Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:1204946 |
Assay Type: |
RT-PCR |
Annotation Date: |
1998-06-01 |
Strength: |
Absent |
Sex: |
Pooled |
Emaps: |
EMAPS:3515128 |
|
Stage: |
TS28 |
Assay Id: |
MGI:1204948 |
Age: |
postnatal week 6-8 |
Image: |
st96_334 |
|
Specimen Label: |
None |
Detected: |
false |
Specimen Num: |
35 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1204946 |
Assay Type: |
RT-PCR |
Annotation Date: |
1998-06-01 |
Strength: |
Absent |
Sex: |
Pooled |
Emaps: |
EMAPS:3528528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:1204948 |
Age: |
postnatal week 6-8 |
Image: |
st96_334 |
|
Specimen Label: |
None |
Detected: |
false |
Specimen Num: |
36 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1204946 |
Assay Type: |
RT-PCR |
Annotation Date: |
1998-06-01 |
Strength: |
Absent |
Sex: |
Pooled |
Emaps: |
EMAPS:3514028 |
|
Stage: |
TS28 |
Assay Id: |
MGI:1204948 |
Age: |
postnatal week 6-8 |
Image: |
st96_334 |
|
Specimen Label: |
None |
Detected: |
false |
Specimen Num: |
37 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1204946 |
Assay Type: |
RT-PCR |
Annotation Date: |
1998-06-01 |
Strength: |
Absent |
Sex: |
Pooled |
Emaps: |
EMAPS:1876828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:1204948 |
Age: |
postnatal week 6-8 |
Image: |
st96_334 |
|
Specimen Label: |
None |
Detected: |
false |
Specimen Num: |
38 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1204946 |
Assay Type: |
RT-PCR |
Annotation Date: |
1998-06-01 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1775928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:1204948 |
Age: |
postnatal week 6-8 |
Image: |
st96_334 |
|
Specimen Label: |
None |
Detected: |
false |
Specimen Num: |
39 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1204946 |
Assay Type: |
RT-PCR |
Annotation Date: |
1998-06-01 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1775928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:1204948 |
Age: |
postnatal week 6-8 |
Image: |
st96_334 |
|
Specimen Label: |
None |
Detected: |
false |
Specimen Num: |
40 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1204946 |
Assay Type: |
RT-PCR |
Annotation Date: |
1998-06-01 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:1204948 |
Age: |
postnatal week 6-8 |
Image: |
st96_334 |
|
Specimen Label: |
None |
Detected: |
false |
Specimen Num: |
41 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1204946 |
Assay Type: |
RT-PCR |
Annotation Date: |
1998-06-01 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1929028 |
|
Stage: |
TS28 |
Assay Id: |
MGI:1204948 |
Age: |
postnatal week 6-8 |
Image: |
st96_334 |
|
Specimen Label: |
None |
Detected: |
false |
Specimen Num: |
42 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1204946 |
Assay Type: |
RT-PCR |
Annotation Date: |
1998-06-01 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:1204948 |
Age: |
postnatal week 6-8 |
Image: |
st96_334 |
|
Specimen Label: |
None |
Detected: |
true |
Specimen Num: |
43 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1204946 |
Assay Type: |
RT-PCR |
Annotation Date: |
1998-06-01 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2992728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:1204948 |
Age: |
postnatal week 6-8 |
Image: |
st96_334 |
|
Specimen Label: |
None |
Detected: |
true |
Specimen Num: |
44 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1204946 |
Assay Type: |
RT-PCR |
Annotation Date: |
1998-06-01 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3568928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:1204948 |
Age: |
postnatal week 6-8 |
Image: |
st96_334 |
|
Specimen Label: |
None |
Detected: |
true |
Specimen Num: |
45 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1204946 |
Assay Type: |
RT-PCR |
Annotation Date: |
1998-06-01 |
Strength: |
Absent |
Sex: |
Pooled |
Emaps: |
EMAPS:1603923 |
|
Stage: |
TS23 |
Assay Id: |
MGI:1204948 |
Age: |
embryonic day 15-16 |
Image: |
st96_334 |
|
Specimen Label: |
None |
Detected: |
false |
Specimen Num: |
46 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7336868 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-09-21 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:2828127 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:7336877 |
Age: |
postnatal day 0 |
Image: |
4B P0 |
|
Specimen Label: |
