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Search results 201 to 244 out of 244 for Lats1

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0.019s

Type

Details

Score

Publication

26530630 | J:269058

First Author:	Mukai S
Year:	2015
Journal:	Sci Rep
Title:	Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B.
Volume:	5

Pages:	16173

•

Publication

28644436 | J:268162

First Author:	Furth N
Year:	2017
Journal:	Cell Death Differ
Title:	The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway.
Volume:	24
Issue:	9
Pages:	1488-1501

•

Publication

9988268 | -

First Author:	Tao W
Year:	1999
Journal:	Nat Genet
Title:	Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity.
Volume:	21
Issue:	2
Pages:	177-81

•

Publication

35394840 | J:339141

First Author:	Zuo Y
Year:	2022
Journal:	Sci Adv
Title:	LATS1 is a central signal transmitter for achieving full type-I interferon activity.
Volume:	8
Issue:	14
Pages:	eabj3887

•

UniProt Feature

Begin:	382
Description:	Phosphoserine; by LATS1 and LATS2
Type:	modified residue
End:	382

•

UniProt Feature

Begin:	149
Description:	Phosphoserine; by LATS1 and LATS2
Type:	modified residue
End:	149

•

Publication

11850843 | -

First Author:	Xia H
Year:	2002
Journal:	Oncogene
Title:	LATS1 tumor suppressor regulates G2/M transition and apoptosis.
Volume:	21
Issue:	8
Pages:	1233-41

•

Publication

15220930 | -

First Author:	Yang X
Year:	2004
Journal:	Nat Cell Biol
Title:	LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1.
Volume:	6
Issue:	7
Pages:	609-17

•

Publication

25026211 | J:213963

First Author:	Li W
Year:	2014
Journal:	Cancer Cell
Title:	Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus.
Volume:	26
Issue:	1
Pages:	48-60

•

HT Experiment

GSE135855 | Evaluation of the roles of Lats1 and Lats2 in the development of the Mullerian ducts


Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	GEO

•

Publication

15746036 | -

First Author:	Takahashi Y
Year:	2005
Journal:	Clin Cancer Res
Title:	Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers.
Volume:	11
Issue:	4
Pages:	1380-5

•

Publication

11641775 | -

First Author:	Yang X
Year:	2001
Journal:	Oncogene
Title:	Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G(2)/M arrest or apoptosis.
Volume:	20
Issue:	45
Pages:	6516-23

•

Protein Domain

IPR042706 | LATS1_STKc

Type:

Domain

Description:

STKs (serine/threonine-protein kinases) catalyse the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS1 functions as a tumour suppressor and is implicated in cell cycle regulation []. Inactivation of LATS1 in mice results in the development of various tumours, including sarcomas and ovarian cancer []. Promoter methylation, loss of heterozygosity, and missense mutations targeting the LATS1 gene have also been found in human sarcomas and ovarian cancers. In addition, decreased expression of LATS1 is associated with an aggressive phenotype and poor prognosis [. LATS1 induces G2 arrest and promotes cytokinesis. It may be a component of the mitotic exit network in higher eukaryotes [, , ].

•

HT Experiment

GSE117013 | Gene expression array of brain, mandible and maxilla tissues from P0 FoxO6-/- and wildtype mice


Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	GEO

•

Publication

19878866 | J:153949

First Author:	Zhao B
Year:	2009
Journal:	Cancer Cell
Title:	Mst out and HCC in.
Volume:	16
Issue:	5
Pages:	363-4

•

Protein Domain

IPR028742 | LATS2

Type:

Family

Description:

There are two mammalian homologue of Drosophila tumor suppressor Lats (large tumor suppressor, also known as Warts): LATS1 and LATS2. Lats/Warts is a serine/threonine-protein kinase that negatively regulates YAP1 (Drosophila Yorkie (Yki) homologue) in the Hippo signaling pathway, which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis [, ]. This entry represents LATS2, which plays an important part in centrosome duplication, maintenance of mitotic fidelity and genomic stability []. This entry also includes Warts from Drosophila melanogaster which is a negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) signalling pathway that plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis [].

•

HT Experiment

GSE182721 | Lats1/2 control TGF-beta directed EMT in the dorsal cranial neuroepithelium through YAP regulation


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	GEO

•

Publication

31825843 | J:296751

First Author:	Song J
Year:	2019
Journal:	Cell Rep
Title:	Kindlin-2 Inhibits the Hippo Signaling Pathway by Promoting Degradation of MOB1.
Volume:	29
Issue:	11
Pages:	3664-3677.e5

•

Publication

34117213 | J:307605

First Author:	Chi X
Year:	2021
Journal:	Cell Death Dis
Title:	Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice.
Volume:	12
Issue:	6
Pages:	604

•

Publication

30821074 | J:295956

First Author:	Shu Z
Year:	2019
Journal:	J Cell Mol Med
Title:	A functional interaction between Hippo-YAP signalling and SREBPs mediates hepatic steatosis in diabetic mice.
Volume:	23
Issue:	5
Pages:	3616-3628

