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Search results 201 to 300 out of 748 for Nudc

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
406472 | nudcd3
Type: gene
Organism: zebrafish
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Gene
445145 | nudcd2
Type: gene
Organism: zebrafish
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Gene
553654 | nudcd1
Type: gene
Organism: zebrafish
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Gene
693699 | LOC693699
Type: gene
Organism: macaque, rhesus
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Gene
697869 | NUDCD2
Type: gene
Organism: macaque, rhesus
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Gene
698632 | NUDCD1
Type: gene
Organism: macaque, rhesus
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Gene
699353 | NUDCD3
Type: gene
Organism: macaque, rhesus
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Gene
548495 | nudcd3
Type: gene
Organism: frog, western clawed
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Gene
549133 | nudcd2
Type: gene
Organism: frog, western clawed
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Gene
549375 | nudcd1
Type: gene
Organism: frog, western clawed
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Gene
119866768 | LOC119866768
Type: gene
Organism: dog, domestic
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Gene
108718597 | LOC108718597
Type: gene
Organism: frog, African clawed
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Publication
27561816 | -
First Author: Zhang D
Year: 2016
Journal: Cell Res
Title: Structural basis of prokaryotic NAD-RNA decapping by NudC.
Volume: 26
Issue: 9
Pages: 1062-6
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Publication
2199460 | -
First Author: Osmani AH
Year: 1990
Journal: J Cell Biol
Title: The molecular cloning and identification of a gene product specifically required for nuclear movement in Aspergillus nidulans.
Volume: 111
Issue: 2
Pages: 543-51
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Protein Domain
IPR022925 | RNA_Hydrolase_NudC
Type: Family
Description: This entry represents NAD-capped RNA hydrolase NudC from bacteria. NudC is a mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolysing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. This enzyme has preference for mRNAs with a 5'-end purine and catalyses the hydrolysis of a broad range of dinucleotide pyrophosphates. NudC assemblies into a homodimer with the appearance of a butterfly. Each monomer shows two tandem Nudix-fold domains, a N-terminal and a C-terminal, and an extended zinc-binding motif in-between. As a subgroup of the Nudix hydrolase family, NudC has a conserved Nudix motif [, ].
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Protein Domain
IPR027761 | NUDCD3
Type: Family
Description: Proteins in this family contain the NudC domain. They share protein sequence similarity with Aspergillus NudC, which is required for nuclear movement [].
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Protein Coding Gene
MGI:2144158 | Nudcd3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR025934 | NudC_N_dom
Type: Domain
Description: Nuclear distribution gene C homologue (nudC) proteins form complexes with other nud proteins and are involved in several cellular division activities. Recently it was shown that nudC regulates platelet-activating factor (PAF) acetylhydrolase with PAF being a pro-inflammatory secondary lipidic messenger []. The N terminus of nudC proteins contain a highly conserved region consisting of a predicted three helix bundle. This entry represents the N-terminal conserved domain.
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UniProt Feature
UniProt Feature
Begin: 1
Description: NudC domain-containing protein 1
Type: chain
End: 582
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UniProt Feature
UniProt Feature
Begin: 2
Description: NudC domain-containing protein 2
Type: chain
End: 157
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UniProt Feature
UniProt Feature
Begin: 1
Description: Nuclear migration protein nudC
Type: chain
End: 332
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UniProt Feature
UniProt Feature
Begin: 1
Description: NudC domain-containing protein 3
Type: chain
End: 363
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Protein Coding Gene
MGI:1277103 | Nudcd2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR037905 | p23_NUDCD3
Type: Domain
Description: NudC domain-containing protein 3 (NUDCD3) has not been characterised. It is a member of the NudC family. All members of the NudC family share a conserved p23 domain, which possesses chaperone activity both in conjunction with and independently of heat shock protein 90 (Hsp90) []. NudC proteins play multiple roles in cell cycle progression, cell migration, inflammatory response, platelet production, carcinogenesis [].
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Publication
38787962 | J:351330
First Author: Chen R
Year: 2024
Journal: Sci Immunol
Title: NUDCD3 deficiency disrupts V(D)J recombination to cause SCID and Omenn syndrome.
Volume: 9
Issue: 95
Pages: eade5705
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Protein
Q8C100
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
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Protein
Q3UZN2
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: false
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Protein
Q8BJK0
Organism: Mus musculus/domesticus
Length: 256  
Fragment?: false
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Publication
29021621 | -
First Author: Asselin-Mullen P
Year: 2017
Journal: Sci Rep
Title: Protein interaction network of alternatively spliced NudCD1 isoforms.
