| Type |
Details |
Score |
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
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•
•
•
•
•
|
| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
|
| Title: |
Cyagen Biosciences Website. |
|
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•
•
•
•
•
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| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
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•
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•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
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•
•
•
•
•
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| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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•
•
•
•
•
|
| Allele |
| Name: |
MAS-related GPR, member D; targeted mutation 5, Mark J Zylka |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reynders A |
| Year: |
2015 |
| Journal: |
Genom Data |
| Title: |
Analysis of cutaneous MRGPRD free nerve endings and C-LTMRs transcriptomes by RNA-sequencing. |
| Volume: |
5 |
|
| Pages: |
132-5 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
E-GEOD-64091 |
| Experiment Type: |
RNA-Seq |
| Study Type: |
Baseline |
| Source: |
GEO |
|
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•
•
•
|
| Publication |
| First Author: |
Shinohara T |
| Year: |
2004 |
| Journal: |
J Biol Chem |
| Title: |
Identification of a G protein-coupled receptor specifically responsive to beta-alanine. |
| Volume: |
279 |
| Issue: |
22 |
| Pages: |
23559-64 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents mas-related G protein-coupled receptor D (MRGPRD), it is thought to be involved with nociceptor function and development, and is directly involved in the modulation of pain. It has been demonstrated that beta-alanine can act as an agonist at MRGPRD []. |
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•
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•
•
•
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| Publication |
| First Author: |
Pandey M |
| Year: |
2023 |
| Journal: |
JCI Insight |
| Title: |
Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors. |
| Volume: |
8 |
| Issue: |
13 |
|
|
•
•
•
•
•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
321
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
321
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu Q |
| Year: |
2009 |
| Journal: |
Cell |
| Title: |
Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. |
| Volume: |
139 |
| Issue: |
7 |
| Pages: |
1353-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bender E |
| Year: |
2002 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. |
| Volume: |
99 |
| Issue: |
13 |
| Pages: |
8573-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee MG |
| Year: |
2008 |
| Journal: |
J Immunol |
| Title: |
Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions. |
| Volume: |
180 |
| Issue: |
4 |
| Pages: |
2251-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wilson SR |
| Year: |
2011 |
| Journal: |
Nat Neurosci |
| Title: |
TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. |
| Volume: |
14 |
| Issue: |
5 |
| Pages: |
595-602 |
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