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Search results 201 to 236 out of 236 for Lta4h

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Type Details Score
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
31085102 | J:279140
 
First Author: Zhao S
Year: 2019
Journal: EBioMedicine
Title: Inhibition of LTA4H by bestatin in human and mouse colorectal cancer.
Volume: 44
Pages: 361-374
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Publication
20432426 | -
First Author: Jiang X
Year: 2010
Journal: Chembiochem
Title: Modulating the substrate specificity of LTA4H aminopeptidase by using chemical compounds and small-molecule-guided mutagenesis.
Volume: 11
Issue: 8
Pages: 1120-8
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Allele
Lta4h<em1Smoc> | MGI:7290889
Name: leukotriene A4 hydrolase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6475721 | C57BL/6JSmoc-Lta4h<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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GO Term
GO:0004463 | leukotriene-A4 hydrolase activity
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Protein
J3QNU3
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Publication
11675384 | -
First Author: Rudberg PC
Year: 2002
Journal: J Biol Chem
Title: Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms.
Volume: 277
Issue: 2
Pages: 1398-404
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Publication
20609366 | -
First Author: Tholander F
Year: 2010
Journal: FEBS Lett
Title: Crystal structure of leukotriene A4 hydrolase in complex with kelatorphan, implications for design of zinc metallopeptidase inhibitors.
Volume: 584
Issue: 15
Pages: 3446-51
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Publication
20097252 | -
First Author: Rinaldo-Matthis A
Year: 2010
Journal: Biochimie
Title: Structures and mechanisms of enzymes in the leukotriene cascade.
Volume: 92
Issue: 6
Pages: 676-81
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Publication
20110560 | -
First Author: Rao NL
Year: 2010
Journal: Am J Respir Crit Care Med
Title: Leukotriene A(4) hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness.
Volume: 181
Issue: 9
Pages: 899-907
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Publication
20952510 | -
First Author: Oi N
Year: 2010
Journal: Cancer Res
Title: Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene Aâ‚„hydrolase.
Volume: 70
Issue: 23
Pages: 9755-64
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Publication
17481555 | -
First Author: Haeggström JZ
Year: 2007
Journal: Prostaglandins Other Lipid Mediat
Title: Structure and catalytic mechanisms of leukotriene A4 hydrolase.
Volume: 83
Issue: 3
Pages: 198-202
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Protein Domain
IPR034015 | M1_LTA4H
Type: Family
Description: This entry includes leukotriene A4 hydrolase (LTA4H; E.C. 3.3.2.6; MEROPS identifier M01.004) and the close homologues cold-active aminopeptidase (Colwellia psychrerythraea-type peptidase; ColAP; MEROPS identifier M01.031), and arginyl aminopeptidase-like 1 (also known as aminopeptidase RNPEPL1, MEROPS identifier M01.022), all members of the aminopeptidase M1 family. LTA4H, is a bifunctional enzyme possessing an aminopeptidase as well as an epoxide hydrolase activity []. The two activities occupy different, but overlapping sites [, ]. The activity and physiological relevance of the aminopeptidase is as yet unknown while the epoxide hydrolase converts leukotriene A4 (LTA4) into leukotriene B4 (LTB4), apotent chemotaxin that is fundamental to the inflammatory response of mammals [, ]. It accepts a variety of substrates, including some opioid, di- and tripeptides, as well as chromogenic aminoacyl-p-nitroanilide derivatives. The aminopeptidase activity of LTA4H is possibly involved in the processing of peptides related to inflammation and host defense. Kinetic analysis shows that LTA4H hydrolyzes arginyl tripeptides with high efficiency and specificity, indicating its function as an arginyl aminopeptidase []. LTA4H is overexpressed in certain human cancers, and has been identified as a functionally important target for mediating anticancer properties of resveratrol, a well known red wine polyphenolic compound with cancer chemopreventive activity [].
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Protein
J3QNA8
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
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Protein
J3QJW7
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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Protein
J3QQ46
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
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Protein
G5E872
Organism: Mus musculus/domesticus
Length: 720  
Fragment?: false
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Protein
Q8K2C3
Organism: Mus musculus/domesticus
Length: 494  
Fragment?: false
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Protein
J3QMP7
Organism: Mus musculus/domesticus
Length: 375  
Fragment?: true
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Protein
Q8VCT3
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: false
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Protein
E9PYF1
Organism: Mus musculus/domesticus
Length: 611  
Fragment?: false
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Protein
Q8BMH2
Organism: Mus musculus/domesticus
Length: 611  
Fragment?: false
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