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Search results 201 to 300 out of 320 for Lpin1

0.017s
Type Details Score
GXD Expression  
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_19
Specimen Label: euxassay_013747_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_20
Specimen Label: euxassay_013747_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_21
Specimen Label: euxassay_013747_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_22
Specimen Label: euxassay_013747_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_23
Specimen Label: euxassay_013747_23
Detected: true
Specimen Num: 23
GXD Expression  
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_11
Specimen Label: euxassay_013747_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_15
Specimen Label: euxassay_013747_15
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:4417291
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825970
Age: embryonic day 14.5
Image: euxassay_013747_16
Specimen Label: euxassay_013747_16
Detected: true
Specimen Num: 16
Publication
First Author: Li TY
Year: 2018
Journal: Nat Commun
Title: Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate.
Volume: 9
Issue: 1
Pages: 1916
Publication
First Author: Dwyer JR
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
Volume: 109
Issue: 37
Pages: E2486-95
Publication
First Author: Reue K
Year: 1996
Journal: J Lipid Res
Title: Naturally occurring mutations in mice affecting lipid transport and metabolism.
Volume: 37
Issue: 7
Pages: 1387-405
Publication  
First Author: Chandran S
Year: 2020
Journal: Front Immunol
Title: Lipin-1 Contributes to IL-4 Mediated Macrophage Polarization.
Volume: 11
Pages: 787
Publication
First Author: Vozenilek AE
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein-Induced Proinflammatory Signaling and Atherosclerosis.
Volume: 38
Issue: 2
Pages: 324-334
Publication
First Author: Grimsey N
Year: 2008
Journal: J Biol Chem
Title: Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2.
Volume: 283
Issue: 43
Pages: 29166-74
Publication
First Author: Sembongi H
Year: 2013
Journal: J Biol Chem
Title: Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells.
Volume: 288
Issue: 48
Pages: 34502-13
Publication
First Author: Péterfy M
Year: 2010
Journal: J Biol Chem
Title: Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes.
Volume: 285
Issue: 6
Pages: 3857-64
Publication
First Author: Boroda S
Year: 2017
Journal: J Biol Chem
Title: The phosphatidic acid-binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3.
Volume: 292
Issue: 50
Pages: 20481-20493
Publication    
First Author: Kawabata M
Year: 1999
Journal: GenBank Submission
Title: Mus musculus mRNA for Trif, complete cds
Pages: AB025010
Publication
First Author: Hall AM
Year: 2010
Journal: J Lipid Res
Title: Dynamic and differential regulation of proteins that coat lipid droplets in fatty liver dystrophic mice.
Volume: 51
Issue: 3
Pages: 554-63
Publication
First Author: Gazit V
Year: 2010
Journal: Hepatology
Title: Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice.
Volume: 52
Issue: 6
Pages: 2109-17
Publication
First Author: Zhang P
Year: 2019
Journal: J Clin Invest
Title: Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis.
Volume: 129
Issue: 1
Pages: 281-295
Publication
First Author: Lu B
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes.
Volume: 295
Issue: 6
Pages: E1502-9
Publication
First Author: Jama A
Year: 2023
Journal: J Physiol
Title: Lipin1 plays complementary roles in myofibre stability and regeneration in dystrophic muscles.
Volume: 601
Issue: 5
Pages: 961-978
Publication  
First Author: Shimizu K
Year: 2017
Journal: Sci Signal
Title: The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.
Volume: 10
Issue: 460
Publication
First Author: Reue K
Year: 1996
Journal: Mamm Genome
Title: Acads gene deletion in BALB/cByJ mouse strain occurred after 1981 and is not present in BALB/cByJ-fld mutant mice.
Volume: 7
Issue: 9
Pages: 694-5
Publication  
First Author: Prabakaran AD
Year: 2024
Journal: J Clin Invest
Title: Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1α/Lipin1 axis in an aging-related sarcopenia model.
Volume: 134
Issue: 11
Publication
First Author: Cardozo Gizzi AM
Year: 2015
Journal: J Biol Chem
Title: The Catalytic Efficiency of Lipin 1β Increases by Physically Interacting with the Proto-oncoprotein c-Fos.
Volume: 290
Issue: 49
Pages: 29578-92
Publication
First Author: Rowe LB
Year: 1996
Journal: Mamm Genome
Title: The fld mutation maps near to but distinct from the Apob locus on mouse chromosome 12.
Volume: 7
Issue: 7
Pages: 555-7
Publication
First Author: Ryu D
Year: 2009
Journal: Cell Metab
Title: TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1.
Volume: 9
Issue: 3
Pages: 240-51
Publication
First Author: Takahashi N
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes.
Volume: 415
Issue: 1
Pages: 200-5
Publication
First Author: Péterfy M
Year: 1999
Journal: Genomics
Title: Genetic, physical, and transcript map of the fld region on mouse chromosome 12.
Volume: 62
Issue: 3
Pages: 436-44
Publication
First Author: Phan J
Year: 2004
Journal: J Biol Chem
Title: Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro.
Volume: 279
Issue: 28
Pages: 29558-64
Publication
First Author: Verdier V
Year: 2012
Journal: Glia
Title: Aging of myelinating glial cells predominantly affects lipid metabolism and immune response pathways.
Volume: 60
Issue: 5
Pages: 751-60
Publication
First Author: Yang C
Year: 2020
Journal: Neuron
Title: Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration.
Volume: 105
Issue: 2
Pages: 276-292.e5
Publication
First Author: Obama T
Year: 2011
Journal: PLoS One
Title: Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice: suppression of lipin-1 and -2 in the glycerol-3-phosphate pathway.
