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Search results 201 to 300 out of 322 for Nr1i2

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Type Details Score
Publication
19489075 | J:270973
First Author: Dong B
Year: 2009
Journal: Hepatology
Title: Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes.
Volume: 50
Issue: 2
Pages: 622-9
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Publication
14742670 | J:128774
First Author: Saini SP
Year: 2004
Journal: Mol Pharmacol
Title: A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification.
Volume: 65
Issue: 2
Pages: 292-300
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Publication
15619241 | J:105336
First Author: Uppal H
Year: 2005
Journal: Hepatology
Title: Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice.
Volume: 41
Issue: 1
Pages: 168-76
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Publication
28756207 | J:255403
 
First Author: Zhao LY
Year: 2017
Journal: Biochem Pharmacol
Title: Pregnane X receptor (PXR) deficiency improves high fat diet-induced obesity via induction of fibroblast growth factor 15 (FGF15) expression.
Volume: 142
Pages: 194-203
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Publication
21826054 | J:177202
First Author: Yamazaki Y
Year: 2011
Journal: Lab Invest
Title: Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver.
Volume: 91
Issue: 11
Pages: 1624-33
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Publication
26612838 | J:257395
First Author: Wahlang B
Year: 2016
Journal: Toxicol Sci
Title: Polychlorinated Biphenyl-Xenobiotic Nuclear Receptor Interactions Regulate Energy Metabolism, Behavior, and Inflammation in Non-alcoholic-Steatohepatitis.
Volume: 149
Issue: 2
Pages: 396-410
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Publication
22917771 | J:216646
First Author: Scheer N
Year: 2012
Journal: Drug Metab Dispos
Title: Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line.
Volume: 40
Issue: 11
Pages: 2212-8
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Publication
18677425 | J:140975
First Author: Scheer N
Year: 2008
Journal: J Clin Invest
Title: A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.
Volume: 118
Issue: 9
Pages: 3228-39
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Publication
21628639 | J:231430
First Author: Hasegawa M
Year: 2011
Journal: Mol Pharmacol
Title: Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line.
Volume: 80
Issue: 3
Pages: 518-28
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Publication
34971590 | J:321665
 
First Author: Skoda J
Year: 2022
Journal: Biochem Pharmacol
Title: Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized mice.
Volume: 197
Pages: 114905
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Publication
30573465 | J:286558
First Author: Crosby M
Year: 2019
Journal: Drug Metab Dispos
Title: Suppression of Hepatic CYP3A4 Expression and Activity by 3-Methylcholanthrene in Humanized PXR-CAR-CYP3A4/3A7 Mice.
Volume: 47
Issue: 3
Pages: 279-282
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Publication
26363009 | J:226785
First Author: MacLeod AK
Year: 2015
Journal: Cancer Res
Title: Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models.
Volume: 75
Issue: 21
Pages: 4573-81
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Publication
20403969 | J:163295
First Author: Ross J
Year: 2010
Journal: Toxicol Sci
Title: Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.
Volume: 116
Issue: 2
Pages: 452-66
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Publication
24690595 | J:215352
First Author: Luisier R
Year: 2014
Journal: Toxicol Sci
Title: Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.
Volume: 139
Issue: 2
Pages: 501-11
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Publication
24863967 | J:213198
First Author: Braeuning A
Year: 2014
Journal: Toxicol Sci
Title: Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR.
Volume: 140
Issue: 2
Pages: 259-70
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Publication
12909012 | J:320074
First Author: Watkins RE
Year: 2003
Journal: J Mol Biol
Title: Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor.
Volume: 331
Issue: 4
Pages: 815-28
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Publication
17215127 | J:320076
First Author: Xue Y
Year: 2007
Journal: Bioorg Med Chem
Title: Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism.
Volume: 15
Issue: 5
Pages: 2156-66
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Publication
11005856 | J:64736
First Author: Handschin C
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR).
