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Search results 201 to 274 out of 274 for Oat

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Hits by Pathway

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Hits by Strain

Type Details Score
Allele
Agfg1<tm1Jvd> | MGI:2182772
Name: ArfGAP with FG repeats 1; targeted mutation 1, Jan M A van Deursen
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Mlx<tm1.2Rne> | MGI:5907738
Name: MAX-like protein X; targeted mutation 1.2, Robert N Eisenman
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Spata20<Tn(pb-Act-RFP)1.1Zhu> | MGI:6163619
Name: spermatogenesis associated 20; transposon insertion 1.1, Yuan Zhuang
Allele Type: Transposon induced
Attribute String: Null/knockout
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Allele
Cfap58<em1Fzh> | MGI:6477396
Name: cilia and flagella associated protein 58; endonuclease-mediated mutation 1, Feng Zhang
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Ppp4c<em1Qys> | MGI:7280773
Name: protein phosphatase 4, catalytic subunit; endonuclease-mediated mutation 1, Qing-Yuan Sun
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready
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Allele
Cfap61<em1Yqt> | MGI:7448443
Name: cilia and flagella associated protein 61; endonuclease-mediated mutation 1, Yue-Qiu Tan
Allele Type: Chemically induced (ENU)
Attribute String: Null/knockout
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Allele
Poc1b<em1Xjzha> | MGI:7528727
Name: POC1 centriolar protein B; endonuclease-mediated mutation 1, XiaoJun Zha
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
Cfap70<em1Chnsr> | MGI:7587719
Name: cilia and flagella associated protein 70; endonuclease-mediated mutation 1, Su-Ren Chen
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Cfap70<em2Chnsr> | MGI:7587720
 
Name: cilia and flagella associated protein 70; endonuclease-mediated mutation 2, Su-Ren Chen
Allele Type: Endonuclease-mediated
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Allele
Ccdc157<em1Ymxi> | MGI:7616768
Name: coiled-coil domain containing 157; endonuclease-mediated mutation 1, Yongmei Xi
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Oat<em1(cre/ERT2)Hzhu> | MGI:6704918
Name: ornithine aminotransferase; endonuclease-mediated mutation 1, Hao Zhu
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Protein Coding Gene
MGI:1333754 | Agfg1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918511 | Poc1b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3041210 | Ccdc157
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2183449 | Spata20
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108398 | Mlx
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923920 | Cfap70
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2685815 | Cfap58
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1926024 | Cfap61
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891763 | Ppp4c
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Agfg1/Agfg1
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spata20/Spata20
Background: FVB/NJ-Spata20
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cfap58/Cfap58
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ppp4c/Ppp4c Tg(Stra8-icre)1Reb/?
Background: involves: 129S/SvEv * C57BL/6 * FVB/NJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ccdc157/Ccdc157
Background: C57BL/6-Ccdc157
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mlx/Mlx
Background: involves: 129S4/SvJaeSor
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cfap61/Cfap61
Background: C57BL/6-Cfap61
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cfap70/Cfap70
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cfap70/Cfap70
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Poc1b/Poc1b
Background: C57BL/6J-Poc1b
Zygosity: hm
Has Mutant Allele: true
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GO Term
GO:0004587 | ornithine aminotransferase activity
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Protein Domain
IPR006044 | 11S_seedstore_pln
Type: Family
Description: Plant seed storage proteins, whose principal function appears to be the majornitrogen source for the developing plant, can be classified, on the basis oftheir structure, into different families. 11S-type globulins are non-glycosylated proteins which form hexameric structures [, ]. Each of the subunits in the hexamer is itself composed of an acidic and a basic chain derived from a single precursor and linked by a disulphide bond. This structure is shown in the followingrepresentation.+-------------------------+| |xxxxxxxxxxxCxxxxxxxxxxxxxxxxxxxxxxNGxCxxxxxxxxxxxxxxxxxxxxxxx|------Acidic-subunit-------------||-----Basic-subunit------||-----------------About-480-to-500-residues-----------------|'C': conserved cysteine involved in a disulphide bond.Members of the 11-S family include pea and broad bean legumins, oil seed rapecruciferin, rice glutelins, cotton beta-globulins, soybean glycinins, pumpkin11-S globulin, oat globulin, sunflower helianthinin G3, etc.This family represents the precursor protein which is cleaved into the two chains. These proteins contain two β-barrel domains.This family is a member of the 'cupin' superfamily on thebasis of their conserved barrel domain ('cupa' is the Latin termfor a small barrel).
