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Search results 201 to 300 out of 2075 for Numb

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Type Details Score
GXD Expression
GXD Expression
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 7
Image: g01221 P7
Note: Expression was region specific and scattered.
Specimen Label: g01221 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 42
Image: g01221 Adult
Note: Expression was region specific and scattered.
Specimen Label: g01221 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 7
Image: g01221 P7
Specimen Label: g01221 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 42
Image: g01221 Adult
Note: Expression was region specific and scattered.
Specimen Label: g01221 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267228
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 42
Image: g01221 Adult
Specimen Label: g01221 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5001800
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1869223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542354
Age: embryonic day 15.5
Image: GUDMAP:10207
Specimen Label: GUDMAP:10207
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945680
Age: embryonic day 11.5
Image: g01221 E11.5
Specimen Label: g01221 E11.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945680
Age: embryonic day 15.5
Image: g01221 E15.5
Specimen Label: g01221 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 42
Image: g01221 Adult
Note: Expression was region specific and scattered.
Specimen Label: g01221 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945680
Age: embryonic day 11.5
Image: g01221 E11.5
Specimen Label: g01221 E11.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1335637
Assay Type: RNA in situ
Annotation Date: 2007-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3695411
Age: embryonic day 12.5
Image: 6G
Specimen Label: 6G
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5001800
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2854023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542354
Age: embryonic day 15.5
Image: GUDMAP:10227
Specimen Label: GUDMAP:10227
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 7
Image: g01221 P7
Specimen Label: g01221 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 42
Image: g01221 Adult
Specimen Label: g01221 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5001800
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2762123
Stage: TS23
Assay Id: MGI:5542354
Age: embryonic day 15.5
Image: GUDMAP:10227
Specimen Label: GUDMAP:10227
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:6231199
Assay Type: Immunohistochemistry
Annotation Date: 2018-11-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6236261
Age: embryonic day 14.0
Image: 3D
Note: Expression was localized at the apical side of distal epithelial cells with little or no staining at the basal pole.
Specimen Label: 3D
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 7
Image: g01221 P7
Specimen Label: g01221 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 42
Image: g01221 Adult
Specimen Label: g01221 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 7
Image: g01221 P7
Specimen Label: g01221 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 42
Image: g01221 Adult
Specimen Label: g01221 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5001800
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5542354
Age: embryonic day 15.5
Image: GUDMAP:10227
Specimen Label: GUDMAP:10227
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5640985
Assay Type: Immunohistochemistry
Annotation Date: 1999-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:1335646
Age: embryonic day 12.5
Image: 7B
Note: Expression was detected in all layers of the cortical neuroepithelium, from the ventricular zone to the cortical plate. In interphase cells within the ventricular zone, immunostaining appeared to be symmetrically distributed.
Specimen Label: 7B
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5640985
Assay Type: Immunohistochemistry
Annotation Date: 1999-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754720
Pattern: Single cells
Stage: TS20
Assay Id: MGI:1335646
Age: embryonic day 12.5
Image: 7D
Note: In dividing cells (metaphase) at the ventricular surface, expression became asymmetrically localized to the apical or apical-lateral membrane.
Specimen Label: 7D
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5640985
Assay Type: Immunohistochemistry
Annotation Date: 1999-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754720
Pattern: Single cells
Stage: TS20
Assay Id: MGI:1335646
Age: embryonic day 12.5
Image: 7E
Note: In dividing cells (anaphase) at the ventricular surface, expression became asymmetrically localized to the apical or apical-lateral membrane.
Specimen Label: 7E
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5001800
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5542354
Age: embryonic day 15.5
Image: GUDMAP:10207
Specimen Label: GUDMAP:10207
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5001800
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5542354
Age: embryonic day 15.5
Image: GUDMAP:10227
Specimen Label: GUDMAP:10227
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 7
Image: g01221 P7
Specimen Label: g01221 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 42
Image: g01221 Adult
Specimen Label: g01221 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5001800
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5542354
Age: embryonic day 15.5
Image: GUDMAP:10227
Specimen Label: GUDMAP:10227
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945680
Age: embryonic day 15.5
Image: g01221 E15.5
Specimen Label: g01221 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 42
Image: g01221 Adult
Note: Expression was region specific and scattered.
Specimen Label: g01221 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945680
Age: embryonic day 15.5
Image: g01221 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g01221 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5001800
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5542354
Age: embryonic day 15.5
Image: GUDMAP:10227
Specimen Label: GUDMAP:10227
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5001800
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2874723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542354
Age: embryonic day 15.5
Image: GUDMAP:10227
Specimen Label: GUDMAP:10227
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 7
Image: g01221 P7
Specimen Label: g01221 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4885831
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945680
Age: postnatal day 42
Image: g01221 Adult
Specimen Label: g01221 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5001800
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542354
Age: embryonic day 15.5
Image: GUDMAP:10227
Specimen Label: GUDMAP:10227
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5698954
Assay Type: Immunohistochemistry
Annotation Date: 2015-12-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5699059
Age: embryonic day 10.5
Image: S2D
Specimen Label: S2D
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5001800
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542354
Age: embryonic day 15.5
Image: GUDMAP:10227
Specimen Label: GUDMAP:10227
Detected: true
Specimen Num: 2
•
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Gene
100488844 | numbl
Type: gene
Organism: frog, western clawed
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Publication
- | J:106229
     
