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Search results 201 to 274 out of 274 for Mrgprx2

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Type Details Score
Publication
38735364 | J:352368
     
First Author: Xing Y
Year: 2024
Journal: J Invest Dermatol
Title: Regional Differences in Itch Transmission.
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Publication
28545921 | J:252265
 
First Author: Yamaguchi S
Year: 2017
Journal: Neurosci Lett
Title: A mechanically activated ion channel is functionally expressed in the MrgprB4 positive sensory neurons, which detect stroking of hairy skin in mice.
Volume: 653
Pages: 139-145
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GXD Expression
GXD Expression
 
Probe: MGI:6694324
Assay Type: RNA in situ
Annotation Date: 2021-04-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2516728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6694328
Age: postnatal adult
Image: 7B
Specimen Label: 7B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6694324
Assay Type: RNA in situ
Annotation Date: 2021-04-23
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:2516728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6694328
Age: postnatal adult
Image: 7E
Note: Authors report over 50% of MrgA-expressing neurons were lost.
Specimen Label: 7E
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7388607
Assay Type: RNA in situ
Annotation Date: 2022-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3667828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7388629
Age: postnatal day 30
Image: 4C Mrgpb4 Control
Specimen Label: 4C Mrgpb4 Control
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7388607
Assay Type: RNA in situ
Annotation Date: 2022-12-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3667828
Stage: TS28
Assay Id: MGI:7388629
Age: postnatal day 30
Image: 4C Mrgprb4 Tlx3 CKO
Note: Expression eliminated.
Specimen Label: 4C Mrgprb4 Tlx3 CKO
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7471455
Assay Type: RNA in situ
Annotation Date: 2023-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7481283
Age: postnatal day 14
Note: Expression in ~52 neurons/section.
Specimen Label: 6O
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7471455
Assay Type: RNA in situ
Annotation Date: 2023-05-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666828
Pattern: Single cells
Stage: TS28
Assay Id: MGI:7481283
Age: postnatal day 14
Note: Expression greatly reduced compared to control. Expression in ~2 neurons/section.
Specimen Label: 6P
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7471455
Assay Type: RNA in situ
Annotation Date: 2023-05-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666827
Pattern: Single cells
Stage: TS27
Assay Id: MGI:7481283
Age: postnatal day 0
Note: Few expressing neurons at P6.
Specimen Label: S7A
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:7471455
Assay Type: RNA in situ
Annotation Date: 2023-05-15
Strength: Trace
Sex: Not Specified
Emaps: EMAPS:1666827
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7481283
Age: postnatal day 0
Note: Expression almost completely lost.
Specimen Label: S7B
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7484594
Assay Type: RNA in situ
Annotation Date: 2023-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7484650
Age: postnatal adult
Specimen Label: S6 Mrgprb4 Control
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7484594
Assay Type: RNA in situ
Annotation Date: 2023-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7484650
Age: postnatal adult
Note: Expression not significantly changed compared to control.
Specimen Label: S6 Mrgprb4 PN-ZB20KO
Detected: true
Specimen Num: 2
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Publication
33358893 | J:329699
First Author: Li X
Year: 2021
Journal: J Allergy Clin Immunol
Title: Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to sensitize TRPV1 in pruriceptors.
Volume: 147
Issue: 6
Pages: 2236-2248.e16
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Publication
11850634 | J:74961
First Author: Lembo PM
Year: 2002
Journal: Nat Neurosci
Title: Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs.
Volume: 5
Issue: 3
Pages: 201-9
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Publication
12915402 | -
First Author: Robas N
Year: 2003
Journal: J Biol Chem
Title: MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion.
Volume: 278
Issue: 45
Pages: 44400-4
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Publication
15862286 | -
 
First Author: Yang S
Year: 2005
Journal: Gene
Title: Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception.
Volume: 352
Pages: 30-5
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Publication
15823563 | -
First Author: Kamohara M
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides.
Volume: 330
Issue: 4
Pages: 1146-52
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Protein Domain
IPR027338 | MRGPCRX1/MRGPCRX2
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents Mas-related G protein-coupled receptor X1 and X2.Mas-related G protein-coupled receptor X1 (MRGPRX1) is thought to be involved with nociceptor function and development, and in the modulation of pain. The receptor is currently orphaned, no specific endogenous ligand having been identified. However, it may potently be activated by enkephalins: BAM22 evokes a large and dose-dependent release of intracellular calcium in cells stably transfected with the receptor []. Mas-related G protein-coupled receptor X2 (MRGPRX2) is thought to be involved with nociceptor function and development, and directly involved in the modulation of pain. The receptor is currently orphaned, no specific endogenous ligand having been identified. However, it may be activated by neuropeptides: stimulation by cortistatin-14 in receptor-expressing cells potently increases intracellular Ca2 [, ]. MRGPRX2 is also thought to be a human PAMP-12 receptor that regulates catecholamine secretion from adrenal glands [].
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Publication
33727332 | J:311626
First Author: Grundy L
Year: 2021
Journal: J Neurosci
Title: Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension.
Volume: 41
Issue: 17
Pages: 3900-3916
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Publication
37909038 | J:342977
     