Volume: 97
Issue: 20
Pages: 10769-74
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Publication
15358766 | J:94993
First Author: Zhang J
Year: 2004
Journal: J Biol Chem
Title: The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity.
Volume: 279
Issue: 47
Pages: 49517-22
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Publication
15347657 | J:95000
First Author: Squires EJ
Year: 2004
Journal: J Biol Chem
Title: Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver.
Volume: 279
Issue: 47
Pages: 49307-14
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Publication
19144646 | J:148818
First Author: Xie Y
Year: 2009
Journal: J Biol Chem
Title: Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1.
Volume: 284
Issue: 14
Pages: 9199-205
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Publication
27113289 | J:250630
First Author: Cui JY
Year: 2016
Journal: Biochim Biophys Acta
Title: RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.
Volume: 1859
Issue: 9
Pages: 1198-217
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Publication
38788959 | J:349748
 
First Author: Shi T
Year: 2024
Journal: Biochem Pharmacol
Title: Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F(2α) (PGF(2α)) levels.
Volume: 225
Pages: 116309
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Publication
29425287 | J:258676
First Author: Sui Y
Year: 2018
Journal: Endocrinology
Title: Perinatal Bisphenol A Exposure Increases Atherosclerosis in Adult Male PXR-Humanized Mice.
Volume: 159
Issue: 4
Pages: 1595-1608
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Publication
19436068 | J:154141
First Author: Zhou C
Year: 2009
Journal: J Lipid Res
Title: Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice.
Volume: 50
Issue: 10
Pages: 2004-13
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Publication
21685500 | J:175563
First Author: Sui Y
Year: 2011
Journal: J Lipid Res
Title: Deficiency of PXR decreases atherosclerosis in apoE-deficient mice.
Volume: 52
Issue: 9
Pages: 1652-9
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Publication
24755147 | J:283480
First Author: Sui Y
Year: 2014
Journal: J Am Heart Assoc
Title: Bisphenol A increases atherosclerosis in pregnane X receptor-humanized ApoE deficient mice.
Volume: 3
Issue: 2
Pages: e000492
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Publication
16682417 | J:114858
First Author: Jung D
Year: 2006
Journal: J Biol Chem
Title: Pregnane X receptor is a target of farnesoid X receptor.
Volume: 281
Issue: 28
Pages: 19081-91
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Publication
19407337 | J:149881
First Author: Cui YJ
Year: 2009
Journal: Toxicol Sci
Title: Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.
Volume: 110
Issue: 1
Pages: 47-60
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Publication
18778245 | J:147474
First Author: Finn RD
Year: 2009
Journal: Biochem J
Title: Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway.
Volume: 417
Issue: 1
Pages: 43-54
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Publication
15340055 | J:92777
First Author: Kodama S
Year: 2004
Journal: Mol Cell Biol
Title: Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes.
Volume: 24
Issue: 18
Pages: 7931-40
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Publication
19815629 | J:157882
First Author: Milona A
Year: 2010
Journal: Am J Physiol Gastrointest Liver Physiol
Title: The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr.
Volume: 298
Issue: 2
Pages: G151-8
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Publication
26265742 | J:320363
First Author: Scheer N
Year: 2015
Journal: Drug Metab Dispos
Title: Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model.
Volume: 43
Issue: 11
Pages: 1679-90
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Publication
23602807 | J:320075
First Author: Wallace BD
Year: 2013
Journal: J Mol Biol
Title: Structural and functional analysis of the human nuclear xenobiotic receptor PXR in complex with RXRα.
Volume: 425
Issue: 14
Pages: 2561-77
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Publication
22285937 | J:318108
First Author: De Marino S
Year: 2012
Journal: Steroids
Title: 4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity.
Volume: 77
Issue: 5
Pages: 484-95
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Publication
25065623 | J:254607
First Author: Venkatesh M
Year: 2014
Journal: Immunity
Title: Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.
