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Search results 201 to 300 out of 385 for Med1

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:6714036
Assay Type: RNA in situ
Annotation Date: 2021-06-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1795228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6714046
Age: postnatal adult
Image: 7D
Specimen Label: 7D
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:7314590
Assay Type: RNA in situ
Annotation Date: 2022-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3578428
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7314592
Age: postnatal adult
Note: Expression is in cells lining the crypts.
Specimen Label: 1K
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4879359
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2854023
Stage: TS23
Assay Id: MGI:5541018
Age: embryonic day 15.5
Image: GUDMAP:6706
Specimen Label: GUDMAP:6706
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7314590
Assay Type: RNA in situ
Annotation Date: 2022-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1920923
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7314592
Age: embryonic day 15.5
Specimen Label: 1H
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6714036
Assay Type: RNA in situ
Annotation Date: 2021-06-07
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684621
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6714046
Age: embryonic day 13.5
Image: 7B
Specimen Label: 7B
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6714036
Assay Type: RNA in situ
Annotation Date: 2021-06-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6714046
Age: postnatal adult
Image: 7D
Specimen Label: 7D
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7314590
Assay Type: RNA in situ
Annotation Date: 2022-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7314592
Age: postnatal adult
Specimen Label: 1N
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882552
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945366
Age: postnatal day 7
Image: g00870 P7
Specimen Label: g00870 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882552
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945366
Age: postnatal day 42
Image: g00870 Adult
Specimen Label: g00870 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6714036
Assay Type: RNA in situ
Annotation Date: 2021-06-07
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1624715
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6714046
Age: embryonic day 9.5
Image: 7A
Specimen Label: 7A
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6714036
Assay Type: RNA in situ
Annotation Date: 2021-06-07
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1624721
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6714046
Age: embryonic day 13.5
Image: 7B
Specimen Label: 7B
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4879359
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2762123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541018
Age: embryonic day 15.5
Image: GUDMAP:6706
Specimen Label: GUDMAP:6706
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4879359
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2762123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541018
Age: embryonic day 15.5
Image: GUDMAP:6707
Specimen Label: GUDMAP:6707
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6714036
Assay Type: RNA in situ
Annotation Date: 2021-06-07
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1718521
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6714046
Age: embryonic day 13.5
Image: 7B
Specimen Label: 7B
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4879359
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1797223
Stage: TS23
Assay Id: MGI:5541018
Age: embryonic day 15.5
Image: GUDMAP:6707
Specimen Label: GUDMAP:6707
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691230
Age: postnatal adult
Image: UC Davis_1888789
Specimen Label: UC Davis_1888789
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882552
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945366
Age: postnatal day 7
Image: g00870 P7
Specimen Label: g00870 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882552
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945366
Age: postnatal day 42
Image: g00870 Adult
Specimen Label: g00870 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882552
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945366
Age: embryonic day 11.5
Image: g00870 E11.5
Specimen Label: g00870 E11.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882552
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945366
Age: postnatal day 7
Image: g00870 P7
Specimen Label: g00870 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4882552
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3266028
Stage: TS28
Assay Id: MGI:4945366
Age: postnatal day 42
Image: g00870 Adult
Specimen Label: g00870 Adult
Detected: false
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4879359
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5541018
Age: embryonic day 15.5
Image: GUDMAP:6706
Specimen Label: GUDMAP:6706
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4879359
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5541018
Age: embryonic day 15.5
Image: GUDMAP:6707
Specimen Label: GUDMAP:6707
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4879359
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2851823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541018
Age: embryonic day 15.5
Image: GUDMAP:6706
Specimen Label: GUDMAP:6706
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4879359
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2851823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541018
Age: embryonic day 15.5
Image: GUDMAP:6707
Specimen Label: GUDMAP:6707
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6714036
Assay Type: RNA in situ
Annotation Date: 2021-06-07
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1790621
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6714046
Age: embryonic day 13.5
Image: 7B
Specimen Label: 7B
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882552
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945366
Age: postnatal day 7
Image: g00870 P7
Specimen Label: g00870 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882552
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945366
Age: postnatal day 42
Image: g00870 Adult
Specimen Label: g00870 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4879359
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2760523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541018
Age: embryonic day 15.5
Image: GUDMAP:6706
Specimen Label: GUDMAP:6706
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4879359
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2760523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541018
Age: embryonic day 15.5
Image: GUDMAP:6707
Specimen Label: GUDMAP:6707
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882552
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945366
Age: embryonic day 15.5
Image: g00870 E15.5
Specimen Label: g00870 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4882552
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945366
Age: postnatal day 7
Image: g00870 P7
Note: Expression was region specific and scattered.
