|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 245 out of 245 for Irak4

<< First    < Previous  |  Next >    Last >>
0.022s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 209
Description: Phosphothreonine; by IRAK4
Type: modified residue
End: 209
•
•
•
•
•
Allele
Irak4<tm1Gram> | MGI:3712883
 
Name: interleukin-1 receptor-associated kinase 4; targeted mutation 1, Hermann Gram
Allele Type: Targeted
•
•
•
•
•
Allele
Irak4<tm1Lix> | MGI:3762911
Name: interleukin-1 receptor-associated kinase 4; targeted mutation 1, Xiaoxia Li
Allele Type: Targeted
Attribute String: Not Specified
•
•
•
•
•
Publication
31197259 | J:284049
First Author: Giménez N
Year: 2020
Journal: Leukemia
Title: Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia.
Volume: 34
Issue: 1
Pages: 100-114
•
•
•
•
•
Publication
34954030 | J:341284
 
First Author: Wu X
Year: 2022
Journal: Pharmacol Res
Title: Pharmacological inhibition of IRAK1 and IRAK4 prevents endothelial inflammation and atherosclerosis in ApoE(-/-) mice.
Volume: 175
Pages: 106043
•
•
•
•
•
Publication
31011167 | J:282896
First Author: Smith MA
Year: 2019
Journal: Nat Cell Biol
Title: U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies.
Volume: 21
Issue: 5
Pages: 640-650
•
•
•
•
•
Publication
28924041 | J:248506
First Author: Cushing L
Year: 2017
Journal: J Biol Chem
Title: IRAK4 kinase activity controls Toll-like receptor-induced inflammation through the transcription factor IRF5 in primary human monocytes.
Volume: 292
Issue: 45
Pages: 18689-18698
•
•
•
•
•
Publication
33508385 | J:303934
 
First Author: Bourn JR
Year: 2021
Journal: Cancer Lett
Title: Tumor cell intrinsic RON signaling suppresses innate immune responses in breast cancer through inhibition of IRAK4 signaling.
Volume: 503
Pages: 75-90
•
•
•
•
•
Publication
31354711 | J:281852
 
First Author: Celhar T
Year: 2019
Journal: Front Immunol
Title: TLR7 Protein Expression in Mild and Severe Lupus-Prone Models Is Regulated in a Leukocyte, Genetic, and IRAK4 Dependent Manner.
Volume: 10
Pages: 1546
•
•
•
•
•
Allele
Ccl24<em1Smoc> | MGI:7288704
Name: C-C motif chemokine ligand 24; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Strain
MGI:6429002 | C57BL/6JSmoc-Irak4<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
•
•
•
•
•
Publication
17878374 | -
First Author: Hoarau C
Year: 2007
Journal: J Immunol
Title: TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway.
Volume: 179
Issue: 7
Pages: 4754-65
•
•
•
•
•
Protein Domain
IPR037970 | IRAK4_Death
Type: Domain
Description: IRAK4 is a serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens []. It is required for the efficient recruitment of IRAK1 to the interleukin-1 (IL-1) receptor complex following IL-1 engagement, triggering intracellular signalling cascades leading to transcriptional up-regulation and mRNA stabilisation [, ]. IRAK4 phosphorylates IRAK1. Pellino-2 may be a substrate for both IRAK1 and IRAK4 [].This entry represents the Death domain of IRAK4.DDs (Death domains) are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [, ].
•
•
•
•
•
Protein
Q9D250
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: false
•
•
•
•
•
Publication
22059479 | J:192069
First Author: Ohba T
Year: 2012
Journal: FEBS J
Title: Identification of interleukin-1 receptor-associated kinase 1 as a critical component that induces post-transcriptional activation of IκB-ζ.
Volume: 279
Issue: 2
Pages: 211-22
•
•
•
•
•
Publication
15492225 | J:93531
First Author: Honda K
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling.
Volume: 101
Issue: 43
Pages: 15416-21
•
•
•
•
•
Publication
38605168 | J:349807
First Author: Liu Y
Year: 2024
Journal: Cell Death Differ
Title: OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation.
Volume: 31
Issue: 6
Pages: 753-767
•
•
•
•
•
HT Experiment
E-MTAB-8185 | RNA-seq of inflammatory monocytes, patrolling monocytes and neutrophils in wild type and ABIN1[D485N] mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Publication
20304961 | J:160770
First Author: Mirza MK
Year: 2010
Journal: Am J Pathol
Title: Caveolin-1 deficiency dampens Toll-like receptor 4 signaling through eNOS activation.
Volume: 176
Issue: 5
Pages: 2344-51
•
•
•
•
•
Publication
31507610 | J:284386
 
First Author: Kato T
Year: 2019
Journal: Front Immunol
Title: Interleukin-1/-33 Signaling Pathways as Therapeutic Targets for Endometriosis.
Volume: 10
Pages: 2021
•
•
•
•
•
Publication
29728508 | J:263319
First Author: Li J
Year: 2018
Journal: J Immunol
Title: Small Molecule Mimetics of α-Helical Domain of IRAK2 Attenuate the Proinflammatory Effects of IL-33 in Asthma-like Mouse Models.
Volume: 200
Issue: 12
Pages: 4036-4043
•
•
•
•
•
Publication
22158417 | J:203182
First Author: Heinz LX
Year: 2012
Journal: Cell Death Differ
Title: The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade.
Volume: 19
Issue: 4
Pages: 722-31
•
•
•
•
•
Publication
25642772 | J:220557
First Author: Li Z
Year: 2015
Journal: J Clin Invest
Title: Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies.
Volume: 125
Issue: 3
Pages: 1081-97
•
•
•
•
•
Publication
26140693 | J:233059
First Author: Srivastav S
Year: 2015
Journal: Eur J Immunol
Title: IRAK-M regulates the inhibition of TLR-mediated macrophage immune response during late in vitro Leishmania donovani infection.
Volume: 45
Issue: 10
Pages: 2787-97
•
•
•
•
•
Publication
29363544 | J:260726
First Author: Zhang D
Year: 2018
Journal: Cancer Res
Title: Tumor-Stroma IL1β-IRAK4 Feedforward Circuitry Drives Tumor Fibrosis, Chemoresistance, and Poor Prognosis in Pancreatic Cancer.
Volume: 78
Issue: 7
Pages: 1700-1712
•
•
•
•
•
Publication
31694920 | J:284888
 
First Author: Nanda SK
Year: 2019
Journal: Life Sci Alliance
Title: Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice.
Volume: 2
Issue: 6
•
•
•
•
•
Publication
36408944 | J:332170
First Author: McCrory EH
Year: 2022
Journal: Biochem J
Title: Identification of ester-linked ubiquitylation sites during TLR7 signalling increases the number of inter-ubiquitin linkages from 8 to 12.
Volume: 479
Issue: 23
Pages: 2419-2431
•
•
•
•
•
Publication
32434410 | J:317990
First Author: Banerjee M
Year: 2020
Journal: Arterioscler Thromb Vasc Biol
Title: Platelets Endocytose Viral Particles and Are Activated via TLR (Toll-Like Receptor) Signaling.
Volume: 40
Issue: 7
Pages: 1635-1650
•
•
•
•
•
Publication
23986494 | J:201048
First Author: Emmerich CH
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.
Volume: 110
Issue: 38
Pages: 15247-52
•
•
•
•
•
Publication
21283748 | J:223710
First Author: Kissner TL
Year: 2011
Journal: PLoS One
Title: Activation of MyD88 signaling upon staphylococcal enterotoxin binding to MHC class II molecules.
Volume: 6
Issue: 1
Pages: e15985
•
•
•
•
•
Publication
38904012 | J:361162
First Author: Yue C
Year: 2024
Journal: Int J Biol Sci
Title: IL-38 Aggravates Atopic Dermatitis via Facilitating Migration of Langerhans cells.
Volume: 20
Issue: 8
Pages: 3094-3112
•
•
•
•
•
Publication
7482697 | -
First Author: Feinstein E
Year: 1995
Journal: Trends Biochem Sci
Title: The death domain: a module shared by proteins with diverse cellular functions.
Volume: 20
Issue: 9
Pages: 342-4
•
•
•
•
•
Publication
17201679 | -
 
First Author: Park HH
Year: 2007
Journal: Annu Rev Immunol
Title: The death domain superfamily in intracellular signaling of apoptosis and inflammation.
Volume: 25
Pages: 561-86
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom