| Type |
Details |
Score |
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang J |
| Year: |
2018 |
| Journal: |
Diabetes |
| Title: |
Long Noncoding RNA lncSHGL Recruits hnRNPA1 to Suppress Hepatic Gluconeogenesis and Lipogenesis. |
| Volume: |
67 |
| Issue: |
4 |
| Pages: |
581-593 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun Y |
| Year: |
2020 |
| Journal: |
Nat Commun |
| Title: |
The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
6349 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim HJ |
| Year: |
2013 |
| Journal: |
Nature |
| Title: |
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. |
| Volume: |
495 |
| Issue: |
7442 |
| Pages: |
467-73 |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
127
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Makeyev AV |
| Year: |
2005 |
| Journal: |
J Exp Zool A Comp Exp Biol |
| Title: |
HnRNP A3 genes and pseudogenes in the vertebrate genomes. |
| Volume: |
303 |
| Issue: |
4 |
| Pages: |
259-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
David CJ |
| Year: |
2010 |
| Journal: |
Nature |
| Title: |
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. |
| Volume: |
463 |
| Issue: |
7279 |
| Pages: |
364-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Paronetto MP |
| Year: |
2007 |
| Journal: |
J Cell Biol |
| Title: |
The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x. |
| Volume: |
176 |
| Issue: |
7 |
| Pages: |
929-39 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li ML |
| Year: |
2019 |
| Journal: |
PLoS One |
| Title: |
EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation. |
| Volume: |
14 |
| Issue: |
9 |
| Pages: |
e0221048 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry includes the heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), a nuclear factor that binds to Pol II transcripts. The family of hnRNP proteins is involved in numerous RNA-related activities []. hnRNPA1 is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection []. hnRNPA1 plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform []. This protein binds to the IRES and inhibits the translation of the apoptosis protease activating factor APAF1. During Enterovirus 71 (EV71) infection, APAF1 expression is essential for virus-induced apoptosis and viral particle release [].hnRNPA1 consists of two RNA recognition motifs (RRM1 and RRM2) followed by an unstructured low complexity (LC) C-terminal domain, represented in this entry [, , ]. This domain, shared by hnRNPA1 and hnRNPA2/B1, can mediate protein-protein and protein-RNA interactions and it is involved in amyloid aggregation, leading to neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and multisystem proteinopathy (MSP) [, ]. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kumar P P |
| Year: |
2014 |
| Journal: |
Elife |
| Title: |
Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. |
| Volume: |
3 |
|
|
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE54418 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Farg MA |
| Year: |
2014 |
| Journal: |
Hum Mol Genet |
| Title: |
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. |
| Volume: |
23 |
| Issue: |
13 |
| Pages: |
3579-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao L |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Quaking I controls a unique cytoplasmic pathway that regulates alternative splicing of myelin-associated glycoprotein. |
| Volume: |
107 |
| Issue: |
44 |
| Pages: |
19061-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bengoechea R |
| Year: |
2015 |
| Journal: |
Hum Mol Genet |
| Title: |
Myofibrillar disruption and RNA-binding protein aggregation in a mouse model of limb-girdle muscular dystrophy 1D. |
| Volume: |
24 |
| Issue: |
23 |
| Pages: |
6588-602 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Paces-Fessy M |
| Year: |
2004 |
| Journal: |
Biochem J |
| Title: |
The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. |
| Volume: |
378 |
| Issue: |
Pt 2 |
| Pages: |
353-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim IM |
| Year: |
2014 |
| Journal: |
Circ Res |
| Title: |
β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing. |
| Volume: |
114 |
| Issue: |
5 |
| Pages: |
833-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Heck MV |
| Year: |
2014 |
| Journal: |
Neurogenetics |
| Title: |
Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue. |
| Volume: |
15 |
| Issue: |
2 |
| Pages: |
135-44 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
353
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
341
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
318
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
318
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
155
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
275
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
320
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
320
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
373
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
320
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
320
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
373
 |
| Fragment?: |
false |
|
•
•
•
•
•
|