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Search results 201 to 239 out of 239 for Inpp5b

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Type Details Score
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
22072788 | -
First Author: Bohdanowicz M
Year: 2012
Journal: Mol Biol Cell
Title: Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling.
Volume: 23
Issue: 1
Pages: 176-87
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Protein
F2Z437
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: true
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Protein
A0A0A0MQG5
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: true
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Publication
7721860 | -
First Author: Jefferson AB
Year: 1995
Journal: J Biol Chem
Title: Properties of type II inositol polyphosphate 5-phosphatase.
Volume: 270
Issue: 16
Pages: 9370-7
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Protein Domain
IPR031896 | INPP5B_PH_dom
Type: Domain
Description: This entry represents the PH domain found in the N terminus of type II inositol 1,4,5-trisphosphate 5-phosphatase (INPP5B). The structure of this domain has been revealed []. INPP5B hydrolyses phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signalling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signalling events [].INPP5B contains a PH domain, a 5-phosphatase domain, an ASH domain and a Rho-GAP domain. It shares ~45% sequence identity with OCRL1 (not included in this entry) and has the same domain organization. However, a loop in the Rho GAP domain contains a second clathrin box which is absent in INPP5B. INPP5B shares most interacting partners with OCRL, except for clathrin and the endocytic clathrin adaptor AP-2 [].
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Publication
22381590 | -
First Author: Pirruccello M
Year: 2012
Journal: Trends Biochem Sci
Title: Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL.
Volume: 37
Issue: 4
Pages: 134-43
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Publication
19536138 | -
First Author: Mao Y
Year: 2009
Journal: EMBO J
Title: A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism.
Volume: 28
Issue: 13
Pages: 1831-42
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Protein Domain
IPR037793 | OCRL1/INPP5B_INPP5c
Type: Domain
Description: OCRL1 hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events []. OCRL1 resides on vesicular structures throughout the endosomal system and the Golgi complex, and is also present at the plasma membrane in membrane ruffles and at late-stage endocytic clathrin-coated pits. It binds clathrin, clathrin adaptors, several GTPases, and the endocytic proteins APPL1 and Ses1/2 []. Mutations in the OCRL1 gene cause Lowe Syndrome, leading to cataracts, mental retardation and renal failure []. Mutations in OCRL can also give rise to a milder pathology, Dent disease 2, which is characterised by renal Fanconi syndrome in the absence of extrarenal pathologies [].OCRL1 shares ~45% sequence identity with INPP5B and has the same domain organization. However, a loop in the Rho GAP domain contains a second clathrin box which is absent in INPP5B. INPP5B shares most interacting partners with OCRL, except for clathrin and the endocytic clathrin adaptor AP-2 []. OCRL1 contains a PH domain, a 5-phosphatase domain, an ASH domain and a Rho-GAP domain. The RhoGAP domain lacks the catalytic arginine and is catalytically inactive. However, the RhoGAP domain of OCRL interacts with Rac and Cdc42, but only the Cdc42 interaction is GTP-dependent. The RhoGAP domain also interacts with three endocytic proteins containing the F&H motif: APPL1, Ses1 and Ses2. OCRL1 interacts with Rab GTPase (Rab8) through its ASH domain []. This entry represents the inositol polyphosphate 5-phosphatase (INPP5c) domain of OCRL1/INPP5B.
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Publication
21901156 | -
First Author: Grieve AG
Year: 2011
Journal: PLoS One
Title: Lowe Syndrome protein OCRL1 supports maturation of polarized epithelial cells.
Volume: 6
Issue: 8
Pages: e24044
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Publication
21971085 | -
First Author: Vicinanza M
Year: 2011
Journal: EMBO J
Title: OCRL controls trafficking through early endosomes via PtdIns4,5Pâ‚‚-dependent regulation of endosomal actin.
Volume: 30
Issue: 24
Pages: 4970-85
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Publication
28669993 | -
First Author: De Matteis MA
Year: 2017
Journal: Nat Rev Nephrol
Title: The 5-phosphatase OCRL in Lowe syndrome and Dent disease 2.
Volume: 13
Issue: 8
Pages: 455-470
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Protein Domain
IPR037787 | OCRL1_PH
Type: Domain
Description: OCRL1 hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events []. OCRL1 resides on vesicular structures throughout the endosomal system and the Golgi complex, and is also present at the plasma membrane in membrane ruffles and at late-stage endocytic clathrin-coated pits. It binds clathrin, clathrin adaptors, several GTPases, and the endocytic proteins APPL1 and Ses1/2 []. Mutations in the OCRL1 gene cause Lowe Syndrome, leading to cataracts, mental retardation and renal failure []. Mutations in OCRL can also give rise to a milder pathology, Dent disease 2, which is characterised by renal Fanconi syndrome in the absence of extrarenal pathologies [].OCRL1 shares ~45% sequence identity with INPP5B (not included in this entry) and has the same domain organization. However, a loop in the Rho GAP domain contains a second clathrin box which is absent in INPP5B. INPP5B shares most interacting partners with OCRL, except for clathrin and the endocytic clathrin adaptor AP-2 []. OCRL1 contains a PH domain, a 5-phosphatase domain, an ASH domain and a Rho-GAP domain. The RhoGAP domain lacks the catalytic arginine and is catalytically inactive. However, the RhoGAP domain of OCRL interacts with Rac and Cdc42, but only the Cdc42 interaction is GTP-dependent. The RhoGAP domain also interacts with three endocytic proteins containing the F&H motif: APPL1, Ses1 and Ses2. OCRL1 interacts with Rab GTPase (Rab8) through its ASH domain []. This entry represents the PH domain of OCRL1 []. The PH domain connects to the 5-phosphatase domain, which has a Dnase I-like fold [].
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Protein
Q8BXT3
Organism: Mus musculus/domesticus
Length: 511  
Fragment?: false
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Protein
Q8K337
Organism: Mus musculus/domesticus
Length: 993  
Fragment?: false
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Protein
A0A2X0SG17
Organism: Mus musculus/domesticus
Length: 995  
Fragment?: true
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Protein
Q6NVF0
Organism: Mus musculus/domesticus
Length: 900  
Fragment?: false
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Protein
Q9DBW2
Organism: Mus musculus/domesticus
Length: 757  
Fragment?: true
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