Type |
Details |
Score |
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
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•
•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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•
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•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
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•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
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•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
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•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
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•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Aghayev T |
Year: |
2022 |
Journal: |
Cancer Discov |
Title: |
IL27 Signaling Serves as an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma. |
Volume: |
12 |
Issue: |
8 |
Pages: |
1960-1983 |
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•
•
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Allele |
Name: |
interleukin 27; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
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Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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Publication |
First Author: |
Batten M |
Year: |
2007 |
Journal: |
J Mol Med (Berl) |
Title: |
The biology and therapeutic potential of interleukin 27. |
Volume: |
85 |
Issue: |
7 |
Pages: |
661-72 |
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•
•
•
•
•
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Publication |
First Author: |
Fakruddin JM |
Year: |
2007 |
Journal: |
Blood |
Title: |
Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27. |
Volume: |
109 |
Issue: |
5 |
Pages: |
1841-9 |
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•
•
•
•
•
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Publication |
First Author: |
Feng XM |
Year: |
2007 |
Journal: |
Hum Immunol |
Title: |
Interleukin-27 upregulates major histocompatibility complex class II expression in primary human endothelial cells through induction of major histocompatibility complex class II transactivator. |
Volume: |
68 |
Issue: |
12 |
Pages: |
965-72 |
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Protein Domain |
Type: |
Family |
Description: |
This entry represents IL27-A proteins (known as IL-30/IL27-p28). Interleukin-27 is a heterodimeric cytokine composed of two subunits; IL27-A (IL27-p28) and Epstein-Barr virus-induced gene 3 (EBI3, also known as IL-27B) []. IL27 is a cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells []. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replivation [, ]. |
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Publication |
First Author: |
Murphy B |
Year: |
2024 |
Journal: |
J Exp Med |
Title: |
Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer. |
Volume: |
221 |
Issue: |
12 |
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•
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•
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Publication |
First Author: |
Mire MM |
Year: |
2024 |
Journal: |
Viruses |
Title: |
Respiratory Virus-Induced PARP1 Alters DC Metabolism and Antiviral Immunity Inducing Pulmonary Immunopathology. |
Volume: |
16 |
Issue: |
6 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
234
 |
Fragment?: |
false |
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Publication |
First Author: |
Rowse AL |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Lithium controls central nervous system autoimmunity through modulation of IFN-γ signaling. |
Volume: |
7 |
Issue: |
12 |
Pages: |
e52658 |
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•
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Publication |
First Author: |
Bockerstett KA |
Year: |
2020 |
Journal: |
Cell Mol Gastroenterol Hepatol |
Title: |
Interleukin 27 Protects From Gastric Atrophy and Metaplasia During Chronic Autoimmune Gastritis. |
Volume: |
10 |
Issue: |
3 |
Pages: |
561-579 |
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•
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Publication |
First Author: |
Chitu V |
Year: |
2015 |
Journal: |
Neurobiol Dis |
Title: |
Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP). |
Volume: |
74 |
|
Pages: |
219-28 |
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Publication |
First Author: |
Mota EA |
Year: |
2020 |
Journal: |
PLoS Negl Trop Dis |
Title: |
Epigenetic and parasitological parameters are modulated in EBi3-/- mice infected with Schistosoma mansoni. |
Volume: |
14 |
Issue: |
2 |
Pages: |
e0008080 |
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Publication |
First Author: |
Canale FP |
Year: |
2018 |
Journal: |
Cancer Res |
Title: |
CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8+ T Cells. |
Volume: |
78 |
Issue: |
1 |
Pages: |
115-128 |
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Publication |
First Author: |
Lavoie S |
Year: |
2020 |
Journal: |
Gastroenterology |
Title: |
Expression of Free Fatty Acid Receptor 2 by Dendritic Cells Prevents Their Expression of Interleukin 27 and Is Required for Maintenance of Mucosal Barrier and Immune Response Against Colorectal Tumors in Mice. |
Volume: |
158 |
Issue: |
5 |
Pages: |
1359-1372.e9 |
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