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Search results 201 to 223 out of 223 for Orai2

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Type Details Score
Allele
Orai2<em1Smoc> | MGI:7291470
Name: ORAI calcium release-activated calcium modulator 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6475941 | C57BL/6JSmoc-Orai2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Protein Domain
IPR030032 | Orai-3
Type: Family
Description: Orai1 is a pore-forming calcium release-activated calcium (CRAC) channel subunit composed of four transmembrane domains []. Paralogues Orai2 and Orai3 have also been shown to be capable of forming CRAC channels and share Orai1 membrane topology. In these experiments, Orai-1, -2, and -3 channels were similarly inhibited by extracellular Ca2+. Orai3 channels seems to differ from Orai1 and -2 inbeing relatively resistant to the process of Ca2+ depotentiation []. However, the physiological roles of Orai2 and Orai3 in vivo are currently not well understood [].This entry represents Orai3.
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Protein Domain
IPR030034 | Orai-2
Type: Family
Description: Orai1 is a pore-forming calcium release-activated calcium (CRAC) channel subunit composed of four transmembrane domains []. Paralogues Orai2 and Orai3 have also been shown to be capable of forming CRAC channels and share Orai1 membrane topology. In these experiments, Orai-1, -2, and -3 channels were similarly inhibited by extracellular Ca2+. Orai3 channels seems to differ from Orai1 and -2 in being relatively resistant to the process of Ca2+ depotentiation []. However, the physiological roles of Orai2 and Orai3 in vivo are currently not well understood [].This entry represents Orai2.
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Protein
Q8BH10
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: false
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Protein
Q6P8G8
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: false
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Protein
A3KCG3
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: false
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Protein
D3YX58
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: false
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Protein
A0A0G2JFL5
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
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Protein
D3Z6X8
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: false
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Protein
Q14BR6
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: false
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Protein
A5CVE1
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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Publication
17452328 | -
First Author: DeHaven WI
Year: 2007
Journal: J Biol Chem
Title: Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels.
Volume: 282
Issue: 24
Pages: 17548-56
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Publication
23890118 | -
 
First Author: Hoth M
Year: 2013
Journal: Curr Top Membr
Title: The neglected CRAC proteins: Orai2, Orai3, and STIM2.
Volume: 71
Pages: 237-71
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Publication
20534587 | -
First Author: Kawasaki T
Year: 2010
Journal: J Biol Chem
Title: Protein kinase C-induced phosphorylation of Orai1 regulates the intracellular Ca2+ level via the store-operated Ca2+ channel.
Volume: 285
Issue: 33
Pages: 25720-30
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Protein
Q8BWG9
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: false
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Protein
A3KCG1
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: false
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Publication
17218360 | -
First Author: Lorin-Nebel C
Year: 2007
Journal: J Physiol
Title: CRAC channel activity in C. elegans is mediated by Orai1 and STIM1 homologues and is essential for ovulation and fertility.
Volume: 580
Issue: Pt 1
Pages: 67-85
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Protein Domain
IPR038350 | Orai_sf
Type: Homologous_superfamily
Description: This entry includes Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 green fluorescent protein (GFP) reporters are co-expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1-related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins [].
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Protein Domain
IPR012446 | CRAC_channel
Type: Family
Description: This entry includes Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 green fluorescent protein (GFP) reporters are co-expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1-related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins [].
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Publication
31166814 | J:294022
First Author: Yan J
Year: 2019
Journal: FASEB J
Title: Leucine-rich repeat kinase 2 regulates mouse dendritic cell migration by ORAI2.
Volume: 33
Issue: 9
Pages: 9775-9784
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Publication
30659848 | J:274350
First Author: Maciąg F
Year: 2019
Journal: Biochim Biophys Acta Mol Cell Res
Title: Behavioral and electrophysiological changes in female mice overexpressing ORAI1 in neurons.
Volume: 1866
Issue: 7
Pages: 1137-1150
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Publication
28202489 | J:264589
First Author: Chen J
Year: 2017
Journal: Circulation
Title: Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension.
Volume: 135
Issue: 16
Pages: 1532-1546
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