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Search results 201 to 300 out of 519 for Hmgcr

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Type Details Score
Publication
First Author: Yubero P
Year: 2004
Journal: Endocrinology
Title: The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism.
Volume: 145
Issue: 9
Pages: 4268-77
Publication
First Author: Cunningham D
Year: 2015
Journal: Hum Mol Genet
Title: Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development.
Volume: 24
Issue: 10
Pages: 2808-25
Publication
First Author: Kim M
Year: 2018
Journal: Genes Dev
Title: Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.
Volume: 32
Issue: 9-10
Pages: 645-657
Publication
First Author: Munkacsi AB
Year: 2017
Journal: J Biol Chem
Title: Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat.
Volume: 292
Issue: 11
Pages: 4395-4410
Publication  
First Author: Van Veldhoven PP
Year: 2020
Journal: Front Cell Dev Biol
Title: Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid.
Volume: 8
Pages: 144
Publication
First Author: Li J
Year: 1999
Journal: Nat Genet
Title: Leukaemia disease genes: large-scale cloning and pathway predictions.
Volume: 23
Issue: 3
Pages: 348-53
Publication
First Author: Shimano H
Year: 1996
Journal: J Clin Invest
Title: Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
Volume: 98
Issue: 7
Pages: 1575-84
Publication  
First Author: Tsushima H
Year: 2018
Journal: Development
Title: Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.
Volume: 145
Issue: 13
Publication
First Author: Patra D
Year: 2014
Journal: PLoS One
Title: Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.
Volume: 9
Issue: 8
Pages: e105674
Publication
First Author: Vergnes L
Year: 2016
Journal: J Lipid Res
Title: SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.
Volume: 57
Issue: 3
Pages: 410-21
Publication
First Author: Wei L
Year: 2020
Journal: J Biol Chem
Title: GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism.
Volume: 295
Issue: 47
Pages: 15988-16001
Publication  
First Author: Guo CG
Year: 2023
Journal: Mol Metab
Title: Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion.
Volume: 79
Pages: 101847
Publication
First Author: Shin SW
Year: 2017
Journal: Nat Commun
Title: Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice.
Volume: 8
Issue: 1
Pages: 1643
Publication
First Author: Beigneux AP
Year: 2004
Journal: J Biol Chem
Title: ATP-citrate lyase deficiency in the mouse.
Volume: 279
Issue: 10
Pages: 9557-64
Publication  
First Author: Kobayashi K
Year: 2023
Journal: Life Sci Alliance
Title: Feto-maternal cholesterol transport regulated by β-Klotho-FGF15 axis is essential for fetal growth.
Volume: 6
Issue: 10
Publication
First Author: Hong AE
Year: 2018
Journal: Mol Cells
Title: PPARα-Target Gene Expression Requires TIS21/BTG2 Gene in Liver of the C57BL/6 Mice under Fasting Condition.
Volume: 41
Issue: 2
Pages: 140-149
Publication
First Author: Seymour AB
Year: 1996
Journal: Genome Res
Title: An integrated genetic map of the pearl locus of mouse chromosome 13.
Volume: 6
Issue: 6
Pages: 538-44
Publication
First Author: Bojanic DD
Year: 2010
Journal: J Lipid Res
Title: Differential expression and function of ABCG1 and ABCG4 during development and aging.
Volume: 51
Issue: 1
Pages: 169-81
Publication
First Author: Fonseca TL
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.
Volume: 112
Issue: 45
Pages: 14018-23
Publication
First Author: Desmazières A
Year: 2008
Journal: J Neurosci
Title: Disruption of Krox20-Nab interaction in the mouse leads to peripheral neuropathy with biphasic evolution.
Volume: 28
Issue: 23
Pages: 5891-900
Publication  
First Author: Jiang M
Year: 2016
Journal: Nat Commun
Title: Regulation of PERK-eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes.
Volume: 7
Pages: 12185
Publication  
First Author: Scortegagna M
Year: 2017
Journal: JCI Insight
Title: The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion.
Volume: 2
Issue: 23
Publication
First Author: Taylor BA
Year: 1993
Journal: Genomics
Title: The MEV mouse linkage testing stock: mapping 30 novel proviral insertions and establishment of an improved stock.
Volume: 16
Issue: 2
Pages: 380-94
Publication
First Author: ÅžiÅŸecioÄŸlu M
Year: 2015
Journal: J Lipid Res
Title: A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.
Volume: 56
Issue: 8
Pages: 1551-9
Publication
First Author: Sacchetti P
Year: 2009
Journal: Cell Stem Cell
Title: Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.
Volume: 5
Issue: 4
Pages: 409-19
Publication
First Author: Briançon N
Year: 2006
Journal: EMBO J
Title: In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping.
Volume: 25
Issue: 6
Pages: 1253-62
Publication
First Author: Lammert F
Year: 2001
Journal: Gastroenterology
Title: Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.
Volume: 120
Issue: 1
Pages: 221-38
Publication
First Author: Warden CH
Year: 1993
Journal: Genomics
Title: Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse.
Volume: 18
Issue: 2
Pages: 295-307
Publication
First Author: Welch CL
Year: 1996
Journal: J Lipid Res
Title: Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes.
Volume: 37
Issue: 7
Pages: 1406-21
Publication  
First Author: Ahuja N
Year: 2022
Journal: Dev Biol
Title: Endothelial Cyp26b1 restrains murine heart valve growth during development.
