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Search results 201 to 270 out of 270 for Mcm8

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Type Details Score
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: DNA helicase MCM8
Type: chain
End: 833
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Protein
Q9CWV1
Organism: Mus musculus/domesticus
Length: 833  
Fragment?: false
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Protein
Q9CWV1-2
Organism: Mus musculus/domesticus
Length: 805  
Fragment?: false
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Allele
Mcm8<em2Smoc> | MGI:7291001
Name: minichromosome maintenance 8 homologous recombination repair factor; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
22771115 | -
First Author: Nishimura K
Year: 2012
Journal: Mol Cell
Title: Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.
Volume: 47
Issue: 4
Pages: 511-22
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Strain
MGI:6770933 | C57BL/6JSmoc-Mcm8<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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GO Term
GO:0097362 | MCM8-MCM9 complex
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Allele
Mcm8<em1Smoc> | MGI:7291000
Name: minichromosome maintenance 8 homologous recombination repair factor; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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DO Term
DOID:0080867 | primary ovarian insufficiency 10
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Strain
MGI:6475761 | C57BL/6JSmoc-Mcm8<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
23401855 | J:203320
First Author: Park J
Year: 2013
Journal: Mol Cell Biol
Title: The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination.
Volume: 33
Issue: 8
Pages: 1632-44
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Publication
30743181 | -
 
First Author: Griffin WC
Year: 2019
Journal: DNA Repair (Amst)
Title: The MCM8/9 complex: A recent recruit to the roster of helicases involved in genome maintenance.
Volume: 76
Pages: 1-10
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Protein
A0A0A0MQF4
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
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Protein Domain
IPR031327 | MCM
Type: Family
Description: MCM proteins are DNA-dependent ATPases required for the initiation of eukaryotic DNA replication [, , ]. In eukaryotes there is a family of eight proteins, MCM2 to MCM9. They were first identified in yeast where most of them have adirect role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called minichromosome maintenance proteins, MCM proteins []. These proteins are evolutionarily related and belong to the AAA+ superfamily. They contain the Mcm family domain, which includes motifs that are required for ATP hydrolysis (such as the Walker A and B, and R-finger motifs). Mcm2-7 forms a hexameric complex []in which individual subunits associate with different affinities, and there is a tightly associated core of Mcm4 (Cdc21), Mcm6 (Mis5) and Mcm7 []. Mcm2-7 complex is the replicative helicase involved in replication initiation and elongation [], whereas Mcm8 and Mcm9 from and separate one, conserved among many eukaryotes except yeast and C. elegans. Mcm8/9 complex play a role during replication elongation or recombination, being involved in the repair of double-stranded DNA breaks and DNA interstrand cross-links by homologous recombination. Drosophila is the only organism that has MCM8 without MCM9, involved in meiotic recombination [, ].This family is also present in the archebacteria in 1 to 4 copies. Methanocaldococcus jannaschii (Methanococcus jannaschii) has four members, MJ0363, MJ0961, MJ1489 and MJECL13.Schizosaccharomyces pombe (Fission yeast) MCMs, like those in metazoans, are found in the nucleus throughout the cell cycle. This is in contrast to the Saccharomyces cerevisiae (Baker's yeast) in which MCM proteins move in and out of the nucleus during each cell cycle. The assembly of the MCM complex in S. pombe is required for MCM localisation, ensuring that only intact MCM complexes remain in the nucleus [].
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Protein Domain
IPR001208 | MCM_dom
Type: Domain
Description: Proteins shown to be required for the initiation of eukaryotic DNA replication share a highly conserved domain of about 210 amino-acid residues [, , ]. The latter shows some similarities []with that of various other families of DNA-dependent ATPases. Eukaryotes seem to possess a family of eight proteins that contain this domain. They were first identified in yeast where most of them have a direct role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called 'minichromosome maintenance proteins' with gene symbols prefixedby MCM. These six proteins are:MCM2, also known as cdc19 (in S.pombe).MCM3, also known as DNA polymerase alphaholoenzyme-associated protein P1,RLF beta subunit or ROA.MCM4, also known as CDC54, cdc21 (in S.pombe) or dpa (in Drosophila).MCM5, also known as CDC46 or nda4 (in S.pombe).MCM6, also known as mis5 (in S.pombe).MCM7, also known as CDC47 or Prolifera (in A.thaliana).MCM8, also known as as REC (in Drosophila).MCMThese proteins are evolutionarily related and belong to the AAA+ superfamily. They contain the Mcm family domain, which includes motifs that are required for ATP hydrolysis (such as the Walker A and B, and R-finger motifs). Mcm2-7 forms a hexameric complex which is the replicative helicase involved in replication initiation and elongation, whereas Mcm8 and Mcm9 from and separate one, conserved among many eukaryotes except yeast and C. elegans. Mcm8/9 complex play a role during replication elongation or recombination, being involved in the repair of double-stranded DNA breaks and DNA interstrand cross-links by homologous recombination. Drosophila is the only organism that has MCM8 without MCM9, involved in meiotic recombination [, ].
