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Search results 201 to 300 out of 328 for Nfic

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2851823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539379
Age: embryonic day 15.5
Image: GUDMAP:5684
Specimen Label: GUDMAP:5684
Detected: true
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2851823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539379
Age: embryonic day 15.5
Image: GUDMAP:12634
Specimen Label: GUDMAP:12634
Detected: true
Specimen Num: 2
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2851823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539379
Age: embryonic day 15.5
Image: GUDMAP:12635
Specimen Label: GUDMAP:12635
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754021
Stage: TS21
Assay Id: MGI:3507888
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
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•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754027
Stage: TS27
Assay Id: MGI:3507888
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
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•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5539379
Age: embryonic day 15.5
Image: GUDMAP:5684
Specimen Label: GUDMAP:5684
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5539379
Age: embryonic day 15.5
Image: GUDMAP:12634
Specimen Label: GUDMAP:12634
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5539379
Age: embryonic day 15.5
Image: GUDMAP:12635
Specimen Label: GUDMAP:12635
Detected: false
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280927
Stage: TS27
Assay Id: MGI:3507888
Age: postnatal newborn
Image: 2
Note: The tissue was olfactory epithelium and/or bulb.
Specimen Label: 2
Detected: false
Specimen Num: 2
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•
•
•
GXD Expression
GXD Expression
Probe: MGI:3841800
Assay Type: RNA in situ
Annotation Date: 2009-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752524
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:3842165
Age: embryonic day 16.5
Image: 5
Note: Expression is present around the whisker follicles.
Specimen Label: 5
Detected: true
Specimen Num: 10
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•
GXD Expression
GXD Expression
   
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267921
Stage: TS21
Assay Id: MGI:3507888
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267927
Stage: TS27
Assay Id: MGI:3507888
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3841800
Assay Type: RNA in situ
Annotation Date: 2009-04-29
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3267919
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:3842165
Age: embryonic day 11.5
Image: 3
Specimen Label: 3
Detected: true
Specimen Num: 4
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•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5539379
Age: embryonic day 15.5
Image: GUDMAP:5684
Specimen Label: GUDMAP:5684
Detected: false
Specimen Num: 1
•
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•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5539379
Age: embryonic day 15.5
Image: GUDMAP:12634
Specimen Label: GUDMAP:12634
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5539379
Age: embryonic day 15.5
Image: GUDMAP:12635
Specimen Label: GUDMAP:12635
Detected: false
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3841800
Assay Type: RNA in situ
Annotation Date: 2009-04-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1756324
Stage: TS24
Assay Id: MGI:3842165
Age: embryonic day 16.5
Image: 5
Specimen Label: 5
Detected: false
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757721
Stage: TS21
Assay Id: MGI:3507888
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757727
Pattern: Single cells
Stage: TS27
Assay Id: MGI:3507888
Age: postnatal newborn
Image: 2
Note: Expression was detected in some cells.
Specimen Label: 2
Detected: true
Specimen Num: 2
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•
•
GXD Expression
GXD Expression
   
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5539379
Age: embryonic day 15.5
Image: GUDMAP:5684
Specimen Label: GUDMAP:5684
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5539379
Age: embryonic day 15.5
Image: GUDMAP:12634
Specimen Label: GUDMAP:12634
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5539379
Age: embryonic day 15.5
Image: GUDMAP:12635
Specimen Label: GUDMAP:12635
Detected: false
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3841800
Assay Type: RNA in situ
Annotation Date: 2009-04-29
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3842165
Age: postnatal week 2
Image: 6
Note: Expression is at the limit of detection in this region.
Specimen Label: 6
Specimen Num: 11
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•
•
GXD Expression
GXD Expression
   
Probe: MGI:3841800
Assay Type: RNA in situ
Annotation Date: 2009-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3842165
Age: postnatal newborn
Specimen Label: Not shown
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3841800
Assay Type: RNA in situ
Annotation Date: 2009-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3842165
Age: postnatal adult
Specimen Label: Not shown
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3506364
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539379
Age: embryonic day 15.5
Image: GUDMAP:12635
Specimen Label: GUDMAP:12635
Detected: true
Specimen Num: 3
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Publication
24801901 | J:216782
First Author: Lee DS
Year: 2014
Journal: Stem Cells
Title: NFI-C regulates osteoblast differentiation via control of osterix expression.
Volume: 32
Issue: 9
Pages: 2467-79
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Publication
20729551 | J:166785
First Author: Plasari G
Year: 2010
Journal: J Biol Chem
Title: Nuclear factor I-C regulates TGF-{beta}-dependent hair follicle cycling.
Volume: 285
Issue: 44
Pages: 34115-25
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Publication
16847321 | J:111417
First Author: Nilsson J
Year: 2006
Journal: Mol Cell Biol
Title: Nuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cells.
Volume: 26
Issue: 15
Pages: 5663-74
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Publication
10486208 | J:55356
First Author: Wattler F
Year: 1999
Journal: Genomics
Title: Cloning, chromosomal location, and expression analysis of murine Smarce1-related, a new member of the high-mobility 365 group gene family.
Volume: 60
Issue: 2
Pages: 172-8
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Publication
9056636 | J:39019
First Author: Chaudhry AZ
Year: 1997
Journal: Dev Dyn
Title: Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in development.
Volume: 208
Issue: 3
Pages: 313-25
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Publication
12568726 | J:81879
 
