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Search results 201 to 300 out of 309 for Orai1

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Type Details Score
Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
20887894 | J:167918
First Author: Feng M
Year: 2010
Journal: Cell
Title: Store-independent activation of Orai1 by SPCA2 in mammary tumors.
Volume: 143
Issue: 1
Pages: 84-98
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Publication
20037597 | J:245347
First Author: Zhou Y
Year: 2010
Journal: Nat Struct Mol Biol
Title: STIM1 gates the store-operated calcium channel ORAI1 in vitro.
Volume: 17
Issue: 1
Pages: 112-6
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Publication
29239723 | J:254964
   
First Author: Dong TX
Year: 2017
Journal: Elife
Title: Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility.
Volume: 6
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Publication
37533369 | J:342668
First Author: Sukkar B
Year: 2023
Journal: Glia
Title: Inhibition of altered Orai1 channels in Müller cells protects photoreceptors in retinal degeneration.
Volume: 71
Issue: 11
Pages: 2511-2526
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Interaction Experiment
Moon H (2020)
Description: Crbn modulates calcium influx by regulating Orai1 during efferocytosis.
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DO Term
DOID:0111976 | immunodeficiency 9
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Publication
28492364 | J:257150
   
First Author: Miao Y
Year: 2017
Journal: Elife
Title: Na+ influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation.
Volume: 6
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Publication
22031864 | J:181576
First Author: Borst O
Year: 2012
Journal: Blood
Title: The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes.
Volume: 119
Issue: 1
Pages: 251-61
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Publication
20534587 | -
First Author: Kawasaki T
Year: 2010
Journal: J Biol Chem
Title: Protein kinase C-induced phosphorylation of Orai1 regulates the intracellular Ca2+ level via the store-operated Ca2+ channel.
Volume: 285
Issue: 33
Pages: 25720-30
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Allele
Orai1<em1Smoc> | MGI:7291469
Name: ORAI calcium release-activated calcium modulator 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6355082 | C57BL/6JSmoc-Orai1<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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DO Term
DOID:0080686 | tubular aggregate myopathy 2
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Publication
17218360 | -
First Author: Lorin-Nebel C
Year: 2007
Journal: J Physiol
Title: CRAC channel activity in C. elegans is mediated by Orai1 and STIM1 homologues and is essential for ovulation and fertility.
Volume: 580
Issue: Pt 1
Pages: 67-85
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Protein Domain
IPR030032 | Orai-3
Type: Family
Description: Orai1 is a pore-forming calcium release-activated calcium (CRAC) channel subunit composed of four transmembrane domains []. Paralogues Orai2 and Orai3 have also been shown to be capable of forming CRAC channels and share Orai1 membrane topology. In these experiments, Orai-1, -2, and -3 channels were similarly inhibited by extracellular Ca2+. Orai3 channels seems to differ from Orai1 and -2 inbeing relatively resistant to the process of Ca2+ depotentiation []. However, the physiological roles of Orai2 and Orai3 in vivo are currently not well understood [].This entry represents Orai3.
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Protein Domain
IPR030034 | Orai-2
Type: Family
Description: Orai1 is a pore-forming calcium release-activated calcium (CRAC) channel subunit composed of four transmembrane domains []. Paralogues Orai2 and Orai3 have also been shown to be capable of forming CRAC channels and share Orai1 membrane topology. In these experiments, Orai-1, -2, and -3 channels were similarly inhibited by extracellular Ca2+. Orai3 channels seems to differ from Orai1 and -2 in being relatively resistant to the process of Ca2+ depotentiation []. However, the physiological roles of Orai2 and Orai3 in vivo are currently not well understood [].This entry represents Orai2.
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Publication
17452328 | -
First Author: DeHaven WI
Year: 2007
Journal: J Biol Chem
Title: Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels.
Volume: 282
Issue: 24
Pages: 17548-56
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Publication
23890118 | -
 