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Publication
2450746 | -
First Author: Hayashi M
Year: 1988
Journal: Eur J Biochem
Title: Nucleotide sequence of cloned cDNA coding for pumpkin 11-S globulin beta subunit.
Volume: 172
Issue: 3
Pages: 627-32
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Publication
10785665 | -
First Author: Eulgem T
Year: 2000
Journal: Trends Plant Sci
Title: The WRKY superfamily of plant transcription factors.
Volume: 5
Issue: 5
Pages: 199-206
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Publication
15705956 | -
First Author: Yamasaki K
Year: 2005
Journal: Plant Cell
Title: Solution structure of an Arabidopsis WRKY DNA binding domain.
Volume: 17
Issue: 3
Pages: 944-56
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Publication
25781171 | J:222840
First Author: Liu Y
Year: 2015
Journal: PLoS Genet
Title: LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility.
Volume: 11
Issue: 3
Pages: e1005090
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Publication
11457711 | J:70874
First Author: Sweet DH
Year: 2001
Journal: Am J Physiol Renal Physiol
Title: The organic anion transporter family: from physiology to ontogeny and the clinic.
Volume: 281
Issue: 2
Pages: F197-205
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Publication
8314581 | J:43905
First Author: Geraghty MT
Year: 1993
Journal: Genomics
Title: The isolation of cDNAs from OATL1 at Xp 11.2 using a 480-kb YAC.
Volume: 16
Issue: 2
Pages: 440-6
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Publication
16403838 | J:104676
First Author: Sekine T
Year: 2006
Journal: Am J Physiol Renal Physiol
Title: Molecular physiology of renal organic anion transporters.
Volume: 290
Issue: 2
Pages: F251-61
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Publication
39747485 | J:361399
First Author: Liu M
Year: 2025
Journal: Sci Rep
Title: Cep78 knockout causes sterility and oligoasthenoteratozoospermia in male mice.
Volume: 15
Issue: 1
Pages: 63
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Publication
8022938 | -
First Author: Rastogi R
Year: 1993
Journal: Plant Physiol
Title: Cloning of tomato (Lycopersicon esculentum Mill.) arginine decarboxylase gene and its expression during fruit ripening.
Volume: 103
Issue: 3
Pages: 829-34
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Protein Domain
IPR002985 | Arg_decrbxlase
Type: Family
Description: Pyridoxal-dependent decarboxylases that act on ornithine-, lysine-, arginine- and related substrates can be classified into different familieson the basis of sequence similarity [, ]. One of these families includeseukaryotic ornithine decarboxylase (ODC), which catalyses the transformation of ornithine into putrescine; prokaryotic diaminopimelic acid decarboxylase(DAPDC), which catalyses the conversion of diaminopimelic acid into lysine,the final step of lysine biosynthesis; Pseudomonas syringae pv. tabaciprotein, tabA, which is probably involved in tabtoxin biosynthesis andis similar to DAPDC; and bacterial and plant biosynthetic argininedecarboxylase (ADC), which catalyses the transformation of arginine into agmatine, the first step in putrescine synthesis from arginine.Although these proteins, which are known collectively as group IVdecarboxylases [], probably share a common evolutionary origin, theirlevels of sequence similarity are low, being confined to a few shortconserved regions.The tomato ADC gene contains an open reading frame encoding a polypeptideof 502 amino acids and a predicted molecular mass of ~55kDa []. The predicted amino acid sequence shares 47 and 38% identify with oat and Escherichia coli ADCs, respectively. Gel blot hybridisation experiments show that,in tomato, ADC is encoded by a single gene and is expressed as a transcriptof ~2.2 kb in the fruit pericarp and leaf tissues [].