Volume: 6
Issue: 8
Pages: e22917
Publication
First Author: Gropler MC
Year: 2009
Journal: J Biol Chem
Title: Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.
Volume: 284
Issue: 11
Pages: 6763-72
Publication  
First Author: Wang J
Year: 2016
Journal: Sci Rep
Title: Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice.
Volume: 6
Pages: 34117
Publication
First Author: Jama A
Year: 2019
Journal: J Physiol
Title: Lipin1 is required for skeletal muscle development by regulating MEF2c and MyoD expression.
Volume: 597
Issue: 3
Pages: 889-901
Publication
First Author: Peterson TR
Year: 2011
Journal: Cell
Title: mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.
Volume: 146
Issue: 3
Pages: 408-20
Publication
First Author: Kim HB
Year: 2010
Journal: Mol Cell Biol
Title: Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors.
Volume: 30
Issue: 12
Pages: 3126-39
Publication
First Author: Grkovich A
Year: 2009
Journal: Biochim Biophys Acta
Title: TLR-4 mediated group IVA phospholipase A(2) activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent.
Volume: 1791
Issue: 10
Pages: 975-82
Publication
First Author: Hirotsu Y
Year: 2012
Journal: Mol Cell Biol
Title: NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes.
Volume: 32
Issue: 14
Pages: 2760-70
Publication      
First Author: Samples R
Year: 1999
Journal: MGI Direct Data Submission
Title: The Jackson Laboratory Mouse Mutant Resource 1999 Mutation Reports
Publication
First Author: Kanagaratham C
Year: 2018
Journal: Mamm Genome
Title: Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion.
Volume: 29
Issue: 3-4
Pages: 281-298
Publication
First Author: Lin JC
Year: 2016
Journal: Biochim Biophys Acta
Title: RBM4-Nova1-SRSF6 splicing cascade modulates the development of brown adipocytes.
Volume: 1859
Issue: 11
Pages: 1368-1379
Publication
First Author: Barroso E
Year: 2011
Journal: Endocrinology
Title: The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.
Volume: 152
Issue: 5
Pages: 1848-59
Publication
First Author: Moran JL
Year: 2006
Journal: Genome Res
Title: Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse.
Volume: 16
Issue: 3
Pages: 436-40
Publication      
First Author: Donahue LR
Year: 1999
Journal: MGI Direct Data Submission
Title: The Jackson Laboratory Mouse Mutant Resource 1999 Mutation Reports
Publication  
First Author: Johnson HL
Year: 2013
Journal: BMC Genomics
Title: Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood-brain barrier disruption.
Volume: 14
Pages: 678
Publication
First Author: Wilkin RJ
Year: 2016
Journal: Am J Pathol
Title: Murine Models of Acute Alcoholic Hepatitis and Their Relevance to Human Disease.
Volume: 186
Issue: 4
Pages: 748-60
Publication
First Author: Klingenspor M
Year: 1999
Journal: J Biol Chem
Title: Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics.
Volume: 274
Issue: 33
Pages: 23078-84
Publication
First Author: Bose SK
Year: 2016
Journal: Endocrinology
Title: Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation.
Volume: 157
Issue: 12
Pages: 4943-4960
Publication  
First Author: Agarwal M
Year: 2020
Journal: Development
Title: Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.
Volume: 147
Issue: 7
Publication
First Author: Okazaki N
Year: 2002
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 9
Issue: 5
Pages: 179-88
UniProt Feature
Begin: 1
Description: Phosphatidate phosphatase LPIN1
Type: chain
End: 924
Publication    
First Author: Li J
Year: 2018
Journal: Database (Oxford)
Title: CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.
Volume: 2018
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication        
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Allele
Name: lipin 1; targeted mutation 1.1, Roman Chrast
Allele Type: Targeted
Attribute String: Null/knockout
Protein
Organism: Mus musculus/domesticus
Length: 891  
Fragment?: false
Publication
First Author: Huffman TA
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin.
Volume: 99
Issue: 2
Pages: 1047-52
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Irie K
Year: 1993
Journal: Mol Gen Genet
Title: A gene, SMP2, involved in plasmid maintenance and respiration in Saccharomyces cerevisiae encodes a highly charged protein.
Volume: 236
Issue: 2-3
Pages: 283-8
Publication
First Author: O'Hara L
Year: 2006
Journal: J Biol Chem
Title: Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+-dependent phosphatidate phosphatase.
Volume: 281
Issue: 45
Pages: 34537-48
Protein Domain
Type: Family
Description: Lipin family consists of lipin proteins, which are magnesium-dependent phosphatidate phosphatase enzymes that provide diacylglycerol for synthesis of triacylglycerol and phospholipids. Mammalian lipin proteins also exhibit transcriptional coactivator activity []. Common polymorphisms in human LPIN1 and LPIN2 genes are associated with traits underlying common metabolic diseases, including increased adiposity, hypertension, insulin sensitivity, and response to commonly used antidiabetic drugs []. Saccharomyces cerevisiae lipin, PAH1, controls transcription of phospholipid biosynthetic genes and nuclear structure by regulating the amount of membrane present at the nuclear envelope. PAH is also involved in plasmid maintenance, in respiration and in cell proliferation [, , ].
Publication
First Author: Clifford BL
Year: 2021
Journal: Cell Metab
Title: FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption.
Volume: 33
Issue: 8
Pages: 1671-1684.e4
Publication      
First Author: LaPoint A
Year: 2023
Journal: bioRxiv
Title: Adipocyte lipin 1 is positively associated with metabolic health in humans and regulates systemic metabolism in mice.