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Search results 201 to 214 out of 214 for Nuf2

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Type

Details

Score

Protein Domain

IPR041112 | Nuf2_DHR10-like

Type:	Domain
Description:	This domain is found at the C-terminal region of Nuf2 proteins. This domain was identified as MazG related domain also designated as Designed helical repeat protein 10 (DHR10) []that actually adopts a coiled-coil structure []. Nuf2 is part of the Ndc80 complex, which complex binds to the spindle and is required for chromosome segregation and spindle checkpoint activity [, , , , , , ].

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Publication

12438418 | -

First Author:	DeLuca JG
Year:	2002
Journal:	J Cell Biol
Title:	hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells.
Volume:	159
Issue:	4
Pages:	549-55

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Publication

4654001 | -

First Author:	Truswell AS
Year:	1972
Journal:	S Afr Med J
Title:	Thiamine deficiency in children with severe gastro-enteritis.
Volume:	46
Issue:	52
Pages:	2083-4

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Publication

15062103 | -

First Author:	Joseph J
Year:	2004
Journal:	Curr Biol
Title:	The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo.
Volume:	14
Issue:	7
Pages:	611-7

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Publication

15235793 | -

First Author:	Stucke VM
Year:	2004
Journal:	Chromosoma
Title:	Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1.
Volume:	113
Issue:	1
Pages:	1-15

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Publication

15239953 | -

First Author:	Meraldi P
Year:	2004
Journal:	Dev Cell
Title:	Timing and checkpoints in the regulation of mitotic progression.
Volume:	7
Issue:	1
Pages:	45-60

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Protein Domain

IPR038275 | Nuf2_N_sf

Type:

Homologous_superfamily

Description:

This superfamily represents a domain found at the N terminus of the Kinetochore protein Nuf2, which is part of the Ndc80 complex. This domain fold as a CH domain consisting of a four-helix bundle containing the parallel helices alphaA, alphaC, alphaE, and alphaG, similar to that in Ndc80. These CH domains from Nuf2 and Ndc80 forms the globular rod at one end the complex [, ]. The ability of the Ndc80 complex to bind microtubules resides on the tightly packed CH domains from Nuf2 and Ndc80 []. This complex binds to the spindle and is required for chromosome segregation and spindle checkpoint activity [, , , , , , ].

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Protein Domain

IPR005549 | Kinetochore_Nuf2_N

Type:

Domain

Description:

This entry represents the N-terminal domain of kinetochore protein Nuf2, which is part of the Ndc80 complex. This domain fold as a CH domain consisting of a four-helix bundle containing the parallel helices alphaA, alphaC, alphaE, and alphaG, similar to that in Ndc80. These CH domains from Nuf2 and Ndc80 forms the globular rod at one end the complex [, ]. The ability of the Ndc80 complex to bind microtubules resides on the tightly packed CH domains from Nuf2 and Ndc80 []. This complex binds to the spindle and is required for chromosome segregation and spindle checkpoint activity [, , , , , , ].

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Publication

16765893 | -

First Author:	Wei RR
Year:	2006
Journal:	Structure
Title:	Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain.
Volume:	14
Issue:	6
Pages:	1003-9

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Protein Domain

IPR038066 | Spc24_Fungi_globular_sf

Type:

Homologous_superfamily

Description:

Spc24 is a component of the evolutionarily conserved kinetochore-associated Ndc80 complex, which is implicated in several essential outer kinetochore functions, including microtubule binding and control the spindle assembly checkpoint [, ].The Ndc80 complex appears to be a long rod with globular 'heads'. Ndc80 and Nuf2 contribute to one head and to the intervening shaft; Spc24 and Spc25 complete the shaft and contribute to the other head. Spc24 and Spc25 fold tightly together. TheC-terminal globular domains of Spc24 and Spc25 form the 'inner' head, which faces the centromere [].

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Publication

17521635 | -

First Author:	Ciferri C
Year:	2007
Journal:	FEBS Lett
Title:	The Ndc80 complex: hub of kinetochore activity.
Volume:	581
Issue:	15
Pages:	2862-9

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

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Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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