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Search results 201 to 300 out of 420 for Ofd1

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Type Details Score
DO Term
DOID:0110412 | retinitis pigmentosa 23
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DO Term
DOID:0110981 | Joubert syndrome 10
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Publication
26643951 | -
First Author: Chevrier V
Year: 2016
Journal: Hum Mol Genet
Title: OFIP/KIAA0753 forms a complex with OFD1 and FOR20 at pericentriolar satellites and centrosomes and is mutated in one individual with oral-facial-digital syndrome.
Volume: 25
Issue: 3
Pages: 497-513
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Allele
Ofd1<tm2.1Bfra> | MGI:4882077
Name: OFD1, centriole and centriolar satellite protein; targeted mutation 2.1, Brunella Franco
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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DO Term
DOID:0080342 | Simpson-Golabi-Behmel syndrome type 2
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Genotype
Genotype
Symbol: Ofd1/? Tg(CAG-cre)1Nagy/?
Background: involves: 129S2/SvPas
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ofd1/Ofd1<+> Tg(CAG-cre)1Nagy/?
Background: involves: 129S2/SvPas
Zygosity: cn
Has Mutant Allele: true
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DO Term
DOID:0060316 | orofaciodigital syndrome I
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Publication
20835237 | J:175330
First Author: Otto EA
Year: 2010
Journal: Nat Genet
Title: Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy.
Volume: 42
Issue: 10
Pages: 840-50
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Publication
24550447 | J:207410
First Author: Singleton RS
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation.
Volume: 111
Issue: 11
Pages: 4031-6
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Publication
20040577 | -
First Author: Kim HS
Year: 2010
Journal: Nucleic Acids Res
Title: Crystal structure of Tpa1 from Saccharomyces cerevisiae, a component of the messenger ribonucleoprotein complex.
Volume: 38
Issue: 6
Pages: 2099-110
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Protein Domain
IPR039558 | TPA1/OFD1_N
Type: Domain
Description: This entry represents the N-terminal domain of prolyl 3,4-dihydroxylase Ofd1 from Schizosaccharomyces pombe and homologues in S. cerevisiae (TPA1) and mammals (OGFOD1) [].Ofd1 is a prolyl 4-hydroxylase-like 2-oxoglutarate-Fe(II) dioxygenase that accelerates the degradation of Sre1N (the N-terminal transcription factor domain of Sre1) in the presence of oxygen []. Yeast Sre1 is the orthologue of mammalian sterol regulatory element binding protein (SREBP), and it responds to changes in oxygen-dependent sterol synthesis as an indirect measure of oxygen availability. However, unlike the prolyl 4-hydroxylases that regulate mammalian hypoxia-inducible factor, Ofd1 uses multiple domains to regulate Sre1N degradation by oxygen; the Ofd1 N-terminal dioxygenase domain is required for oxygen sensing and this Ofd1 C-terminal domain accelerates Sre1N degradation in yeasts [, ].
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Protein Domain
IPR043044 | TPA1/Ofd1_C
Type: Homologous_superfamily
Description: This superfamily entry represents the C-terminal domain of Ofd1 (oxoglutarate and iron-dependent oxygenase, from Schizosaccharomyces pombe), a prolyl 4-hydroxylase-like 2-oxoglutarate-Fe(II) dioxygenase that accelerates the degradation of Sre1N (the N-terminal transcription factor domain of Sre1) in the presence of oxygen []. The domain is conserved from yeasts to humans and was also characterised in S. cerevisiae Tpa1 [, ]. Yeast Sre1 is the orthologue of mammalian sterol regulatory element binding protein (SREBP), and it responds to changes in oxygen-dependent sterol synthesis as an indirect measure of oxygen availability. However, unlike the prolyl 4-hydroxylases that regulate mammalian hypoxia-inducible factor, Ofd1 uses multiple domains to regulate Sre1N degradation by oxygen; the Ofd1 N-terminal dioxygenase domain is required for oxygen sensing and this Ofd1 C-terminal domain accelerates Sre1N degradation in yeasts [].
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Publication
18418381 | -
First Author: Hughes BT
Year: 2008
Journal: EMBO J
Title: Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member.
Volume: 27
Issue: 10
Pages: 1491-501
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Publication
25728928 | -
First Author: Horita S
Year: 2015
Journal: Structure
Title: Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases.