First Author: Gründer A
Year: 2003
Journal: Gene
Title: Genomic organization, splice products and mouse chromosomal localization of genes for transcription factor Nuclear Factor One.
Volume: 304
Pages: 171-81
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Publication
19752192 | J:154930
First Author: Plasari G
Year: 2009
Journal: Mol Cell Biol
Title: Nuclear factor I-C links platelet-derived growth factor and transforming growth factor beta1 signaling to skin wound healing progression.
Volume: 29
Issue: 22
Pages: 6006-17
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Publication
12955085 | J:85531
First Author: Johansson EM
Year: 2003
Journal: Oncogene
Title: The p53 tumor suppressor gene is regulated in vivo by nuclear factor 1-C2 in the mouse mammary gland during pregnancy.
Volume: 22
Issue: 38
Pages: 6061-70
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Publication
19706729 | J:161755
First Author: Riffel AK
Year: 2009
Journal: Mol Pharmacol
Title: Regulation of the CYP3A4 and CYP3A7 promoters by members of the nuclear factor I transcription factor family.
Volume: 76
Issue: 5
Pages: 1104-14
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Publication
10959417 | J:82305
 
First Author: Kane R
Year: 2000
Journal: Adv Exp Med Biol
Title: Transcription factor NF 1 expression in involuting mammary gland.
Volume: 480
Pages: 117-22
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Publication
10762365 | J:63349
First Author: Behrens M
Year: 2000
Journal: Eur J Neurosci
Title: NFI in the development of the olfactory neuroepithelium and the regulation of olfactory marker protein gene expression.
Volume: 12
Issue: 4
Pages: 1372-84
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Publication
21270437 | J:182875
First Author: Wang W
Year: 2011
Journal: Mol Biol Cell
Title: Temporal control of a dendritogenesis-linked gene via REST-dependent regulation of nuclear factor I occupancy.
Volume: 22
Issue: 6
Pages: 868-79
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Publication
20178747 | J:160383
First Author: Messina G
Year: 2010
Journal: Cell
Title: Nfix regulates fetal-specific transcription in developing skeletal muscle.
Volume: 140
Issue: 4
Pages: 554-66
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Publication
10087299 | J:54120
First Author: Fletcher CF
Year: 1999
Journal: Mamm Genome
Title: Exon structure of the nuclear factor I DNA-binding domain from C. elegans to mammals.
Volume: 10
Issue: 4
Pages: 390-6
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Publication
32537777 | J:339059
First Author: Ihn HJ
Year: 2021
Journal: J Cell Physiol
Title: Bobby sox homolog regulates tooth root formation through modulation of dentin sialophosphoprotein.
Volume: 236
Issue: 1
Pages: 480-488
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Publication
17553984 | J:121963
First Author: Wang W
Year: 2007
Journal: J Neurosci
Title: Nuclear factor I coordinates multiple phases of cerebellar granule cell development via regulation of cell adhesion molecules.
Volume: 27
Issue: 23
Pages: 6115-27
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Publication
17150988 | J:117793
First Author: Kudo LC
Year: 2007
Journal: Cereb Cortex
Title: Genetic analysis of anterior posterior expression gradients in the developing mammalian forebrain.
Volume: 17
Issue: 9
Pages: 2108-22
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Publication
15632069 | J:96006
First Author: Steele-Perkins G
Year: 2005
Journal: Mol Cell Biol
Title: The transcription factor gene Nfib is essential for both lung maturation and brain development.
Volume: 25
Issue: 2
Pages: 685-98
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Publication
26655900 | J:314576
First Author: Narayanan R
Year: 2015
Journal: Cell Rep
Title: Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.
Volume: 13
Issue: 9
Pages: 1842-54
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
GSE126907 | RNA-Seq of wild type and Nfic-/- mice pancreata
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE69054 | An Nfic-Hedgehog Signaling Cascade Regulates Tooth Root Development
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
28962832 | J:249329
 
