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Search results 201 to 262 out of 262 for Iapp

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Type Details Score
Publication
27999871 | J:240112
First Author: Courtade JA
Year: 2017
Journal: Diabetologia
Title: Loss of prohormone convertase 2 promotes beta cell dysfunction in a rodent transplant model expressing human pro-islet amyloid polypeptide.
Volume: 60
Issue: 3
Pages: 453-463
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Publication
28808140 | J:256411
First Author: Wijesekara N
Year: 2017
Journal: FASEB J
Title: Amyloid-β and islet amyloid pathologies link Alzheimer's disease and type 2 diabetes in a transgenic model.
Volume: 31
Issue: 12
Pages: 5409-5418
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Publication
34088954 | J:321042
First Author: de Pablo S
Year: 2021
Journal: Sci Rep
Title: 4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity.
Volume: 11
Issue: 1
Pages: 11878
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Allele
Tg(Ins2-IAPP)25-3Rpa | MGI:6188081
Name: transgene insertion 25-3, Richard D Palmiter
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Iapp<tm2(IAPP*S53G)Nole> | MGI:7620150
Name: islet amyloid polypeptide; targeted mutation 2, Norman L Eberhardt
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Iapp-cre)1Oyak/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Publication
26970755 | J:234723
First Author: Wijesekara N
Year: 2016
Journal: Diabetologia
Title: ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice.
Volume: 59
Issue: 6
Pages: 1242-6
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Publication
9588445 | J:133694
First Author: Soeller WC
Year: 1998
Journal: Diabetes
Title: Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide.
Volume: 47
Issue: 5
Pages: 743-50
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Publication
33797777 | J:321044
First Author: Wijesekara N
Year: 2021
Journal: J Pathol
Title: Combination of human tau and islet amyloid polypeptide exacerbates metabolic dysfunction in transgenic mice.
Volume: 254
Issue: 3
Pages: 244-253
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Publication
25036708 | J:215615
First Author: Rivera JF
Year: 2014
Journal: J Clin Invest
Title: Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity.
Volume: 124
Issue: 8
Pages: 3489-500
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Publication
24879150 | J:321046
First Author: Costes S
Year: 2014
Journal: Autophagy
Title: UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy.
Volume: 10
Issue: 6
Pages: 1004-14
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Publication
25036706 | J:213959
First Author: Shigihara N
Year: 2014
Journal: J Clin Invest
Title: Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy.
Volume: 124
Issue: 8
Pages: 3634-44
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Publication
12941770 | J:132530
First Author: Butler AE
Year: 2003
Journal: Diabetes
Title: Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid.
Volume: 52
Issue: 9
Pages: 2304-14
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Publication
33420039 | J:301059
First Author: Kim J
Year: 2021
Journal: Nat Commun
Title: An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer.
Volume: 12
Issue: 1
Pages: 183
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Publication
31984442 | J:289532
First Author: Chen YC
Year: 2020
Journal: Diabetologia
Title: PAM haploinsufficiency does not accelerate the development of diet- and human IAPP-induced diabetes in mice.
Volume: 63
Issue: 3
Pages: 561-576
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Publication
23736544 | J:203209
First Author: Aston-Mourney K
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: One year of sitagliptin treatment protects against islet amyloid-associated β-cell loss and does not induce pancreatitis or pancreatic neoplasia in mice.
Volume: 305
Issue: 4
Pages: E475-84
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Publication
12540610 | J:133246
First Author: Hull RL
Year: 2003
Journal: Diabetes
Title: Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid.
Volume: 52
Issue: 2
Pages: 372-9
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Publication
29474443 | J:259077
First Author: Zhang Y
Year: 2018
Journal: PLoS One
Title: Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling.
Volume: 13
Issue: 2
Pages: e0193184
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Publication
30046852 | J:270225
First Author: Templin AT
Year: 2018
Journal: Diabetologia
Title: Use of the PET ligand florbetapir for in vivo imaging of pancreatic islet amyloid deposits in hIAPP transgenic mice.
Volume: 61
Issue: 10
Pages: 2215-2224
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Publication
27404391 | J:240127
First Author: Hogan MF
Year: 2016
Journal: Endocrinology
Title: Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition in Vitro.
Volume: 157
Issue: 9
Pages: 3462-8
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Publication
28729244 | J:246401
First Author: Templin AT
Year: 2017
Journal: Diabetes
Title: Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation.
Volume: 66
Issue: 10
Pages: 2636-2645
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Publication
22038516 | J:181668
First Author: Subramanian SL
Year: 2012
Journal: Diabetologia
Title: cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets.
Volume: 55
Issue: 1
Pages: 166-74
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Publication
8468047 | J:4235
First Author: Hoovers JM
Year: 1993
Journal: Genomics
Title: High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members.
Volume: 15
Issue: 3
Pages: 525-9
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Publication
14613923 | J:87038
First Author: Andrikopoulos S
Year: 2004
Journal: Am J Physiol Endocrinol Metab
Title: Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide.
