| Type |
Details |
Score |
| Protein Domain |
| Type: |
Family |
| Description: |
Polycomb group RING finger protein 6 (PCGF6 or MBLR) is a transcriptional repressor []. It may activate KDM5D histone demethylase, which modulates the levels of histone H3K4Me3 []. PCGF6 is a component of the Polycomb group (PcG) multiprotein PRC1-like complex [], in which it regulates RNF2 ubiquitin ligase activity [], and the E2F6.com-1 complex []. PCGF6 contains a RING-type zinc finger. |
|
•
•
•
•
•
|
| Allele |
| Name: |
deletion, Chr Y, 6 Harwell |
| Allele Type: |
Spontaneous |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
duplication, Chr Y, 1 Harwell |
| Allele Type: |
Spontaneous |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
deletion, Chr Y, 5 Harwell; deletion, Chr Y, Harwell 5 |
| Allele Type: |
Spontaneous |
|
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Del(Y)6H/? |
| Background: |
mixed |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dp(Y)1H/? |
| Background: |
mixed |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Del(Y)5H/? |
| Background: |
mixed |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Samanta MK |
| Year: |
2022 |
| Journal: |
Nat Commun |
| Title: |
Activation of Xist by an evolutionarily conserved function of KDM5C demethylase. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
2602 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jia H |
| Year: |
2015 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation. |
| Volume: |
112 |
| Issue: |
1 |
| Pages: |
E56-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vandamme J |
| Year: |
2011 |
| Journal: |
Mol Cell Proteomics |
| Title: |
Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. |
| Volume: |
10 |
| Issue: |
4 |
| Pages: |
M110.002642 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ogawa H |
| Year: |
2002 |
| Journal: |
Science |
| Title: |
A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. |
| Volume: |
296 |
| Issue: |
5570 |
| Pages: |
1132-6 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
353
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
239
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
194
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
281
 |
| Fragment?: |
false |
|
•
•
•
•
•
|