First Author: Chen KS
Year: 2017
Journal: Cancer Lett
Title: The convergent roles of the nuclear factor I transcription factors in development and cancer.
Volume: 410
Pages: 124-138
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Publication
7590749 | J:34412
First Author: Qian F
Year: 1995
Journal: Genomics
Title: Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH.
Volume: 28
Issue: 1
Pages: 66-73
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Publication
17353270 | J:122250
First Author: Driller K
Year: 2007
Journal: Mol Cell Biol
Title: Nuclear factor I X deficiency causes brain malformation and severe skeletal defects.
Volume: 27
Issue: 10
Pages: 3855-3867
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Publication
34483952 | J:326939
 
First Author: Mu H
Year: 2021
Journal: Front Physiol
Title: Epithelial Bone Morphogenic Protein 2 and 4 Are Indispensable for Tooth Development.
Volume: 12
Pages: 660644
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Publication
23776487 | J:203345
First Author: Harris L
Year: 2013
Journal: PLoS One
Title: Heterozygosity for nuclear factor one x affects hippocampal-dependent behaviour in mice.
Volume: 8
Issue: 6
Pages: e65478
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Publication
21513708 | J:173651
First Author: Hsu YC
Year: 2011
Journal: Dev Biol
Title: Mesenchymal nuclear factor I B regulates cell proliferation and epithelial differentiation during lung maturation.
Volume: 354
Issue: 2
Pages: 242-52
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Publication
24661679 | J:355934
 
First Author: Lajoie M
Year: 2014
Journal: BMC Genomics
Title: An overlapping set of genes is regulated by both NFIB and the glucocorticoid receptor during lung maturation.
Volume: 15
Pages: 231
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Protein Domain
IPR019739 | CTF/NFI_DNA-bd_CS
Type: Conserved_site
Description: Nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF) [, , ](also known as TGGCA-binding proteins) are a family of vertebrate nuclear proteins which recognise and bind, as dimers, the palindromic DNA sequence 5'-TGGCANNNTGCCA-3'. This family was first described for its role in stimulating the initiation of adenovirus DNA replication []. In vertebrates there are four members NFIA, NFIB, NFIC, and NFIX and an orthologue from Caenorhabditis elegans has been described, called Nuclear factor I family protein (NFI-I) []. The CTF/NF-I proteins are individually capable of activating transcription and DNA replication, thus they function by regulating cell proliferation and differentiation. They are involved in normal development and have been associated with developmental abnormalities and cancer in humans []. In a given species, there are a large number of different CTF/NF-I proteins, generated both by alternative splicing and by the occurrence of four different genes. CTF/NF-1 proteins contain 400 to 600 amino acids. The N-terminal 200 amino-acid sequence, almost perfectly conserved in all species and genes sequenced, mediates site-specific DNA recognition, protein dimerisation and Adenovirus DNA replication. The C-terminal 100 amino acids contain the transcriptional activation domain. This activation domain is the target of gene expression regulatory pathways elicited by growth factors and it interacts with basal transcription factors and with histone H3 [].This entry represents a specific signature for this family of proteins, which includes the four vertebrate members NFIA, NFIB, NFIC and NFIX. The signature is a perfectly conserved, highly charged 12-residue peptide located in the DNA-binding domain of CTF/NF-I. It does not contain the four conserved Cys residues, which are required for its DNA-binding activity [].
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Publication
1618796 | -
First Author: Novak A
Year: 1992
Journal: J Biol Chem
Title: Four conserved cysteine residues are required for the DNA binding activity of nuclear factor I.
Volume: 267
Issue: 18
Pages: 12986-90
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Publication
2504497 | -
First Author: Mermod N
Year: 1989
Journal: Cell
Title: The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain.
Volume: 58
Issue: 4
Pages: 741-53
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Publication
8543151 | -
First Author: Alevizopoulos A
Year: 1995
Journal: Genes Dev
Title: A proline-rich TGF-beta-responsive transcriptional activator interacts with histone H3.
Volume: 9
Issue: 24
Pages: 3051-66
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Publication
2339052 | -
First Author: Rupp RA
Year: 1990
Journal: Nucleic Acids Res
Title: Chicken NFI/TGGCA proteins are encoded by at least three independent genes: NFI-A, NFI-B and NFI-C with homologues in mammalian genomes.
Volume: 18
Issue: 9
Pages: 2607-16
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Publication
6216480 | -
First Author: Nagata K
Year: 1982
Journal: Proc Natl Acad Sci U S A
Title: Adenovirus DNA replication in vitro: identification of a host factor that stimulates synthesis of the preterminal protein-dCMP complex.
Volume: 79
Issue: 21
Pages: 6438-42
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Publication
19584245 | -
First Author: Whittle CM
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: DNA-binding specificity and in vivo targets of Caenorhabditis elegans nuclear factor I.
Volume: 106
Issue: 29
Pages: 12049-54
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