Type |
Details |
Score |
Publication |
First Author: |
Santel A |
Year: |
2003 |
Journal: |
J Cell Sci |
Title: |
Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. |
Volume: |
116 |
Issue: |
Pt 13 |
Pages: |
2763-74 |
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•
•
•
•
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Publication |
First Author: |
Legros F |
Year: |
2002 |
Journal: |
Mol Biol Cell |
Title: |
Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. |
Volume: |
13 |
Issue: |
12 |
Pages: |
4343-54 |
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•
•
•
•
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Publication |
First Author: |
Head BP |
Year: |
2011 |
Journal: |
Mol Biol Cell |
Title: |
A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans. |
Volume: |
22 |
Issue: |
6 |
Pages: |
831-41 |
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•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
Mitofusin-1 (MNF1) is an essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression of MNF1 induces the formation of mitochondrial networks [, , , ]. This entry includes the protein Marf from Drosophila (also known as Mitofusin) and the closely related protein fzo-1 from C. elegans, which is a transmembrane GTPase reported to be encoded by a mitochondrial fusion gene []. |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
319
 |
Fragment?: |
true |
|
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•
•
•
•
|
Publication |
First Author: |
Huang G |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
WBSCR16 Is a Guanine Nucleotide Exchange Factor Important for Mitochondrial Fusion. |
Volume: |
20 |
Issue: |
4 |
Pages: |
923-934 |
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•
•
•
•
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Publication |
First Author: |
Yu CY |
Year: |
2015 |
Journal: |
PLoS Pathog |
Title: |
Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins. |
Volume: |
11 |
Issue: |
12 |
Pages: |
e1005350 |
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•
•
•
•
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Publication |
First Author: |
Filadi R |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2. |
Volume: |
15 |
Issue: |
10 |
Pages: |
2226-2238 |
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•
•
•
•
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Publication |
First Author: |
Mandemakers W |
Year: |
2007 |
Journal: |
J Cell Sci |
Title: |
A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases. |
Volume: |
120 |
Issue: |
Pt 10 |
Pages: |
1707-16 |
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•
•
•
•
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Publication |
First Author: |
Tanaka A |
Year: |
2010 |
Journal: |
J Cell Biol |
Title: |
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. |
Volume: |
191 |
Issue: |
7 |
Pages: |
1367-80 |
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•
•
•
•
•
|
Publication |
First Author: |
Chan NC |
Year: |
2011 |
Journal: |
Hum Mol Genet |
Title: |
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. |
Volume: |
20 |
Issue: |
9 |
Pages: |
1726-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu T |
Year: |
2019 |
Journal: |
PLoS Biol |
Title: |
Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1. |
Volume: |
17 |
Issue: |
6 |
Pages: |
e2004413 |
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•
•
•
•
•
|
Publication |
First Author: |
Santel A |
Year: |
2001 |
Journal: |
J Cell Sci |
Title: |
Control of mitochondrial morphology by a human mitofusin. |
Volume: |
114 |
Issue: |
Pt 5 |
Pages: |
867-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamada T |
Year: |
2019 |
Journal: |
Autophagy |
Title: |
SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy. |
Volume: |
15 |
Issue: |
11 |
Pages: |
2012-2018 |
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•
•
•
•
|
Publication |
First Author: |
Martin OJ |
Year: |
2014 |
Journal: |
Circ Res |
Title: |
A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth. |
Volume: |
114 |
Issue: |
4 |
Pages: |
626-36 |
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•
•
•
•
|
Publication |
First Author: |
Kitaoka Y |
Year: |
2019 |
Journal: |
Physiol Rep |
Title: |
Effects of Nrf2 deficiency on mitochondrial oxidative stress in aged skeletal muscle. |
Volume: |
7 |
Issue: |
3 |
Pages: |
e13998 |
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•
•
•
•
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Publication |
First Author: |
Hull TD |
Year: |
2016 |
Journal: |
JCI Insight |
Title: |
Heme oxygenase-1 regulates mitochondrial quality control in the heart. |
Volume: |
1 |
Issue: |
2 |
Pages: |
e85817 |
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•
•
•
•
|
Publication |
First Author: |
Cassina L |
Year: |
2020 |
Journal: |
FASEB J |
Title: |
Increased mitochondrial fragmentation in polycystic kidney disease acts as a modifier of disease progression. |
Volume: |
34 |
Issue: |
5 |
Pages: |
6493-6507 |
|
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•
•
•
•
|
Publication |
First Author: |
Dongil P |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Pas Kinase Deficiency Triggers Antioxidant Mechanisms in the Liver. |
Volume: |
8 |
Issue: |
1 |
Pages: |
13810 |
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•
•
•
•
•
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Publication |
First Author: |
Misko A |
Year: |
2010 |
Journal: |
J Neurosci |
Title: |
Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex. |
Volume: |
30 |
Issue: |
12 |
Pages: |
4232-40 |
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•
•
•
•
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Publication |
First Author: |
Tyagi A |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain. |
Volume: |
8 |
Issue: |
1 |
Pages: |
17547 |
|
•
•
•
•
•
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Publication |
First Author: |
Greene NP |
Year: |
2015 |
Journal: |
Physiol Rep |
Title: |
Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice. |
Volume: |
3 |
Issue: |
7 |
|
|
•
•
•
•
•
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Publication |
First Author: |
Li G |
Year: |
2018 |
Journal: |
Autophagy |
Title: |
PTENα regulates mitophagy and maintains mitochondrial quality control. |
Volume: |
14 |
Issue: |
10 |
Pages: |
1742-1760 |
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•
•
•
•
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Publication |
First Author: |
Liu W |
Year: |
2022 |
Journal: |
Atherosclerosis |
Title: |
Low shear stress inhibits endothelial mitophagy via caveolin-1/miR-7-5p/SQSTM1 signaling pathway. |
Volume: |
356 |
|
Pages: |
9-17 |
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•
•
•
•
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Publication |
First Author: |
Choi SH |
Year: |
2021 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Intracellular AIBP (Apolipoprotein A-I Binding Protein) Regulates Oxidized LDL (Low-Density Lipoprotein)-Induced Mitophagy in Macrophages. |
Volume: |
41 |
Issue: |
2 |
Pages: |
e82-e96 |
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•
•
•
•
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Publication |
First Author: |
Bai Q |
Year: |
2023 |
Journal: |
Front Immunol |
Title: |
DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma. |
Volume: |
14 |
|
Pages: |
1289774 |
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•
•
•
•
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Publication |
First Author: |
White JP |
Year: |
2011 |
Journal: |
Am J Physiol Regul Integr Comp Physiol |
Title: |
Muscle oxidative capacity during IL-6-dependent cancer cachexia. |
Volume: |
300 |
Issue: |
2 |
Pages: |
R201-11 |
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•
•
•
•
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Publication |
First Author: |
Manczak M |
Year: |
2011 |
Journal: |
Hum Mol Genet |
Title: |
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. |
Volume: |
20 |
Issue: |
13 |
Pages: |
2495-509 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
239
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
189
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
749
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
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