First Author: Zilian O
Year: 2006
Journal: MGI Direct Data Submission
Title: Numb/Numblike double mutant
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Publication
16508311 | -
First Author: Toriya M
Year: 2006
Journal: Dev Neurosci
Title: Distinct functions of human numb isoforms revealed by misexpression in the neural stem cell lineage in the Drosophila larval brain.
Volume: 28
Issue: 1-2
Pages: 142-55
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•
Publication
32555153 | J:293238
First Author: Choi HY
Year: 2020
Journal: Nat Commun
Title: p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs.
Volume: 11
Issue: 1
Pages: 3084
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•
•
Publication
12606711 | J:230357
First Author: Calderwood DA
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.
Volume: 100
Issue: 5
Pages: 2272-7
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Publication
35342338 | J:322948
First Author: Li MR
Year: 2022
Journal: Int J Biol Sci
Title: MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy.
Volume: 18
Issue: 5
Pages: 1896-1911
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Publication
28041903 | J:238412
First Author: Hayashi T
Year: 2017
Journal: Dev Cell
Title: Exosomal MicroRNA Transport from Salivary Mesenchyme Regulates Epithelial Progenitor Expansion during Organogenesis.
Volume: 40
Issue: 1
Pages: 95-103
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•
Publication
37843276 | J:341636
 
First Author: Su D
Year: 2023
Journal: J Clin Invest
Title: SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling.
Volume: 133
Issue: 20
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•
Publication
28011038 | J:238712
First Author: Bélanger MC
Year: 2017
Journal: Dev Cell
Title: Msx1-Positive Progenitors in the Retinal Ciliary Margin Give Rise to Both Neural and Non-neural Progenies in Mammals.
Volume: 40
Issue: 2
Pages: 137-150
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Publication
28974699 | J:315924
First Author: Swarnkar G
Year: 2017
Journal: Sci Rep
Title: NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis.
Volume: 7
Issue: 1
Pages: 12600
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Publication
22865640 | J:202652
First Author: Yang J
Year: 2012
Journal: Cardiovasc Res
Title: Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart.
Volume: 96
Issue: 2
Pages: 276-85
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Publication
9169836 | J:41027
First Author: Zhong W
Year: 1997
Journal: Development
Title: Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis.
Volume: 124
Issue: 10
Pages: 1887-97
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Publication
19122831 | J:149860
 
First Author: Raji B
Year: 2008
Journal: Mol Vis
Title: Analysis of partner of inscuteable (mPins) expression in the developing mouse eye.
Volume: 14
Pages: 2575-96
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•
Publication
26849305 | J:296290
First Author: Bu P
Year: 2016
Journal: Cell Stem Cell
Title: A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer.
Volume: 18
Issue: 2
Pages: 189-202
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Protein
Q9QZS3
Organism: Mus musculus/domesticus
Length: 653  
Fragment?: false
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•
Protein
Q05BE7
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Publication
25535389 | J:218238
First Author: Swarnkar G
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling.
Volume: 112
Issue: 1
Pages: 154-9
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Publication
22174158 | J:215867
First Author: Ting SB
Year: 2012
Journal: Blood
Title: Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2.
Volume: 119
Issue: 11
Pages: 2510-22
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Publication
20639863 | J:162770
First Author: Ito T
Year: 2010
Journal: Nature
Title: Regulation of myeloid leukaemia by the cell-fate determinant Musashi.
Volume: 466
Issue: 7307
Pages: 765-8
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Allele
Stat2<m1Btlr> | MGI:6200395
Name: signal transducer and activator of transcription 2; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Publication
25313962 | J:259125
First Author: Yang J
Year: 2014
Journal: Dev Cell
Title: RBM24 is a major regulator of muscle-specific alternative splicing.
Volume: 31
Issue: 1
Pages: 87-99
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Publication
26507506 | J:227912
 
