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Search results 201 to 251 out of 251 for Nck2

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Type

Details

Score

Publication

22737085 | J:187177

First Author:	Bochkis IM
Year:	2012
Journal:	PLoS Genet
Title:	Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2.
Volume:	8
Issue:	6
Pages:	e1002770

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Publication

24952961 | J:215487

First Author:	Thompson CL
Year:	2014
Journal:	Neuron
Title:	A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume:	83
Issue:	2
Pages:	309-323

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Publication

34321999 | J:313619

First Author:	Bedogni F
Year:	2021
Journal:	Front Mol Neurosci
Title:	Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume:	14

Pages:	686034

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Publication

18799693 | J:142754

First Author:	Hansen GM
Year:	2008
Journal:	Genome Res
Title:	Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume:	18
Issue:	10
Pages:	1670-9

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Publication

- | J:342604

First Author:	UniProt-GOA
Year:	2012

Title:	Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

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Publication

16602821 | J:162220

First Author:	Magdaleno S
Year:	2006
Journal:	PLoS Biol
Title:	BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume:	4
Issue:	4
Pages:	e86

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Publication

- | J:85000

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2003

Title:	MGI Sequence Curation Reference

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Publication

- | J:78475

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2002

Title:	Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database

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Publication

11217851 | J:65060

First Author:	Kawai J
Year:	2001
Journal:	Nature
Title:	Functional annotation of a full-length mouse cDNA collection.
Volume:	409
Issue:	6821
Pages:	685-90

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Publication

14610273 | J:86696

First Author:	Zambrowicz BP
Year:	2003
Journal:	Proc Natl Acad Sci U S A
Title:	Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume:	100
Issue:	24
Pages:	14109-14

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Publication

- | J:293217

First Author:	GemPharmatech
Year:	2020

Title:	GemPharmatech Website.

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Publication

- | J:141210

First Author:	Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year:	2008
Journal:	Database Download
Title:	Mouse Gene Trap Data Load from dbGSS

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Publication

- | J:342605

First Author:	GOA curators
Year:	2016

Title:	Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

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Publication

- | J:68900

First Author:	The Jackson Laboratory Mouse Radiation Hybrid Database
Year:	2004
Journal:	Database Release
Title:	Mouse T31 Radiation Hybrid Data Load

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Publication

12466851 | J:80000

First Author:	Okazaki Y
Year:	2002
Journal:	Nature
Title:	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume:	420
Issue:	6915
Pages:	563-73

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Publication

- | J:164563

First Author:	The Gene Ontology Consortium
Year:	2010

Title:	Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs

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Publication

21267068 | J:153498

First Author:	Diez-Roux G
Year:	2011
Journal:	PLoS Biol
Title:	A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume:	9
Issue:	1
Pages:	e1000582

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Publication

- | J:157972

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2010
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).

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Publication

- | J:161428

First Author:	Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year:	2010

Title:	Annotation inferences using phylogenetic trees

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Publication

- | J:63103

First Author:	Mouse Genome Database and National Center for Biotechnology Information
Year:	2000
Journal:	Database Release
Title:	Entrez Gene Load

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Publication

- | J:262123

First Author:	Allen Institute for Brain Science
Year:	2004
Journal:	Allen Institute
Title:	Allen Brain Atlas: mouse riboprobes

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Publication

- | J:144086

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform

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Publication

- | J:155721

First Author:	Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year:	2010
Journal:	Database Download
Title:	Consensus CDS project

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Publication

- | J:85324

First Author:	Mouse Genome Informatics Group
Year:	2003
Journal:	Database Procedure
Title:	Automatic Encodes (AutoE) Reference

•

Publication

- | J:53168

First Author:	Bairoch A
Year:	1999
Journal:	Database Release
Title:	SWISS-PROT Annotated protein sequence database

•

Publication

- | J:91388

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations

•

Publication

- | J:155221

First Author:	Mouse Genome Informatics
Year:	2010
Journal:	Database Release
Title:	Protein Ontology Association Load.

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Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

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Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

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UniProt Feature

Begin:	2
Description:	Cytoplasmic protein NCK2
Type:	chain
End:	380

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Protein

A0A0A0MQF0

Organism:	Mus musculus/domesticus
Length:	77
Fragment?:	true

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Protein

A0A087WQT7

Organism:	Mus musculus/domesticus
Length:	21
Fragment?:	true

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HT Experiment

E-GEOD-63510 | Nck2 Regulates Adiposity and Adiposity-Related Metabolic Disorders in Mice and Human

Series Id:	GSE63510
Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	ArrayExpress

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Publication

16752908 | -

First Author:	Liu J
Year:	2006
Journal:	Biochemistry
Title:	Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins.
Volume:	45
Issue:	23
Pages:	7171-84

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Publication

20637038 | -

First Author:	Funasaka K
Year:	2010
Journal:	FEBS J
Title:	Cas utilizes Nck2 to activate Cdc42 and regulate cell polarization during cell migration in response to wound healing.
Volume:	277
Issue:	17
Pages:	3502-13