Specimen Label: g00870 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882552
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945366
Age: postnatal day 42
Image: g00870 Adult
Specimen Label: g00870 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6714036
Assay Type: RNA in situ
Annotation Date: 2021-06-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3544028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6714046
Age: postnatal adult
Image: 7D
Specimen Label: 7D
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882552
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945366
Age: embryonic day 15.5
Image: g00870 E15.5
Specimen Label: g00870 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6714036
Assay Type: RNA in situ
Annotation Date: 2021-06-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3580428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6714046
Age: postnatal adult
Image: 7D
Specimen Label: 7D
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691230
Age: postnatal adult
Image: UC Davis_1888790
Specimen Label: UC Davis_1888790
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4879359
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541018
Age: embryonic day 15.5
Image: GUDMAP:6706
Specimen Label: GUDMAP:6706
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4879359
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541018
Age: embryonic day 15.5
Image: GUDMAP:6707
Specimen Label: GUDMAP:6707
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4879359
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2874723
Stage: TS23
Assay Id: MGI:5541018
Age: embryonic day 15.5
Image: GUDMAP:6706
Specimen Label: GUDMAP:6706
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4882552
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945366
Age: embryonic day 15.5
Image: g00870 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00870 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882552
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945366
Age: postnatal day 7
Image: g00870 P7
Specimen Label: g00870 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882552
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945366
Age: postnatal day 42
Image: g00870 Adult
Specimen Label: g00870 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4879359
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541018
Age: embryonic day 15.5
Image: GUDMAP:6706
Specimen Label: GUDMAP:6706
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4879359
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541018
Age: embryonic day 15.5
Image: GUDMAP:6707
Specimen Label: GUDMAP:6707
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6714036
Assay Type: RNA in situ
Annotation Date: 2021-06-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3576128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6714046
Age: postnatal adult
Image: 7D
Specimen Label: 7D
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6714036
Assay Type: RNA in situ
Annotation Date: 2021-06-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3586328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6714046
Age: postnatal adult
Image: 7D
Specimen Label: 7D
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4879359
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:5541018
Age: embryonic day 15.5
Image: GUDMAP:6706
Specimen Label: GUDMAP:6706
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7314590
Assay Type: RNA in situ
Annotation Date: 2022-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2880628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7314592
Age: postnatal adult
Specimen Label: 1C
Detected: true
Specimen Num: 1
•
•
•
•
•
Publication
14500757 | J:86857
First Author: Landles C
Year: 2003
Journal: Mol Endocrinol
Title: The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development.
Volume: 17
Issue: 12
Pages: 2418-35
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Publication
16828057 | J:111289
First Author: Guo D
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver.
Volume: 347
Issue: 2
Pages: 485-95
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•
Publication
21979373 | J:177428
First Author: Lin JJ
Year: 2011
Journal: Genes Dev
Title: Mediator coordinates PIC assembly with recruitment of CHD1.
Volume: 25
Issue: 20
Pages: 2198-209
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Publication
20007298 | J:156765
First Author: Matsumoto K
Year: 2010
Journal: Carcinogenesis
Title: Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse.
Volume: 31
Issue: 2
Pages: 318-25
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Publication
34453978 | J:312890
First Author: Zhang J
Year: 2021
Journal: Biochim Biophys Acta Mol Cell Res
Title: Double knockout of vitamin D receptor and its coactivator mediator complex subunit 1 unexpectedly enhances epidermal permeability barrier function in mice.
Volume: 1868
Issue: 12
Pages: 119131
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Publication
30130256 | J:271388
First Author: Martinez MF
Year: 2018
Journal: J Clin Invest
Title: Super-enhancers maintain renin-expressing cell identity and memory to preserve multi-system homeostasis.
Volume: 128
Issue: 11
Pages: 4787-4803
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Protein
Q925J9
Organism: Mus musculus/domesticus
Length: 1575  
Fragment?: false
•
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Protein
B1AQH6
Organism: Mus musculus/domesticus
Length: 629  
Fragment?: false
•
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•
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Publication
12150923 | -
First Author: Boube M
Year: 2002
Journal: Cell
Title: Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man.
Volume: 110
Issue: 2
Pages: 143-51
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Protein Domain
IPR019680 | Mediator_Med1
Type: Domain
Description: The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. On recruitment the Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. The Mediator complex is composed of at least 31 subunits: MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The subunits form at least three structurally distinct submodules. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation.The head module contains: MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22. The middle module contains: MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31. CSE2/MED9 interacts directly with MED4. The tail module contains: MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The CDK8 module contains: MED12, MED13, CCNC and CDK8. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.This entry represents subunit Med1 of the Mediator complex. The Med1 forms part of the Med9 submodule of the Srb/Med complex. It is one of three subunits essential for viability of the whole organism via its role in environmentally-directed cell-fate decisions [].