Volume: 286
Issue: 3
Pages: E418-24
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Publication
38218538 | J:345944
 
First Author: Mukherjee N
Year: 2024
Journal: Mol Metab
Title: RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes.
Volume: 80
Pages: 101877
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Publication
3181427 | J:17773
First Author: Mosselman S
Year: 1988
Journal: FEBS Lett
Title: Islet amyloid polypeptide: identification and chromosomal localization of the human gene.
Volume: 239
Issue: 2
Pages: 227-32
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Publication
8344641 | J:12922
First Author: Tokuyama Y
Year: 1993
Journal: Horm Metab Res
Title: Islet amyloid polypeptide/amylin contents in pancreata increase in genetically obese and diabetic mice.
Volume: 25
Issue: 6
Pages: 289-91
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Publication
34027899 | J:322286
 
First Author: Xu J
Year: 2021
Journal: JCI Insight
Title: Pancreatic β cell-selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis.
Volume: 6
Issue: 10
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Publication
18633116 | J:142009
First Author: Wong WP
Year: 2008
Journal: Diabetes
Title: Spontaneous diabetes in hemizygous human amylin transgenic mice that developed neither islet amyloid nor peripheral insulin resistance.
Volume: 57
Issue: 10
Pages: 2737-44
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Protein
S4R2C5
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: true
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Protein
A0A0U1RNG0
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: false
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Protein
A0A0U1RNZ0
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: true
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Publication
20835230 | J:164683
First Author: Masters SL
Year: 2010
Journal: Nat Immunol
Title: Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.
Volume: 11
Issue: 10
Pages: 897-904
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Publication
29754817 | J:262839
First Author: Wei Z
Year: 2018
Journal: Cell
Title: Vitamin D Switches BAF Complexes to Protect β Cells.
Volume: 173
Issue: 5
Pages: 1135-1149.e15
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Publication
21813778 | J:179268
First Author: Westwell-Roper C
Year: 2011
Journal: J Immunol
Title: IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction.
Volume: 187
Issue: 5
Pages: 2755-65
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Iapp-cre)1Oyak/?
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Protein
P70160
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: false
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Protein
Q99MP3
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: false
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Protein
Q99JA0
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Protein
Q7TNK8
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
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Protein
Q3V1A7
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: false
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Protein
S4R2N3
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
O88610
Organism: Mus musculus/domesticus
Length: 48  
Fragment?: true
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Protein
Q3UW96
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: false
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Publication
2407732 | -
First Author: Nishi M
Year: 1990
Journal: J Biol Chem
Title: Islet amyloid polypeptide. A new beta cell secretory product related to islet amyloid deposits.
Volume: 265
Issue: 8
Pages: 4173-6
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Protein Domain
IPR018360 | Calcitonin_CS
Type: Conserved_site
Description: Calcitonin []is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in the blood, by promoting the incorporation of these ions in the bones. This is the alpha type. Alternative splicing of the gene coding for calcitonin produces a distantly related peptide of 37 amino acids, called calcitonin gene-related peptide (CGRP), beta type. CGRP induces vasodilatation in a variety of vessels, including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.Islet amyloid polypeptide (IAPP) [](also known as diabetes-associated peptide (DAP), or amylin) is a peptide of 37 amino acids that selectively inhibits insulin-stimulated glucose utilisation and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Structurally, IAPP is closely related to CGRP.Calcitonin receptor-stimulating peptide 1 stimulates cAMP production via the calcitonin receptor.Two conserved cysteines in the N-terminal of these peptides are known to be involved in a disulphide bond. The C-terminal residue of all three peptides is amidated.xCxxxxxCxxxxxxxxxxxxxxxxxxxxxxxxxxxx-NH(2)| | Amide group+-----+'C': conserved cysteine involved in a disulphide bond.
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Protein Domain
IPR021117 | Calcitonin-like
Type: Family
Description: Calcitonin []is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in the blood, by promoting the incorporation of these ions in the bones. This is the alpha type. Alternative splicing of the gene coding for calcitonin produces a distantly related peptide of 37 amino acids, called calcitonin gene-related peptide (CGRP), beta type. CGRP induces vasodilatation in a variety of vessels, including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.Islet amyloid polypeptide (IAPP) [](also known as diabetes-associated peptide (DAP), or amylin) is a peptide of 37 amino acids that selectively inhibits insulin-stimulated glucose utilisation and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Structurally, IAPP is closely related to CGRP.Calcitonin receptor-stimulating peptide 1 stimulates cAMP production via the calcitonin receptor.Two conserved cysteines in the N-terminal of these peptides are known to be involved in a disulphide bond. The C-terminal residue of all three peptides is amidated.xCxxxxxCxxxxxxxxxxxxxxxxxxxxxxxxxxxx-NH(2)| | Amide group+-----+'C': conserved cysteine involved in a disulphide bond.
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Protein Domain
IPR001693 | Calcitonin_peptide-like
Type: Domain
Description: Calcitonin []is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in the blood, by promoting the incorporation of these ions in the bones. This is the alpha type. Alternative splicing of the gene coding for calcitonin produces a distantly related peptide of 37 amino acids, called calcitonin gene-related peptide (CGRP), beta type. CGRP induces vasodilatation in a variety of vessels, including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.Islet amyloid polypeptide (IAPP) [](also known as diabetes-associated peptide (DAP), or amylin) is a peptide of 37 amino acids that selectively inhibits insulin-stimulated glucose utilisation and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Structurally, IAPP is closely related to CGRP.Calcitonin receptor-stimulating peptide 1 stimulates cAMP production via the calcitonin receptor.Two conserved cysteines in the N-terminal of these peptides are known to be involved in a disulphide bond. The C-terminal residue of all three peptides is amidated.xCxxxxxCxxxxxxxxxxxxxxxxxxxxxxxxxxxx-NH(2)| | Amide group+-----+'C': conserved cysteine involved in a disulphide bond.
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Protein Domain
IPR021116 | Calcitonin/adrenomedullin
Type: Family
Description: Calcitonin []is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in the blood, by promoting the incorporation of these ions in the bones. This is the alpha type. Alternative splicing of the gene coding for calcitonin produces a distantly related peptide of 37 amino acids, called calcitonin gene-related peptide (CGRP), beta type. CGRP induces vasodilatation in a variety of vessels, including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.Islet amyloid polypeptide (IAPP) [](also known as diabetes-associated peptide (DAP), or amylin) is a peptide of 37 amino acids that selectively inhibits insulin-stimulated glucose utilisation and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Structurally, IAPP is closely related to CGRP.Calcitonin receptor-stimulating peptide 1 stimulates cAMP production via the calcitonin receptor.Two conserved cysteines in the N-terminal of these peptides are known to be involved in a disulphide bond. The C-terminal residue of all three peptides is amidated.xCxxxxxCxxxxxxxxxxxxxxxxxxxxxxxxxxxx-NH(2)| | Amide group+-----+'C': conserved cysteine involved in a disulphide bond.This entry represents procalcitonin (before cleavage into the calcitonin peptide) and adrenomedullin.
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Publication
3060108 | -
First Author: Breimer LH
Year: 1988
Journal: Biochem J
Title: Peptides from the calcitonin genes: molecular genetics, structure and function.
Volume: 255
Issue: 2
Pages: 377-90
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Publication
35093145 | J:319745
First Author: Zhang G
Year: 2022
Journal: Mol Neurodegener
Title: Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease.
Volume: 17
Issue: 1
Pages: 12
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Publication
25922077 | J:223325
First Author: Oskarsson ME
Year: 2015
Journal: J Biol Chem
Title: Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis.
Volume: 290
Issue: 24
Pages: 15121-32
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Publication
2608057 | J:10204
First Author: Nishi M
Year: 1989
Journal: Mol Endocrinol
Title: Human islet amyloid polypeptide gene: complete nucleotide sequence, chromosomal localization, and evolutionary history.
Volume: 3
Issue: 11
Pages: 1775-81
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Publication
12686466 | J:129094
First Author: Wong HY
Year: 2003
Journal: Regul Pept
Title: Postnatally disturbed pancreatic islet cell distribution in human islet amyloid polypeptide transgenic mice.
Volume: 113
Issue: 1-3
Pages: 89-94
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Publication
21834879 | J:190785
First Author: Westermark GT
Year: 2011
Journal: FEBS J
Title: Localized amyloids important in diseases outside the brain--lessons from the islets of Langerhans and the thoracic aorta.
Volume: 278
Issue: 20
Pages: 3918-29
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Publication
9284894 | J:344055
First Author: Tokuyama T
Year: 1997
Journal: Metabolism
Title: Expression of human islet amyloid polypeptide/amylin impairs insulin secretion in mouse pancreatic beta cells.
Volume: 46
Issue: 9
Pages: 1044-51
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Publication
8078905 | J:344056
First Author: de Koning EJ
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.
Volume: 91
Issue: 18
Pages: 8467-71
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Publication
8168639 | J:344057
First Author: de Koning EJ
Year: 1994
Journal: Diabetes
Title: Human islet amyloid polypeptide accumulates at similar sites in islets of transgenic mice and humans.
Volume: 43
Issue: 5
Pages: 640-4
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Publication
37806486 | J:341479
 
First Author: Onodera T
Year: 2023
Journal: Mol Metab
Title: Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells.
Volume: 78
Pages: 101821
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Publication
25036705 | J:213960
First Author: Kim J
Year: 2014
Journal: J Clin Invest
Title: Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes.
Volume: 124
Issue: 8
Pages: 3311-24
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Protein
P97297
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Publication
9833947 | J:344054
First Author: Ahrén B
Year: 1998
Journal: Diabetologia
Title: Transgenic overexpression of human islet amyloid polypeptide inhibits insulin secretion and glucose elimination after gastric glucose gavage in mice.
Volume: 41
Issue: 11
Pages: 1374-80
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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