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Search results 201 to 300 out of 351 for Lat

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Type Details Score
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
GO Term
DO Term
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (ii)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (ii)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (ii)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (ii)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (ii)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (ii)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (ii)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (ii)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (ii)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (ii)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (ii)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (ii)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (ii)
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal day 1
Stage: 27
Structure . Name: cochlea epithelium
Notes: Lat SC (i)
Curation Status: Curated
Publication
First Author: Paster W
Year: 2013
Journal: J Immunol
Title: GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
Volume: 190
Issue: 7
Pages: 3749-56
Allele
Name: linker for activation of T cells; targeted mutation 5.1, Bernard Malissen
Allele Type: Targeted
Attribute String: Null/knockout
Publication
First Author: Mahon RN
Year: 2012
Journal: Cell Immunol
Title: Mycobacterium tuberculosis ManLAM inhibits T-cell-receptor signaling by interference with ZAP-70, Lck and LAT phosphorylation.
Volume: 275
Issue: 1-2
Pages: 98-105
Publication
First Author: Houtman JC
Year: 2006
Journal: Nat Struct Mol Biol
Title: Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1.
Volume: 13
Issue: 9
Pages: 798-805
Publication  
First Author: Joachim A
Year: 2023
Journal: J Exp Med
Title: Defective LAT signalosome pathology in mice mimics human IgG4-related disease at single-cell level.
Volume: 220
Issue: 11
Publication
First Author: Thien CB
Year: 1999
Journal: J Immunol
Title: Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes.
Volume: 162
Issue: 12
Pages: 7133-9
Publication      
First Author: Arkee T
Year: 2021
Journal: J Immunol
Title: TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling.
Publication
First Author: Yamasaki S
Year: 2003
Journal: Mol Cell Biol
Title: Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells.
Volume: 23
Issue: 7
Pages: 2515-29
Publication
First Author: Hundt M
Year: 2006
Journal: Immunity
Title: Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect.
Volume: 24
Issue: 5
Pages: 513-22
Publication
First Author: Larghi P
Year: 2013
Journal: Nat Immunol
Title: VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites.
Volume: 14
Issue: 7
Pages: 723-31
Publication
First Author: Garreau A
Year: 2017
Journal: J Immunol
Title: Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection.
Volume: 199
Issue: 8
Pages: 2758-2766
Publication  
First Author: Jun JE
Year: 2019
Journal: Sci Signal
Title: Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation.
Volume: 12
Issue: 591
Publication
First Author: Gussow AM
Year: 2006
Journal: J Virol
Title: Tissue-specific splicing of the herpes simplex virus type 1 latency-associated transcript (LAT) intron in LAT transgenic mice.
Volume: 80
Issue: 19
Pages: 9414-23
Allele
Name: linker for activation of T cells; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
Publication
First Author: Allen SJ
Year: 2011
Journal: J Virol
Title: The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1.
Volume: 85
Issue: 9
Pages: 4184-97
Interaction Experiment
Description: Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes.
Publication
First Author: Gringhuis SI
Year: 2002
Journal: Mol Cell Biol
Title: Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signaling pathways.
Volume: 22
Issue: 2
Pages: 400-11
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
GO Term
GO Term
Publication
First Author: Astier A
Year: 2000
Journal: J Immunol
Title: Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation.
Volume: 164
Issue: 12
Pages: 6091-5
Allele
Name: linker for activation of T cells; endonuclease-mediated mutation 1, Enrique Aguado
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
Publication  
First Author: Gascoigne NR
Year: 2015
Journal: Curr Opin Immunol
Title: THEMIS: a critical TCR signal regulator for ligand discrimination.
Volume: 33
Pages: 86-92
Publication
First Author: Choi S
Year: 2017
Journal: Nat Immunol
Title: THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.
Volume: 18
Issue: 4
Pages: 433-441
Protein Domain
Type: Family
Description: This entry includes THEMIS1/2/3 from animals. THEMIS1 and THEMIS2 are restricted to B and myeloid cells, and the more distantly related THEMIS3 is expressed in the large and small intestine. THEMIS is involved in the early TCR (T-cell antigen receptor) signal transduction and thymocyte selection []. It is recruited to LAT through GRB2 association and LAT phosphotyrosine GRB2 binding sites []. THEMIS contains CABIT modules that bind directly to the SHP-1 PTP (protein tyrosine phosphatase) domain and inhibit SHP-1 PTP activity by promoting or stabilizing oxidation of the catalytic cysteine [].
Protein Domain
Type: Family
Description: TESPA1 (Thymocyte-expressed positive selection-associated protein 1) is required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. It plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes [].
