| Type |
Details |
Score |
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
antisense_lncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Traister A |
| Year: |
2008 |
| Journal: |
Biochem J |
| Title: |
Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface. |
| Volume: |
410 |
| Issue: |
3 |
| Pages: |
503-11 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
20 |
| Description: |
Palmitoleoyl-protein carboxylesterase NOTUM |
| Type: |
chain |
| End: |
503 |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kakugawa S |
| Year: |
2015 |
| Journal: |
Nature |
| Title: |
Notum deacylates Wnt proteins to suppress signalling activity. |
| Volume: |
519 |
| Issue: |
7542 |
| Pages: |
187-192 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
328
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kelson CO |
| Year: |
2024 |
| Journal: |
Cells |
| Title: |
Upregulation of Fatty Acid Synthase Increases Activity of β-Catenin and Expression of NOTUM to Enhance Stem-like Properties of Colorectal Cancer Cells. |
| Volume: |
13 |
| Issue: |
19 |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; wild type |
| Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Antisense lncRNA Gene |
| Type: |
antisense_lncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase, opposite strand; wild type |
| Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; targeted mutation 1.1, Genoway |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; gene trap E206B10, German Gene Trap Consortium |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase, opposite strand; gene trap OST23790, Lexicon Genetics |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; gene trap OST172035, Lexicon Genetics |
| Allele Type: |
Gene trapped |
| Attribute String: |
Not Specified |
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; gene trap OST204303, Lexicon Genetics |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; gene trap OST209188, Lexicon Genetics |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase, opposite strand; gene trap OST324389, Lexicon Genetics |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase, opposite strand; gene trap OST464316, Lexicon Genetics |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; targeted mutation 1e, Wellcome Trust Sanger Institute |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; targeted mutation 1a, Wellcome Trust Sanger Institute |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; endonuclease-mediated mutation 1, The Centre for Phenogenomics |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; endonuclease-mediated mutation 150, Debora Sinner |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; targeted mutation 1.1, Christine Perret |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; targeted mutation 1b, Wellcome Trust Sanger Institute |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; endonuclease-mediated mutation 2, Cyagen Biosciences |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; gene trap IST10792F3, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; gene trap IST10792F4, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase, opposite strand; gene trap IST12618C12, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; gene trap IST13606A6, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
notum palmitoleoyl-protein carboxylesterase; gene trap IST14634C1, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Notum/Notum |
| Background: |
Not Specified |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Notum/Notum |
| Background: |
involves: 129S5/SvEvBrd * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Notum/Notum |
| Background: |
C57BL/6NCrl-Notum/Tcp |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vercauteren I |
| Year: |
2002 |
| Journal: |
Mol Plant Microbe Interact |
| Title: |
An Arabidopsis thaliana pectin acetylesterase gene is upregulated in nematode feeding sites induced by root-knot and cyst nematodes. |
| Volume: |
15 |
| Issue: |
4 |
| Pages: |
404-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
de Souza A |
| Year: |
2014 |
| Journal: |
Planta |
| Title: |
Identification and functional characterization of the distinct plant pectin esterases PAE8 and PAE9 and their deletion mutants. |
| Volume: |
240 |
| Issue: |
5 |
| Pages: |
1123-38 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This family includes protein Notum from animals and pectinacetylesterase (PAE) from plants. Notum is a carboxylesterase that removes an essential palmitoleate moiety from Wnt proteins. Notum constitutes the first known extracellular protein deacylase [, ]. PAEs catalyse the deacetylation of pectin, a major compound of primary cell walls [, ]. |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Notum/Notum<+> |
| Background: |
involves: 129S5/SvEvBrd * C57BL/6 |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Notum/Notum<+> |
| Background: |
C57BL/6NCrl-Notum/Tcp |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Axin2/Axin2 Notum/Notum<+> |
| Background: |
involves: 129P2/OlaHsd |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Axin2/Axin2<+> Notum/Notum<+> |
| Background: |
involves: 129P2/OlaHsd |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Seldin MM |
| Year: |
2018 |
| Journal: |
Cell Metab |
| Title: |
A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism. |
| Volume: |
27 |
| Issue: |
5 |
| Pages: |
1138-1155.e6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kozmik Z |
| Year: |
2001 |
| Journal: |
Genomics |
| Title: |
Characterization of mammalian orthologues of the Drosophila osa gene: cDNA cloning, expression, chromosomal localization, and direct physical interaction with Brahma chromatin-remodeling complex. |
| Volume: |
73 |
| Issue: |
2 |
| Pages: |
140-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reissland M |
| Year: |
2024 |
| Journal: |
Oncogene |
| Title: |
USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer. |
| Volume: |
43 |
| Issue: |
50 |
| Pages: |
3645-3659 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
Data Curation Using Mouse Genome Assembly |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gerhard DS |
| Year: |
2004 |
| Journal: |
Genome Res |
| Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| Volume: |
14 |
| Issue: |
10B |
| Pages: |
2121-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Church DM |
| Year: |
2009 |
| Journal: |
PLoS Biol |
| Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
| Volume: |
7 |
| Issue: |
5 |
| Pages: |
e1000112 |
|
•
•
•
•
•
|