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Search results 201 to 300 out of 398 for Keap1

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Type Details Score
Publication
31932477 | J:291599
 
First Author: Uruno A
Year: 2020
Journal: Mol Cell Biol
Title: Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer's Disease Model Mice.
Volume: 40
Issue: 6
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Publication
35203398 | J:321621
 
First Author: Kim EY
Year: 2022
Journal: Cells
Title: Basal Autophagy Is Necessary for A Pharmacologic PPARα Transactivation.
Volume: 11
Issue: 4
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Publication
22789539 | J:191016
First Author: Mitsuishi Y
Year: 2012
Journal: Cancer Cell
Title: Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
Volume: 22
Issue: 1
Pages: 66-79
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Publication
25777368 | J:230344
First Author: Goto M
Year: 2015
Journal: Genes Cells
Title: Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis.
Volume: 20
Issue: 6
Pages: 464-80
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Publication
29515034 | J:271172
 
First Author: Chartoumpekis DV
Year: 2018
Journal: JCI Insight
Title: Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice.
Volume: 3
Issue: 5
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Publication
16135796 | J:101374
First Author: Katsuoka F
Year: 2005
Journal: Mol Cell Biol
Title: Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes.
Volume: 25
Issue: 18
Pages: 8044-51
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Publication
21185264 | J:168468
First Author: Inoue D
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Inducible disruption of autophagy in the lung causes airway hyper-responsiveness.
Volume: 405
Issue: 1
Pages: 13-8
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Publication
29240881 | J:246048
First Author: Hamada S
Year: 2017
Journal: Carcinogenesis
Title: Nrf2 promotes mutant K-ras/p53-driven pancreatic carcinogenesis.
Volume: 38
Issue: 6
Pages: 661-670
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Publication
36963288 | J:346347
 
First Author: Xu T
Year: 2023
Journal: Redox Biol
Title: Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling.
Volume: 62
Pages: 102682
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Publication
22222206 | J:181228
First Author: Kwon J
Year: 2012
Journal: EMBO Rep
Title: Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade.
Volume: 13
Issue: 2
Pages: 150-6
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Publication
20173742 | J:172945
First Author: Komatsu M
Year: 2010
Journal: Nat Cell Biol
Title: The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Volume: 12
Issue: 3
Pages: 213-23
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Publication
22586274 | J:186656
First Author: Hirotsu Y
Year: 2012
Journal: Mol Cell Biol
Title: NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes.
Volume: 32
Issue: 14
Pages: 2760-70
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Publication
35031770 | J:327150
First Author: Vallelian F
Year: 2022
Journal: Cell Death Differ
Title: Heme-stress activated NRF2 skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages in hemolytic anemia.
Volume: 29
Issue: 8
Pages: 1450-1465
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Publication
17591699 | J:125008
First Author: Cho MK
Year: 2007
Journal: Mol Cell Biol
Title: Role of Galpha12 and Galpha13 as novel switches for the activity of Nrf2, a key antioxidative transcription factor.
Volume: 27
Issue: 17
Pages: 6195-208
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Publication
37597423 | J:339677
 
First Author: Baird L
Year: 2023
Journal: Redox Biol
Title: A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells.
Volume: 66
Pages: 102845
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Publication
25049227 | J:216807
First Author: Kageyama S
Year: 2014
Journal: J Biol Chem
Title: Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.
Volume: 289
Issue: 36
Pages: 24944-55
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Publication
17709388 | J:126776
First Author: Shin S
Year: 2007
Journal: Mol Cell Biol
Title: NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis.
Volume: 27
Issue: 20
Pages: 7188-97
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Publication
24859727 | J:302767
 
First Author: Walsh J
Year: 2014
Journal: J Proteomics
Title: Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.
Volume: 108
Pages: 171-87
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Publication
21245377 | J:170616
First Author: Rada P
Year: 2011
Journal: Mol Cell Biol
Title: SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.
Volume: 31
Issue: 6
Pages: 1121-33
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Publication
31242413 | J:294372
First Author: Brandsma I
Year: 2019
Journal: Cell Rep
Title: HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.
Volume: 27
Issue: 13
Pages: 3790-3798.e7
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Publication
35425962 | J:324033
First Author: Yousefi M
Year: 2022
Journal: Cancer Res
Title: Combinatorial Inactivation of Tumor Suppressors Efficiently Initiates Lung Adenocarcinoma with Therapeutic Vulnerabilities.
Volume: 82
Issue: 8
Pages: 1589-1602
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Publication
35588739 | J:326215
First Author: Eisenstein A
Year: 2022
Journal: Immunity
Title: Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs.
Volume: 55
Issue: 6
Pages: 1082-1095.e5
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Publication
22567161 | J:334659
First Author: Chen H
Year: 2012
Journal: PLoS One
Title: Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2/Keap1 pathway in the developing mouse esophagus.
Volume: 7
Issue: 5
Pages: e36504
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Publication
21554947 | J:172598
First Author: Brewer AC
Year: 2011
Journal: Free Radic Biol Med
Title: Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo.
Volume: 51
Issue: 1
Pages: 205-15
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Publication
14517290 | J:85958
First Author: Cullinan SB
Year: 2003
Journal: Mol Cell Biol
Title: Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival.
Volume: 23
Issue: 20
Pages: 7198-209
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Publication
23237955 | J:191045
First Author: Huebner AJ
Year: 2012
Journal: Dev Cell
Title: Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero.
Volume: 23
Issue: 6
Pages: 1238-46
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Publication
27211851 | J:239920
 
