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Search results 201 to 300 out of 414 for Mis12

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Type Details Score
Allele  
Name: MIS12 kinetochore complex component; gene trap OST109493, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: MIS12 kinetochore complex component; gene trap OST199795, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: MIS12 kinetochore complex component; gene trap RRN081, BayGenomics
Allele Type: Gene trapped
Allele
Name: NSL1, MIS12 kinetochore complex component; endonuclease-mediated mutation 1, Jackson
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: MIS12 kinetochore complex component; endonuclease-mediated mutation 1, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: MIS12 kinetochore complex component; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele  
Name: MIS12 kinetochore complex component; gene trap PST13736, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
Allele  
Name: NSL1, MIS12 kinetochore complex component; gene trap E102E11, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: DSN1 homolog, MIS12 kinetochore complex component; gene trap E198C08, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: DSN1 homolog, MIS12 kinetochore complex component; gene trap PST118, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
Allele  
Name: DSN1 homolog, MIS12 kinetochore complex component; gene trap OST209869, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: DSN1 homolog, MIS12 kinetochore complex component; gene trap OST374878, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: NSL1, MIS12 kinetochore complex component; gene trap W036C01, German Gene Trap Consortium
Allele Type: Gene trapped
Allele
Name: NSL1, MIS12 kinetochore complex component; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Allele
Name: MIS12 kinetochore complex component; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: MIS12 kinetochore complex component; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Allele
Name: DSN1 homolog, MIS12 kinetochore complex component; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Allele
Name: DSN1 homolog, MIS12 kinetochore complex component; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele  
Name: MIS12 kinetochore complex component; gene trap EUCJ0148a01, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: DSN1 homolog, MIS12 kinetochore complex component; gene trap EUCJ0019c07, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: MIS12 kinetochore complex component; gene trap IST13167D7, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: MIS12 kinetochore complex component; gene trap IST14474H3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Genotype
Symbol: Nsl1/Nsl1
Background: C57BL/6NJ-Nsl1/Mmjax
Zygosity: hm
Has Mutant Allele: true
Allele  
Name: DSN1 homolog, MIS12 kinetochore complex component; gene trap IST12286C5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Allele  
Name: DSN1 homolog, MIS12 kinetochore complex component; gene trap IST10947B11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: DSN1 homolog, MIS12 kinetochore complex component; gene trap IST13327F7, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: DSN1 homolog, MIS12 kinetochore complex component; gene trap IST13537E9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: DSN1 homolog, MIS12 kinetochore complex component; gene trap IST14274H7, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: DSN1 homolog, MIS12 kinetochore complex component; gene trap IST15029D1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: DSN1 homolog, MIS12 kinetochore complex component; gene trap IST15073A2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Genotype
Symbol: Nsl1/Nsl1<+>
Background: C57BL/6NJ-Nsl1/Mmjax
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Li Y
Year: 2020
Journal: Nat Commun
Title: Long noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly.
Volume: 11
Issue: 1
Pages: 2725
Protein Domain
Type: Domain
Description: This domain is found in Knl1, a sub-unit of the KMN network, present in Homo sapiens. The KMN network is the core of the outer kinetochore which is responsible for microtubule binding/stabilization and controls the spindle assembly checkpoint. This domain is the second of two RING finger, WD repeat, DEAD-like helicase (RWD) domains. The tandem RWD domains mediate kinetochore targeting of the microtubule-binding subunits by interacting with the Mis12 complex. The Mis12 complex is a KMN sub-complex that tethers directly onto the underlying chromatin layer [].
Protein
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: true
Publication
First Author: Wang H
Year: 2004
Journal: J Biol Chem
Title: Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling.
Volume: 279
Issue: 52
Pages: 54590-8
Publication
First Author: Lin YT
Year: 2006
Journal: Oncogene
Title: Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control.
Volume: 25
Issue: 52
Pages: 6901-14
Publication
First Author: Kasuboski JM
Year: 2011
Journal: Mol Biol Cell
Title: Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores.
Volume: 22
Issue: 18
Pages: 3318-30
Protein Domain
Type: Domain
Description: CENP-C is a vertebrate family that forms a core component of the centromeric chromatin. On depletion of CENP-C, proper formation of both centromeres and kinetochores is prevented. In kinetochores, the KMN (KNL1/Mis12/Ndc80) network regulates kinetochore microtubule binding []. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex to centromeres [, ].
Protein Domain
Type: Family
Description: This entry includes polyamine-modulated factor 1 (PMF1) from animals and Nnf1 from yeasts. PMF1 is part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis []. Nnf1 is an essential component of the MIND kinetochore complex required for accurate chromosome segregation [].