Protein
Organism: Mus musculus/domesticus
Length: 242  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 242  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 242  
Fragment?: false
Protein Domain
Type: Family
Description: A key event in the regulation of the adaptive immune response is the bindingof major histocompatibility complex (MHC)-peptide complexes to T cellantigen receptors (TCRs). The formation of such ternary complexes inducessignificant biochemical changes within T cells of the host animal. The firstdetectable response of the T cell is the rapid accumulation of numeroustyrosine-phosphorylated proteins within the cell. Increased phosphotyrosineoccurs as a consequence of the activation of several different TCR-associated, hematopoietic-specific protein kinases (PTKs), thereby perturbingthe balance between those enzymes that add, and those that remove,phosphates from key tyrosine residues. These initial phosphorylation eventsare required for the subsequent activation of the small guanosinetriphosphatase (GTPase) proteins Ras and Rac, the lipid kinase P13K and PLC-gamma1. Activation of these cytoplasmic signalling proteins ultimately leadsto activation of various transcription factors (NF-AT, NF-kB, and AP-1) andincreased transcription from genes that have an important role in initiatingT cell proliferation, such as interleukin-2 (IL-2) [].An unresolved question in the field has been which molecules and whatsequence of events tie together the early tyrosine phosphorylation eventswith the activation of these downstream signalling molecules. A likelycandidate for linking the proximal and distal portions of the TCR signallingpathway is a 36kDa transmembrane protein termed LAT. LAT becomesphosphorylated after TCR engagement, thereby creating binding sites for theSrc homology 2 (SH2) domains of other proteins, including PLC-gamma1, Grb2,Gads, Grap, 3BP2 and Shb. It also indirectly binds SOS, c-Cbl, Vav, SLP-76and Itk.LAT is expressed in peripheral blood lymphocytes, thymus and spleen, aswell as in other blood cells, including megakaryocytes, platelets, naturalkiller cells and mast cells. It is excluded from the cytosol, and is foundat the plasma membrane and in the perinuclear compartment. The cellularlocalisation of LAT seems to be extremely sensitive to alternations in theintracellular redox balance. Reduced intracellular levels of antioxidantsresult in the membrane displacement of LAT (a consequence of aconformational change interfering with its insertion into the membrane),abrogation of TCR-mediated signalling and, consequently, hyporesponsivenessof T lymphocytes.The amino acid sequence of LAT contains no recognised functional domains,but, consistent with its strong tyrosine phosphorylation upon TCRstimulation, its predicted cytoplasmic tail contains 10 tyrosines, 9 ofwhich are conserved between mouse, rat and human proteins. In addition,LAT also has 2 cysteine residues (Cys26 and Cys29 in human) that areconserved among human, rat, mouse and bovine proteins. These residues lieproximal to the inner face of the plasma membrane: Cys26 within the TMregion andCys29 located juxtamembrane. These membrane-proximal residuesare thought to play a vital role in LAT function. In fact, LAT is subject topost-translational palmitoylation of these residues, which appears to benecessary to target LAT to lipid rafts in the membrane, where it canrecruit key cytosolic signalling proteins to the aggregated rafts upon TCRstimulation. Raft membrane domains are envisaged as lateral assemblies ofsphingolipids and cholesterol that form ordered membrane phases [].
Allele
Name: linker for activation of T cells; targeted mutation 6.1, Bernard Malissen
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, No functional change, Reporter
Allele
Name: lymphocyte cytosolic protein 2; targeted mutation 5, Gary A Koretzky
Allele Type: Targeted
Attribute String: Inserted expressed sequence
Genotype
Symbol: Lcp2/Lcp2
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
Protein
Organism: Mus musculus/domesticus
Length: 569  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 636  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: false
Strain
Attribute String: congenic, targeted mutation, mutant strain
Genotype
Symbol: Lat/Lat Lcp2/Lcp2
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Lat/Lat
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Lat/Lat
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Parravicini V
Year: 2002
Journal: Nat Immunol
Title: Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation.
Volume: 3
Issue: 8
Pages: 741-8
Publication
First Author: Yoder J
Year: 2001
Journal: Science
Title: Requirement for the SLP-76 adaptor GADS in T cell development.
Volume: 291
Issue: 5510
Pages: 1987-91
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: false
Genotype
Symbol: Lat/? Rag2/Rag2 Tg(TcraH-Y,TcrbH-Y)1Pas/?
Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Lat/Lat
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Protein Domain
Type: Family
Description: This entry includes TESPA1, ITPRID1 (also known CCDC129) and ITPRID2 (also known as SSFA2). SSFA2, also known as Ki-ras-induced actin-interacting protein (KRAP), interacts with inositol 1,4,5-trisphosphate receptor (IP3R, also known as ITPR) []. SSFA2 was first localised as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells []. It has now been shown to be critical for the proper subcellular localisation and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialised endoplasmic reticulum membranes, so the subcellular localisation of IP3R is crucial for its proper function [].TESPA1 (Thymocyte-expressed positive selection-associated protein 1) is required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. It plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes []. TESPA1 shows sequence homology to SSFA2 and physically associates with IP3R in T and B lymphocytes [].The function of ITPRID1 is not clear.
Publication
First Author: Dorn T
Year: 2007
Journal: Blood
Title: RhoH is important for positive thymocyte selection and T-cell receptor signaling.
Volume: 109
Issue: 6
Pages: 2346-55
Publication
First Author: Zhu M
Year: 2005
Journal: J Immunol
Title: Negative regulation of lymphocyte activation by the adaptor protein LAX.
Volume: 174
Issue: 9
Pages: 5612-9
Publication
First Author: Ahn E
Year: 2006
Journal: Blood
Title: LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.
Volume: 107
Issue: 4
Pages: 1521-7
Publication
First Author: Wolfe JH
Year: 1992
Journal: Nat Genet
Title: Herpesvirus vector gene transfer and expression of beta-glucuronidase in the central nervous system of MPS VII mice.
Volume: 1
Issue: 5
Pages: 379-84