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Search results 201 to 232 out of 232 for Hexim1

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Type Details Score
Publication
23300697 | J:195728
First Author: Yoshikawa N
Year: 2012
Journal: PLoS One
Title: Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice.
Volume: 7
Issue: 12
Pages: e52522
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GXD Expression
GXD Expression
 
Probe: MGI:5817384
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1610525
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5817414
Age: embryonic day 17.5
Note: Authors report decreased expression.
Specimen Label: 4C FGF9 HEXIM1 1-312
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5817388
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610525
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5817416
Age: embryonic day 17.5
Note: Authors report no obvious difference in expression between the hearts of wild type and mutant mice.
Specimen Label: S3 HEXIM1 1-312
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5817380
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1916023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5817410
Age: embryonic day 15.5
Note: Expression in an abundance of coronary vessels in the epicardium. Markedly decreased vascularization of the myocardium.
Specimen Label: 4A section HEXIM1 1-312
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:5817381
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3274823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5817412
Age: embryonic day 15.5
Note: Authors report decreased expression in ventricular myocardium.
Specimen Label: 4B VEGF HEXIM1 1-312
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5817380
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1916023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5817410
Age: embryonic day 15.5
Note: Expression in coronary arteries with a disorganized pattern of branching.
Specimen Label: 4A whole mount HEXIM1 1-312
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5817235
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5817417
Age: embryonic day 13.5
Note: Authors report a decrease in expression.
Specimen Label: S4B Ser1 Phosph RNAP II HEXIM1 1-312
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5817235
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5817419
Age: embryonic day 13.5
Note: Authors report a decrease in expression.
Specimen Label: S4B Ser1 Phosph RNAP II HEXIM1 1-312
Detected: true
Specimen Num: 2
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Publication
14580347 | -
First Author: Yik JH
Year: 2003
Journal: Mol Cell
Title: Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA.
Volume: 12
Issue: 4
Pages: 971-82
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Publication
15713661 | -
First Author: Yik JH
Year: 2005
Journal: J Biol Chem
Title: Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription.
Volume: 280
Issue: 16
Pages: 16368-76
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Protein
Q3TVI4
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
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Protein
A2AB65
Organism: Mus musculus/domesticus
Length: 52  
Fragment?: true
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Protein
A2AB66
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: true
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Protein
A2AB67
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
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Protein Domain
IPR024876 | HEXIM2
Type: Family
Description: Hexamethylene bisacetamide-inducible proteins (HEXIMs) are transcriptional regulators that function as general RNA polymerase II transcription inhibitors. HEXIMs, aided by the 7SK snRNA, sequester positive transcriptional elongation factor b (P-TEFb) into a large inactive 7SK snRNP complex [, ]. This prevents P-TEFb from phosphorylating RNA polymerase II and blocks subsequent transcriptional elongation.Two HEXIM family members have been identified in mammals, termed HEXIM1 and HEXIM2, which exhibit distinct expression patterns []. In HEXIM1-knocked down cells, HEXIM2 can functionally and quantitatively compensate for the loss of HEXIM1 to maintain a constant level of the 7SK/HEXIM-bound P-TEFb [].
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Publication
16109376 | J:101015
First Author: Jang MK
Year: 2005
Journal: Mol Cell
Title: The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.
Volume: 19
Issue: 4
Pages: 523-34
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Protein
Q8BNZ8
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
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Protein
Q8BS78
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: false
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Protein Domain
IPR031354 | BRD4_CDT
Type: Domain
Description: This entry represents the short highly conserved C-terminal domain of certain bromodomain proteins, notably Brd4. The Brd4 CTD interacts with the cyclin T1 and Cdk9 subunits of positive transcription elongation factor b (pTEFb) complex. Brd4 displaces negative regulators, the HEXIM1 and 7SKsnRNA complex, from pTEFb, thereby transforming it into an active form that can phosphorylate RNA pol II [, ].
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Protein Domain
IPR024872 | HEXIM
Type: Family
Description: Hexamethylene bisacetamide-inducible proteins (HEXIMs) are transcriptional regulators that function as general RNA polymerase II transcription inhibitors. HEXIMs, aided by the 7SK snRNA, sequester positive transcriptional elongation factor b (P-TEFb) into a large inactive 7SK snRNP complex [, ]. This prevents P-TEFb from phosphorylating RNA polymerase II and blocks subsequent transcriptional elongation.Two HEXIM family members have been identified in mammals, termed HEXIM1 and HEXIM2, which exhibit distinct expression patterns [].
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Publication
21555454 | -
First Author: Rahman S
Year: 2011
Journal: Mol Cell Biol
Title: The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.
Volume: 31
Issue: 13
Pages: 2641-52
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Publication
31183407 | J:338737
First Author: Sun Y
Year: 2019
Journal: Sci Adv
Title: Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease.
Volume: 5
Issue: 6
Pages: eaaw3593
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Publication
33199370 | J:338704
 
First Author: Jiang M
Year: 2021
Journal: J Biol Chem
Title: The G4 resolvase RHAU modulates mRNA translation and stability to sustain postnatal heart function and regeneration.
Volume: 296
Pages: 100080
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Publication
23852730 | J:198780
First Author: Cherrier T
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: CTIP2 is a negative regulator of P-TEFb.
Volume: 110
Issue: 31
Pages: 12655-60
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Publication
24860166 | J:218137
First Author: Itzen F
Year: 2014
Journal: Nucleic Acids Res
Title: Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation.
Volume: 42
Issue: 12
Pages: 7577-90
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Protein
Q9ESU6
Organism: Mus musculus/domesticus
Length: 1400  
Fragment?: false
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Protein
Q91Y44
Organism: Mus musculus/domesticus
Length: 956  
Fragment?: false
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Protein
Q3UH70
Organism: Mus musculus/domesticus
Length: 1401  
Fragment?: false
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Publication
17242355 | -
First Author: Villén J
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Large-scale phosphorylation analysis of mouse liver.
Volume: 104
Issue: 5
Pages: 1488-93
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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