•
•
•
•
Publication
33199370 | J:338704
 
First Author: Jiang M
Year: 2021
Journal: J Biol Chem
Title: The G4 resolvase RHAU modulates mRNA translation and stability to sustain postnatal heart function and regeneration.
Volume: 296
Pages: 100080
•
•
•
•
•
Publication
23852730 | J:198780
First Author: Cherrier T
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: CTIP2 is a negative regulator of P-TEFb.
Volume: 110
Issue: 31
Pages: 12655-60
•
•
•
•
•
Publication
24860166 | J:218137
First Author: Itzen F
Year: 2014
Journal: Nucleic Acids Res
Title: Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation.
Volume: 42
Issue: 12
Pages: 7577-90
•
•
•
•
•
Protein
Q9ESU6
Organism: Mus musculus/domesticus
Length: 1400  
Fragment?: false
•
•
•
•
•
Protein
Q91Y44
Organism: Mus musculus/domesticus
Length: 956  
Fragment?: false
•
•
•
•
•
Protein
Q3UH70
Organism: Mus musculus/domesticus
Length: 1401  
Fragment?: false
•
•
•
•
•
Publication
17242355 | -
First Author: Villén J
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Large-scale phosphorylation analysis of mouse liver.
Volume: 104
Issue: 5
Pages: 1488-93
•
•
•
•
•
Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
•
•
•
•
•
Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
•
•
•
•
•
Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom