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Search results 201 to 291 out of 291 for Map3k8

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Type Details Score
Publication
29562203 | J:272415
First Author: O'Reilly LA
Year: 2018
Journal: Immunity
Title: Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.
Volume: 48
Issue: 3
Pages: 570-583.e8
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Publication
22124325 | J:181776
First Author: Gugasyan R
Year: 2012
Journal: EMBO J
Title: The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties.
Volume: 31
Issue: 3
Pages: 692-706
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Publication
35082159 | J:322244
First Author: Blair L
Year: 2022
Journal: J Immunol
Title: TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages.
Volume: 208
Issue: 4
Pages: 941-954
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Publication
24713702 | J:214118
First Author: Rowley SM
Year: 2014
Journal: J Biol Chem
Title: Tumor progression locus 2 (Tpl2) kinase promotes chemokine receptor expression and macrophage migration during acute inflammation.
Volume: 289
Issue: 22
Pages: 15788-97
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Publication
25634095 | J:222892
First Author: Luo M
Year: 2015
Journal: PLoS Genet
Title: Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis.
Volume: 11
Issue: 1
Pages: e1004954
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Publication
8107195 | J:16804
First Author: Justice MJ
Year: 1994
Journal: J Virol
Title: Identification of Evi-3, a novel common site of retroviral integration in mouse AKXD B-cell lymphomas.
Volume: 68
Issue: 3
Pages: 1293-300
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Publication
18187448 | J:131083
First Author: Rousseau S
Year: 2008
Journal: J Cell Sci
Title: TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages.
Volume: 121
Issue: Pt 2
Pages: 149-54
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Publication
22988300 | J:189231
First Author: Roget K
Year: 2012
Journal: Mol Cell Biol
Title: IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400.
Volume: 32
Issue: 22
Pages: 4684-90
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Publication
9070650 | J:38895
First Author: Liao X
Year: 1997
Journal: Oncogene
Title: Proviral integrations at the Evi5 locus disrupt a novel 90 kDa protein with homology to the Tre2 oncogene and cell-cycle regulatory proteins.
Volume: 14
Issue: 9
Pages: 1023-9
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Publication
24912162 | J:211623
First Author: Ben-Addi A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases.
Volume: 111
Issue: 23
Pages: E2394-403
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Publication
16291755 | J:116388
First Author: Eliopoulos AG
Year: 2006
Journal: J Biol Chem
Title: The tyrosine kinase Syk regulates TPL2 activation signals.
Volume: 281
Issue: 3
Pages: 1371-80
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Publication
12486099 | J:108572
First Author: Kontoyiannis D
Year: 2002
Journal: J Exp Med
Title: Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease.
Volume: 196
Issue: 12
Pages: 1563-74
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Publication
18855897 | J:141097
First Author: Craig EA
Year: 2008
Journal: Dev Dyn
Title: MAP3Ks as central regulators of cell fate during development.
Volume: 237
Issue: 11
Pages: 3102-14
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Publication
9151674 | J:40187
First Author: Miner JH
Year: 1997
Journal: J Cell Biol
Title: The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.
Volume: 137
Issue: 3
Pages: 685-701
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Publication
1354644 | J:1701
First Author: Justice MJ
Year: 1992
Journal: Genomics
Title: A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18.
Volume: 13
Issue: 4
Pages: 1281-8
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Publication
8626800 | J:37068
First Author: Wang Y
Year: 1996
Journal: J Biol Chem
Title: A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.
Volume: 271
Issue: 8
Pages: 4468-76
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Publication
27022143 | J:233073
First Author: de Valle E
Year: 2016
Journal: J Exp Med
Title: NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells.
Volume: 213
Issue: 4
Pages: 621-41
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Publication
23070814 | J:188254
First Author: Budry L
Year: 2012
Journal: Genes Dev
Title: The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling.
Volume: 26
Issue: 20
Pages: 2299-310
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
33443087 | J:303906
First Author: Zannikou M
Year: 2021
Journal: J Immunol
Title: MAP3K8 Regulates Cox-2-Mediated Prostaglandin E2 Production in the Lung and Suppresses Pulmonary Inflammation and Fibrosis.
Volume: 206
Issue: 3
Pages: 607-620
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Pathway
R-MMU-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation
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Allele
Tg(Alb-Map3k8)1Zgs | MGI:7492359
Name: transgene insertion 1, Zhi-Gang She
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
15169888 | -
First Author: Lang V
Year: 2004
Journal: Mol Cell Biol
Title: ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.
Volume: 24
Issue: 12
Pages: 5235-48
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Publication
15670770 | -
First Author: Chan H
Year: 2005
Journal: Biochem Biophys Res Commun
Title: TRAF-dependent association of protein kinase Tpl2/COT1 (MAP3K8) with CD40.
Volume: 328
Issue: 1
Pages: 198-205
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Protein Domain
IPR017424 | MAPKKK8
Type: Family
Description: This entry represents mitogen-activated protein kinase kinase kinase 8 (MAP3K8 or COT or TPL2) (), which plays a role in the cell cycle. MAP3K8 is required for TLR4 activation of the MEK/ERK pathway. MAP3K8 is able to activate NF-kappa-B 1 (NFKB1) by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105 []. MAP3K8 forms a ternary complex with NFKB1 and TNIP2 []. MAP3K8 is recruited to the CD40 complex via a mechanism dependent on TRAF-binding sites in CD40 [].
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Allele
Tg(Lck-Map3k8)3456Ngc | MGI:2388710
Name: transgene insertion 3456, Neal G Copeland
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
9087424 | J:39450
First Author: Ceci JD
Year: 1997
Journal: Genes Dev
Title: Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation.
Volume: 11
Issue: 6
Pages: 688-700
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Genotype
Genotype
Symbol: Tg(Lck-Map3k8)3456Ngc/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Protein
Q07174
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Publication
30463015 | J:270675
First Author: Wehde BL
Year: 2018
Journal: Cell Rep
Title: Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression.
Volume: 25
Issue: 8
Pages: 2192-2207.e5
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Protein Coding Gene
MGI:2386643 | Tnip2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q99JG7
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
Q3U086
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Protein
Q3UEB8
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Protein Coding Gene
MGI:2144023 | Fbxw11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q5SRY7
Organism: Mus musculus/domesticus
Length: 542  
Fragment?: false
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Protein Coding Gene
MGI:99484 | Chuk
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97312 | Nfkb1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1338071 | Ikbkb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O88351
Organism: Mus musculus/domesticus
Length: 757  
Fragment?: false
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Protein
Q60680
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false
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Protein
P25799
Organism: Mus musculus/domesticus
Length: 971  
Fragment?: false
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Protein Coding Gene
MGI:103575 | Skp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1349658 | Cul1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1338074 | Ikbkg
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9WTX6
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: false
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Protein
O88522
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: false
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Protein
Q9WTX5
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: false
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Protein Coding Gene
MGI:1925544 | Rps27a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98887 | Uba52
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98888 | Ubb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98889 | Ubc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P62984
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Protein
P0CG50
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
P62983
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
P0CG49
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
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