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Protein Domain
IPR036576 | WRKY_dom_sf
Type: Homologous_superfamily
Description: This entry represents the WRKY domain superfamily.The WRKY domain is a 60 amino acid region that is defined by the conserved amino acid sequence WRKYGQK at its N-terminal end, together with a novel zinc-finger-like motif. The WRKY domain is found in one or two copies in a superfamily of plant transcription factors involved in the regulation of various physiological programs that are unique to plants, including pathogen defence, senescence, trichome development and the biosynthesis of secondary metabolites. The WRKY domain binds specifically to the DNA sequence motif (T)(T)TGAC(C/T), which is known as the W box. The invariant TGAC core of the W box is essential for function and WRKY binding []. Some proteins known to contain a WRKY domain include Arabidopsis thaliana ZAP1 (Zinc-dependent Activator Protein-1) and AtWRKY44/TTG2, a protein involved in trichome development and anthocyanin pigmentation; and wild oat ABF1-2, two proteins involved in the gibberelic acid-induced expression of the alpha-Amy2 gene.Structural studies indicate that this domain is a four-stranded β-sheet with a zinc binding pocket, forming a novel zinc and DNA binding structure []. The WRKYGQK residues correspond to the most N-terminal β-strand, which enables extensive hydrophobic interactions, contributing to the structural stability of the β-sheet.
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Protein Domain
IPR022379 | 11S_seedstore_CS
Type: Conserved_site
Description: Plant seed storage proteins, whose principal function appears to be the majornitrogen source for the developing plant, can be classified, on the basis oftheir structure, into different families. 11-S are non-glycosylated proteinswhich form hexameric structures [, ]. Each of the subunits in the hexamer isitself composed of an acidic and a basic chain derived from a single precursorand linked by a disulphide bond. This structure is shown in the followingrepresentation.+-------------------------+| |xxxxxxxxxxxCxxxxxxxxxxxxxxxxxxxxxxNGxCxxxxxxxxxxxxxxxxxxxxxxx|------Acidic-subunit-------------||-----Basic-subunit------||-----------------About-480-to-500-residues-----------------|'C': conserved cysteine involved in a disulphide bond.Members of the 11-S family include pea and broad bean legumins, oil seed rapecruciferin, rice glutelins, cotton beta-globulins, soybean glycinins, pumpkin11-S globulin, oat globulin, sunflower helianthinin G3, etc.This family represents the precursor protein which is cleaved into the two chains. These proteins contain two β-barrel domains.This family is a member of the 'cupin' superfamily on thebasis of their conserved barrel domain ('cupa' is the Latin termfor a small barrel).The signature pattern for this family includes the conserved cleavage site between the acidic and basic subunits (Asn-Gly) and a proximal cysteine residue which is involved in the inter-chain disulphide bond.
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Protein Domain
IPR003657 | WRKY_dom
Type: Domain
Description: The WRKY domain is a 60 amino acid region that is defined by the conserved amino acid sequence WRKYGQK at its N-terminal end, together with a novel zinc-finger-like motif. The WRKY domain is found in one or two copies in a superfamily of plant transcription factors involved in the regulation of various physiological programs that are unique to plants, including pathogen defence, senescence, trichome development and the biosynthesis of secondary metabolites. The WRKY domain binds specifically to the DNA sequence motif (T)(T)TGAC(C/T), which is known as the W box. The invariant TGAC core of the W box is essential for function and WRKY binding []. Some proteins known to contain a WRKY domain include Arabidopsis thaliana ZAP1 (Zinc-dependent Activator Protein-1) and AtWRKY44/TTG2, a protein involved in trichome development and anthocyanin pigmentation; and wild oat ABF1-2, two proteins involved in the gibberelic acid-induced expression of the alpha-Amy2 gene.Structural studies indicate that this domain is a four-stranded β-sheet with a zinc binding pocket, forming a novel zinc and DNA binding structure []. The WRKYGQK residues correspond to the most N-terminal β-strand, which enables extensive hydrophobic interactions, contributing to the structural stability of the β-sheet.