Volume: 23
Issue: 4
Pages: 639-52
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Publication
21610214 | -
First Author: Rispal D
Year: 2011
Journal: RNA
Title: Structural and functional analysis of Nro1/Ett1: a protein involved in translation termination in S. cerevisiae and in O2-mediated gene control in S. pombe.
Volume: 17
Issue: 7
Pages: 1213-24
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Publication
14671320 | -
First Author: Kushner DB
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus.
Volume: 100
Issue: 26
Pages: 15764-9
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Publication
20630870 | -
First Author: Henri J
Year: 2010
Journal: J Biol Chem
Title: Structural and functional insights into Saccharomyces cerevisiae Tpa1, a putative prolylhydroxylase influencing translation termination and transcription.
Volume: 285
Issue: 40
Pages: 30767-78
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Protein Domain
IPR024318 | Nro1/ETT1
Type: Family
Description: In fission yeast, Nro1 is a positive regulator of the stability of Sre1N, the sterol regulatory element-binding protein, which is an ER membrane-bound transcription factor that controls adaptation to low oxygen-growth []. In addition, the fission yeast Nro1 is a direct inhibitor of a protein that inhibits SreN1 degradation, Ofd1 (an oxoglutamate deoxygenase). The outcome of this reactivity is that Ofd1 acts as an oxygen sensor that regulates the binding of Nro1 to Ofd1 to control the stability of Sre1N [].This entry also represents ETT1, an Nro1 ortholog []. ETT1 is required for correct translation termination and probably involved in regulation of hypoxic gene expression in association TPA1 []. It inhibits replication of Brome mosaic virus [].
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Protein Domain
IPR019601 | Oxoglutarate/Fe-dep_Oase_C
Type: Domain
Description: This entry represents the C-terminal degradation domain of oxoglutarate and iron-dependent oxygenase (Ofd1), the domain being conserved from yeasts to humans.Ofd1 is a prolyl 4-hydroxylase-like 2-oxoglutarate-Fe(II) dioxygenase that accelerates the degradation of Sre1N (the N-terminal transcription factor domain of Sre1) in the presence of oxygen []. Yeast Sre1 is the orthologue of mammalian sterol regulatory element binding protein (SREBP), and it responds to changes in oxygen-dependent sterol synthesis as an indirect measure of oxygen availability. However, unlike the prolyl 4-hydroxylases that regulate mammalian hypoxia-inducible factor, Ofd1 uses multiple domains to regulate Sre1N degradation by oxygen; the Ofd1 N-terminal dioxygenase domain is required for oxygen sensing and this Ofd1 C-terminal domain accelerates Sre1N degradation in yeasts [, ].
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Allele
Yaa | MGI:1856277
 
Name: accelerated autoimmunity and lymphoproliferation transposition; accelerated autoimmunity and lymphoproliferation
Allele Type: Spontaneous
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Protein
Q3U0K8
Organism: Mus musculus/domesticus
Length: 545  
Fragment?: false
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Protein
D3YTU2
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Publication
10684247 | -
First Author: Rout MP
Year: 2000
Journal: J Cell Biol
Title: The yeast nuclear pore complex: composition, architecture, and transport mechanism.
Volume: 148
Issue: 4
Pages: 635-51
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Publication
34089617 | J:314650
First Author: Su MT
Year: 2021
Journal: Int Immunol
Title: Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice.
Volume: 33
Issue: 8
Pages: 447-458
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Strain
MGI:5656856 | (NZB x B6.SB/Le-Yaa)F1
Attribute String: F1 hybrid
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Strain
MGI:2173716 | B6.BXSB-Yaa/Dcr
Attribute String: congenic, mutant strain
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Strain
MGI:2159957 | BXSB/MpJ
Attribute String: recombinant inbred (RI)
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Strain
MGI:2163466 | B6.SB-Yaa/J
Attribute String: congenic, mutant strain
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Strain
MGI:2174316 | BXSB.B6-Il15<tm1Imx>/Dcr
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:2164514 | BXSB.129P2(B6)-B2m<tm1Unc>/Dcr
Attribute String: congenic, mutant strain, recombinant inbred (RI), targeted mutation
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Strain
MGI:5494443 | B10ScSn.BXSB-(D1Mit123-D1Mit1000) Chr Y<BXSB/MpJ>/BjmjrH
Attribute String: chromosome aberration, congenic, consomic, insertion, mutant strain, spontaneous mutation
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Strain
MGI:3836996 | B10.BXSB-(D13Mit3-D13Mit78) Yaa
Attribute String: congenic, spontaneous mutation, translocation
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Strain
MGI:5494438 | B10ScSn.BXSB-(D1Mit235-D1Mit1000) Chr Y<BXSB/MpJ>/BjmjrH
Attribute String: chromosome aberration, congenic, consomic, insertion, mutant strain, spontaneous mutation
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Strain
MGI:5494445 | B10ScSn.BXSB-(D1Mit3-D1Mit320) Chr Y<BXSB/MpJ>/BjmjrH
Attribute String: congenic, consomic, insertion, mutant strain, spontaneous mutation
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Strain
MGI:5494444 | B10ScSn.BXSB-(D1Mit3-D1Mit235) Chr Y<BXSB/MpJ>/BjmjrH
Attribute String: spontaneous mutation, mutant strain, insertion, consomic, congenic
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Strain
MGI:5494323 | B10ScSn.BXSB-(D1Mit33-D1Mit223) Chr Y<BXSB/MpJ>/BjmjrH
Attribute String: congenic, consomic, insertion, spontaneous mutation, chromosome aberration
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Strain
MGI:6093716 | BXSB.129P2(Cg)-Tcra<tm1Mjo>/TheoDcr
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:5494326 | B10ScSn.BXSB-(D1Mit303-D1Mit305) Chr Y<BXSB/MpJ>/BjmjrH
Attribute String: chromosome aberration, congenic, consomic, insertion, mutant strain, spontaneous mutation
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Strain
MGI:6107871 | B10.BXSB-(D1Mit303-D1Mit33) Yaa
Attribute String: spontaneous mutation, QTL, mutant strain, congenic
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Strain
MGI:6107875 | B10.BXSB-(D1Mit3-D1Mit1000) Yaa
Attribute String: congenic, mutant strain, QTL, spontaneous mutation
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Strain
MGI:6107865 | B10.BXSB-(D1Mit135-D1Mit223) Yaa
Attribute String: congenic, mutant strain, QTL, spontaneous mutation
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Strain
MGI:5504650 | B6.Cg-Sle1<NZM2410/Aeg> Yaa/DcrJ
Attribute String: congenic, mutant strain, QTL, spontaneous mutation
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Strain
MGI:6195182 | (NZW/LacJ x BXSB/MpJ)F1
Attribute String: F1 hybrid
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Strain
MGI:6107878 | B10.BXSB-(D1Mit235-D1Mit305) Yaa
Attribute String: spontaneous mutation, QTL, mutant strain, congenic
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Publication
315777 | J:6235
First Author: Murphy ED
Year: 1979
Journal: Arthritis Rheum
Title: A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation.
Volume: 22
Issue: 11
Pages: 1188-94
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Publication
29980767 | J:268475
First Author: Masum MA
Year: 2018
Journal: Sci Rep
Title: Modified scanning electron microscopy reveals pathological crosstalk between endothelial cells and podocytes in a murine model of membranoproliferative glomerulonephritis.
Volume: 8
Issue: 1
Pages: 10276
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Publication
11279592 | J:72331
First Author: Denenberg VH
Year: 2001
Journal: Dev Psychobiol
Title: Effects of the uterine environment and neocortical ectopias upon behavior of BXSB-Yaa+ mice.
Volume: 38
Issue: 3
Pages: 154-63
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Publication
16777955 | J:111064
First Author: Subramanian S
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: A Tlr7 translocation accelerates systemic autoimmunity in murine lupus.
Volume: 103
Issue: 26
Pages: 9970-5
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Publication
7930846 | J:21990
First Author: Izui S
Year: 1994
Journal: Int Rev Immunol
Title: The role of the Yaa gene in lupus syndrome.
Volume: 11
Issue: 3
Pages: 211-30
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Publication
6363600 | J:7308
First Author: Wofsy D
Year: 1984
Journal: J Exp Med
Title: Monocytosis in the BXSB model for systemic lupus erythematosus.
Volume: 159
Issue: 2
Pages: 629-34
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Publication
8566031 | J:31227
First Author: Fossati L
Year: 1995
Journal: Eur J Immunol
Title: The Yaa gene-mediated acceleration of murine lupus: Yaa- T cells from non-autoimmune mice collaborate with Yaa+ B cells to produce lupus autoantibodies in vivo.
Volume: 25
Issue: 12
Pages: 3412-7
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Publication
33110193 | J:298938
First Author: Santiago-Raber ML
Year: 2020
Journal: Sci Rep
Title: Atherosclerotic plaque vulnerability is increased in mouse model of lupus.
