Type |
Details |
Score |
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
•
•
|
Publication |
First Author: |
Girard BM |
Year: |
2013 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Decrease in neuronal nicotinic acetylcholine receptor subunit and PSD-93 transcript levels in the male mouse MPG after cavernous nerve injury or explant culture. |
Volume: |
305 |
Issue: |
10 |
Pages: |
F1504-12 |
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•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
491
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
582
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Leona D Samson |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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•
•
•
•
•
|
Publication |
First Author: |
Broekema MF |
Year: |
2019 |
Journal: |
Mol Metab |
Title: |
Natural helix 9 mutants of PPARγ differently affect its transcriptional activity. |
Volume: |
20 |
|
Pages: |
115-127 |
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•
•
•
•
•
|
Publication |
First Author: |
Sun J |
Year: |
2023 |
Journal: |
Nature |
Title: |
A vertebral skeletal stem cell lineage driving metastasis. |
Volume: |
621 |
Issue: |
7979 |
Pages: |
602-609 |
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•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
Methylpurine-DNA glycosylase (MPG, or alkyladenine DNA glycosylase (AAG)) is a base excision-repair protein, catalyzing the first step in base excision repair by cleaving damaged DNA bases within double-stranded DNA to produce an abasic site. MPG bends DNA by intercalating between the base pairs, causing the damaged base to flip out of the double helix and into the enzyme active site for cleavage. It is responsible for the hydrolysis of the deoxyribose N-glycosidic bond, excising 3-methyladenine and 3-methylguanine from damaged DNA [, , , , , , , , , , ]. Its action is induced by alkylating chemotherapeutics, as well as deaminated and lipid peroxidation-induced purine adducts []. MPG without an N-terminal extension excises hypoxanthine with one-third of the efficiency of full-length MPG under similar conditions, suggesting that is function may largely be attributable to the N-terminal extension [].Although AAG represents one of six DNA glycosylase classes, it lacks the helix-hairpin-helix active site motif associated with other base excision repair glycosylases and is structurally distinct from them. |
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•
•
•
•
•
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Publication |
First Author: |
Allocca M |
Year: |
2017 |
Journal: |
Oncotarget |
Title: |
PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration. |
Volume: |
8 |
Issue: |
40 |
Pages: |
68707-68720 |
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•
•
•
•
•
|
Publication |
First Author: |
Fowler BE |
Year: |
2022 |
Journal: |
iScience |
Title: |
Regional specialization of the tongue revealed by gustatory ganglion imaging. |
Volume: |
25 |
Issue: |
12 |
Pages: |
105700 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yasumatsu K |
Year: |
2012 |
Journal: |
J Physiol |
Title: |
Umami taste in mice uses multiple receptors and transduction pathways. |
Volume: |
590 |
Issue: |
5 |
Pages: |
1155-70 |
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•
•
•
•
•
|
Publication |
First Author: |
Hariharan N |
Year: |
2011 |
Journal: |
Antioxid Redox Signal |
Title: |
Oxidative stress stimulates autophagic flux during ischemia/reperfusion. |
Volume: |
14 |
Issue: |
11 |
Pages: |
2179-90 |
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•
•
•
•
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Publication |
First Author: |
Becerra R |
Year: |
2016 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart. |
Volume: |
311 |
Issue: |
3 |
Pages: |
H713-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim NK |
Year: |
1998 |
Journal: |
Mol Cells |
Title: |
Tissue-specific expression and activation of N-methylpurine-DNA glycosylase in thymic carcinomas of transgenic mice expressing the SV40 large T-antigen gene. |
Volume: |
8 |
Issue: |
4 |
Pages: |
383-7 |
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•
•
•
•
•
|
Publication |
First Author: |
Adhikari S |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Magnesium, essential for base excision repair enzymes, inhibits substrate binding of N-methylpurine-DNA glycosylase. |
Volume: |
281 |
Issue: |
40 |
Pages: |
29525-32 |
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•
•
•
•
•
|
Publication |
First Author: |
Crombez L |
Year: |
2009 |
Journal: |
Nucleic Acids Res |
Title: |
Targeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growth. |
Volume: |
37 |
Issue: |
14 |
Pages: |
4559-69 |
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•
•
•
•
•
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Publication |
First Author: |
Maegawa T |
Year: |
2018 |
Journal: |
Mamm Genome |
Title: |
Congenic mapping and candidate gene analysis for streptozotocin-induced diabetes susceptibility locus on mouse chromosome 11. |
Volume: |
29 |
Issue: |
3-4 |
Pages: |
273-280 |
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•
•
•
•
•
|
Publication |
First Author: |
Kabir AM |
Year: |
2006 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Cardioprotection initiated by reactive oxygen species is dependent on activation of PKCepsilon. |
Volume: |
291 |
Issue: |
4 |
Pages: |
H1893-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kielman MF |
Year: |
1996 |
Journal: |
Mamm Genome |
Title: |
Characterization and localization of the mProx1 gene directly upstream of the mouse alpha-globin gene cluster: identification of a polymorphic direct repeat in the 5'UTR. |
Volume: |
7 |
Issue: |
12 |
Pages: |
877-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chitaev NA |
Year: |
1998 |
Journal: |
J Cell Sci |
Title: |
Molecular organization of the desmoglein-plakoglobin complex. |
Volume: |
111 ( Pt 14) |
|
Pages: |
1941-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Palomeque J |
Year: |
2009 |
Journal: |
Circ Res |
Title: |
Angiotensin II-induced oxidative stress resets the Ca2+ dependence of Ca2+-calmodulin protein kinase II and promotes a death pathway conserved across different species. |
Volume: |
105 |
Issue: |
12 |
Pages: |
1204-12 |
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