Protein Domain
Type: Family
Description: ZW10 interactor (also known as Zwint-1) is part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity []. It recruits ZW10 to unattached kinetochores at prometaphase []. It is essential for stable binding of a Mad1-Mad2 complex to unattached kinetochores []. It can be phosphoryltated by Aurora B (AurB) kinase [].
Publication  
First Author: Kong W
Year: 2025
Journal: Life Sci Alliance
Title: CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation.
Volume: 8
Issue: 1
Publication
First Author: Cheeseman IM
Year: 2006
Journal: Cell
Title: The conserved KMN network constitutes the core microtubule-binding site of the kinetochore.
Volume: 127
Issue: 5
Pages: 983-97
Publication
First Author: Lachner M
Year: 2001
Journal: Nature
Title: Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
Volume: 410
Issue: 6824
Pages: 116-20
Publication
First Author: Duong HA
Year: 2014
Journal: Nat Struct Mol Biol
Title: Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes.
Volume: 21
Issue: 2
Pages: 126-32
Protein
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: true
Publication
First Author: Kim S
Year: 2015
Journal: J Cell Biol
Title: Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores.
Volume: 208
Issue: 2
Pages: 181-96
Publication
First Author: Kiyomitsu T
Year: 2007
Journal: Dev Cell
Title: Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1.
Volume: 13
Issue: 5
Pages: 663-76
Publication
First Author: Bot C
Year: 2017
Journal: J Cell Sci
Title: Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage.
Volume: 130
Issue: 6
Pages: 1134-1146
Protein Domain
Type: Family
Description: Chromobox protein homologue 3 (CBX3, also known as HP1 gamma) is a component of heterochromatin that binds histone H3 tails methylated at 'Lys-9' which leads to epigenetic repression []. By interacting with MIS12 complex, it is involved in the formation of a functional kinetochore []. It recruits NIPBL to sites of DNA damage at double-strand breaks []. It is a component of the E2F6.com-1 []and PER []complexes. The PER complex controls the circadian clock [].
Protein Domain
Type: Family
Description: The KMN network (for KNL1, MIS12 and NDC80 complexes) is a hub for signalling at the outer kinetochore []that acts as a receptor for both microtubules and checkpoint proteins []. Kinetochore scaffold 1, also known as Blinkin or KNL1, is a component of the KMN network. It is required to localize a subset of outer kinetochore proteins and is essential for chromosome segregation [, ].
Protein
Organism: Mus musculus/domesticus
Length: 2119  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1777828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875215
Specimen Label: UC Davis_1875215
Detected: true
Specimen Num: 30
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1777828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875261
Specimen Label: UC Davis_1875261
Detected: true
Specimen Num: 71
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1777828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875262
Specimen Label: UC Davis_1875262
Detected: true
Specimen Num: 72
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875202
Note: kidney
Specimen Label: UC Davis_1875202
Detected: true
Specimen Num: 17
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875203
Note: kidney
Specimen Label: UC Davis_1875203
Detected: true
Specimen Num: 18
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875204
Note: kidney
Specimen Label: UC Davis_1875204
Detected: true
Specimen Num: 19
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875251
Note: kidney
Specimen Label: UC Davis_1875251
Detected: true
Specimen Num: 61
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875252
Note: kidney
Specimen Label: UC Davis_1875252
Detected: true
Specimen Num: 62
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1775928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875231
Specimen Label: UC Davis_1875231
Detected: true
Specimen Num: 42
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1775928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875232
Specimen Label: UC Davis_1875232
Detected: true
Specimen Num: 43
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1619828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875209
Specimen Label: UC Davis_1875209
Detected: true
Specimen Num: 24
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1619828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875210
Specimen Label: UC Davis_1875210
Detected: true
Specimen Num: 25
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1619828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875257
Specimen Label: UC Davis_1875257
Detected: true
Specimen Num: 67
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1697428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875218
Specimen Label: UC Davis_1875218
Detected: true
Specimen Num: 31
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1697428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875266
Specimen Label: UC Davis_1875266
Detected: true
Specimen Num: 73
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1706828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875188
Specimen Label: UC Davis_1875188
Detected: true
Specimen Num: 3
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1706828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875239
Specimen Label: UC Davis_1875239
Detected: true
Specimen Num: 50
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1706828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875240
Specimen Label: UC Davis_1875240
Detected: true
Specimen Num: 51
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3519728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875201
Specimen Label: UC Davis_1875201
Detected: true
Specimen Num: 16
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875278
Note: vas deferens
Specimen Label: UC Davis_1875278
Detected: true
Specimen Num: 84
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1898428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691784
Age: postnatal adult
Image: UC Davis_1875223
Specimen Label: UC Davis_1875223
Detected: true
Specimen Num: 35