First Author: Son H
Year: 2023
Journal: Neuron
Title: Mast-cell-specific receptor mediates alcohol-withdrawal-associated headache in male mice.
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Publication
23263443 | J:197482
First Author: Han L
Year: 2013
Journal: Nat Neurosci
Title: A subpopulation of nociceptors specifically linked to itch.
Volume: 16
Issue: 2
Pages: 174-82
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Publication
17618277 | J:124203
First Author: Liu Q
Year: 2007
Journal: Nat Neurosci
Title: Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch.
Volume: 10
Issue: 8
Pages: 946-8
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Publication
24549959 | J:346363
First Author: Qu L
Year: 2014
Journal: Brain
Title: Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain.
Volume: 137
Issue: Pt 4
Pages: 1039-50
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Publication
22472648 | J:260207
First Author: Wang F
Year: 2012
Journal: Sci Signal
Title: Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+.
Volume: 5
Issue: 218
Pages: ra26
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Publication
33091423 | J:305032
First Author: Xing Y
Year: 2021
Journal: J Invest Dermatol
Title: Visualizing the Itch-Sensing Skin Arbors.
Volume: 141
Issue: 5
Pages: 1308-1316
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Publication
30657454 | J:277452
   
First Author: Meixiong J
Year: 2019
Journal: Elife
Title: Identification of a bilirubin receptor that may mediate a component of cholestatic itch.
Volume: 8
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Publication
23364746 | J:194547
First Author: Vrontou S
Year: 2013
Journal: Nature
Title: Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo.
Volume: 493
Issue: 7434
Pages: 669-73
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Publication
38689089 | J:360413
First Author: Ji Z
Year: 2024
Journal: Exp Mol Med
Title: Mrgprb2-mediated mast cell activation exacerbates Modic changes by regulating immune niches.
Volume: 56
Issue: 5
Pages: 1178-1192
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Publication
27643442 | J:237364
First Author: Gaudenzio N
Year: 2016
Journal: J Clin Invest
Title: Different activation signals induce distinct mast cell degranulation strategies.
Volume: 126
Issue: 10
Pages: 3981-3998
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Publication
38802819 | J:350522
First Author: Son H
Year: 2024
Journal: J Headache Pain
Title: PACAP38/mast-cell-specific receptor axis mediates repetitive stress-induced headache in mice.
Volume: 25
Issue: 1
Pages: 87
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Publication
23000623 | J:192750
 