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Publication
16926188 | J:114839
First Author: de Bruijn DR
Year: 2006
Journal: Hum Mol Genet
Title: Targeted disruption of the synovial sarcoma-associated SS18 gene causes early embryonic lethality and affects PPARBP expression.
Volume: 15
Issue: 19
Pages: 2936-44
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Publication
19282365 | J:148516
First Author: Bugge A
Year: 2009
Journal: Mol Endocrinol
Title: The PPARgamma2 A/B-domain plays a gene-specific role in transactivation and cofactor recruitment.
Volume: 23
Issue: 6
Pages: 794-808
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Publication
22331472 | J:183797
First Author: Villar J
Year: 2012
Journal: Mol Cell Biol
Title: Androgen-induced activation of gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) transcription: essential role of a nonclassical androgen response element half-site.
Volume: 32
Issue: 8
Pages: 1566-80
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Publication
12093747 | J:77765
First Author: Ito M
Year: 2002
Journal: EMBO J
Title: The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development.
Volume: 21
Issue: 13
Pages: 3464-75
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Publication
24043798 | J:201135
First Author: Lande-Diner L
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery.
Volume: 110
Issue: 40
Pages: 16021-6
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Publication
15843544 | J:98407
First Author: Meissner NN
Year: 2005
Journal: J Immunol
Title: Role of type I IFNs in pulmonary complications of Pneumocystis murina infection.
Volume: 174
Issue: 9
Pages: 5462-71
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Publication
16104378 | J:100797
First Author: Palmer AA
Year: 2005
Journal: Mamm Genome
Title: Gene expression differences in mice divergently selected for methamphetamine sensitivity.
Volume: 16
Issue: 5
Pages: 291-305
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Publication
29519872 | J:262213
First Author: Lo KA
Year: 2018
Journal: Diabetes
Title: Adipocyte Long-Noncoding RNA Transcriptome Analysis of Obese Mice Identified Lnc-Leptin, Which Regulates Leptin.
Volume: 67
Issue: 6
Pages: 1045-1056
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9708794 | J:49107
First Author: Jain S
Year: 1998
Journal: Am J Pathol
Title: Differential expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and its coactivators steroid receptor coactivator-1 and PPAR-binding protein PBP in the brown fat, urinary bladder, colon, and breast of the mouse.
Volume: 153
Issue: 2
Pages: 349-54
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HT Experiment
GSE65873 | Med1 Deletion in Heart Causes Dilated Cardiomyopathy
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
12037571 | J:76817
First Author: Ge K
Year: 2002
Journal: Nature
Title: Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.
Volume: 417
Issue: 6888
Pages: 563-7
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Publication
9325263 | J:43438
First Author: Zhu Y
Year: 1997
Journal: J Biol Chem
Title: Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor.
Volume: 272
Issue: 41
Pages: 25500-6
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Publication
15150259 | J:94123
First Author: Jia Y
Year: 2004
Journal: J Biol Chem
Title: Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver.
Volume: 279
Issue: 23
Pages: 24427-34
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Publication
27596966 | J:239007
First Author: Tanaka S
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Periostin supports hematopoietic progenitor cells and niche-dependent myeloblastoma cells in vitro.
Volume: 478
Issue: 4
Pages: 1706-12
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Publication
17962186 | J:128919
First Author: Guo D
Year: 2007
Journal: J Biol Chem
Title: Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver.
Volume: 282
Issue: 50
Pages: 36766-76
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Publication
15365296 | J:93175
First Author: Proctor WR
Year: 2004
Journal: Alcohol Clin Exp Res
Title: Differential effects of ethanol on gamma-aminobutyric acid-A receptor-mediated synaptic currents in congenic strains of inbred long and short-sleep mice.
Volume: 28
Issue: 9
Pages: 1277-83
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Publication
14638676 | J:88488
First Author: Tomomori-Sato C
Year: 2004
Journal: J Biol Chem
Title: A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.
Volume: 279
Issue: 7
Pages: 5846-51
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Publication
12709428 | J:222684
First Author: Wansa KD
Year: 2003
Journal: J Biol Chem
Title: The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine.
Volume: 278
Issue: 27
Pages: 24776-90
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Publication
11724781 | J:74328
First Author: Crawford SE
Year: 2002
Journal: J Biol Chem
Title: Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors.