First Author: Yu CH
Year: 2015
Journal: Nat Commun
Title: Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force.
Volume: 6
Pages: 8672
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Publication
20844536 | J:164664
First Author: Aguirre A
Year: 2010
Journal: Nature
Title: Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal.
Volume: 467
Issue: 7313
Pages: 323-7
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Publication
27940916 | J:239068
First Author: Dustrude ET
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Hierarchical CRMP2 posttranslational modifications control NaV1.7 function.
Volume: 113
Issue: 52
Pages: E8443-E8452
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Publication
24168030 | J:205046
 
First Author: Moore R
Year: 2013
Journal: BMC Dev Biol
Title: Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues.
Volume: 13
Pages: 39
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Publication
14641329 | J:86239
First Author: Yoshida T
Year: 2003
Journal: Differentiation
Title: Distinct expression patterns of splicing isoforms of mNumb in the endocrine lineage of developing pancreas.
Volume: 71
Issue: 8
Pages: 486-95
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Publication
28981589 | J:279312
First Author: Sapir T
Year: 2018
Journal: Cereb Cortex
Title: Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin Ligases.
Volume: 28
Issue: 9
Pages: 3115-3128
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Publication
20643355 | J:162625
First Author: Wu M
Year: 2010
Journal: Dev Cell
Title: Epicardial spindle orientation controls cell entry into the myocardium.
Volume: 19
Issue: 1
Pages: 114-25
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Publication
21246661 | J:167828
First Author: El-Hashash AH
Year: 2011
Journal: Dev Dyn
Title: Cell polarity and spindle orientation in the distal epithelium of embryonic lung.
Volume: 240
Issue: 2
Pages: 441-5
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Publication
17050694 | J:116100
First Author: Chen L
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly.
Volume: 103
Issue: 44
Pages: 16520-5
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Publication
25127137 | J:314320
First Author: Wang H
Year: 2014
Journal: Cell Rep
Title: Gli3 repressor controls cell fates and cell adhesion for proper establishment of neurogenic niche.
Volume: 8
Issue: 4
Pages: 1093-104
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Protein Domain
IPR010449 | Numb_domain
Type: Domain
Description: This entry represents a domain found in the cell-fate determinant Numb, and in related proteins. In Drosophila, two signalling pathways, one mediated by Numb and the other by Notch, play essential but antagonistic roles in enabling the two daughters to adopt different fates after a wide variety of asymmetric cell divisions []. Numb acts to inhibit Notch signalling, this inhibition being critical for many cell fate decisions []. Mammalian Numb (mNumb) has multiple functions and plays important roles in the regulation of neural development, including maintenance of neural progenitor cells and promotion of neuronal differentiation in the central nervous system (CNS) [].
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Publication
26437238 | J:227201
 
First Author: Feutlinske F
Year: 2015
Journal: Nat Commun
Title: Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility.
Volume: 6
Pages: 8535
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Publication
20233719 | J:164475
First Author: Kennedy KA
Year: 2010
Journal: J Biol Chem
Title: Mammalian numb-interacting protein 1/dual oxidase maturation factor 1 directs neuronal fate in stem cells.
Volume: 285
Issue: 23
Pages: 17974-85
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Publication
28808228 | J:255488
First Author: Premarathne S
Year: 2017
Journal: Sci Rep
Title: Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors.
Volume: 7
Issue: 1
Pages: 8109
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Publication
19146812 | J:147307
First Author: Yokota Y
Year: 2009
Journal: Neuron
Title: The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral cortex.
Volume: 61
Issue: 1
Pages: 42-56
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Publication
23028652 | J:191793
First Author: Schnatwinkel C
Year: 2012
Journal: PLoS One
Title: Nubp1 is required for lung branching morphogenesis and distal progenitor cell survival in mice.
Volume: 7
Issue: 9
Pages: e44871
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Publication
26755700 | J:239974
First Author: Lacomme M
Year: 2016
Journal: Development
Title: The LGN protein promotes planar proliferative divisions in the neocortex but apicobasal asymmetric terminal divisions in the retina.
Volume: 143
Issue: 4
Pages: 575-81
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Publication
15037549 | J:89028
First Author: Klezovitch O
Year: 2004
Journal: Genes Dev
Title: Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice.
Volume: 18
Issue: 5
Pages: 559-71
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Gene
111094034 | LOC111094034
Type: gene
Organism: dog, domestic
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Gene
100462918 | numbl.L
Type: gene
Organism: frog, African clawed
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Gene
108699734 | numb.S
Type: gene
Organism: frog, African clawed
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Gene
108700267 | numbl.S
Type: gene
Organism: frog, African clawed
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Publication
23817546 | J:203743
First Author: Higginbotham H
Year: 2013
Journal: Nat Neurosci
Title: Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation.
Volume: 16
Issue: 8
Pages: 1000-7
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Publication
23160044 | J:197487
First Author: Tiberi L
Year: 2012
Journal: Nat Neurosci
Title: BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets.
Volume: 15
Issue: 12
Pages: 1627-35
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Publication
36943865 | J:334752
First Author: Liu W
Year: 2023
Journal: Cell Rep
Title: PQBP1 regulates striatum development through balancing striatal progenitor proliferation and differentiation.
Volume: 42
Issue: 3
Pages: 112277
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Publication
16518823 | J:108618
First Author: Carson C
Year: 2006
Journal: Dev Dyn
Title: Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium.
Volume: 235
Issue: 6
Pages: 1678-88
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Publication
20573213 | J:355868
 
First Author: Revil T
Year: 2010
Journal: BMC Genomics
Title: Alternative splicing is frequent during early embryonic development in mouse.
Volume: 11
Pages: 399
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Publication
16168404 | J:103594
First Author: Theil T
Year: 2005
Journal: Dev Biol
Title: Gli3 is required for the specification and differentiation of preplate neurons.
Volume: 286
Issue: 2
Pages: 559-71
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Publication
33899739 | J:308321
   
First Author: Lau EO
Year: 2021
Journal: Elife
Title: DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction.
Volume: 10
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Publication
21826226 | J:176531
First Author: Nowakowski TJ
Year: 2011
Journal: PLoS One
Title: Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon.
Volume: 6
Issue: 8
Pages: e23013
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Publication
19923290 | J:155751
First Author: Kang W
Year: 2009
Journal: J Neurosci
Title: The transition from radial glial to intermediate progenitor cell is inhibited by FGF signaling during corticogenesis.
Volume: 29
Issue: 46
Pages: 14571-80
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Publication
24552588 | J:213069
First Author: Vanorny DA
Year: 2014
Journal: Mol Endocrinol
Title: Notch signaling regulates ovarian follicle formation and coordinates follicular growth.
Volume: 28
Issue: 4
Pages: 499-511
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Publication
36218069 | J:331486
 
First Author: Hirose T
Year: 2022
Journal: Development
Title: PAR3 restricts the expansion of neural precursor cells by regulating hedgehog signaling.
Volume: 149
Issue: 21
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Publication
24391519 | J:226670
First Author: Moayedi Y
Year: 2014
Journal: PLoS Genet
Title: The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs.
Volume: 10
Issue: 1
Pages: e1004055
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Publication
25936505 | J:221657
First Author: Kong JH
Year: 2015
Journal: Dev Cell
Title: Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling.
Volume: 33
Issue: 4
Pages: 373-87
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Publication
22802532 | J:185949
First Author: Licatalosi DD
Year: 2012
Journal: Genes Dev
Title: Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.
Volume: 26
Issue: 14
Pages: 1626-42
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Publication
26371508 | J:226997
   
First Author: Bebee TW
Year: 2015
Journal: Elife
Title: The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development.
Volume: 4
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Publication
27510977 | J:236406
First Author: Takada Y
Year: 2016
Journal: Development
Title: Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.
Volume: 143
Issue: 19
Pages: 3532-3539
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Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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