First Author: Kobayashi EH
Year: 2016
Journal: Nat Commun
Title: Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription.
Volume: 7
Pages: 11624
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Publication
9798653 | J:62630
First Author: Chu CC
Year: 1998
Journal: Mol Immunol
Title: Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis.
Volume: 35
Issue: 8
Pages: 487-502
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Publication
27383629 | J:316639
 
First Author: He MY
Year: 2016
Journal: Open Biol
Title: Nrf2 signalling and autophagy are involved in diabetes mellitus-induced defects in the development of mouse placenta.
Volume: 6
Issue: 7
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Publication
31220272 | J:277277
First Author: Zieman AG
Year: 2019
Journal: Hum Mol Genet
Title: Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.
Volume: 28
Issue: 13
Pages: 2255-2270
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Publication
26644517 | J:230728
First Author: Kumar V
Year: 2015
Journal: J Cell Biol
Title: A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.
Volume: 211
Issue: 5
Pages: 1057-75
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Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
- | J:104881
     
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
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Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
34414377 | J:309098
First Author: Romero R
Year: 2020
Journal: Nat Cancer
Title: Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1.
Volume: 1
Issue: 6
Pages: 589-602
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HT Experiment
E-GEOD-11287 | Transcription profiling of mouse liver from conditional Keap1 knockout mice vs. genetic control mice
Series Id: GSE11287
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-71647 | Gene expression change in Keap1 knockdown (KD) mice in kidneys of ischemia-reperfusion injury (IRI)
Series Id: GSE71647
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-35124 | Comparison of gene expression profiles among Nrf1 liver-specific conditional knockout, Nrf2 knockout and Keap1 knockdown mice
Series Id: GSE35124
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
28967920 | J:251982
First Author: Romero R
Year: 2017
Journal: Nat Med
Title: Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.
Volume: 23
Issue: 11
Pages: 1362-1368
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Publication
33393215 | J:306296
First Author: Tan CT
Year: 2021
Journal: EMBO Rep
Title: MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.
Volume: 22
Issue: 1
Pages: e50854
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Publication
33895141 | J:306223
   
First Author: Siswanto FM
Year: 2021
Journal: J Biol Chem
Title: Sp1 is a substrate of Keap1 and regulates the activity of CRL4AWDR23 ubiquitin ligase toward Nrf2.
Pages: 100704
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Publication
31913745 | J:337050
First Author: Lee DH
Year: 2020
Journal: Autophagy
Title: SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Volume: 16
Issue: 11
Pages: 1949-1973
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Publication
20600852 | J:187567
First Author: Kim JE
Year: 2010
Journal: Cell Signal
Title: Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation.
Volume: 22
Issue: 11
Pages: 1645-54
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Publication
38885324 | J:353565
First Author: Li L
Year: 2024
Journal: Cancer Res
Title: WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma.
Volume: 84
Issue: 17
Pages: 2776-2791
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Interaction Experiment
Cloer EW (2018)
Description: p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2.
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Publication
29795117 | J:263522
First Author: Dayalan Naidu S
Year: 2018
Journal: Sci Rep
Title: C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape.
Volume: 8
Issue: 1
Pages: 8037
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HT Experiment
E-GEOD-50575 | Comparison of gene expression profiles of Pten, Keap1 and Nrf2 knockout mouse livers
Series Id: GSE50575
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
22014577 | J:177485
First Author: Adam J
Year: 2011
Journal: Cancer Cell
Title: Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.
Volume: 20
Issue: 4
Pages: 524-37
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Publication
28935570 | J:250100
First Author: Anzovino A
Year: 2017
Journal: Am J Pathol
Title: Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis.
Volume: 187
Issue: 12
Pages: 2858-2875
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Interaction Experiment
Padmanabhan B (2006)
Description: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer.
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Interaction Experiment
Zipper LM (2002)
Description: The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm.
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Interaction Experiment
McMahon M (2018)
Description: Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2.
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Publication
20495340 | -
First Author: Fan W
Year: 2010
Journal: Autophagy
Title: Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy.
Volume: 6
Issue: 5
Pages: 614-21
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Publication
30126895 | -
 
First Author: Cloer EW
Year: 2018
Journal: Mol Cell Biol
Title: p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2.
Volume: 38
Issue: 22
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Allele
Keap1<em1Smoc> | MGI:7290701
Name: kelch-like ECH-associated protein 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Interaction Experiment
Itoh K (1999)
Description: Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.
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Interaction Experiment
Tong KI (2006)
Description: Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model.
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Interaction Experiment
Ogura T (2010)
Description: Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains.
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Publication
30261176 | -
 
First Author: McMahon M
Year: 2018
Journal: Toxicol Appl Pharmacol
Title: Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2.
Volume: 360
Pages: 45-57
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Publication
18391415 | -
First Author: Padmanabhan B
Year: 2008
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun
Title: Structural analysis of the complex of Keap1 with a prothymosin alpha peptide.
Volume: 64
Issue: Pt 4
Pages: 233-8
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Interaction Experiment
He X (2006)
Description: Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer.
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Strain
MGI:6770884 | C57BL/6JSmoc-Keap1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
14764894 | -
First Author: Wakabayashi N
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.
Volume: 101
Issue: 7
Pages: 2040-5
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Strain
MGI:7781357 | C57BL/6JSmoc-Kras<em4Smoc> Keap1<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Publication
15379550 | -
First Author: Strachan GD
Year: 2004
Journal: Biochemistry
Title: Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein.
Volume: 43
Issue: 38
Pages: 12113-22
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Publication
14609955 | J:114774
First Author: Barak O
Year: 2003
Journal: EMBO J
Title: Isolation of human NURF: a regulator of Engrailed gene expression.
Volume: 22
Issue: 22
Pages: 6089-100
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