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Search results 201 to 283 out of 283 for Lrrc8a

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Type Details Score
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1915328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: UC Davis_1885597
Specimen Label: UC Davis_1885597
Detected: true
Specimen Num: 57
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•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1915328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: UC Davis_1885673
Specimen Label: UC Davis_1885673
Detected: true
Specimen Num: 133
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•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: TCP_2460870
Specimen Label: TCP_2460870
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: UC Davis_1885594
Specimen Label: UC Davis_1885594
Detected: true
Specimen Num: 54
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•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: UC Davis_1885595
Specimen Label: UC Davis_1885595
Detected: true
Specimen Num: 55
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: TCP_2460861
Specimen Label: TCP_2460861
Detected: true
Specimen Num: 87
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: UC Davis_1885666
Specimen Label: UC Davis_1885666
Detected: true
Specimen Num: 127
•
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•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: UC Davis_1885667
Specimen Label: UC Davis_1885667
Detected: true
Specimen Num: 128
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•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3281228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: UC Davis_1885556
Specimen Label: UC Davis_1885556
Detected: true
Specimen Num: 20
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•
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•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3281228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: UC Davis_1885631
Specimen Label: UC Davis_1885631
Detected: true
Specimen Num: 95
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: UC Davis_1885616
Specimen Label: UC Davis_1885616
Detected: true
Specimen Num: 73
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: UC Davis_1885617
Specimen Label: UC Davis_1885617
Detected: true
Specimen Num: 74
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•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: TCP_2460863
Specimen Label: TCP_2460863
Detected: true
Specimen Num: 2
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•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: TCP_2460854
Specimen Label: TCP_2460854
Detected: true
Specimen Num: 81
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•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: UC Davis_1885612
Specimen Label: UC Davis_1885612
Detected: true
Specimen Num: 69
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•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: UC Davis_1885613
Specimen Label: UC Davis_1885613
Detected: true
Specimen Num: 70
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: UC Davis_1885695
Specimen Label: UC Davis_1885695
Detected: true
Specimen Num: 152
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: UC Davis_1885696
Specimen Label: UC Davis_1885696
Detected: true
Specimen Num: 153
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•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: UC Davis_1885545
Specimen Label: UC Davis_1885545
Detected: true
Specimen Num: 9
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•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692750
Age: postnatal adult
Image: UC Davis_1885623
Specimen Label: UC Davis_1885623
Detected: true
Specimen Num: 88
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•
GXD Expression
GXD Expression
   
Probe: MGI:7469886
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-10
Strength: Present
Sex: Male
Emaps: EMAPS:3754128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7470963
Age: postnatal
Specimen Label: S3B WT
Detected: true
Specimen Num: 9
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•
GXD Expression
GXD Expression
 
Probe: MGI:7469886
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-10
Strength: Present
Sex: Male
Emaps: EMAPS:3754128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7470963
Age: postnatal
Note: Less expression compared with the wild-type.
Specimen Label: S3B cKO
Detected: true
Specimen Num: 10
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•
GXD Expression
GXD Expression
     
Probe: MGI:7469886
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-10
Strength: Absent
Sex: Male
Emaps: EMAPS:3813122
Stage: TS22
Assay Id: MGI:7470963
Age: embryonic day 14.5
Specimen Label: 1 E14.5
Detected: false
Specimen Num: 1
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Publication
30982627 | J:273644
     
First Author: Yang J
Year: 2019
Journal: Neuron
Title: Glutamate-Releasing SWELL1 Channel in Astrocytes Modulates Synaptic Transmission and Promotes Brain Damage in Stroke.
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Publication
35145074 | J:322234
First Author: Gunasekar SK
Year: 2022
Journal: Nat Commun
Title: Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
Volume: 13
Issue: 1
Pages: 784
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Publication
10555545 | J:59683
First Author: Batias C
Year: 1999
Journal: Cell Tissue Res
Title: Modified expression of testicular gap-junction connexin 43 during normal spermatogenic cycle and in altered spermatogenesis.
Volume: 298
Issue: 1
Pages: 113-21
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Publication
36989353 | J:334935
First Author: Chu J
Year: 2023
Journal: Sci Adv
Title: ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain.
Volume: 9
Issue: 13
Pages: eade9931
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Publication
36681074 | J:353969
First Author: Yang J
Year: 2023
Journal: Neuron
Title: Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA.
Volume: 111
Issue: 7
Pages: 1104-1117.e6
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Publication
34968783 | J:319765
 
First Author: Chen L
Year: 2022
Journal: Biochem Biophys Res Commun
Title: Effect of Swell1 on regulating chondrocyte hypertrophy during the condylar osteochondral development process in mice.
Volume: 590
Pages: 42-48
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
20562862 | J:161922
First Author: Tang T
Year: 2010
Journal: Nat Biotechnol
Title: A mouse knockout library for secreted and transmembrane proteins.
Volume: 28
Issue: 7
Pages: 749-55
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Publication
- | J:171883
     
First Author: Lexicon Genetics, Inc
Year: 2011
Journal: Database Download
Title: MGI download of Lexicon knockout data
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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UniProt Feature
UniProt Feature
Begin: 1
Description: Volume-regulated anion channel subunit LRRC8A
Type: chain
End: 810
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Publication
29957062 | J:284287
First Author: Formaggio F
Year: 2019
Journal: FASEB J
Title: LRRC8A is essential for swelling-activated chloride current and for regulatory volume decrease in astrocytes.
Volume: 33
Issue: 1
Pages: 101-113
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Publication
15094057 | -
First Author: Kubota K
Year: 2004
Journal: FEBS Lett
Title: LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins.
Volume: 564
Issue: 1-2
Pages: 147-52
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Publication
24725410 | -
First Author: Qiu Z
Year: 2014
Journal: Cell
Title: SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel.
Volume: 157
Issue: 2
Pages: 447-458
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Protein
Q80WG5
Organism: Mus musculus/domesticus
Length: 810  
Fragment?: false
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Allele
Lrrc8a<em1Smoc> | MGI:7290878
Name: leucine rich repeat containing 8A VRAC subunit A; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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DO Term
DOID:0080588 | agammaglobulinemia 5
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Allele
Lrrc8a<em1Tjj> | MGI:7278860
Name: leucine rich repeat containing 8A VRAC subunit A; endonuclease-mediated mutation 1, Thomas J Jentsch
Allele Type: Endonuclease-mediated
Attribute String: Epitope tag
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Strain
MGI:6770912 | C57BL/6JSmoc-Lrrc8a<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Lrrc8a<tm1Smoc> | MGI:7786899
Name: leucine rich repeat containing 8A VRAC subunit A; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
24782309 | -
First Author: Lee CC
Year: 2014
Journal: J Biol Chem
Title: The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D.
Volume: 289
Issue: 24
Pages: 17124-31
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Strain
MGI:7788738 | C57BL/6JSmoc-Lrrc8a<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Publication
25941382 | J:221655
First Author: Milenkovic A
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells.
Volume: 112
Issue: 20
Pages: E2630-9
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Publication
28695146 | J:244698
First Author: Bugiani M
Year: 2017
Journal: Ann Clin Transl Neurol
Title: Megalencephalic leukoencephalopathy with cysts: the Glialcam-null mouse model.
Volume: 4
Issue: 7
Pages: 450-465
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Publication
33139539 | J:299680
First Author: Li P
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses.
Volume: 117
Issue: 46
Pages: 29155-29165
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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