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Search results 201 to 283 out of 283 for Kcnh2

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:2684595
Assay Type: RNA in situ
Annotation Date: 2004-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:2684598
Age: embryonic day 13.5
Specimen Label: Table 1, E13.5
Detected: true
Specimen Num: 23
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GXD Expression
GXD Expression
 
Probe: MGI:2684595
Assay Type: RNA in situ
Annotation Date: 2004-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:2684598
Age: embryonic day 13.5
Image: 3G
Specimen Label: 3G
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
   
Probe: MGI:2684595
Assay Type: RNA in situ
Annotation Date: 2004-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:2684598
Age: embryonic day 13.5
Specimen Label: Table 1, E13.5
Detected: true
Specimen Num: 23
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GXD Expression
GXD Expression
 
Probe: MGI:6188882
Assay Type: Immunohistochemistry
Annotation Date: 2018-07-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Not Specified
Stage: TS02
Assay Id: MGI:6188886
Age: embryonic day 1.5
Note: Expression is increasingly located in the nucleus and the nuclear and plasma membranes and is weaker in the cytoplasm.
Specimen Label: 5E
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:6188882
Assay Type: Immunohistochemistry
Annotation Date: 2018-07-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Not Specified
Stage: TS02
Assay Id: MGI:6188886
Age: embryonic day 1.0
Note: Expression is mainly cytoplasmic.
Specimen Label: 5D
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:6188882
Assay Type: Immunohistochemistry
Annotation Date: 2018-07-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Not Specified
Stage: TS02
Assay Id: MGI:6188886
Age: embryonic day 1.0
Note: Expression is around the chromatin.
Specimen Label: 6C
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:2684595
Assay Type: RNA in situ
Annotation Date: 2004-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1738321
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:2684598
Age: embryonic day 13.5
Image: 3M
Specimen Label: 3M
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
   
Probe: MGI:2684595
Assay Type: RNA in situ
Annotation Date: 2004-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1738321
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:2684598
Age: embryonic day 13.5
Specimen Label: Table 1, E13.5
Detected: true
Specimen Num: 23
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GXD Expression
GXD Expression
 
Probe: MGI:2684595
Assay Type: RNA in situ
Annotation Date: 2004-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:2684598
Age: embryonic day 11.5
Image: 1D
Specimen Label: 1D
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:2684595
Assay Type: RNA in situ
Annotation Date: 2004-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:2684598
Age: postnatal adult
Image: 5A
Note: Strong in the periglomerular cell layer, mitral layer, in some sparse neurons of the granular cell layer, and in the deep cerebellar nuclei. Also expression in the inferior collicolus and olfactory tubercle.
Specimen Label: 5A
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
   
Probe: MGI:2684595
Assay Type: RNA in situ
Annotation Date: 2004-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:2684598
Age: embryonic day 11.5
Specimen Label: Table 1, E11.5
Detected: true
Specimen Num: 22
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GXD Expression
GXD Expression
   
Probe: MGI:2684595
Assay Type: RNA in situ
Annotation Date: 2004-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:2684598
Age: postnatal adult
Specimen Label: Table 2, adult
Detected: true
Specimen Num: 24
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GXD Expression
GXD Expression
   
Probe: MGI:5690081
Assay Type: Immunohistochemistry
Annotation Date: 2015-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274824
Pattern: Uniform
Stage: TS24
Assay Id: MGI:5690090
Age: embryonic day 16.5
Specimen Label: 3C
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5690081
Assay Type: Immunohistochemistry
Annotation Date: 2015-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274824
Pattern: Uniform
Stage: TS24
Assay Id: MGI:5690090
Age: embryonic day 16.5
Specimen Label: 3D
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2684595
Assay Type: RNA in situ
Annotation Date: 2004-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717121
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:2684598
Age: embryonic day 13.5
Image: 3G
Specimen Label: 3G
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
   
Probe: MGI:2684595
Assay Type: RNA in situ
Annotation Date: 2004-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717121
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:2684598
Age: embryonic day 13.5
Specimen Label: Table 1, E13.5
Detected: true
Specimen Num: 23
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GXD Expression
GXD Expression
   
Probe: MGI:2684595
Assay Type: RNA in situ
Annotation Date: 2004-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3561128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:2684598
Age: postnatal adult
Specimen Label: Table 2, adult
Detected: true
Specimen Num: 24
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Publication
8159766 | J:18517
First Author: Warmke JW
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: A family of potassium channel genes related to eag in Drosophila and mammals.
Volume: 91
Issue: 8
Pages: 3438-42
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Publication
21471216 | J:173500
First Author: Tominaga T
Year: 2011
Journal: J Biol Chem
Title: Activation of bone morphogenetic protein 4 signaling leads to glomerulosclerosis that mimics diabetic nephropathy.
Volume: 286
Issue: 22
Pages: 20109-16
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Publication
14643686 | J:86965
First Author: Polvani S
Year: 2003
Journal: Gene Expr Patterns
Title: Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3.
Volume: 3
Issue: 6
Pages: 767-76
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Publication
19129398 | J:144340
First Author: Hagendorf S
Year: 2009
Journal: J Neurosci
Title: Homeostatic control of sensory output in basal vomeronasal neurons: activity-dependent expression of ether-à-go-go-related gene potassium channels.
Volume: 29
Issue: 1
Pages: 206-21
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Publication
9351462 | J:44554
First Author: London B
Year: 1997
Journal: Circ Res
Title: Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current.
Volume: 81
Issue: 5
Pages: 870-8
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Publication
18948620 | J:155273
First Author: Teng GQ
Year: 2008
Journal: Circ Res
Title: Homozygous missense N629D hERG (KCNH2) potassium channel mutation causes developmental defects in the right ventricle and its outflow tract and embryonic lethality.
Volume: 103
Issue: 12
Pages: 1483-91
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Publication
22855790 | J:186629
First Author: Huang X
Year: 2012
Journal: Genes Dev
Title: Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
Volume: 26
Issue: 16
Pages: 1780-96
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Publication
19965931 | J:156955
First Author: Alaynick WA
Year: 2010
Journal: Mol Endocrinol
Title: ERRgamma regulates cardiac, gastric, and renal potassium homeostasis.
Volume: 24
Issue: 2
Pages: 299-309
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Publication
27671872 | J:237944
First Author: Mishra S
Year: 2016
Journal: Dev Biol
Title: Cerebrovascular defects in Foxc1 mutants correlate with aberrant WNT and VEGF-A pathways downstream of retinoic acid from the meninges.
Volume: 420
Issue: 1
Pages: 148-165
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Publication
29107716 | J:276621
 
First Author: Semmler J
Year: 2018
Journal: Pharmacol Res
Title: Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.
Volume: 128
Pages: 200-210
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Publication
31138815 | J:283500
First Author: Genet G
Year: 2019
Journal: Nat Commun
Title: Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis.
Volume: 10
Issue: 1
Pages: 2350
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Publication
19015276 | J:142220
First Author: Liu N
Year: 2008
Journal: Genes Dev
Title: microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart.
Volume: 22
Issue: 23
Pages: 3242-54
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Publication
23542581 | J:211437
First Author: de la Rosa AJ
Year: 2013
Journal: Cardiovasc Res
Title: Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis.
Volume: 98
Issue: 3
Pages: 504-14
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Publication
28302382 | J:251389
 
First Author: Zakariyah AF
Year: 2017
Journal: J Mol Cell Cardiol
Title: Congenital heart defect causing mutation in Nkx2.5 displays in vivo functional deficit.
Volume: 105
Pages: 89-98
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Publication
30787001 | J:273025
 
First Author: Moreau JLM
Year: 2019
Journal: Development
Title: Gene-environment interaction impacts on heart development and embryo survival.
Volume: 146
Issue: 4
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Publication
35649376 | J:326086
First Author: Sinha T
Year: 2022
Journal: Cell Rep
Title: Differential Etv2 threshold requirement for endothelial and erythropoietic development.
Volume: 39
Issue: 9
Pages: 110881
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Publication
10843805 | J:62530
First Author: Tarantino LM
Year: 2000
Journal: Genomics
Title: A high-resolution radiation hybrid map of the proximal portion of mouse chromosome 5.
Volume: 66
Issue: 1
Pages: 55-64
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Publication
26378152 | J:263568
First Author: Kim GE
Year: 2015
Journal: Cardiovasc Res
Title: LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.
Volume: 108
Issue: 1
Pages: 197-208
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Publication
25979088 | J:242531
First Author: Bedogni F
Year: 2016
Journal: Cereb Cortex
Title: Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.
Volume: 26
Issue: 6
Pages: 2517-2529
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Publication
16985003 | J:119550
First Author: Harrell MD
Year: 2007
Journal: Physiol Genomics
Title: Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.
Volume: 28
Issue: 3
Pages: 273-83
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
28049825 | J:239539
First Author: Caballero R
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Tbx20 controls the expression of the KCNH2 gene and of hERG channels.
Volume: 114
Issue: 3
Pages: E416-E425
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Gene
144245 | ALG10B
Type: gene
Organism: human
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DO Term
DOID:0110645 | long QT syndrome 2
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Publication
7904557 | J:15282
First Author: Lints TJ
Year: 1993
Journal: Development
Title: Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.
Volume: 119
Issue: 2
Pages: 419-31
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Publication
9584153 | J:166035
First Author: Lee Y
Year: 1998
Journal: Mol Cell Biol
Title: The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression.
Volume: 18
Issue: 6
Pages: 3120-9
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Publication
7690144 | J:14414
First Author: Komuro I
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Csx: a murine homeobox-containing gene specifically expressed in the developing heart.
Volume: 90
Issue: 17
Pages: 8145-9
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Publication
19546853 | J:151895
First Author: Takeda M
Year: 2009
Journal: Lab Invest
Title: Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation.
Volume: 89
Issue: 9
Pages: 983-93
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Publication
10021345 | J:52597
First Author: Tanaka M
Year: 1999
Journal: Development
Title: The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development.
Volume: 126
Issue: 6
Pages: 1269-80
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Publication
14607454 | -
First Author: McElhinney DB
Year: 2003
Journal: J Am Coll Cardiol
Title: NKX2.5 mutations in patients with congenital heart disease.
Volume: 42
Issue: 9
Pages: 1650-5
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Publication
9651244 | -
First Author: Schott JJ
Year: 1998
Journal: Science
Title: Congenital heart disease caused by mutations in the transcription factor NKX2-5.
Volume: 281
Issue: 5373
Pages: 108-11
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Publication
26679770 | -
First Author: Ellesøe SG
Year: 2016
Journal: Congenit Heart Dis
Title: Familial Atrial Septal Defect and Sudden Cardiac Death: Identification of a Novel NKX2-5 Mutation and a Review of the Literature.
Volume: 11
Issue: 3
Pages: 283-90
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Protein Domain
IPR033629 | NKX-2.5
Type: Family
Description: Homeobox genes play fundamental roles in specifying cell fate and positional identity in embryos. Homeobox gene Csx/Nkx2.5, one of the vertebrate homologues of Drosophila tinman, is expressed in the precardiac mesoderm and in the myocardium of the embryonic and adult heart [, ]and is one of the master regulators of cardiac development, homeostasis and disease [, ]. Csx associates with the transcription factor GATA4 and this interaction may regulate a subset of cardiac muscle-specific genes []. Nkx2-5 regulates the gene encoding the Kcnh2 channel [].Mutations of the human Nkx2.5 gene cause congenital heart disease ASD7, characterised by incomplete closure of the wall between the atria [, , ].
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Publication
28356343 | J:247843
First Author: King EC
Year: 2017
Journal: FASEB J
Title: Targeted deletion of Kcne3 impairs skeletal muscle function in mice.
Volume: 31
Issue: 7
Pages: 2937-2947
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Protein
P42582
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: false
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Protein
A0A494B983
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: true
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Protein
Q925V3
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: false
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Protein
Q3UQU2
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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