Volume: 277
Issue: 5
Pages: 3585-92
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Publication
10882104 | J:61840
First Author: Ito M
Year: 2000
Journal: Mol Cell
Title: Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action.
Volume: 5
Issue: 4
Pages: 683-93
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Publication
27570068 | J:239012
First Author: Aranda-Orgilles B
Year: 2016
Journal: Cell Stem Cell
Title: MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.
Volume: 19
Issue: 6
Pages: 784-799
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Publication
27721240 | J:239619
First Author: Rué L
Year: 2016
Journal: J Clin Invest
Title: Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.
Volume: 126
Issue: 11
Pages: 4319-4330
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Publication
12446761 | J:80609
First Author: Kim SW
Year: 2002
Journal: Mol Cell Biol
Title: Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract.
Volume: 22
Issue: 24
Pages: 8409-14
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Publication
15681609 | J:96189
First Author: Guan HP
Year: 2005
Journal: Genes Dev
Title: Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.
Volume: 19
Issue: 4
Pages: 453-61
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Publication
15340084 | J:92973
First Author: Malik S
Year: 2004
Journal: Mol Cell Biol
Title: Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.
Volume: 24
Issue: 18
Pages: 8244-54
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Publication
22982455 | J:189008
First Author: Jia Y
Year: 2012
Journal: Mech Dev
Title: Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene.
Volume: 129
Issue: 9-12
Pages: 193-207
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Publication
12955145 | J:85113
First Author: Kile BT
Year: 2003
Journal: Nature
Title: Functional genetic analysis of mouse chromosome 11.
Volume: 425
Issue: 6953
Pages: 81-6
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Publication
28291835 | J:241367
First Author: Carroll SH
Year: 2017
Journal: PLoS One
Title: Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling.
Volume: 12
Issue: 3
Pages: e0173823
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Publication
11559591 | J:320035
First Author: Mittler G
Year: 2001
Journal: EMBO Rep
Title: Novel critical role of a human Mediator complex for basal RNA polymerase II transcription.
Volume: 2
Issue: 9
Pages: 808-13
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Publication
19000668 | J:143544
First Author: Cortellino S
Year: 2009
Journal: Dev Biol
Title: Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4.
Volume: 325
Issue: 1
Pages: 225-37
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Publication
38690566 | J:347774
 
First Author: Kolonay DW
Year: 2024
Journal: Front Cell Dev Biol
Title: Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.
Volume: 12
Pages: 1331563
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Publication
34506481 | J:309620
First Author: Tan C
Year: 2021
Journal: PLoS Genet
Title: Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.
Volume: 17
Issue: 9
Pages: e1009785
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Publication
20720539 | J:164442
First Author: Kagey MH
Year: 2010
Journal: Nature
Title: Mediator and cohesin connect gene expression and chromatin architecture.
Volume: 467
Issue: 7314
Pages: 430-5
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Publication
20508642 | J:162104
First Author: Krebs AR
Year: 2010
Journal: EMBO Rep
Title: ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.
Volume: 11
Issue: 7
Pages: 541-7
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Publication
24880616 | J:226885
First Author: Tannour-Louet M
Year: 2014
Journal: Nat Med
Title: Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.
Volume: 20
Issue: 7
Pages: 715-24
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Publication
18722179 | J:138818
First Author: Tatarakis A
Year: 2008
Journal: Mol Cell
Title: Dominant and redundant functions of TFIID involved in the regulation of hepatic genes.
Volume: 31
Issue: 4
Pages: 531-43
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Publication
21779340 | J:175792
First Author: Jelcick AS
Year: 2011
Journal: PLoS One
Title: Genetic variations strongly influence phenotypic outcome in the mouse retina.
Volume: 6
Issue: 7
Pages: e21858
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Publication
11471062 | J:70827
First Author: Ehringer MA
Year: 2001
Journal: Mamm Genome
Title: High-throughput sequence identification of gene coding variants within alcohol-related QTLs.
Volume: 12
Issue: 8
Pages: 657-63
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Publication
29055695 | J:256883
First Author: Zhou J
Year: 2017
Journal: Biochim Biophys Acta
Title: Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system.
Volume: 1860
Issue: 12
Pages: 1159-1168
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Publication
22323595 | J:181994
First Author: Kamileri I
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.
Volume: 109
Issue: 8
Pages: 2995-3000
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Publication
16537572 | J:108241
First Author: Desai J
Year: 2006
Journal: Hum Mol Genet
Title: Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.
Volume: 15
Issue: 8
Pages: 1329-41
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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