Volume: 7
Issue: 1
Pages: 12987
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Publication
11416219 | -
First Author: Yang XF
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: CML66, a broadly immunogenic tumor antigen, elicits a humoral immune response associated with remission of chronic myelogenous leukemia.
Volume: 98
Issue: 13
Pages: 7492-7
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Publication
18534745 | -
First Author: Wang Q
Year: 2008
Journal: Cancer Lett
Title: RNA interference targeting CML66, a novel tumor antigen, inhibits proliferation, invasion and metastasis of HeLa cells.
Volume: 269
Issue: 1
Pages: 127-38
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Publication
24633332 | -
First Author: Rao W
Year: 2014
Journal: PLoS One
Title: OVA66, a tumor associated protein, induces oncogenic transformation of NIH3T3 cells.
Volume: 9
Issue: 3
Pages: e85705
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Protein Domain
IPR037895 | NUDCD1
Type: Family
Description: NudCD1, also known as CML66 or OVA66, belongs to the NudC family, whose members share a conserved p23 domain. It is the more distant and less characterised family member. NudCD1 is a tumour associated antigen highly expressed in human leukaemia, some solid tumours and tumour cell lines []. Its expression in normal tissues is restricted to testis [, ]. Different NudCD1 isoforms have unique interacting partners, with the first isoform binding to a putative RNA helicase named DHX15 involved in mRNA splicing [].
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Gene
106992582 | LOC106992582
Type: gene
Organism: macaque, rhesus
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Gene
106992613 | LOC106992613
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1914679 | Nudcd1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
14688378 | -
First Author: Yan Y
Year: 2004
Journal: J Immunol
Title: A novel mechanism of alternative promoter and splicing regulates the epitope generation of tumor antigen CML66-L.
Volume: 172
Issue: 1
Pages: 651-60
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Protein
Q8R1N4-4
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: false
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Protein
Q8R1N4-3
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
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Protein
Q8R1N4-2
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Protein
A0A2I3BQP7
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: false
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Publication
27428510 | -
First Author: Höfer K
Year: 2016
Journal: Nat Chem Biol
Title: Structure and function of the bacterial decapping enzyme NudC.
Volume: 12
Issue: 9
Pages: 730-4
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Publication
20133715 | -
First Author: Yang Y
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90.
Volume: 107
Issue: 8
Pages: 3499-504
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Gene
120093841 | Nudcd2-ps1
Type: gene
Organism: rat
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Gene
100036878 | nudcd3.S
Type: gene
Organism: frog, African clawed
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Gene
380474 | nudcd1.S
Type: gene
Organism: frog, African clawed
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Gene
432020 | nudc.L
Type: gene
Organism: frog, African clawed
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Gene
444226 | nudcd3.L
Type: gene
Organism: frog, African clawed
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Gene
494725 | nudc.S
Type: gene
Organism: frog, African clawed
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Gene
496162 | nudcd2.L
Type: gene
Organism: frog, African clawed
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Protein Domain
IPR037902 | p23_NUDCD2
Type: Domain
Description: NudC-like 2/NudC domain-containing protein 2 (NudCL2/NUDCD2) regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. LIS1 is a key regulator of cytoplasmic dynein, and is critical for cell proliferation, survival, and neuronal migration []. Like other members of the NudC family, NUDCD2 has a conserved p23 domain, which possesses chaperone activity both in conjunction with and independently of Hsp90 [, ]. This entry represents the p23 domain of NUDCD2.
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Publication
21777812 | -
First Author: Echtenkamp FJ
Year: 2011
Journal: Mol Cell
Title: Global functional map of the p23 molecular chaperone reveals an extensive cellular network.
Volume: 43
Issue: 2
Pages: 229-41
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Protein
B0FTY3
Organism: Mus musculus/domesticus
Length: 363  
Fragment?: false
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Protein Coding Gene
MGP_CAROLIEiJ_G0016066 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_CAROLIEiJ_G0016213 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_CAROLIEiJ_G0019772 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018015 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0018162 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0021829 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017988 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018135 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0021789 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017952 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018099 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0021770 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017956 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018104 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0021796 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017769 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017917 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021570 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2144158 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1277103 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1914679 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018408 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018558 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0022235 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017331 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017481 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0021087 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017744 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017890 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0021539 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017854 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0018000 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0021663 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017846 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017994 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0021641 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017925 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018072 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0021733 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017872 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0018018 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0021665 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018448 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018597 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0022258 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0017111 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0017262 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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