Type |
Details |
Score |
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (ii) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (ii) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (ii) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (ii) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (ii) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (ii) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (ii) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (ii) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (ii) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (ii) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (ii) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (ii) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (ii) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
postnatal day 1 |
Stage: |
27 |
Structure . Name: |
cochlea epithelium |
Notes: |
Lat SC (i) |
Curation Status: |
Curated |
|
•
•
•
•
•
|
Publication |
First Author: |
Paster W |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. |
Volume: |
190 |
Issue: |
7 |
Pages: |
3749-56 |
|
•
•
•
•
•
|
Allele |
Name: |
linker for activation of T cells; targeted mutation 5.1, Bernard Malissen |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Mahon RN |
Year: |
2012 |
Journal: |
Cell Immunol |
Title: |
Mycobacterium tuberculosis ManLAM inhibits T-cell-receptor signaling by interference with ZAP-70, Lck and LAT phosphorylation. |
Volume: |
275 |
Issue: |
1-2 |
Pages: |
98-105 |
|
•
•
•
•
•
|
Publication |
First Author: |
Houtman JC |
Year: |
2006 |
Journal: |
Nat Struct Mol Biol |
Title: |
Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1. |
Volume: |
13 |
Issue: |
9 |
Pages: |
798-805 |
|
•
•
•
•
•
|
Publication |
First Author: |
Joachim A |
Year: |
2023 |
Journal: |
J Exp Med |
Title: |
Defective LAT signalosome pathology in mice mimics human IgG4-related disease at single-cell level. |
Volume: |
220 |
Issue: |
11 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Thien CB |
Year: |
1999 |
Journal: |
J Immunol |
Title: |
Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes. |
Volume: |
162 |
Issue: |
12 |
Pages: |
7133-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arkee T |
Year: |
2021 |
Journal: |
J Immunol |
Title: |
TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Yamasaki S |
Year: |
2003 |
Journal: |
Mol Cell Biol |
Title: |
Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells. |
Volume: |
23 |
Issue: |
7 |
Pages: |
2515-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hundt M |
Year: |
2006 |
Journal: |
Immunity |
Title: |
Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect. |
Volume: |
24 |
Issue: |
5 |
Pages: |
513-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Larghi P |
Year: |
2013 |
Journal: |
Nat Immunol |
Title: |
VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites. |
Volume: |
14 |
Issue: |
7 |
Pages: |
723-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garreau A |
Year: |
2017 |
Journal: |
J Immunol |
Title: |
Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection. |
Volume: |
199 |
Issue: |
8 |
Pages: |
2758-2766 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jun JE |
Year: |
2019 |
Journal: |
Sci Signal |
Title: |
Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation. |
Volume: |
12 |
Issue: |
591 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gussow AM |
Year: |
2006 |
Journal: |
J Virol |
Title: |
Tissue-specific splicing of the herpes simplex virus type 1 latency-associated transcript (LAT) intron in LAT transgenic mice. |
Volume: |
80 |
Issue: |
19 |
Pages: |
9414-23 |
|
•
•
•
•
•
|
Allele |
Name: |
linker for activation of T cells; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Not Specified |
|
•
•
•
•
•
|
Publication |
First Author: |
Allen SJ |
Year: |
2011 |
Journal: |
J Virol |
Title: |
The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. |
Volume: |
85 |
Issue: |
9 |
Pages: |
4184-97 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes. |
|
•
•
•
•
•
|
Publication |
First Author: |
Gringhuis SI |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signaling pathways. |
Volume: |
22 |
Issue: |
2 |
Pages: |
400-11 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Astier A |
Year: |
2000 |
Journal: |
J Immunol |
Title: |
Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation. |
Volume: |
164 |
Issue: |
12 |
Pages: |
6091-5 |
|
•
•
•
•
•
|
Allele |
Name: |
linker for activation of T cells; endonuclease-mediated mutation 1, Enrique Aguado |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Not Specified |
|
•
•
•
•
•
|
Publication |
First Author: |
Gascoigne NR |
Year: |
2015 |
Journal: |
Curr Opin Immunol |
Title: |
THEMIS: a critical TCR signal regulator for ligand discrimination. |
Volume: |
33 |
|
Pages: |
86-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Choi S |
Year: |
2017 |
Journal: |
Nat Immunol |
Title: |
THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1. |
Volume: |
18 |
Issue: |
4 |
Pages: |
433-441 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes THEMIS1/2/3 from animals. THEMIS1 and THEMIS2 are restricted to B and myeloid cells, and the more distantly related THEMIS3 is expressed in the large and small intestine. THEMIS is involved in the early TCR (T-cell antigen receptor) signal transduction and thymocyte selection []. It is recruited to LAT through GRB2 association and LAT phosphotyrosine GRB2 binding sites []. THEMIS contains CABIT modules that bind directly to the SHP-1 PTP (protein tyrosine phosphatase) domain and inhibit SHP-1 PTP activity by promoting or stabilizing oxidation of the catalytic cysteine []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
TESPA1 (Thymocyte-expressed positive selection-associated protein 1) is required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. It plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
242
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
232
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
242
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
105
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
242
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
