Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:3506600 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757727 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3508080 |
Age: |
postnatal newborn |
Image: |
2 |
|
Specimen Label: |
2 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506600 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2850023 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539585 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5934 |
|
Specimen Label: |
GUDMAP:5934 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Max EE |
Year: |
1980 |
Journal: |
Cell |
Title: |
Variation in the crossover point of kappa immunoglobulin gene V-J recombination: evidence from a cryptic gene. |
Volume: |
21 |
Issue: |
3 |
Pages: |
793-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Atchley WR |
Year: |
1995 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner. |
Volume: |
92 |
Issue: |
22 |
Pages: |
10217-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yuan J |
Year: |
1998 |
Journal: |
Oncogene |
Title: |
The C. elegans MDL-1 and MXL-1 proteins can functionally substitute for vertebrate MAD and MAX. |
Volume: |
17 |
Issue: |
9 |
Pages: |
1109-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chappell J |
Year: |
2013 |
Journal: |
Genes Dev |
Title: |
MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7. |
Volume: |
27 |
Issue: |
7 |
Pages: |
725-33 |
|
•
•
•
•
•
|
QTL |
Type: |
QTL |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee CM |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. |
Volume: |
99 |
Issue: |
22 |
Pages: |
14189-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Max M |
Year: |
1995 |
Journal: |
Science |
Title: |
Pineal opsin: a nonvisual opsin expressed in chick pineal. |
Volume: |
267 |
Issue: |
5203 |
Pages: |
1502-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Quéva C |
Year: |
2001 |
Journal: |
Mol Cell Biol |
Title: |
Targeted deletion of the S-phase-specific Myc antagonist Mad3 sensitizes neuronal and lymphoid cells to radiation-induced apoptosis. |
Volume: |
21 |
Issue: |
3 |
Pages: |
703-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hurlin PJ |
Year: |
2003 |
Journal: |
EMBO J |
Title: |
Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. |
Volume: |
22 |
Issue: |
18 |
Pages: |
4584-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hurlin PJ |
Year: |
1995 |
Journal: |
EMBO J |
Title: |
Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. |
Volume: |
14 |
Issue: |
22 |
Pages: |
5646-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ayer DE |
Year: |
1995 |
Journal: |
Cell |
Title: |
Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. |
Volume: |
80 |
Issue: |
5 |
Pages: |
767-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Edelhoff S |
Year: |
1994 |
Journal: |
Oncogene |
Title: |
Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19. |
Volume: |
9 |
Issue: |
2 |
Pages: |
665-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie Y |
Year: |
2005 |
Journal: |
FEBS Lett |
Title: |
Acquisition of essential somatic cell cycle regulatory protein expression and implied activity occurs at the second to third cell division in mouse preimplantation embryos. |
Volume: |
579 |
Issue: |
2 |
Pages: |
398-408 |
|
•
•
•
•
•
|
QTL |
Type: |
QTL |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
QTL |
Type: |
QTL |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Rahl PB |
Year: |
2010 |
Journal: |
Cell |
Title: |
c-Myc regulates transcriptional pause release. |
Volume: |
141 |
Issue: |
3 |
Pages: |
432-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim J |
Year: |
2010 |
Journal: |
Cell |
Title: |
A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. |
Volume: |
143 |
Issue: |
2 |
Pages: |
313-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mochizuki K |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing. |
Volume: |
12 |
Issue: |
1 |
Pages: |
7020 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gupta K |
Year: |
1998 |
Journal: |
Oncogene |
Title: |
Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc. |
Volume: |
16 |
Issue: |
9 |
Pages: |
1149-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qi Y |
Year: |
2004 |
Journal: |
Nature |
Title: |
p19ARF directly and differentially controls the functions of c-Myc independently of p53. |
Volume: |
431 |
Issue: |
7009 |
Pages: |
712-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Domashenko AD |
Year: |
1997 |
Journal: |
Mol Reprod Dev |
Title: |
Expression of myc-family, myc-interacting, and myc-target genes during preimplantation mouse development. |
Volume: |
47 |
Issue: |
1 |
Pages: |
57-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morgenbesser SD |
Year: |
1995 |
Journal: |
EMBO J |
Title: |
Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo. |
Volume: |
14 |
Issue: |
4 |
Pages: |
743-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Trumpp A |
Year: |
2001 |
Journal: |
Nature |
Title: |
c-Myc regulates mammalian body size by controlling cell number but not cell size. |
Volume: |
414 |
Issue: |
6865 |
Pages: |
768-73 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
206
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kojic S |
Year: |
2010 |
Journal: |
Arch Biochem Biophys |
Title: |
A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein. |
Volume: |
502 |
Issue: |
1 |
Pages: |
60-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qin J |
Year: |
2012 |
Journal: |
Cell Stem Cell |
Title: |
