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  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
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Search results 201 to 290 out of 290 for Orc1

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein Coding Gene
MGI:104772 | Cdk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891829 | Rbx1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108069 | Ccna2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108042 | Ccna1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P62878
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Protein
P51943
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
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Protein
Q61456
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
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Protein
P97377
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: false
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Publication
20130679 | -
First Author: Kawakami H
Year: 2010
Journal: Biochem Cell Biol
Title: DnaA, ORC, and Cdc6: similarity beyond the domains of life and diversity.
Volume: 88
Issue: 1
Pages: 49-62
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Publication
19344485 | -
First Author: Duncker BP
Year: 2009
Journal: Genome Biol
Title: The origin recognition complex protein family.
Volume: 10
Issue: 3
Pages: 214
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Publication
18048387 | -
First Author: Borlado LR
Year: 2008
Journal: Carcinogenesis
Title: CDC6: from DNA replication to cell cycle checkpoints and oncogenesis.
Volume: 29
Issue: 2
Pages: 237-43
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Publication
12628342 | -
First Author: Pelizon C
Year: 2003
Journal: Trends Cell Biol
Title: Down to the origin: Cdc6 protein and the competence to replicate.
Volume: 13
Issue: 3
Pages: 110-3
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Publication
15004237 | -
First Author: Ofir Y
Year: 2004
Journal: Mol Biol Cell
Title: The role and regulation of the preRC component Cdc6 in the initiation of premeiotic DNA replication.
Volume: 15
Issue: 5
Pages: 2230-42
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Protein Domain
IPR015163 | Cdc6_C
Type: Domain
Description: Cdc6 (also known as Cell division cycle 6 or Cdc18) functions as a regulator at the early stages of DNA replication, by helping to recruit and load the Minichromosome Maintenance Complex (MCM) onto DNA and may have additional roles in the control of mitotic entry. Precise duplication of chromosomal DNA is required for genomic stability during replication. Cdc6 has an essential role in DNA replication and irregular expression of Cdc6 may lead to genomic instability. Cdc6 over-expression is observed in many cancerous lesions. DNA replication begins when an origin recognition complex (ORC) binds to a replication origin site on the chromatin. Studies indicate that Cdc6 interacts with ORC through the Orc1 subunit, and that this association increases the specificity of the ORC-origins interaction. Further studies suggest that hydrolysis of Cdc6-bound ATP promotes the association of the replication licensing factor Cdt1 with origins through an interaction with Orc6 and this in turn promotes the loading of MCM2-7 helicase onto chromatin. The MCM2-7 complex promotes the unwinding of DNA origins, and the binding of additional factors to initiate the DNA replication. S-Cdk (S-phase cyclin and cyclin-dependent kinase complex) prevents rereplication by causing the Cdc6 protein to dissociate from ORC and prevents the Cdc6 and MCM proteins from reassembling at any origin. By phosphorylating Cdc6, S-Cdk also triggers Cdc6's ubiquitination. The Cdc6 protein is composed of three domains, an N-terminal AAA+ domain with Walker A and B, and Sensor-1 and -2 motifs. The central region contains a conserved nucleotide binding/ATPase domain and is a member of the ATPase superfamily. [, , , , ].The C-terminal domain of cell division control protein 6 (CDC6) assumes a winged helix fold, with a five α-helical bundle (α15-α19) structure, backed on one side by three beta strands (β6-β8). It has been shown that this domain acts as a DNA-localisation factor, however its exact function is, as yet, unknown. Putative functions include: (1) mediation of protein-protein interactions and (2) regulation of nucleotide binding and hydrolysis. Mutagenesis studies have shown that this domain is essential for appropriate CDC6 activity [].
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Protein Coding Gene
MGI:103575 | Skp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1349658 | Cul1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9WTX6
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: false
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Protein
Q9WTX5
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: false
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Publication
11030343 | -
First Author: Liu J
Year: 2000
Journal: Mol Cell
Title: Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control.
Volume: 6
Issue: 3
Pages: 637-48
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Protein Coding Gene
MGI:1917497 | Psmd1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104880 | Psmb6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916327 | Psmd11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347014 | Psmb3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98858 | Psmd3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:105047 | Psmc5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914247 | Psmd12
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347006 | Psma6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104883 | Psma3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:106054 | Psmc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104885 | Psma2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913663 | Psmd6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914339 | Psmc6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1194513 | Psmb5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1096584 | Psmd2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104884 | Psmb1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107637 | Psmb7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913284 | Psmd14
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1098754 | Psmc3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347070 | Psma7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1929289 | Adrm1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1098257 | Psmb4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347009 | Psma5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347045 | Psmb2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109555 | Psmc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1346093 | Psmc4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1888669 | Psmd8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347005 | Psma1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1345192 | Psmd13
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1351511 | Psmd7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347060 | Psma4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9JKV1
Organism: Mus musculus/domesticus
Length: 407  
Fragment?: false
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Protein
Q9R1P1
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
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Protein
P99026
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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Protein
Q60692
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: false
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Protein
P70195
Organism: Mus musculus/domesticus
Length: 277  
Fragment?: false
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Protein
P46471
Organism: Mus musculus/domesticus
Length: 433  
Fragment?: false
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Protein
Q9R1P0
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
Q9WVJ2
Organism: Mus musculus/domesticus
Length: 376  
Fragment?: false
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Protein
Q8BG32
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
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Protein
Q9Z2U0
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
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Protein
P54775
Organism: Mus musculus/domesticus
Length: 418  
Fragment?: false
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Protein
P14685
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Protein
Q9Z2U1
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
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Protein
Q9R1P3
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: false
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Protein
Q99JI4
Organism: Mus musculus/domesticus
Length: 389  
Fragment?: false
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Protein
O70435
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: false
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Protein
P62334
Organism: Mus musculus/domesticus
Length: 389  
Fragment?: false
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Protein
Q9D8W5
Organism: Mus musculus/domesticus
Length: 456  
Fragment?: false
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Protein
Q9QUM9
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: false
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Protein
O09061
Organism: Mus musculus/domesticus
Length: 240  
Fragment?: false
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Protein
O88685
Organism: Mus musculus/domesticus
Length: 442  
Fragment?: false
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Protein
Q9CX56
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
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Protein
O35593
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: false
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Protein
Q8VDM4
Organism: Mus musculus/domesticus
Length: 908  
Fragment?: false
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Protein
P26516
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: false
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Protein
O55234
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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Protein
P62196
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
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Protein
Q3TXS7
Organism: Mus musculus/domesticus
Length: 953  
Fragment?: false
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Protein
P62192
Organism: Mus musculus/domesticus
Length: 440  
Fragment?: false
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Protein
Q9R1P4
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: false
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Protein
P49722
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
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Protein
A0A0R4J145
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein Coding Gene
MGI:1925544 | Rps27a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98887 | Uba52
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98888 | Ubb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98889 | Ubc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P62984
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Protein
P0CG50
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
P62983
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
P0CG49
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom