| Type |
Details |
Score |
| Allele |
| Name: |
modifier of Nek1 (NIMA-related expressed kinase 1, kidney weight; CAST/Ei |
| Allele Type: |
QTL |
|
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Nek1 and TAZ interact to maintain normal levels of polycystin 2. |
|
•
•
•
•
•
|
| Allele |
| Name: |
modifier of Nek1 (NIMA-related expressed kinase 1), kidney weight and hematocrit; CAST/Ei |
| Allele Type: |
QTL |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
modifier of Nek1 (NIMA-related expressed kinase 1), kidney weight and hematocrit; C57BL/6J |
| Allele Type: |
QTL |
|
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Mnek1c/Mnek1c |
| Background: |
involves: C57BL/6J-Nek1/+ * CAST/Ei |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Mnek1b/Mnek1b |
| Background: |
involves: C57BL/6J-Nek1/+ * CAST/Ei |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Mnek1a/Mnek1a |
| Background: |
involves: C57BL/6J-Nek1/+ * CAST/Ei |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Allele |
| Name: |
NIMA (never in mitosis gene a)-related expressed kinase 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Mnek1b/Mnek1b |
| Background: |
involves: C57BL/6J-Nek1/+ * CAST/Ei |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Mnek1c/Mnek1c |
| Background: |
involves: C57BL/6J-Nek1/+ * CAST/Ei |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Allele |
| Name: |
NIMA (never in mitosis gene a)-related expressed kinase 1; endonuclease-mediated mutation 13, Cathy Lutz |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, endonuclease-mediated mutation, coisogenic |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This family includes Protein chibby homolog 2 (also known as Spermatid-associated protein). The function of this family is unclear. However, mouse spermatid-associated protein (SPERT, also known as Nurit) can form homodimers and can bind to NEK1 kinase. Its expression is restricted to the flower-like structure in spermatids []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
446
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
419
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hayashi K |
| Year: |
1999 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Activity and substrate specificity of the murine STK2 Serine/Threonine kinase that is structurally related to the mitotic regulator protein NIMA of Aspergillus nidulans. |
| Volume: |
264 |
| Issue: |
2 |
| Pages: |
449-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhu Y |
| Year: |
2020 |
| Journal: |
Mol Cell |
| Title: |
Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis. |
| Volume: |
77 |
| Issue: |
1 |
| Pages: |
138-149.e5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tanaka K |
| Year: |
1999 |
| Journal: |
J Biol Chem |
| Title: |
Cloning and characterization of the murine Nek3 protein kinase, a novel member of the NIMA family of putative cell cycle regulators. |
| Volume: |
274 |
| Issue: |
19 |
| Pages: |
13491-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Levedakou EN |
| Year: |
1994 |
| Journal: |
Oncogene |
| Title: |
Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. |
| Volume: |
9 |
| Issue: |
7 |
| Pages: |
1977-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ballif BA |
| Year: |
2004 |
| Journal: |
Mol Cell Proteomics |
| Title: |
Phosphoproteomic analysis of the developing mouse brain. |
| Volume: |
3 |
| Issue: |
11 |
| Pages: |
1093-101 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gerhard DS |
| Year: |
2004 |
| Journal: |
Genome Res |
| Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| Volume: |
14 |
| Issue: |
10B |
| Pages: |
2121-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huttlin EL |
| Year: |
2010 |
| Journal: |
Cell |
| Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
| Volume: |
143 |
| Issue: |
7 |
| Pages: |
1174-89 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Church DM |
| Year: |
2009 |
| Journal: |
PLoS Biol |
| Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
| Volume: |
7 |
| Issue: |
5 |
| Pages: |
e1000112 |
|
•
•
•
•
•
|