Volume: 41
Issue: 2
Pages: 296-310
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Publication
12923173 | J:129256
First Author: Guo GL
Year: 2003
Journal: J Biol Chem
Title: Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity.
Volume: 278
Issue: 46
Pages: 45062-71
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Publication
16844773 | J:111798
First Author: Stedman C
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Benefit of farnesoid X receptor inhibition in obstructive cholestasis.
Volume: 103
Issue: 30
Pages: 11323-8
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Publication
15004017 | J:90692
First Author: Assem M
Year: 2004
Journal: J Biol Chem
Title: Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice.
Volume: 279
Issue: 21
Pages: 22250-7
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Publication
22503787 | J:187856
First Author: Park YJ
Year: 2012
Journal: Toxicol Appl Pharmacol
Title: Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice.
Volume: 263
Issue: 2
Pages: 131-7
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Publication
31374856 | J:290091
 
First Author: Barretto SA
Year: 2019
Journal: Int J Mol Sci
Title: Gene Expression Profiling Reveals that PXR Activation Inhibits Hepatic PPARα Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice.
Volume: 20
Issue: 15
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Publication
28911860 | J:357977
 
First Author: Gotoh S
Year: 2017
Journal: Cell Signal
Title: Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal.
Volume: 40
Pages: 200-209
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Publication
23626729 | J:200100
First Author: Shizu R
Year: 2013
Journal: PLoS One
Title: Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.
Volume: 8
Issue: 4
Pages: e61802
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Publication
30193838 | J:269997
First Author: Takeuchi Y
Year: 2018
Journal: Exp Cell Res
Title: Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling.
Volume: 371
Issue: 2
Pages: 417-425
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Publication
21933665 | J:180709
First Author: Buler M
Year: 2011
Journal: Biochem Pharmacol
Title: Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and function.
Volume: 82
Issue: 12
Pages: 2008-15
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Publication
26574435 | J:237668
First Author: Shizu R
Year: 2016
Journal: Biochem J
Title: PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor.
Volume: 473
Issue: 3
Pages: 257-66
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Publication
26883953 | J:250753
First Author: Cui W
Year: 2016
Journal: Biochim Biophys Acta
Title: A SUMO-acetyl switch in PXR biology.
Volume: 1859
Issue: 9
Pages: 1170-82
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Publication
17521389 | J:216127
First Author: Amador-Noguez D
Year: 2007
Journal: Aging Cell
Title: Alterations in xenobiotic metabolism in the long-lived Little mice.
Volume: 6
Issue: 4
Pages: 453-70
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Publication
36720308 | J:347001
First Author: Yang X
Year: 2023
Journal: J Biol Chem
Title: Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR.
Volume: 299
Issue: 3
Pages: 102955
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Publication
12447992 | J:80697
First Author: Gartner H
Year: 2003
Journal: J Cell Physiol
Title: Development of the fetal intestine in mice lacking the glucocorticoid receptor (GR).
Volume: 194
Issue: 1
Pages: 80-7
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29718219 | J:262945
First Author: Kim KH
Year: 2018
Journal: Endocrinology
Title: Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis.
Volume: 159
Issue: 6
Pages: 2435-2446
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Publication
16606610 | J:113721
First Author: Yamamoto Y
Year: 2006
Journal: J Biol Chem
Title: Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity.
Volume: 281
Issue: 24
Pages: 16625-31
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Publication
16614213 | J:108344
First Author: Huang W
Year: 2006
Journal: Science
Title: Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration.
Volume: 312
Issue: 5771
Pages: 233-6
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Publication
15611112 | J:128570
First Author: Yu L
Year: 2005
Journal: J Biol Chem
Title: Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion.
Volume: 280
Issue: 10
Pages: 8742-7
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Publication
23091169 | J:192852
First Author: Lempiäinen H
Year: 2013
Journal: Toxicol Sci
Title: Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion.
Volume: 131
Issue: 2
Pages: 375-86
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Publication
16825189 | J:117299
First Author: Ding X
Year: 2006
Journal: J Biol Chem
Title: Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha.