4B P0 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7336868 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-09-21 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:2800323 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:7336877 |
Age: |
embryonic day 15.5 |
Image: |
4B E15.5 |
|
Specimen Label: |
4B E15.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Aravind L |
Year: |
2004 |
Journal: |
Genome Biol |
Title: |
A novel family of P-loop NTPases with an unusual phyletic distribution and transmembrane segments inserted within the NTPase domain. |
Volume: |
5 |
Issue: |
5 |
Pages: |
R30 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
121
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuhn F |
Year: |
1999 |
Journal: |
Mech Dev |
Title: |
Pmg-1 and pmg-2 constitute a novel family of KAP genes differentially expressed during skin and mammary gland development. |
Volume: |
86 |
Issue: |
1-2 |
Pages: |
193-6 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
NTPase KAP family P-loop domain-containing protein 1 |
Type: |
chain |
End: |
599 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Rogers MA |
Year: |
2005 |
Journal: |
J Invest Dermatol |
Title: |
Human KAP genes, only the half of it? Extensive size polymorphisms in hair keratin-associated protein genes. |
Volume: |
124 |
Issue: |
6 |
Pages: |
vii-ix |
|
•
•
•
•
•
|
Allele |
Name: |
angiotensin I converting enzyme; targeted mutation 4, Kenneth E Bernstein |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion L49, Anna Meseguer |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
NTPase, KAP family P-loop domain containing 1; wild type |
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
211
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
315
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
NTPase, KAP family P-loop domain containing 1; endonuclease-mediated mutation 1, Jackson |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
NTPase, KAP family P-loop domain containing 1; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
419
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Chinami M |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2. |
Volume: |
280 |
Issue: |
17 |
Pages: |
17235-42 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1554
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1693
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1793
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1182
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1672
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1672
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1763
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Rosmalen JG |
Year: |
2000 |
Journal: |
Lab Invest |
Title: |
Islet abnormalities associated with an early influx of dendritic cells and macrophages in NOD and NODscid mice. |
Volume: |
80 |
Issue: |
5 |
Pages: |
769-77 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nkpd1/Nkpd1 |
Background: |
C57BL/6NJ-Nkpd1/Mmjax |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Nelson LM |
Year: |
2003 |
Journal: |
Virology |
Title: |
The L1 major capsid protein of human papillomavirus type 11 interacts with Kap beta2 and Kap beta3 nuclear import receptors. |
Volume: |
306 |
Issue: |
1 |
Pages: |
162-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
61
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gong H |
Year: |
2014 |
Journal: |
Springerplus |
Title: |
The sheep KAP8-2 gene, a new KAP8 family member that is absent in humans. |
Volume: |
3 |
|
Pages: |
528 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gong H |
Year: |
2016 |
Journal: |
Genes (Basel) |
Title: |
Wool Keratin-Associated Protein Genes in Sheep-A Review. |
Volume: |
7 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The keratin-associated proteins (KAPs) are fundamental components of hair and wool fibres []. This entry represents KRTAP8-1, which is a high sulphur (HS) KAP []. |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1827/1, Curt Sigmund |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Yoshitaka Isaka |
Allele Type: |
Transgenic |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 64.9, Mouse Clinical Institute |
Allele Type: |
Transgenic |
Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
Publication |
First Author: |
Donato JL |
Year: |
2002 |
Journal: |
J Clin Invest |
Title: |