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Protein Domain

IPR035559 | Nck2_SH3_1

Type:

Domain

Description:

This entry represent the first SH3 domain of Nck2. It binds the PxxDY sequence in the CD3e cytoplasmic tail; this binding inhibits phosphorylation by Src kinases, resulting in the downregulation of TCR surface expression []. Nck2 (also known as Grb4) is a member of the Nck family. It plays a crucial role in connecting signaling pathways of tyrosine kinase receptors and important effectors in actin dynamics and cytoskeletal remodeling []. It binds neuronal signaling proteins such as ephrinB []. Cytoplasmic proteins Nck are non-enzymatic adaptor proteins composed of three SH3 (Src homology 3) domains and a C-terminal SH2 domain []. They regulate actin cytoskeleton dynamics by linking proline-rich effector molecules to protein tyrosine kinases and phosphorylated signaling intermediates []. They function downstream of the PDGFbeta receptor and are involved in Rho GTPase signaling and actin dynamics []. They associate with tyrosine-phosphorylated growth factor receptors or their cellular substrates [, ]. There are two vertebrate Nck proteins, Nck1 and Nck2.

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Protein Domain

IPR035560 | Nck2_SH3_2

Type:

Domain

Description:

This entry represent the second SH3 domain of Nck2. The second SH3 domain of Nck appears to prefer ligands containing the APxxPxR motif []. Nck2 (also known as Grb4) is a member of the Nck family. It plays a crucial role in connecting signaling pathways of tyrosine kinase receptors and important effectors in actin dynamics and cytoskeletal remodeling []. It binds neuronal signaling proteins such as ephrinB []. Cytoplasmic proteins Nck are non-enzymatic adaptor proteins composed of three SH3 (Src homology 3) domains and a C-terminal SH2 domain []. They regulate actin cytoskeleton dynamics by linking proline-rich effector molecules to protein tyrosine kinases and phosphorylated signaling intermediates []. They function downstream of the PDGFbeta receptor and are involved in Rho GTPase signaling and actin dynamics []. They associate with tyrosine-phosphorylated growth factor receptors or their cellular substrates [, ]. There are two vertebrate Nck proteins, Nck1 and Nck2.

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Publication

30089263 | J:270949

First Author:	Levy AD
Year:	2018
Journal:	Cell Rep
Title:	Noonan Syndrome-Associated SHP2 Dephosphorylates GluN2B to Regulate NMDA Receptor Function.
Volume:	24
Issue:	6
Pages:	1523-1535

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Publication

24913231 | J:214448

First Author:	Ogawa K
Year:	2014
Journal:	J Exp Med
Title:	DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.
Volume:	211
Issue:	7
Pages:	1407-19

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Publication

26802179 | J:287724

First Author:	New LA
Year:	2016
Journal:	J Am Soc Nephrol
Title:	Nephrin Tyrosine Phosphorylation Is Required to Stabilize and Restore Podocyte Foot Process Architecture.
Volume:	27
Issue:	8
Pages:	2422-35

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Publication

37085492 | J:357204

First Author:	Brase L
Year:	2023
Journal:	Nat Commun
Title:	Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers.
Volume:	14
Issue:	1
Pages:	2314

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Publication

18555270 | -

First Author:	Takeuchi K
Year:	2008
Journal:	J Mol Biol
Title:	Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity.
Volume:	380
Issue:	4
Pages:	704-16

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Publication

32468886 | J:304167

First Author:	Alfaidi M
Year:	2020
Journal:	J Am Heart Assoc
Title:	Nck1, But Not Nck2, Mediates Disturbed Flow-Induced p21-Activated Kinase Activation and Endothelial Permeability.
Volume:	9
Issue:	11
Pages:	e016099

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Publication

9344857 | -

First Author:	Matuoka K
Year:	1997
Journal:	Biochem Biophys Res Commun
Title:	A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs.
Volume:	239
Issue:	2
Pages:	488-92

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Publication

12034353 | -

First Author:	Buday L
Year:	2002
Journal:	Cell Signal
Title:	The Nck family of adapter proteins: regulators of actin cytoskeleton.
Volume:	14
Issue:	9
Pages:	723-31

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Publication

17947660 | -

First Author:	Cao L
Year:	2007
Journal:	J Immunol
Title:	Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
Volume:	179
Issue:	9
Pages:	5864-76

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Publication

18034455 | -

First Author:	Ballif BA
Year:	2008
Journal:	J Proteome Res
Title:	Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
Volume:	7
Issue:	1
Pages:	311-8

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Publication

15345747 | -

First Author:	Ballif BA
Year:	2004
Journal:	Mol Cell Proteomics
Title:	Phosphoproteomic analysis of the developing mouse brain.
Volume:	3
Issue:	11
Pages:	1093-101

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

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Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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