Volume: 281
Issue: 36
Pages: 26540-51
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Publication
21983082 | J:323723
First Author: Fujiwara R
Year: 2012
Journal: Gastroenterology
Title: Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia.
Volume: 142
Issue: 1
Pages: 109-118.e2
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Publication
18794335 | J:146035
First Author: van Waterschoot RA
Year: 2009
Journal: FASEB J
Title: Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver.
Volume: 23
Issue: 1
Pages: 224-31
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Publication
32341518 | J:297852
First Author: Peng S
Year: 2020
Journal: Lab Invest
Title: The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability.
Volume: 100
Issue: 8
Pages: 1057-1067
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Publication
30910785 | J:286122
First Author: Henderson CJ
Year: 2019
Journal: Drug Metab Dispos
Title: An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials.
Volume: 47
Issue: 6
Pages: 601-615
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Publication
33828301 | J:334847
First Author: Chen ML
Year: 2021
Journal: Nature
Title: CAR directs T cell adaptation to bile acids in the small intestine.
Volume: 593
Issue: 7857
Pages: 147-151
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Publication
18648086 | J:141993
First Author: Cheng X
Year: 2008
Journal: Toxicol Sci
Title: Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors.
Volume: 106
Issue: 1
Pages: 29-36
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Publication
29142166 | J:273929
First Author: Miyata M
Year: 2017
Journal: J Toxicol Sci
Title: Fish oil feeding reverses hepatomegaly and disrupted hepatic function due to the lack of FXR signaling.
Volume: 42
Issue: 6
Pages: 671-681
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Publication
28751364 | J:244975
First Author: Kriebs A
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.
Volume: 114
Issue: 33
Pages: 8776-8781
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Publication
12837957 | J:84711
First Author: Lyons MA
Year: 2003
Journal: Physiol Genomics
Title: New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice.
Volume: 14
Issue: 3
Pages: 225-39
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Publication
18703564 | J:142114
First Author: Cheng X
Year: 2008
Journal: Toxicol Sci
Title: Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.
Volume: 106
Issue: 1
Pages: 37-45
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11891224 | J:76833
First Author: Gonzalez MM
Year: 2002
Journal: J Biol Chem
Title: Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors.
Volume: 277
Issue: 21
Pages: 18501-9
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Publication
31875848 | J:294043
First Author: Song X
Year: 2020
Journal: Nature
Title: Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis.
Volume: 577
Issue: 7790
Pages: 410-415
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16912278 | J:111670
First Author: Kyrmizi I
Year: 2006
Journal: Genes Dev
Title: Plasticity and expanding complexity of the hepatic transcription factor network during liver development.
Volume: 20
Issue: 16
Pages: 2293-305
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22496360 | J:317552
First Author: Casey SC
Year: 2012
Journal: Mol Endocrinol
Title: The steroid and xenobiotic receptor negatively regulates B-1 cell development in the fetal liver.
Volume: 26
Issue: 6
Pages: 916-25
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27531557 | J:289492
First Author: Yi J
Year: 2016
Journal: Hepatology
Title: Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ.
Volume: 64
Issue: 5
Pages: 1757-1772
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11002334 | J:64984
First Author: Duncan SA
Year: 2000
Journal: Dev Dyn
Title: Transcriptional regulation of liver development.
Volume: 219
Issue: 2
Pages: 131-42
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16498401 | J:106993
First Author: Briançon N
Year: 2006
Journal: EMBO J
Title: In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping.
Volume: 25
Issue: 6
Pages: 1253-62
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16971476 | J:119560
First Author: Choi MY
Year: 2006
Journal: Development
Title: A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.
Volume: 133
Issue: 20
Pages: 4119-29
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20932939 | J:168654
First Author: Chung YC
Year: 2011
Journal: Gene Expr Patterns
Title: Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.
Volume: 11
Issue: 1-2
Pages: 84-92
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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