Human HTm4 is a hematopoietic cell cycle regulator. |
Volume: |
109 |
Issue: |
1 |
Pages: |
51-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kutok JL |
Year: |
2011 |
Journal: |
J Cell Mol Med |
Title: |
Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues. |
Volume: |
15 |
Issue: |
1 |
Pages: |
86-93 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Membrane-spanning 4-domains subfamily A member 3 (MS4A3), also known as HTm4, is an hematopoietic modulator for the G1-S cell cycle transition []. HTm4 binds to the Cdk-associated Phosphatase (KAP)-Cdk2-Cyclin A complex, triggering the dissociation of cyclin A and facilitating dephosphorylation of Cdk2 by KAP [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Ding Y |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. |
Volume: |
272 |
Issue: |
44 |
Pages: |
28142-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song T |
Year: |
2018 |
Journal: |
Kaohsiung J Med Sci |
Title: |
miR-17-92 ameliorates renal ischemia reperfusion injury. |
Volume: |
34 |
Issue: |
5 |
Pages: |
263-273 |
|
•
•
•
•
•
|
Publication |
First Author: |
de Quixano BB |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Kidney Androgen-Regulated Protein (KAP) Transgenic Mice Are Protected Against High-Fat Diet Induced Metabolic Syndrome. |
Volume: |
7 |
Issue: |
1 |
Pages: |
16102 |
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Publication |
First Author: |
Ding Y |
Year: |
2001 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice. |
Volume: |
280 |
Issue: |
1 |
Pages: |
F54-60 |
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Allele |
Name: |
transgene insertion 562, Didier Portilla |
Allele Type: |
Transgenic |
Attribute String: |
Inducible, Inserted expressed sequence |
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Publication |
First Author: |
Li S |
Year: |
2009 |
Journal: |
Kidney Int |
Title: |
Transgenic expression of proximal tubule peroxisome proliferator-activated receptor-alpha in mice confers protection during acute kidney injury. |
Volume: |
76 |
Issue: |
10 |
Pages: |
1049-62 |
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Publication |
First Author: |
Li S |
Year: |
2013 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction. |
Volume: |
305 |
Issue: |
5 |
Pages: |
F618-27 |
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Publication |
First Author: |
Clar J |
Year: |
2014 |
Journal: |
Kidney Int |
Title: |
Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy. |
Volume: |
86 |
Issue: |
4 |
Pages: |
747-56 |
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Strain |
Attribute String: |
congenic, mutant strain, transgenic |
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Genotype |
Symbol: |
Tg(Kap-Ppara/AGT)562Dpo/? |
Background: |
Not Specified |
Zygosity: |
ot |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
G6pc1/G6pc1 Tg(Kap-cre/ERT2)64.9Ics/? |
Background: |
involves: 129S2/SvPas * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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Publication |
First Author: |
Ramos D |
Year: |
2019 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Vascular Interstitial Cells in Retinal Arteriolar Annuli Are Altered During Hypertension. |
Volume: |
60 |
Issue: |
2 |
Pages: |
473-487 |
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•
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Publication |
First Author: |
Minami S |
Year: |
2017 |
Journal: |
Autophagy |
Title: |
Lipophagy maintains energy homeostasis in the kidney proximal tubule during prolonged starvation. |
Volume: |
13 |
Issue: |
10 |
Pages: |
1629-1647 |
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Publication |
First Author: |
Takahashi A |
Year: |
2017 |
Journal: |
Diabetes |
Title: |
Autophagy Inhibits the Accumulation of Advanced Glycation End Products by Promoting Lysosomal Biogenesis and Function in the Kidney Proximal Tubules. |
Volume: |
66 |
Issue: |
5 |
Pages: |
1359-1372 |
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•
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•
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Publication |
First Author: |
Maejima I |
Year: |
2013 |
Journal: |
EMBO J |
Title: |
Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury. |
Volume: |
32 |
Issue: |
17 |
Pages: |
2336-47 |
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