First Author: Akiyama T
Year: 2012
Journal: Neuroscience
Title: Cross-sensitization of histamine-independent itch in mouse primary sensory neurons.
Volume: 226
Pages: 305-12
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Protein
Q8CIP3
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Protein
B2RWR5
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Publication
36329102 | J:332466
First Author: Yoshida K
Year: 2022
Journal: Sci Rep
Title: P2X4 receptor stimulation enhances MrgprB2-mediated mast cell activation and pseudoallergic reactions in mice.
Volume: 12
Issue: 1
Pages: 18613
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Publication
29812984 | J:266037
First Author: Jain S
Year: 2018
Journal: Am J Physiol Endocrinol Metab
Title: Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.
Volume: 315
Issue: 3
Pages: E357-E366
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Publication
31027996 | J:282447
First Author: Meixiong J
Year: 2019
Journal: Immunity
Title: Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch.
Volume: 50
Issue: 5
Pages: 1163-1171.e5
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Publication
36693373 | J:337518
First Author: Elias LJ
Year: 2023
Journal: Cell
Title: Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity.
Volume: 186
Issue: 3
Pages: 577-590.e16
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Publication
31591569 | J:305539
First Author: Serhan N
Year: 2019
Journal: Nat Immunol
Title: House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation.
Volume: 20
Issue: 11
Pages: 1435-1443
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Publication
33765440 | J:305469
First Author: Zhang S
Year: 2021
Journal: Cell
Title: Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis.
Volume: 184
Issue: 8
Pages: 2151-2166.e16
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Publication
30886406 | J:280094
First Author: Zhang Q
Year: 2019
Journal: Nat Neurosci
Title: Multiplexed peroxidase-based electron microscopy labeling enables simultaneous visualization of multiple cell types.
Volume: 22
Issue: 5
Pages: 828-839
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Publication
12084918 | J:77352
First Author: Bender E
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule.
Volume: 99
Issue: 13
Pages: 8573-8
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Publication
18250432 | -
First Author: Lee MG
Year: 2008
Journal: J Immunol
Title: Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions.
Volume: 180
Issue: 4
Pages: 2251-5
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Publication
21460831 | J:172290
First Author: Wilson SR
Year: 2011
Journal: Nat Neurosci
Title: TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch.
Volume: 14
Issue: 5
Pages: 595-602
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Publication
22787056 | J:186470
First Author: Lopes C
Year: 2012
Journal: J Neurosci
Title: Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors.
Volume: 32
Issue: 28
Pages: 9706-15
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Publication
25834056 | J:221586
First Author: Lou S
Year: 2015
Journal: J Neurosci
Title: Incoherent feed-forward regulatory loops control segregation of C-mechanoreceptors, nociceptors, and pruriceptors.
Volume: 35
Issue: 13
Pages: 5317-29
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Publication
39243765 | J:359444
First Author: Jiang H
Year: 2024
Journal: Cell
Title: Divergent sensory pathways of sneezing and coughing.
Volume: 187
Issue: 21
Pages: 5981-5997.e14
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Publication
25369838 | J:225328
 
First Author: Ren AJ
Year: 2014
Journal: Nat Commun
Title: ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.
Volume: 5
Pages: 4984
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Publication
29045838 | J:254788
First Author: Chen Z
Year: 2017
Journal: Cell Rep
Title: p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling.
Volume: 21
Issue: 3
Pages: 707-720
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Publication
35875660 | J:326957
 
First Author: Cao Z
Year: 2022
Journal: Front Mol Neurosci
Title: Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli.
Volume: 15
Pages: 901466
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Publication
21151121 | J:170402
First Author: Guo T
Year: 2011
Journal: Nat Neurosci
Title: An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates.
Volume: 14
Issue: 1
Pages: 31-6
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Publication
33116307 | J:297417
First Author: Choi S
Year: 2020
Journal: Nature
Title: Parallel ascending spinal pathways for affective touch and pain.
Volume: 587
Issue: 7833
Pages: 258-263
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Publication
34932943 | J:325014
First Author: Xie Z
Year: 2022
Journal: Neuron
Title: A brain-to-spinal sensorimotor loop for repetitive self-grooming.
Volume: 110
Issue: 5
Pages: 874-890.e7
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Publication
37541195 | J:341426
First Author: Wolfson RL
Year: 2023
Journal: Cell
Title: DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.
Volume: 186
Issue: 16
Pages: 3368-3385.e18
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Publication
17553423 | J:126484
First Author: Luo W
Year: 2007
Journal: Neuron
Title: A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons.
Volume: 54
Issue: 5
Pages: 739-54
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Publication
16446141 | J:106971
First Author: Chen CL
Year: 2006
Journal: Neuron
Title: Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain.
Volume: 49
Issue: 3
Pages: 365-77
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Publication
28476948 | J:242690
First Author: Qi L
Year: 2017
Journal: J Neurosci
Title: Hierarchical Specification of Pruriceptors by Runt-Domain Transcription Factor Runx1.
Volume: 37
Issue: 22
Pages: 5549-5561
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Publication
38915692 | J:353123
     
First Author: Zhang D
Year: 2024
Journal: bioRxiv
Title: C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway.
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Publication
24516396 | J:210892
First Author: Gorokhova S
Year: 2014
Journal: PLoS Genet
Title: Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor.
Volume: 10
Issue: 2
Pages: e1004081
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Publication
21300867 | J:169302
First Author: da Silva S
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling.
Volume: 108
Issue: 8
Pages: 3395-400
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Publication
- | J:200814
     
First Author: Toronto Centre for Phenogenomics
Year: 2013
Journal: MGI Direct Data Submission
Title: Strains and alleles submitted by Toronto Centre for Phenogenomics (NorCOMM2, funded by Genome Canada and Ontario Genomics Institute OGI-051).
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Publication
- | J:101977
     
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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