•

Publication

26050962 | J:307274

First Author:	Mohamed AD
Year:	2015
Journal:	Biochim Biophys Acta
Title:	The Hippo signal transduction pathway in soft tissue sarcomas.
Volume:	1856
Issue:	1
Pages:	121-9

•

Publication

39122845 | J:354350

First Author:	Xu D
Year:	2024
Journal:	Exp Mol Med
Title:	The Foxo1-YAP-Notch1 axis reprograms STING-mediated innate immunity in NASH progression.
Volume:	56
Issue:	8
Pages:	1843-1855

•

Publication

17379520 | J:121661

First Author:	Guo C
Year:	2007
Journal:	Curr Biol
Title:	RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network.
Volume:	17
Issue:	8
Pages:	700-5

•

Publication

29229597 | J:257853

First Author:	Zhang Y
Year:	2018
Journal:	Cancer Res
Title:	Nkx2-2as Suppression Contributes to the Pathogenesis of Sonic Hedgehog Medulloblastoma.
Volume:	78
Issue:	4
Pages:	962-973

•

Publication

39160347 | J:357732

First Author:	Jeong W
Year:	2024
Journal:	EMBO Rep
Title:	Retinoic acid-induced protein 14 links mechanical forces to Hippo signaling.
Volume:	25
Issue:	9
Pages:	4033-4061

•

Publication

18328708 | J:135359

First Author:	Praskova M
Year:	2008
Journal:	Curr Biol
Title:	MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.
Volume:	18
Issue:	5
Pages:	311-21

•

Publication

22037235 | J:179215

First Author:	Zhang H
Year:	2012
Journal:	Dev Biol
Title:	Negative regulation of Yap during neuronal differentiation.
Volume:	361
Issue:	1
Pages:	103-15

•

Publication

22632819 | J:184832

First Author:	Zhi X
Year:	2012
Journal:	Am J Pathol
Title:	YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor.
Volume:	180
Issue:	6
Pages:	2452-61

•

Publication

23942117 | J:211378

First Author:	Li C
Year:	2013
Journal:	Biochem Biophys Res Commun
Title:	Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related protein.
Volume:	438
Issue:	4
Pages:	607-12

•

Publication

24997360 | J:215308

First Author:	Kono K
Year:	2014
Journal:	Dev Biol
Title:	Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst.
Volume:	394
Issue:	1
Pages:	142-55

•

Publication

27215387 | J:236175

First Author:	Li F
Year:	2016
Journal:	Mol Cell Biol
Title:	Poly(rC)-Binding Protein 2 Regulates Hippo Signaling To Control Growth in Breast Epithelial Cells.
Volume:	36
Issue:	16
Pages:	2121-31

•

Publication

30135582 | J:265296

First Author:	Meng Z
Year:	2018
Journal:	Nature
Title:	RAP2 mediates mechanoresponses of the Hippo pathway.
Volume:	560
Issue:	7720
Pages:	655-660

•

Publication

32767654 | J:301544

First Author:	Jeong W
Year:	2020
Journal:	EMBO Rep
Title:	LDL receptor-related protein LRP6 senses nutrient levels and regulates Hippo signaling.
Volume:	21
Issue:	9
Pages:	e50103

•

Publication

30467379 | J:310020

First Author:	Zhou PJ
Year:	2019
Journal:	Oncogene
Title:	Loss of Par3 promotes prostatic tumorigenesis by enhancing cell growth and changing cell division modes.
Volume:	38
Issue:	12
Pages:	2192-2205

•

Publication

18927464 | J:155278

First Author:	Matsui Y
Year:	2008
Journal:	Circ Res
Title:	Lats2 is a negative regulator of myocyte size in the heart.
Volume:	103
Issue:	11
Pages:	1309-18

•

Publication

36317529 | J:338120

First Author:	Zheng M
Year:	2022
Journal:	Circulation
Title:	Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis.
Volume:	146
Issue:	22
Pages:	1694-1711

•

Protein

G3UYM3

Organism:	Mus musculus/domesticus
Length:	288
Fragment?:	true

•

Protein

G3UY78

Organism:	Mus musculus/domesticus
Length:	895
Fragment?:	false

•

Protein

G3UXG3

Organism:	Mus musculus/domesticus
Length:	853
Fragment?:	false

•

Protein

Q7TSJ6

Organism:	Mus musculus/domesticus
Length:	1042
Fragment?:	false

•

Publication

19144319 | J:143718

First Author:	Trost M
Year:	2009
Journal:	Immunity
Title:	The phagosomal proteome in interferon-gamma-activated macrophages.
Volume:	30
Issue:	1
Pages:	143-54

•

Publication

17242355 | -

First Author:	Villén J
Year:	2007
Journal:	Proc Natl Acad Sci U S A
Title:	Large-scale phosphorylation analysis of mouse liver.
Volume:	104
Issue:	5
Pages:	1488-93

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

•

Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

•

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