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Publication
16256982 | J:336069
First Author: Kobayashi Y
Year: 2005
Journal: Eur J Pharmacol
Title: Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8]) mediates the renal transport of bumetanide.
Volume: 524
Issue: 1-3
Pages: 44-8
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Publication
16478971 | J:110651
First Author: Schnabolk GW
Year: 2006
Journal: Am J Physiol Renal Physiol
Title: Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20).
Volume: 291
Issue: 2
Pages: F314-21
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Publication
22361732 | J:187486
First Author: Singh K
Year: 2012
Journal: Am J Physiol Gastrointest Liver Physiol
Title: L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution.
Volume: 302
Issue: 9
Pages: G1061-73
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Publication
17686999 | J:128703
First Author: Deignan JL
Year: 2007
Journal: Am J Physiol Cell Physiol
Title: Polyamine homeostasis in arginase knockout mice.
Volume: 293
Issue: 4
Pages: C1296-301
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Publication
28765282 | J:245215
First Author: Bush KT
Year: 2017
Journal: J Biol Chem
Title: The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis.
Volume: 292
Issue: 38
Pages: 15789-15803
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Publication
21672546 | J:174961
First Author: Smetanina MA
Year: 2011
Journal: Toxicol Appl Pharmacol
Title: Ortho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes.
Volume: 255
Issue: 1
Pages: 76-85
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Publication
32272448 | J:302233
First Author: Kusari F
Year: 2020
Journal: Reproduction
Title: Meiotic epigenetic factor PRDM9 impacts sperm quality of hybrid mice.
Volume: 160
Issue: 1
Pages: 53-64
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Publication
33543287 | J:309155
 
First Author: Han F
Year: 2021
Journal: Mol Hum Reprod
Title: Oligoasthenoteratospermia and sperm tail bending in PPP4C-deficient mice.
Volume: 27
Issue: 1
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Publication
38509755 | J:346468
First Author: Zheng H
Year: 2024
Journal: J Cell Mol Med
Title: CCDC157 is essential for sperm differentiation and shows oligoasthenoteratozoospermia-related mutations in men.
Volume: 28
Issue: 7
Pages: e18215
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Publication
38139332 | J:343763
 
First Author: Key J
Year: 2023
Journal: Int J Mol Sci
Title: Translation Fidelity and Respiration Deficits in CLPP-Deficient Tissues: Mechanistic Insights from Mitochondrial Complexome Profiling.
Volume: 24
Issue: 24
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Publication
24245814 | J:215726
First Author: Udagawa O
Year: 2014
Journal: Genes Cells
Title: Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family.
Volume: 19
Issue: 1
Pages: 13-27
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Publication
34096614 | J:322392
First Author: Wei X
Year: 2021
Journal: Clin Genet
Title: Biallelic mutations in KATNAL2 cause male infertility due to oligo-astheno-teratozoospermia.
Volume: 100
Issue: 4
Pages: 376-385
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Publication
36398584 | J:333351
First Author: Zhu H
Year: 2022
Journal: FASEB J
Title: Hadh deficiency induced oligoasthenoteratozoospermia through the TNF-α/Bcl-2 pathway in male mice.
Volume: 36
Issue: 12
Pages: e22661
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Publication
35387802 | J:333342
First Author: Hu T
Year: 2023
Journal: J Med Genet
Title: Biallelic CFAP61 variants cause male infertility in humans and mice with severe oligoasthenoteratozoospermia.