Volume: 486
Pages: 81-95
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication      
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Acimovic J
Year: 2008
Journal: Biochem Biophys Res Commun
Title: CREM modulates the circadian expression of CYP51, HMGCR and cholesterogenesis in the liver.
Volume: 376
Issue: 1
Pages: 206-10
Protein
Organism: Mus musculus/domesticus
Length: 552  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
Allele  
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; gene trap A005H04, German Gene Trap Consortium
Allele Type: Gene trapped
Strain
Attribute String: congenic, gene trap, mutant strain
Allele
Name: transgene insertion, Laurent Pradier
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion 579, Eugene Lukanidin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 581, Eugene Lukanidin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion L, Peter Staeheli
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 1, Susan M Dymecki
Allele Type: Transgenic
Attribute String: Reporter
Strain
Attribute String: mutant strain, transgenic
Publication
First Author: Liu TF
Year: 2012
Journal: Cell Metab
Title: Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis.
Volume: 16
Issue: 2
Pages: 213-25
Publication
First Author: Hefti HP
Year: 1999
Journal: J Virol
Title: Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections.
Volume: 73
Issue: 8
Pages: 6984-91
Allele
Name: transgene insertion 23, Jean-Pierre Brion
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Publication
First Author: Wirths O
Year: 2001
Journal: Neurosci Lett
Title: Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.
Volume: 306
Issue: 1-2
Pages: 116-20
Publication
First Author: Petiet A
Year: 2012
Journal: Neurobiol Aging
Title: Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice.
Volume: 33
Issue: 8
Pages: 1533-44
Publication
First Author: Delatour B
Year: 2004
Journal: Neurobiol Dis
Title: Alzheimer pathology disorganizes cortico-cortical circuitry: direct evidence from a transgenic animal model.
Volume: 16
Issue: 1
Pages: 41-7
Publication
First Author: Trujillo-Estrada L
Year: 2014
Journal: J Alzheimers Dis
Title: Early neuronal loss and axonal/presynaptic damage is associated with accelerated amyloid-β accumulation in AβPP/PS1 Alzheimer's disease mice subiculum.
Volume: 42
Issue: 2
Pages: 521-41
Publication
First Author: Moreno-Gonzalez I
Year: 2009
Journal: J Alzheimers Dis
Title: Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice.
Volume: 18
Issue: 4
Pages: 755-76
Genotype
Symbol: Tg(Hmgcr-PSEN1*M146L)#Lpr/? Tg(PDGFB-APPSwDutLon)46Lpr/?
Background: involves: C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Ifnar1/Ifnar1 Tg(Hmgcr-MX1)LStae/Tg(Hmgcr-MX1)LStae
Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Hmgcr-MX1)LStae/Tg(Hmgcr-MX1)LStae
Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Jimenez S
Year: 2008
Journal: J Neurosci
Title: Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic.
Volume: 28
Issue: 45
Pages: 11650-61
Publication
First Author: Delatour B
Year: 2006
Journal: Neurobiol Aging
Title: In vivo MRI and histological evaluation of brain atrophy in APP/PS1 transgenic mice.
Volume: 27
Issue: 6
Pages: 835-47
Publication
First Author: Baglietto-Vargas D
Year: 2010
Journal: J Alzheimers Dis
Title: Calretinin interneurons are early targets of extracellular amyloid-beta pathology in PS1/AbetaPP Alzheimer mice hippocampus.
Volume: 21
Issue: 1
Pages: 119-32
Publication
First Author: Baglietto-Vargas D
Year: 2017
Journal: Sci Rep
Title: Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer's disease.
Volume: 7
Issue: 1
Pages: 10085
Publication
First Author: Ramos B
Year: 2006
Journal: Neurobiol Aging
Title: Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease.
Volume: 27
Issue: 11
Pages: 1658-72
Publication
First Author: Fernandez-Valenzuela JJ
Year: 2020
Journal: Sci Rep
Title: Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer's disease model.
Volume: 10
Issue: 1
Pages: 14776
Publication  
First Author: Trujillo-Estrada L
Year: 2013
Journal: Acta Neuropathol Commun
Title: In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.
Volume: 1
Pages: 73
Publication
First Author: Sanchez-Varo R
Year: 2012
Journal: Acta Neuropathol
Title: Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus.
Volume: 123
Issue: 1
Pages: 53-70
Publication
First Author: Latta-Mahieu M
Year: 2018
Journal: Glia
Title: Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-β burden in several amyloid transgenic mouse models.
Volume: 66
Issue: 3
Pages: 492-504
Publication
First Author: Gomez-Arboledas A
Year: 2018
Journal: Glia
Title: Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease.
Volume: 66
Issue: 3
Pages: 637-653
Publication
First Author: Poisnel G
Year: 2012
Journal: Neurobiol Aging
Title: Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease.
Volume: 33
Issue: 9
Pages: 1995-2005
Publication  
First Author: Torres M
Year: 2012
Journal: Mol Neurodegener
Title: Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.
Volume: 7
Pages: 59
Publication
First Author: Rutten BP
Year: 2005
Journal: Am J Pathol
Title: Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice.
Volume: 167
Issue: 1
Pages: 161-73
Publication
First Author: Brion JP
Year: 1999
Journal: Am J Pathol
Title: Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease.
Volume: 154
Issue: 1
Pages: 255-70