Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:5645495 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-07-29 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2772126 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5645513 |
Age: |
embryonic day 18.5 |
Image: |
3J |
|
Specimen Label: |
3J |
Detected: |
false |
Specimen Num: |
25 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5645495 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-07-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:2778226 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:5645513 |
Age: |
embryonic day 18.5 |
Image: |
3J |
|
Specimen Label: |
3J |
Detected: |
true |
Specimen Num: |
25 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5645495 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-07-29 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:2778228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5645513 |
Age: |
postnatal adult |
Image: |
3K |
|
Specimen Label: |
3K |
Detected: |
true |
Specimen Num: |
26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nilsson J |
Year: |
1998 |
Journal: |
GenBank Submission |
Title: |
Mus musculus ornithine decarboxylase antizyme mRNA, complete cds |
|
|
Pages: |
U52822 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ivanov IP |
Year: |
1998 |
Journal: |
Genomics |
Title: |
A second mammalian antizyme: conservation of programmed ribosomal frameshifting. |
Volume: |
52 |
Issue: |
2 |
Pages: |
119-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nilsson J |
Year: |
1997 |
Journal: |
Eur J Biochem |
Title: |
Polyamines regulate both transcription and translation of the gene encoding ornithine decarboxylase antizyme in mouse. |
Volume: |
250 |
Issue: |
2 |
Pages: |
223-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nilsson J |
Year: |
2000 |
Journal: |
Biochem J |
Title: |
Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases ornithine decarboxylase from antizyme suppression. |
Volume: |
346 Pt 3 |
|
Pages: |
699-704 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feith DJ |
Year: |
2001 |
Journal: |
Cancer Res |
Title: |
Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis. |
Volume: |
61 |
Issue: |
16 |
Pages: |
6073-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ivanov IP |
Year: |
2000 |
Journal: |
Nucleic Acids Res |
Title: |
Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit. |
Volume: |
28 |
Issue: |
17 |
Pages: |
3185-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feith DJ |
Year: |
2013 |
Journal: |
Carcinogenesis |
Title: |
Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice. |
Volume: |
34 |
Issue: |
3 |
Pages: |
570-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gritli-Linde A |
Year: |
2001 |
Journal: |
Dev Dyn |
Title: |
Nuclear translocation of antizyme and expression of ornithine decarboxylase and antizyme are developmentally regulated. |
Volume: |
220 |
Issue: |
3 |
Pages: |
259-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
López-Contreras AJ |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Antizyme inhibitor 2 (AZIN2/ODCp) stimulates polyamine uptake in mammalian cells. |
Volume: |
283 |
Issue: |
30 |
Pages: |
20761-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ramos-Molina B |
Year: |
2014 |
Journal: |
FEBS Open Bio |
Title: |
Structural and degradative aspects of ornithine decarboxylase antizyme inhibitor 2. |
Volume: |
4 |
|
Pages: |
510-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
López-Contreras AJ |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity. |
Volume: |
281 |
Issue: |
41 |
Pages: |
30896-906 |
|
•
•
•
•
•
|
Publication |
First Author: |
López-Contreras AJ |
Year: |
2009 |
Journal: |
J Cell Biochem |
Title: |
Subcellular localization of antizyme inhibitor 2 in mammalian cells: Influence of intrinsic sequences and interaction with antizymes. |
Volume: |
107 |
Issue: |
4 |
Pages: |
732-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Franzoni E |
Year: |
2015 |
Journal: |
Elife |
Title: |
miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6. |
Volume: |
4 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng LE |
Year: |
2007 |
Journal: |
Dev Biol |
Title: |
The transcription factor Zfp423/OAZ is required for cerebellar development and CNS midline patterning. |
Volume: |
307 |
Issue: |
1 |
Pages: |
43-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lopez-Garcia C |
Year: |
2009 |
Journal: |
Placenta |
Title: |
Transcriptomic analysis of polyamine-related genes and polyamine levels in placenta, yolk sac and fetus during the second half of mouse pregnancy. |
Volume: |
30 |
Issue: |
3 |
Pages: |
241-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stevens J |
Year: |
2010 |
Journal: |
BMC Dev Biol |
Title: |
Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow. |
Volume: |
10 |
|
Pages: |
54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Puttagunta R |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. |
Volume: |
10 |
Issue: |
9 |
Pages: |
1369-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
López-García C |
Year: |
2008 |
Journal: |
Endocrinology |
Title: |
Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice. |
Volume: |
149 |
Issue: |
10 |
Pages: |
5012-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brown AC |
Year: |
2005 |
Journal: |
BMC Genet |
Title: |
Searching QTL by gene expression: analysis of diabesity. |
Volume: |
6 |
|
Pages: |
12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Freeman TC |
Year: |
1998 |
Journal: |
MGI Direct Data Submission |
Title: |
Expression Mapping of Mouse Genes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kahana C |
Year: |
2007 |
Journal: |
Amino Acids |
Title: |
Ubiquitin dependent and independent protein degradation in the regulation of cellular polyamines. |
Volume: |
33 |
Issue: |
2 |
Pages: |
225-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murakami Y |
Year: |
1992 |
Journal: |
Nature |
Title: |
Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination. |
Volume: |
360 |
Issue: |
6404 |
Pages: |
597-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fong LY |
Year: |
2003 |
Journal: |
Cancer Res |
Title: |
Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis. |
Volume: |
63 |
Issue: |
14 |
Pages: |
3945-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki T |
Year: |
1994 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Antizyme protects against abnormal accumulation and toxicity of polyamines in ornithine decarboxylase-overproducing cells. |
Volume: |
91 |
Issue: |
19 |
Pages: |
8930-4 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Ornithine decarboxylase (ODC) is the first and rate-limiting enzyme of polyamine biosynthesis. Polyamines (putrescine, spermidine, etc) are essential for cell growth. ODC has a very short half-life due to a strong interaction with ODC antizyme 1 (OAZ1) that prevents its homodimerisation and promotes destruction of the monomer units by the 26S proteasome [, ]. In addition to its effects on ODC, OAZ1 also negatively regulates polyamine transport into cells [, ]. By regulating ODC activity, OAZ1 is considered a tumour suppressor gene []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Tokuhiro K |
Year: |
2009 |
Journal: |
PLoS Genet |
Title: |
OAZ-t/OAZ3 is essential for rigid connection of sperm tails to heads in mouse. |
Volume: |
5 |
Issue: |
11 |
Pages: |
e1000712 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mitchell JL |
Year: |
1994 |
Journal: |
Biochem J |
Title: |
Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells. |
Volume: |
299 ( Pt 1) |
|
Pages: |
19-22 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
227
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
49
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
226
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
210
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
177
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
166
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|