Volume: 60
Issue: 2
Pages: 144-153
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Publication
37070736 | J:340269
First Author: Hua J
Year: 2023
Journal: Hum Mol Genet
Title: Homozygous frameshift variant in POC1B causes male infertility with oligoasthenoteratozoospermia in human and mice.
Volume: 32
Issue: 14
Pages: 2307-2317
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Publication
11398193 | J:69714
First Author: Kropachev KY
Year: 2001
Journal: Mol Carcinog
Title: Involvement of transcription factor HNF3gamma in the effect of o-aminoazotoluene on glucocorticoid induction of tyrosine aminotransferase in mice sensitive to its hepatocarcinogenic action.
Volume: 31
Issue: 1
Pages: 10-5
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Publication
1652630 | J:24273
First Author: Hundemer JK
Year: 1991
Journal: J Nutr
Title: Dietary fiber sources lower blood cholesterol in C57BL/6 mice.
Volume: 121
Issue: 9
Pages: 1360-5
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Publication
8754686 | J:342923
First Author: van der Hoeven PC
Year: 1996
Journal: Plant Physiol
Title: A calcium and free fatty acid-modulated protein kinase as putative effector of the fusicoccin 14-3-3 receptor.
Volume: 111
Issue: 3
Pages: 857-65
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Publication
18174163 | J:135175
First Author: Truong DM
Year: 2008
Journal: J Biol Chem
Title: Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination.
Volume: 283
Issue: 13
Pages: 8654-63
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Publication
14749323 | J:182497
First Author: Tanaka K
Year: 2004
Journal: J Biol Chem
Title: Role of glycosylation in the organic anion transporter OAT1.
Volume: 279
Issue: 15
Pages: 14961-6
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Publication
20448048 | J:165322
First Author: Shiraya K
Year: 2010
Journal: J Biol Chem
Title: A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules.
Volume: 285
Issue: 29
Pages: 22141-51
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Publication
23196129 | J:197670
 
First Author: Nagle MA
Year: 2013
Journal: Neurosci Lett
Title: Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue.
Volume: 534
Pages: 133-8
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Publication
23920220 | J:306734
First Author: Wu W
Year: 2013
Journal: Drug Metab Dispos
Title: Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways.
Volume: 41
Issue: 10
Pages: 1825-34
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Publication
37352829 | J:338031
 
First Author: Jin HJ
Year: 2023
Journal: EBioMedicine
Title: CFAP70 is a solid and valuable target for the genetic diagnosis of oligo-astheno-teratozoospermia in infertile men.
Volume: 93
Pages: 104675
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Publication
15944205 | J:105002
First Author: Bahn A
Year: 2005
Journal: Am J Physiol Cell Physiol
Title: Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites.
Volume: 289
Issue: 5
Pages: C1075-84
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Publication
19737926 | J:156338
First Author: Ahn SY
Year: 2009
Journal: J Biol Chem
Title: Interaction of organic cations with organic anion transporters.
Volume: 284
Issue: 45
Pages: 31422-30
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Publication
8099313 | J:12701
First Author: Hanigan MH
Year: 1993
Journal: Carcinogenesis
Title: Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice.
Volume: 14
Issue: 5
Pages: 1035-40
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Publication
3143046 | -
First Author: Martin C
Year: 1988
Journal: Mol Biol Evol
Title: Pseudomonas aeruginosa diaminopimelate decarboxylase: evolutionary relationship with other amino acid decarboxylases.
Volume: 5
Issue: 5
Pages: 549-59
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Publication
8181483 | -
First Author: Sandmeier E
Year: 1994
Journal: Eur J Biochem
Title: Multiple evolutionary origin of pyridoxal-5'-phosphate-dependent amino acid decarboxylases.
Volume: 221
Issue: 3
Pages: 997-1002
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