First Author: Hoth M
Year: 2013
Journal: Curr Top Membr
Title: The neglected CRAC proteins: Orai2, Orai3, and STIM2.
Volume: 71
Pages: 237-71
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Protein
Q8BH10
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: false
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Protein
Q6P8G8
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: false
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Protein
A3KCG3
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: false
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Protein
A3KCG2
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Protein
D3YX58
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: false
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Protein
A0A0G2JFL5
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
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Protein
D3Z6X8
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: false
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Protein
Q14BR6
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: false
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Protein
A5CVE1
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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Publication
35879451 | J:330601
First Author: Ito-Kureha T
Year: 2022
Journal: Nat Immunol
Title: The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells.
Volume: 23
Issue: 8
Pages: 1208-1221
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Publication
30208327 | J:270937
First Author: Saint Fleur-Lominy S
Year: 2018
Journal: Cell Rep
Title: STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia.
Volume: 24
Issue: 11
Pages: 3045-3060.e5
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Publication
32750041 | J:302510
First Author: Volz J
Year: 2020
Journal: J Clin Invest
Title: BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation.
Volume: 130
Issue: 11
Pages: 6064-6079
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Publication
23922331 | J:202696
First Author: Weidinger C
Year: 2013
Journal: EMBO Mol Med
Title: STIM1 and STIM2-mediated Ca(2+) influx regulates antitumour immunity by CD8(+) T cells.
Volume: 5
Issue: 9
Pages: 1311-21
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Publication
37171959 | J:337581
First Author: Lacombe J
Year: 2023
Journal: Cell Rep
Title: Vitamin K-dependent carboxylation regulates Ca(2+) flux and adaptation to metabolic stress in β cells.
Volume: 42
Issue: 5
Pages: 112500
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Publication
28165446 | J:243961
 
First Author: Wu T
Year: 2017
Journal: Nat Commun
Title: Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor.
Volume: 8
Pages: 14118
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Publication
31601621 | J:282225
First Author: Tiscione SA
Year: 2019
Journal: J Cell Biol
Title: Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity.
Volume: 218
Issue: 12
Pages: 4141-4156
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Publication
30390422 | J:293834
 
First Author: Gamage TH
Year: 2018
Journal: Cell Calcium
Title: STIM1 R304W causes muscle degeneration and impaired platelet activation in mice.
Volume: 76
Pages: 87-100
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Publication
24241282 | J:212576
 
First Author: Wei-Lapierre L
Year: 2013
Journal: Nat Commun
Title: Orai1-dependent calcium entry promotes skeletal muscle growth and limits fatigue.
Volume: 4
Pages: 2805
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Publication
26184105 | J:224453
 
First Author: Ma G
Year: 2015
Journal: Nat Commun
Title: Inside-out Ca(2+) signalling prompted by STIM1 conformational switch.
Volume: 6
Pages: 7826
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Publication
26033257 | J:227140
First Author: Rana A
Year: 2015
Journal: J Cell Biol
Title: Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels.
Volume: 209
Issue: 5
Pages: 653-69
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Publication
21385992 | J:172878
First Author: Eylenstein A
Year: 2011
Journal: FASEB J
Title: Stimulation of Ca2+-channel Orai1/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1).
Volume: 25
Issue: 6
Pages: 2012-21
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Publication
25384971 | J:221514
First Author: Makowski SL
Year: 2015
Journal: Mol Cell Biol
Title: A protease-independent function for SPPL3 in NFAT activation.
Volume: 35
Issue: 2
Pages: 451-67
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Publication
25938788 | J:222964
First Author: Desvignes L
Year: 2015
Journal: J Clin Invest
Title: STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection.
Volume: 125
Issue: 6
Pages: 2347-62
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Publication
24522202 | J:212042
First Author: Borst O
Year: 2014
Journal: FASEB J
Title: 1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice.
Volume: 28
Issue: 5
Pages: 2108-19
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Publication
21368296 | J:174250
First Author: Linde CI
Year: 2011
Journal: Am J Physiol Cell Physiol
Title: Dysregulation of Ca2+ signaling in astrocytes from mice lacking amyloid precursor protein.
Volume: 300
Issue: 6
Pages: C1502-12
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Publication
34547769 | J:323302
First Author: Abbonante V
Year: 2021
Journal: Blood Adv
Title: Ablation of collagen VI leads to the release of platelets with altered function.
Volume: 5
Issue: 23
Pages: 5150-5163
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Publication
27871077 | J:324436
First Author: Umbach AT
Year: 2016
Journal: Kidney Blood Press Res
Title: Impact of Annexin A 7 Deficiency on FGF23 Plasma Concentrations.
Volume: 41
Issue: 6
Pages: 828-836
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Publication
26424448 | J:225570
First Author: Zhang H
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.
Volume: 112
Issue: 41
Pages: E5618-27
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Publication
34359900 | J:327797
 