Volume: 10
Issue: 1
Pages: 18324
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Publication
12110458 | J:108472
First Author: Hyde LA
Year: 2002
Journal: Behav Brain Res
Title: Spatial and nonspatial Morris maze learning: impaired behavioral flexibility in mice with ectopias located in the prefrontal cortex.
Volume: 133
Issue: 2
Pages: 247-59
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Publication
8996242 | J:37574
First Author: Santiago ML
Year: 1997
Journal: J Exp Med
Title: Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome.
Volume: 185
Issue: 1
Pages: 65-70
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Publication
7252427 | J:38157
First Author: Hang LM
Year: 1981
Journal: J Exp Med
Title: (NZW x BXSB)F1 hybrid. A model of acute lupus and coronary vascular disease with myocardial infarction.
Volume: 154
Issue: 1
Pages: 216-21
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Publication
1991974 | J:10973
First Author: Kofler R
Year: 1991
Journal: J Immunol
Title: An autosomal recessive gene that delays expression of lupus in BXSB mice.
Volume: 146
Issue: 4
Pages: 1375-9
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Publication
15634889 | J:132847
First Author: Moll T
Year: 2005
Journal: J Immunol
Title: Differential activation of anti-erythrocyte and anti-DNA autoreactive B lymphocytes by the Yaa mutation.
Volume: 174
Issue: 2
Pages: 702-9
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Publication
26865621 | J:231621
First Author: Anderson LA
Year: 2016
Journal: J Neurosci
Title: Mind the Gap: Two Dissociable Mechanisms of Temporal Processing in the Auditory System.
Volume: 36
Issue: 6
Pages: 1977-95
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Publication
9661985 | J:49007
First Author: Boehm GW
Year: 1998
Journal: Physiol Behav
Title: Learning in year-old female autoimmune BXSB mice.
Volume: 64
Issue: 1
Pages: 75-82
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Publication
8804696 | J:33655
First Author: Denenberg VH
Year: 1996
Journal: Brain Res Dev Brain Res
Title: Effects of embryo transfer and cortical ectopias upon the behavior of BXSB-Yaa and BXSB-Yaa + mice.
Volume: 93
Issue: 1-2
Pages: 100-8
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Publication
16168499 | J:115747
First Author: Arabo A
Year: 2005
Journal: Behav Brain Res
Title: Spatial and motor abilities during the course of autoimmune disease in (NZW x BXSB)F1 lupus-prone mice.
Volume: 165
Issue: 1
Pages: 126-37
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Publication
8040305 | J:19547
First Author: Merino R
Year: 1994
Journal: J Clin Invest
Title: The Yaa gene abrogates the major histocompatibility complex association of murine lupus in (NZB x BXSB)F1 hybrid mice.
Volume: 94
Issue: 2
Pages: 521-5
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Publication
25468389 | J:269052
 
First Author: Kimura J
Year: 2014
Journal: Sci Rep
Title: Overexpression of Toll-like receptor 8 correlates with the progression of podocyte injury in murine autoimmune glomerulonephritis.
Volume: 4
Pages: 7290
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Publication
15860660 | J:117292
First Author: Kikuchi S
Year: 2005
Journal: Blood
Title: Identification of 2 major loci linked to autoimmune hemolytic anemia in NZB mice.
Volume: 106
Issue: 4
Pages: 1323-9
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Publication
1451334 | J:3381
First Author: Kawano H
Year: 1992
Journal: Clin Immunol Immunopathol
Title: Heterozygosity of the major histocompatibility complex controls the autoimmune disease in (NZW x BXSB) F1 mice.
Volume: 65
Issue: 3
Pages: 308-14
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Publication
7843228 | J:22499
First Author: Fossati L
Year: 1995
Journal: Eur J Immunol
Title: Selective enhancing effect of the Yaa gene on immune responses against self and foreign antigens.
Volume: 25
Issue: 1
Pages: 166-73
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Publication
8147964 | J:14455
First Author: Schrott LM
Year: 1993
Journal: Brain Behav Immun
Title: Behavior, cortical ectopias, and autoimmunity in BXSB-Yaa and BXSB-Yaa+ mice.
Volume: 7
Issue: 3
Pages: 205-23
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Publication
7410826 | J:6372
First Author: Eisenberg RA
Year: 1980
Journal: J Immunol
Title: Male determined accelerated autoimmune disease in BXSB mice: transfer by bone marrow and spleen cells.
