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Search results 201 to 216 out of 216 for Icmt

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0.022s

Type

Details

Score

Allele

Icmt<tm1Sgy> | MGI:2680650

Name:	isoprenylcysteine carboxyl methyltransferase; targeted mutation 1, Stephen G Young
Allele Type:	Targeted
Attribute String:	Null/knockout

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Interaction Experiment

Bergo MO (2004)

Description:

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.

•

Allele

Hprt1<tm59(Ple123-lacZ)Ems> | MGI:4834875

Name:	hypoxanthine phosphoribosyltransferase 1; targeted mutation 59, Elizabeth M Simpson
Allele Type:	Targeted

•

Publication

11451995 | -

First Author:	Romano JD
Year:	2001
Journal:	Mol Biol Cell
Title:	Topological and mutational analysis of Saccharomyces cerevisiae Ste14p, founding member of the isoprenylcysteine carboxyl methyltransferase family.
Volume:	12
Issue:	7
Pages:	1957-71

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Publication

22195972 | -

First Author:	Yang J
Year:	2011
Journal:	Mol Cell
Title:	Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT.
Volume:	44
Issue:	6
Pages:	997-1004

•

Protein Domain

IPR007269 | ICMT_MeTrfase

Type:

Family

Description:

The isoprenylcysteine o-methyltransferase () carries out carboyxl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae, this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology [].This entry also includes ICMT from Methanosarcina acetivorans (). It comprises a core of five transmembrane α-helices and a cofactor-binding pocket enclosed within a highly conserved C-terminal catalytic subdomain [].

•

Strain

MGI:4835701 | B6.129P2(Cg)-Hprt1<tm59(Ple123-lacZ)Ems>/Mmjax

Attribute String:

congenic, mutant strain, targeted mutation

•

Genotype

Symbol:	Hprt1/?
Background:	B6.129P2(Cg)-Hprt1/Mmjax
Zygosity:	ot
Has Mutant Allele:	true

•

Protein

Q9EQK7

Organism:	Mus musculus/domesticus
Length:	283
Fragment?:	false

•

Protein

Q3U4N2

Organism:	Mus musculus/domesticus
Length:	284
Fragment?:	false

•

Publication

17652517 | J:123768

First Author:	Coffinier C
Year:	2007
Journal:	Proc Natl Acad Sci U S A
Title:	HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells.
Volume:	104
Issue:	33
Pages:	13432-7

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Publication

15659645 | J:99222

First Author:	Michaelson D
Year:	2005
Journal:	Mol Biol Cell
Title:	Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases.
Volume:	16
Issue:	4
Pages:	1606-16

•

Publication

24761428 | J:212452

First Author:	de Leeuw CN
Year:	2014
Journal:	Mol Ther Methods Clin Dev
Title:	Targeted CNS Delivery Using Human MiniPromoters and Demonstrated Compatibility with Adeno-Associated Viral Vectors.
Volume:	1

Pages:	5

•

Publication

18950699 | J:144244

First Author:	Yang GS
Year:	2009
Journal:	Genomics
Title:	Next generation tools for high-throughput promoter and expression analysis employing single-copy knock-ins at the Hprt1 locus.
Volume:	93
Issue:	3
Pages:	196-204

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Publication

- | J:145689

First Author:	The Pleiades Promoter Project
Year:	2009
Journal:	MGI Direct Data Submission
Title:	Generation of reporter and cre-expressing targeted transgenic mice in the Hprt1 gene using human MiniPromoters that drive region- and cell-specific gene expression in the mouse brain

•

Publication

20807748 | J:164356

First Author:	Portales-Casamar E
Year:	2010
Journal:	Proc Natl Acad Sci U S A
Title:	A regulatory toolbox of MiniPromoters to drive selective expression in the brain.
Volume:	107
Issue:	38
Pages:	16589-94

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