The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. |
Volume: |
11 |
Issue: |
3 |
Pages: |
319-32 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
227
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
121
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Childress P |
Year: |
2015 |
Journal: |
Mol Endocrinol |
Title: |
Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis. |
Volume: |
29 |
Issue: |
9 |
Pages: |
1269-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh S |
Year: |
2007 |
Journal: |
Birth Defects Res A Clin Mol Teratol |
Title: |
Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development. |
Volume: |
79 |
Issue: |
1 |
Pages: |
35-44 |
|
•
•
•
•
•
|
Pseudogene |
Type: |
pseudogene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
2 |
Description: |
Protein max |
Type: |
chain |
End: |
160 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lowenstein ED |
Year: |
2021 |
Journal: |
Elife |
Title: |
Olig3 regulates early cerebellar development. |
Volume: |
10 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ravasi T |
Year: |
2010 |
Journal: |
Cell |
Title: |
An atlas of combinatorial transcriptional regulation in mouse and man. |
Volume: |
140 |
Issue: |
5 |
Pages: |
744-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stevens JD |
Year: |
2008 |
Journal: |
Differentiation |
Title: |
Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation. |
Volume: |
76 |
Issue: |
9 |
Pages: |
1006-22 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
209
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang F |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Deterministic and stochastic allele specific gene expression in single mouse blastomeres. |
Volume: |
6 |
Issue: |
6 |
Pages: |
e21208 |
|
•
•
•
•
•
|
Publication |
First Author: |
Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom |
Year: |
2023 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wiese CB |
Year: |
2012 |
Journal: |
Front Neurosci |
Title: |
A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. |
Volume: |
6 |
|
Pages: |
130 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo G |
Year: |
2010 |
Journal: |
Dev Cell |
Title: |
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. |
Volume: |
18 |
Issue: |
4 |
Pages: |
675-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gray PA |
Year: |
2004 |
Journal: |
Science |
Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
Volume: |
306 |
Issue: |
5705 |
Pages: |
2255-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Chin L |
Year: |
1995 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Contrasting roles for Myc and Mad proteins in cellular growth and differentiation. |
Volume: |
92 |
Issue: |
18 |
Pages: |
8488-92 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
94
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Lafita-Navarro MC |
Year: |
2016 |
Journal: |
Oncotarget |
Title: |
MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis. |
Volume: |
7 |
Issue: |
43 |
Pages: |
69536-69548 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
MXD1, also known as MAD, binds Max to form a repressive transcription factor. It antagonizes MYC transcriptional activity by competing for MAX []. It has also been shown to regulate rRNA synthesis []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Shimizu E |
Year: |
1996 |
Journal: |
Gene |
Title: |
Expression, regulation and polymorphism of the mxi1 genes. |
Volume: |
176 |
Issue: |
1-2 |
Pages: |
45-8 |
|
•
•
•
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Publication |
First Author: |
Västrik I |
Year: |
1995 |
Journal: |
J Cell Biol |
Title: |
Expression of the mad gene during cell differentiation in vivo and its inhibition of cell growth in vitro. |
Volume: |
128 |
Issue: |
6 |
Pages: |
1197-208 |
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Publication |
First Author: |
Cascón A |
Year: |
2012 |
Journal: |
Cancer Res |
Title: |
MAX and MYC: a heritable breakup. |
Volume: |
72 |
Issue: |
13 |
Pages: |
3119-24 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
3003
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
3042
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2833
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
124
 |
Fragment?: |
false |
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Gene |
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Gene |
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Gene |
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Gene |
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Gene |
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Gene |
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Gene |
Type: |
gene |
Organism: |
dog, domestic |
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Gene |
Type: |
gene |
Organism: |
dog, domestic |
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Gene |
Type: |
gene |
Organism: |
dog, domestic |
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Gene |
Type: |
gene |
Organism: |
dog, domestic |
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Gene |
Type: |
gene |
Organism: |
dog, domestic |
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Gene |
Type: |
gene |
Organism: |
chimpanzee |
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Gene |
Type: |
gene |
Organism: |
chimpanzee |
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Gene |
Type: |
gene |
Organism: |
chimpanzee |
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