Type |
Details |
Score |
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
691 |
Description: |
(3S)-3-hydroxyaspartate; by HIF1AN |
Type: |
modified residue |
End: |
691 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
757 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
757 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
460 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
460 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
625 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
625 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
658 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
658 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
724 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
724 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
229 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
229 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
427 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
427 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
244 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
244 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
210 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
210 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
671 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
671 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
706 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
706 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
739 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
739 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
553 |
Description: |
(3S)-3-hydroxyhistidine; by HIF1AN |
Type: |
modified residue |
End: |
553 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
238 |
Description: |
(3S)-3-hydroxyhistidine; by HIF1AN |
Type: |
modified residue |
End: |
238 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
203 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
203 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
271 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
271 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
427 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
427 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
518 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
518 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
586 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
586 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
100 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
100 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
67 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
67 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
226 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
226 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
674 |
Description: |
(3S)-3-hydroxyasparagine; by HIF1AN |
Type: |
modified residue |
End: |
674 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
256 |
Description: |
Essential for interaction with HIF1AN |
Type: |
site |
End: |
256 |
|
•
•
•
•
•
|
Allele |
Name: |
hypoxia-inducible factor 1, alpha subunit inhibitor; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoff S |
Year: |
2013 |
Journal: |
Nat Genet |
Title: |
ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3. |
Volume: |
45 |
Issue: |
8 |
Pages: |
951-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pause A |
Year: |
1997 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. |
Volume: |
94 |
Issue: |
6 |
Pages: |
2156-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aso T |
Year: |
2000 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity. |
Volume: |
276 |
Issue: |
1 |
Pages: |
355-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tanimoto K |
Year: |
2000 |
Journal: |
EMBO J |
Title: |
Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. |
Volume: |
19 |
Issue: |
16 |
Pages: |
4298-309 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qi H |
Year: |
2004 |
Journal: |
Mol Cancer Res |
Title: |
Molecular cloning and characterization of the von Hippel-Lindau-like protein. |
Volume: |
2 |
Issue: |
1 |
Pages: |
43-52 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
VHL (von Hippel-Lindau disease tumor suppressor) is a component of the VCB (VHL-Elongin BC-CUL2) complex; this complex acts as a ubiquitin-ligase E3 and directs proteasome-dependent degradation of targeted proteins []. Human VHL has been demonstrated to form a ternary complex with elonginB and elonginC proteins []. This complex binds Cul2, which then is involved in regulation of vascular endothelial growth factor mRNA. VHL appears to act as the target recruitment subunit in the E3 ubiquitin ligase complex and recruit hydroxylated hypoxia-inducible factor (HIF) under normal oxygen conditions []. VHL is also involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases []. Like human VHL, Drosophila VHL complex containing Cul-2, Rbx1, Elongins B and C, exhibits E3 ubiquitin ligase activity []. However, proteins in this entry also include Von Hippel-Lindau-like (VHLL) protein from human. It may has little or no E3 ubiquitin ligase activity as it lacks the alpha domain required for nucleating the multiprotein E3 ubiquitin ligase complex []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
181
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
181
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Stebbins CE |
Year: |
1999 |
Journal: |
Science |
Title: |
Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. |
Volume: |
284 |
Issue: |
5413 |
Pages: |
455-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hon WC |
Year: |
2002 |
Journal: |
Nature |
Title: |
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. |
Volume: |
417 |
Issue: |
6892 |
Pages: |
975-8 |
|
•
•
•
•
•
|