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Protein
A0A1W2P804
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
A0A1W2P801
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
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Protein
E9Q956
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: false
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Protein
H9KV11
Organism: Mus musculus/domesticus
Length: 604  
Fragment?: false
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Protein
H7BXC1
Organism: Mus musculus/domesticus
Length: 692  
Fragment?: false
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Publication
9305914 | -
First Author: Ishimi Y
Year: 1997
Journal: J Biol Chem
Title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
Volume: 272
Issue: 39
Pages: 24508-13
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Publication
9366552 | -
First Author: Adachi Y
Year: 1997
Journal: Genes Cells
Title: A globular complex formation by Nda1 and the other five members of the MCM protein family in fission yeast.
Volume: 2
Issue: 7
Pages: 467-79
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Publication
9658174 | -
First Author: Sherman DA
Year: 1998
Journal: Mol Biol Cell
Title: Multiple domains of fission yeast Cdc19p (MCM2) are required for its association with the core MCM complex.
Volume: 9
Issue: 7
Pages: 1833-45
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Publication
10588642 | -
First Author: Pasion SG
Year: 1999
Journal: Mol Biol Cell
Title: Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly.
Volume: 10
Issue: 12
Pages: 4043-57
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Protein
Q2KHI9
Organism: Mus musculus/domesticus
Length: 1134  
Fragment?: false
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Protein
Q8C1Z0
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q8C2I9
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: true
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Protein
Q8C5L1
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: true
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Publication
1454522 | -
First Author: Coxon A
Year: 1992
Journal: Nucleic Acids Res
Title: Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication.
Volume: 20
Issue: 21
Pages: 5571-7
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Publication
8332451 | -
First Author: Koonin EV
Year: 1993
Journal: Nucleic Acids Res
Title: A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication.
Volume: 21
Issue: 11
Pages: 2541-7
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Publication
8265339 | -
First Author: Hu B
Year: 1993
Journal: Nucleic Acids Res
Title: The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.
Volume: 21
Issue: 23
Pages: 5289-93
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Publication
14731643 | -
First Author: Tye BK
Year: 1994
Journal: Trends Cell Biol
Title: The MCM2-3-5 proteins: are they replication licensing factors?
Volume: 4
Issue: 5
Pages: 160-6
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Protein
P97311
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q61881
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
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Protein
P97310
Organism: Mus musculus/domesticus
Length: 904  
Fragment?: false
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Protein
P49718
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
P49717
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
P25206
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
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Protein
Q542I2
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q3U4T8
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
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Protein
Q3V122
Organism: Mus musculus/domesticus
Length: 720  
Fragment?: false
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Protein
Q921D5
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q3UJN1
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
Q3UA65
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q3UK39
Organism: Mus musculus/domesticus
Length: 904  
Fragment?: false
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Protein
Q3UC10
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q8BQ03
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
Q3UZH2
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
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Protein
Q9D077
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q3ULD6
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
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Protein
Q5DTS8
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: true
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Protein
Q542F4
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q3UDI8
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
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Protein
Q3UI57
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
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Protein
Q3ULG5
Organism: Mus musculus/domesticus
Length: 794  
Fragment?: false
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Protein Coding Gene
MGI:1918817 | Mcm9
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q3UXG9
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: false
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Protein
A0A2R8VHP7
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: true
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Protein
D3Z2K9
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: true
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Protein
D3Z6N3
Organism: Mus musculus/domesticus
Length: 389  
Fragment?: false
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Protein
A0A2R8VKJ4
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
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Protein
D3Z0J6
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom