Type |
Details |
Score |
Publication |
First Author: |
Diehl AG |
Year: |
2006 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Extraocular muscle morphogenesis and gene expression are regulated by Pitx2 gene dose. |
Volume: |
47 |
Issue: |
5 |
Pages: |
1785-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kelly RG |
Year: |
2004 |
Journal: |
Hum Mol Genet |
Title: |
The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis. |
Volume: |
13 |
Issue: |
22 |
Pages: |
2829-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eng SR |
Year: |
2004 |
Journal: |
Development |
Title: |
Coordinated regulation of gene expression by Brn3a in developing sensory ganglia. |
Volume: |
131 |
Issue: |
16 |
Pages: |
3859-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harel I |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis. |
Volume: |
109 |
Issue: |
46 |
Pages: |
18839-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eng SR |
Year: |
2007 |
Journal: |
Neural Dev |
Title: |
POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia. |
Volume: |
2 |
|
Pages: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Welcker JE |
Year: |
2013 |
Journal: |
Development |
Title: |
Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. |
Volume: |
140 |
Issue: |
24 |
Pages: |
4947-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weng J |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. |
Volume: |
105 |
Issue: |
16 |
Pages: |
6081-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kong P |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication. |
Volume: |
23 |
Issue: |
16 |
Pages: |
4215-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Millien G |
Year: |
2008 |
Journal: |
Gene Expr Patterns |
Title: |
Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction. |
Volume: |
8 |
Issue: |
2 |
Pages: |
124-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishiyama A |
Year: |
2009 |
Journal: |
Cell Stem Cell |
Title: |
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. |
Volume: |
5 |
Issue: |
4 |
Pages: |
420-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tarantino C |
Year: |
2010 |
Journal: |
FASEB J |
Title: |
miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. |
Volume: |
24 |
Issue: |
9 |
Pages: |
3255-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stevens JD |
Year: |
2008 |
Journal: |
Differentiation |
Title: |
Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation. |
Volume: |
76 |
Issue: |
9 |
Pages: |
1006-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Mouse Synonym Curation |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gray PA |
Year: |
2004 |
Journal: |
Science |
Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
Volume: |
306 |
Issue: |
5705 |
Pages: |
2255-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Takashima Y |
Year: |
2007 |
Journal: |
Cell |
Title: |
Neuroepithelial cells supply an initial transient wave of MSC differentiation. |
Volume: |
129 |
Issue: |
7 |
Pages: |
1377-88 |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu X |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
MSC p43 required for axonal development in motor neurons. |
Volume: |
106 |
Issue: |
37 |
Pages: |
15944-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Johnson GP |
Year: |
2021 |
Journal: |
Bone |
Title: |
Primary cilium-mediated MSC mechanotransduction is dependent on Gpr161 regulation of hedgehog signalling. |
Volume: |
145 |
|
Pages: |
115846 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Y |
Year: |
2023 |
Journal: |
Bone Res |
Title: |
Neutralization of excessive levels of active TGF-β1 reduces MSC recruitment and differentiation to mitigate peritendinous adhesion. |
Volume: |
11 |
Issue: |
1 |
Pages: |
24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao B |
Year: |
2020 |
Journal: |
Sci Adv |
Title: |
Biochemical and structural cues of 3D-printed matrix synergistically direct MSC differentiation for functional sweat gland regeneration. |
Volume: |
6 |
Issue: |
10 |
Pages: |
eaaz1094 |
|
•
•
•
•
•
|
Publication |
First Author: |
He X |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
TLR4 Activation Promotes Bone Marrow MSC Proliferation and Osteogenic Differentiation via Wnt3a and Wnt5a Signaling. |
Volume: |
11 |
Issue: |
3 |
Pages: |
e0149876 |
|
•
•
•
•
•
|
Publication |
First Author: |
Iyer S |
Year: |
2014 |
Journal: |
Stem Cells Dev |
Title: |
SHIP1 regulates MSC numbers and their osteolineage commitment by limiting induction of the PI3K/Akt/β-catenin/Id2 axis. |
Volume: |
23 |
Issue: |
19 |
Pages: |
2336-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ye G |
Year: |
2023 |
Journal: |
Exp Mol Med |
Title: |
ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression. |
Volume: |
55 |
Issue: |
8 |
Pages: |
1743-1756 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jones FK |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Syndecan-3 regulates MSC adhesion, ERK and AKT signalling in vitro and its deletion enhances MSC efficacy in a model of inflammatory arthritis in vivo. |
Volume: |
10 |
Issue: |
1 |
Pages: |
20487 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abdi R |
Year: |
2015 |
Journal: |
Stem Cells |
Title: |
HCELL Expression on Murine MSC Licenses Pancreatotropism and Confers Durable Reversal of Autoimmune Diabetes in NOD Mice. |
Volume: |
33 |
Issue: |
5 |
Pages: |
1523-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mentink A |
Year: |
2013 |
Journal: |
Biomaterials |
Title: |
Predicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1. |
Volume: |
34 |
Issue: |
19 |
Pages: |
4592-601 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun H |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Therapeutic potential of mesenchymal stromal cells and MSC conditioned medium in Amyotrophic Lateral Sclerosis (ALS)--in vitro evidence from primary motor neuron cultures, NSC-34 cells, astrocytes and microglia. |
Volume: |
8 |
Issue: |
9 |
Pages: |
e72926 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shen GS |
Year: |
2018 |
Journal: |
Biochim Biophys Acta Mol Basis Dis |
Title: |
The GDF11-FTO-PPARγ axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis. |
Volume: |
1864 |
Issue: |
12 |
Pages: |
3644-3654 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang JW |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Leukocytic Toll-Like Receptor 2 Deficiency Preserves Cardiac Function And Reduces Fibrosis In Sustained Pressure Overload. |
Volume: |
7 |
Issue: |
1 |
Pages: |
9193 |
|
•
•
•
•
•
|
CL Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Ucuncu E |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia. |
Volume: |
11 |
Issue: |
1 |
Pages: |
6087 |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Ofir-Birin Y |
Year: |
2013 |
Journal: |
Mol Cell |
Title: |
Structural switch of lysyl-tRNA synthetase between translation and transcription. |
Volume: |
49 |
Issue: |
1 |
Pages: |
30-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaminska M |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Dissection of the structural organization of the aminoacyl-tRNA synthetase complex. |
Volume: |
284 |
Issue: |
10 |
Pages: |
6053-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tange Y |
Year: |
2016 |
Journal: |
Genes Cells |
Title: |
Inner nuclear membrane protein Lem2 augments heterochromatin formation in response to nutritional conditions. |
Volume: |
21 |
Issue: |
8 |
Pages: |
812-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rumpf C |
Year: |
2010 |
Journal: |
Cell Cycle |
Title: |
High-throughput knockout screen in Schizosaccharomyces pombe identifies a novel gene required for efficient homolog disjunction during meiosis I. |
Volume: |
9 |
Issue: |
9 |
Pages: |
1802-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hirano Y |
Year: |
2018 |
Journal: |
Genes Cells |
Title: |
Lem2 is retained at the nuclear envelope through its interaction with Bqt4 in fission yeast. |
Volume: |
23 |
Issue: |
3 |
Pages: |
122-135 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the lysyl-tRNA synthetase (LysRS) binding domain of AIMP2 (aminoacyl tRNA synthase complex-interacting multifunctional protein 2). LysRS can serve as a transcription regulator that can be released from the cytoplasmic multi-tRNA synthetase complex (MSC) to activate the transcription factor MITF in stimulated mast cells. In quiescent cells, LysRS is held in the MSC via its interactions with AIMP2 []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This is a thioredoxin like domain found in AIMP2 proteins (aminoacyl tRNA synthetase complex interacting multifunctional protein 2). AIMP2 is a component of human multi-tRNA synthetase complex (MSC). MSC is a macromolecular protein complex consisting of nine different ARSs and three ARS-interacting multifunctional proteins (AIMPs) []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This family includes inner membrane proteins from plants and fungi, including Heh2/Src1 from budding yeasts and Lem2/Mug61 from fission yeasts [, , , ]. These proteins contain the N-terminal HEH/LEM domain that anchors the chromatin to the nuclear periphery, and a MSC (MAN1/Src1C-terminal) domain in their C-terminal region. They are involved in meiosis, required for the correct meiotic chromosome segregation. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2), also known as multisynthase complex auxiliary component p38, is required for assembly and stability of the multi-tRNA synthetase complex (MSC complex) []. MSC is a macromolecular protein complex consisting of nine different ARSs and three ARS-interacting multifunctional proteins (AIMPs) []. |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
E-GEOD-61695 |
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Cho HY |
Year: |
2015 |
Journal: |
J Biol Chem |
Title: |
Assembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-homology Domains. |
Volume: |
290 |
Issue: |
49 |
Pages: |
29313-28 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE21523 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
320
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kilpatrick AM |
Year: |
2023 |
Journal: |
STAR Protoc |
Title: |
Protocol to analyze and validate transcriptomic changes in PDGFRβ-KO mesenchymal stem cell osteogenic potential in the mouse embryo. |
Volume: |
4 |
Issue: |
1 |
Pages: |
102016 |
|
•
•
•
•
•
|
Publication |
First Author: |
Valluet A |
Year: |
2012 |
Journal: |
Cell Rep |
Title: |
B-Raf and C-Raf are required for melanocyte stem cell self-maintenance. |
Volume: |
2 |
Issue: |
4 |
Pages: |
774-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakamura Y |
Year: |
2015 |
Journal: |
FEBS Lett |
Title: |
Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration. |
Volume: |
589 |
Issue: |
11 |
Pages: |
1257-65 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
280
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Rico P |
Year: |
2020 |
Journal: |
Commun Biol |
Title: |
Borax induces osteogenesis by stimulating NaBC1 transporter via activation of BMP pathway. |
Volume: |
3 |
Issue: |
1 |
Pages: |
717 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inomata K |
Year: |
2009 |
Journal: |
Cell |
Title: |
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation. |
Volume: |
137 |
Issue: |
6 |
Pages: |
1088-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang M |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
SHP1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Differentiation. |
Volume: |
16 |
Issue: |
3 |
Pages: |
769-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guarnerio J |
Year: |
2015 |
Journal: |
Cancer Discov |
Title: |
A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells. |
Volume: |
5 |
Issue: |
4 |
Pages: |
396-409 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roelofs AJ |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
Joint morphogenetic cells in the adult mammalian synovium. |
Volume: |
8 |
|
Pages: |
15040 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishihara S |
Year: |
2017 |
Journal: |
Cancer Res |
Title: |
Mechano-Signal Transduction in Mesenchymal Stem Cells Induces Prosaposin Secretion to Drive the Proliferation of Breast Cancer Cells. |
Volume: |
77 |
Issue: |
22 |
Pages: |
6179-6189 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giri J |
Year: |
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