| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:4417291 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4825970 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_013747_19 |
|
| Specimen Label: |
euxassay_013747_19 |
| Detected: |
true |
| Specimen Num: |
19 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417291 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4825970 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_013747_20 |
|
| Specimen Label: |
euxassay_013747_20 |
| Detected: |
true |
| Specimen Num: |
20 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417291 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4825970 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_013747_21 |
|
| Specimen Label: |
euxassay_013747_21 |
| Detected: |
true |
| Specimen Num: |
21 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417291 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4825970 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_013747_22 |
|
| Specimen Label: |
euxassay_013747_22 |
| Detected: |
true |
| Specimen Num: |
22 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417291 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4825970 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_013747_23 |
|
| Specimen Label: |
euxassay_013747_23 |
| Detected: |
true |
| Specimen Num: |
23 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417291 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1791823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4825970 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_013747_11 |
|
| Specimen Label: |
euxassay_013747_11 |
| Detected: |
true |
| Specimen Num: |
11 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417291 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1791823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4825970 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_013747_15 |
|
| Specimen Label: |
euxassay_013747_15 |
| Detected: |
true |
| Specimen Num: |
15 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417291 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1791823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4825970 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_013747_16 |
|
| Specimen Label: |
euxassay_013747_16 |
| Detected: |
true |
| Specimen Num: |
16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li TY |
| Year: |
2018 |
| Journal: |
Nat Commun |
| Title: |
Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
1916 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dwyer JR |
| Year: |
2012 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum. |
| Volume: |
109 |
| Issue: |
37 |
| Pages: |
E2486-95 |
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•
•
•
|
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J Lipid Res |
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Naturally occurring mutations in mice affecting lipid transport and metabolism. |
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37 |
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•
•
•
|
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Chandran S |
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2020 |
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Front Immunol |
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Lipin-1 Contributes to IL-4 Mediated Macrophage Polarization. |
| Volume: |
11 |
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787 |
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•
•
•
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Vozenilek AE |
| Year: |
2018 |
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Arterioscler Thromb Vasc Biol |
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| Volume: |
38 |
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2 |
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•
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J Biol Chem |
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Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2. |
| Volume: |
283 |
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43 |
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•
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Sembongi H |
| Year: |
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J Biol Chem |
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Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells. |
| Volume: |
288 |
| Issue: |
48 |
| Pages: |
34502-13 |
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•
•
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| First Author: |
Péterfy M |
| Year: |
2010 |
| Journal: |
J Biol Chem |
| Title: |
Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes. |
| Volume: |
285 |
| Issue: |
6 |
| Pages: |
3857-64 |
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•
•
•
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Boroda S |
| Year: |
2017 |
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J Biol Chem |
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The phosphatidic acid-binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3. |
| Volume: |
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50 |
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GenBank Submission |
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Mus musculus mRNA for Trif, complete cds |
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•
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| Year: |
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J Lipid Res |
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Dynamic and differential regulation of proteins that coat lipid droplets in fatty liver dystrophic mice. |
| Volume: |
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•
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Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis. |
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Sci Signal |
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The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. |
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The fld mutation maps near to but distinct from the Apob locus on mouse chromosome 12. |
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| UniProt Feature |
| Begin: |
1 |
| Description: |
Phosphatidate phosphatase LPIN1 |
| Type: |
chain |
| End: |
924 |
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•
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Shanghai Model Organisms Center |
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UniProt-GOA |
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Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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|
| Allele |
| Name: |
lipin 1; targeted mutation 1.1, Roman Chrast |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
891
 |
| Fragment?: |
false |
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•
•
•
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| Publication |
| First Author: |
Huffman TA |
| Year: |
2002 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin. |
| Volume: |
99 |
| Issue: |
2 |
| Pages: |
1047-52 |
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•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
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•
•
•
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| Publication |
| First Author: |
Irie K |
| Year: |
1993 |
| Journal: |
Mol Gen Genet |
| Title: |
A gene, SMP2, involved in plasmid maintenance and respiration in Saccharomyces cerevisiae encodes a highly charged protein. |
| Volume: |
236 |
| Issue: |
2-3 |
| Pages: |
283-8 |
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•
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•
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| Publication |
| First Author: |
O'Hara L |
| Year: |
2006 |
| Journal: |
J Biol Chem |
| Title: |
Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+-dependent phosphatidate phosphatase. |
| Volume: |
281 |
| Issue: |
45 |
| Pages: |
34537-48 |
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•
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•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Lipin family consists of lipin proteins, which are magnesium-dependent phosphatidate phosphatase enzymes that provide diacylglycerol for synthesis of triacylglycerol and phospholipids. Mammalian lipin proteins also exhibit transcriptional coactivator activity []. Common polymorphisms in human LPIN1 and LPIN2 genes are associated with traits underlying common metabolic diseases, including increased adiposity, hypertension, insulin sensitivity, and response to commonly used antidiabetic drugs []. Saccharomyces cerevisiae lipin, PAH1, controls transcription of phospholipid biosynthetic genes and nuclear structure by regulating the amount of membrane present at the nuclear envelope. PAH is also involved in plasmid maintenance, in respiration and in cell proliferation [, , ]. |
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•
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•
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| Publication |
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Clifford BL |
| Year: |
2021 |
| Journal: |
Cell Metab |
| Title: |
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption. |
| Volume: |
33 |
| Issue: |
8 |
| Pages: |
1671-1684.e4 |
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•
•
•
•
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| Publication |
| First Author: |
LaPoint A |
| Year: |
2023 |
| Journal: |
bioRxiv |
| Title: |
Adipocyte lipin 1 is positively associated with metabolic health in humans and regulates systemic metabolism in mice. |
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