First Author: Silva-Rojas R
Year: 2021
Journal: Cells
Title: Pathophysiological Effects of Overactive STIM1 on Murine Muscle Function and Structure.
Volume: 10
Issue: 7
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Publication
30576443 | J:277842
First Author: Silva-Rojas R
Year: 2019
Journal: Hum Mol Genet
Title: STIM1 over-activation generates a multi-systemic phenotype affecting the skeletal muscle, spleen, eye, skin, bones and immune system in mice.
Volume: 28
Issue: 10
Pages: 1579-1593
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Publication
31666234 | J:285187
 
First Author: Cordero-Sanchez C
Year: 2019
Journal: Dis Model Mech
Title: A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy.
Volume: 13
Issue: 2
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Publication
23576580 | J:201204
First Author: Linde CI
Year: 2013
Journal: Am J Physiol Cell Physiol
Title: Histidine triad nucleotide-binding protein 1 (HINT1) regulates Ca(2+) signaling in mouse fibroblasts and neuronal cells via store-operated Ca(2+) entry pathway.
Volume: 304
Issue: 11
Pages: C1098-104
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Publication
31470105 | J:282633
 
First Author: Wei T
Year: 2019
Journal: Neurobiol Dis
Title: KCa3.1 deficiency attenuates neuroinflammation by regulating an astrocyte phenotype switch involving the PI3K/AKT/GSK3β pathway.
Volume: 132
Pages: 104588
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Publication
22176814 | J:330460
First Author: Ramanathan G
Year: 2012
Journal: J Thromb Haemost
Title: Defective diacylglycerol-induced Ca2+ entry but normal agonist-induced activation responses in TRPC6-deficient mouse platelets.
Volume: 10
Issue: 3
Pages: 419-29
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Publication
26929330 | J:230995
First Author: Woo JS
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells.
Volume: 113
Issue: 10
Pages: 2762-7
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Publication
33661765 | J:308949
 
First Author: Pham AK
Year: 2021
Journal: JCI Insight
Title: ORMDL3 expression in ASM regulates hypertrophy, hyperplasia via TPM1 and TPM4, and contractility.
Volume: 6
Issue: 7
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Publication
22005466 | J:178719
First Author: Schmidt EM
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Ion channels in the regulation of platelet migration.
Volume: 415
Issue: 1
Pages: 54-60
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Publication
29628897 | J:275884
 
First Author: López E
Year: 2018
Journal: Front Physiol
Title: Stanniocalcin 2 Regulates Non-capacitative Ca2+ Entry and Aggregation in Mouse Platelets.
Volume: 9
Pages: 266
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Publication
29895614 | J:284372
 
First Author: Zheng H
Year: 2018
Journal: Sci Signal
Title: SOCE mediated by STIM and Orai is essential for pacemaker activity in the interstitial cells of Cajal in the gastrointestinal tract.
Volume: 11
Issue: 534
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Publication
31166814 | J:294022
First Author: Yan J
Year: 2019
Journal: FASEB J
Title: Leucine-rich repeat kinase 2 regulates mouse dendritic cell migration by ORAI2.
Volume: 33
Issue: 9
Pages: 9775-9784
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Publication
37452066 | J:339219
First Author: Yang K
Year: 2023
Journal: Signal Transduct Target Ther
Title: SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells.
Volume: 8
Issue: 1
Pages: 276
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Publication
17360584 | J:248261
First Author: Liao Y
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Orai proteins interact with TRPC channels and confer responsiveness to store depletion.
Volume: 104
Issue: 11
Pages: 4682-7
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Publication
20571036 | J:165989
First Author: Suzuki R
Year: 2010
Journal: J Leukoc Biol
Title: Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells.
Volume: 88
Issue: 5
Pages: 863-75
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Publication
21148796 | J:168785
First Author: Newton RH
Year: 2011
Journal: J Immunol
Title: Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.
Volume: 186
Issue: 2
Pages: 940-50
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Publication
21663969 | J:177222
First Author: Yarkoni Y
Year: 2011
Journal: Mol Immunol
Title: Differential STIM1 expression in T and B cell subsets suggests a role in determining antigen receptor signal amplitude.
Volume: 48
Issue: 15-16
Pages: 1851-8
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Publication
28185894 | J:255369
First Author: Antigny F
Year: 2017
Journal: Biochim Biophys Acta
Title: TRPC1 and TRPC4 channels functionally interact with STIM1L to promote myogenesis and maintain fast repetitive Ca2+ release in human myotubes.
Volume: 1864
Issue: 5
Pages: 806-813
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Publication
35861698 | J:345029
 
First Author: Wang L
Year: 2022
Journal: J Gen Physiol
Title: ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages.
Volume: 154
Issue: 10
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