Volume: 125
Issue: 3
Pages: 1032-6
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Publication
6690614 | J:7276
First Author: Izui S
Year: 1984
Journal: J Immunol
Title: Acute SLE in F1 hybrids between SB/Le and NZW mice; prominently enhanced formation of gp70 immune complexes by a Y chromosome-associated factor from SB/Le mice.
Volume: 132
Issue: 2
Pages: 701-4
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Publication
10753498 | J:114277
First Author: Hügin AW
Year: 2000
Journal: Cell Immunol
Title: The autoimmune accelerating yaa mutation does not accelerate murine AIDS.
Volume: 200
Issue: 2
Pages: 76-80
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Publication
11490025 | J:120153
First Author: Lawson BR
Year: 2001
Journal: J Immunol
Title: The role of alpha beta+ T cells and homeostatic T cell proliferation in Y-chromosome-associated murine lupus.
Volume: 167
Issue: 4
Pages: 2354-60
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Publication
3989299 | J:7823
First Author: Hudgins CC
Year: 1985
Journal: J Immunol
Title: Studies of consomic mice bearing the Y chromosome of the BXSB mouse.
Volume: 134
Issue: 6
Pages: 3849-54
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Publication
16702550 | J:110221
First Author: Teuscher C
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Evidence that the Y chromosome influences autoimmune disease in male and female mice.
Volume: 103
Issue: 21
Pages: 8024-9
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Publication
1537372 | J:2011
First Author: Merino R
Year: 1992
Journal: Eur J Immunol
Title: H-2-linked control of the Yaa gene-induced acceleration of lupus-like autoimmune disease in BXSB mice.
Volume: 22
Issue: 2
Pages: 295-9
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Publication
8181531 | J:18810
First Author: Jansson L
Year: 1994
Journal: Eur J Immunol
Title: The Y chromosome-linked "autoimmune accelerating" yaa gene suppresses collagen-induced arthritis.
Volume: 24
Issue: 5
Pages: 1213-7
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Genotype
Genotype
Symbol: Nba10/Nba10 Yaa/?
Background: C57BL/6-Nba2 Yaa
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Yaa/?
Background: (C57BL/6J x BXSB)F1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Yaa/?
Background: involves: BXSB * NZB
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Yaa/?
Background: BXSB/MpJ
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Yaa/?
Background: (NZW x SB)F1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Yaa/?
Background: (NZW x BXSB)F1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Yaa/?
Background: BXSB/MpJScr
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: ll/ll Yaa/?
Background: BXSB/MpJScr-ll
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Yaa/?
Background: (NZB x BXSB)F1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Yaa/?
Background: (SJL/J x BXSB)F1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Yaa/?
Background: (NZB x B6.SB/Le-Yaa)F1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Yaa/?
Background: B6.SB-Yaa/J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: B2m/B2m Yaa/?
Background: BXSB.129P2(B6)-B2m/Dcr
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il15/Il15 Yaa/?
Background: BXSB.B6-Il15/Dcr
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tcra/Tcra Yaa/?
Background: BXSB.129P2(Cg)-Tcra/Theo
Zygosity: cx
Has Mutant Allele: true
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Strain
MGI:5507705 | BXSB.129X1-Fcgrt<tm1Dcr>/J
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5564648 | B6.Cg-Btk<m1Anu> Yaa/AnuApb
Attribute String: chemically induced mutation, congenic, mutant strain
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Strain
MGI:6094245 | BXSB.129X1-Fcgrt<tm1Dcr>/Dcr
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5504649 | BXSB.129S2(B6)-Cd8a<tm1Mak>/4DcrJ
Attribute String: targeted mutation, mutant strain, congenic, spontaneous mutation
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Strain
MGI:2174224 | BXSB.129S2(B6)-Cd8a<tm1Mak>/4Dcr
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:2174222 | BXSB.129S2(B6)-Cd8a<tm1Mak>/1Dcr
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:2174225 | BXSB.129S2(B6)-Ighm<tm1Cgn>/Dcr
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:2174221 | BXSB.129S2(B6)-Tap1<tm1Arp>/Dcr
Attribute String: congenic, mutant strain, targeted mutation
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Publication
34039637 | J:312203
     
First Author: Schell SL
Year: 2021
Journal: J Immunol
Title: Context-Dependent miR-21 Regulation of TLR7-Mediated Autoimmune and Foreign Antigen-Driven Antibody-Forming Cell and Germinal Center Responses.
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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