A key event in the regulation of the adaptive immune response is the bindingof major histocompatibility complex (MHC)-peptide complexes to T cellantigen receptors (TCRs). The formation of such ternary complexes inducessignificant biochemical changes within T cells of the host animal. The firstdetectable response of the T cell is the rapid accumulation of numeroustyrosine-phosphorylated proteins within the cell. Increased phosphotyrosineoccurs as a consequence of the activation of several different TCR-associated, hematopoietic-specific protein kinases (PTKs), thereby perturbingthe balance between those enzymes that add, and those that remove,phosphates from key tyrosine residues. These initial phosphorylation eventsare required for the subsequent activation of the small guanosinetriphosphatase (GTPase) proteins Ras and Rac, the lipid kinase P13K and PLC-gamma1. Activation of these cytoplasmic signalling proteins ultimately leadsto activation of various transcription factors (NF-AT, NF-kB, and AP-1) andincreased transcription from genes that have an important role in initiatingT cell proliferation, such as interleukin-2 (IL-2) [].An unresolved question in the field has been which molecules and whatsequence of events tie together the early tyrosine phosphorylation eventswith the activation of these downstream signalling molecules. A likelycandidate for linking the proximal and distal portions of the TCR signallingpathway is a 36kDa transmembrane protein termed LAT. LAT becomesphosphorylated after TCR engagement, thereby creating binding sites for theSrc homology 2 (SH2) domains of other proteins, including PLC-gamma1, Grb2,Gads, Grap, 3BP2 and Shb. It also indirectly binds SOS, c-Cbl, Vav, SLP-76and Itk.LAT is expressed in peripheral blood lymphocytes, thymus and spleen, aswell as in other blood cells, including megakaryocytes, platelets, naturalkiller cells and mast cells. It is excluded from the cytosol, and is foundat the plasma membrane and in the perinuclear compartment. The cellularlocalisation of LAT seems to be extremely sensitive to alternations in theintracellular redox balance. Reduced intracellular levels of antioxidantsresult in the membrane displacement of LAT (a consequence of aconformational change interfering with its insertion into the membrane),abrogation of TCR-mediated signalling and, consequently, hyporesponsivenessof T lymphocytes.The amino acid sequence of LAT contains no recognised functional domains,but, consistent with its strong tyrosine phosphorylation upon TCRstimulation, its predicted cytoplasmic tail contains 10 tyrosines, 9 ofwhich are conserved between mouse, rat and human proteins. In addition,LAT also has 2 cysteine residues (Cys26 and Cys29 in human) that areconserved among human, rat, mouse and bovine proteins. These residues lieproximal to the inner face of the plasma membrane: Cys26 within the TMregion andCys29 located juxtamembrane. These membrane-proximal residuesare thought to play a vital role in LAT function. In fact, LAT is subject topost-translational palmitoylation of these residues, which appears to benecessary to target LAT to lipid rafts in the membrane, where it canrecruit key cytosolic signalling proteins to the aggregated rafts upon TCRstimulation. Raft membrane domains are envisaged as lateral assemblies ofsphingolipids and cholesterol that form ordered membrane phases []. |
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Allele |
Name: |
linker for activation of T cells; targeted mutation 6.1, Bernard Malissen |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Inserted expressed sequence, No functional change, Reporter |
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Allele |
Name: |
lymphocyte cytosolic protein 2; targeted mutation 5, Gary A Koretzky |
Allele Type: |
Targeted |
Attribute String: |
Inserted expressed sequence |
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Genotype |
Symbol: |
Lcp2/Lcp2 |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
569
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
636
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
663
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
203
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
94
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Fragment?: |
false |
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Strain |
Attribute String: |
congenic, targeted mutation, mutant strain |
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Genotype |
Symbol: |
Lat/Lat Lcp2/Lcp2 |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Lat/Lat |
Background: |
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Lat/Lat |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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Publication |
First Author: |
Parravicini V |
Year: |
2002 |
Journal: |
Nat Immunol |
Title: |
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. |
Volume: |
3 |
Issue: |
8 |
Pages: |
741-8 |
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Publication |
First Author: |
Yoder J |
Year: |
2001 |
Journal: |
Science |
Title: |
Requirement for the SLP-76 adaptor GADS in T cell development. |
Volume: |
291 |
Issue: |
5510 |
Pages: |
1987-91 |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
458
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Fragment?: |
false |
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Genotype |
Symbol: |
Lat/? Rag2/Rag2 Tg(TcraH-Y,TcrbH-Y)1Pas/? |
Background: |
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Lat/Lat |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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Protein Domain |
Type: |
Family |
Description: |
This entry includes TESPA1, ITPRID1 (also known CCDC129) and ITPRID2 (also known as SSFA2). SSFA2, also known as Ki-ras-induced actin-interacting protein (KRAP), interacts with inositol 1,4,5-trisphosphate receptor (IP3R, also known as ITPR) []. SSFA2 was first localised as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells []. It has now been shown to be critical for the proper subcellular localisation and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialised endoplasmic reticulum membranes, so the subcellular localisation of IP3R is crucial for its proper function [].TESPA1 (Thymocyte-expressed positive selection-associated protein 1) is required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. It plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes []. TESPA1 shows sequence homology to SSFA2 and physically associates with IP3R in T and B lymphocytes [].The function of ITPRID1 is not clear. |
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Publication |
First Author: |
Dorn T |
Year: |
2007 |
Journal: |
Blood |
Title: |
RhoH is important for positive thymocyte selection and T-cell receptor signaling. |
Volume: |
109 |
Issue: |
6 |
Pages: |
2346-55 |
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Publication |
First Author: |
Zhu M |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
Negative regulation of lymphocyte activation by the adaptor protein LAX. |
Volume: |
174 |
Issue: |
9 |
Pages: |
5612-9 |
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Publication |
First Author: |
Ahn E |
Year: |
2006 |
Journal: |
Blood |
Title: |
LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation. |
Volume: |
107 |
Issue: |
4 |
Pages: |
1521-7 |
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Publication |
First Author: |
Wolfe JH |
Year: |
1992 |
Journal: |
Nat Genet |
Title: |
Herpesvirus vector gene transfer and expression of beta-glucuronidase in the central nervous system of MPS VII mice. |
Volume: |
1 |
Issue: |
5 |
Pages: |
379-84 |
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