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Search results 201 to 300 out of 3366 for Otx2

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Type Details Score
Publication
25910836 | J:222398
First Author: Hoshino H
Year: 2015
Journal: Dev Biol
Title: AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression.
Volume: 402
Issue: 2
Pages: 175-91
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Publication
33195252 | J:309045
 
First Author: García-Guillén IM
Year: 2020
Journal: Front Cell Dev Biol
Title: Netrin-1/DCC Signaling Differentially Regulates the Migration of Pax7, Nkx6.1, Irx2, Otp, and Otx2 Cell Populations in the Developing Interpeduncular Nucleus.
Volume: 8
Pages: 588851
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Publication
10375352 | J:55443
First Author: Klein WH
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Function and evolution of Otx proteins.
Volume: 258
Issue: 2
Pages: 229-33
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GXD Expression
GXD Expression
Probe: MGI:2149762
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2150160
Age: embryonic day 10.5
Image: 8K Otx2 l/l
Note: Expression in the mutant is present in a smaller domain than in wild type.
Specimen Label: 8K Otx2 l/l
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:1098117
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3285713
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:2150158
Age: embryonic day 8.5
Image: 7E Otx2 l/l
Specimen Label: 7E Otx2 l/l
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1098117
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3285717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2150158
Age: embryonic day 10.5
Image: 8E Otx2 l/l
Specimen Label: 8E Otx2 l/l
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:1321259
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3285713
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:2150155
Age: embryonic day 8.5
Image: 7H Otx2 l/l
Specimen Label: 7H Otx2 l/l
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:1321259
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3285717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2150155
Age: embryonic day 10.5
Image: 8H Otx2 l/l
Specimen Label: 8H Otx2 l/l
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
Probe: MGI:2150047
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607511
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:2150157
Age: embryonic day 7.5
Image: 6N Otx2 l/-
Note: Expression in the mutant is similar to that seen in wild type.
Specimen Label: 6N Otx2 l/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1321239
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607511
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:2150154
Age: embryonic day 7.5
Image: 6P Otx2 l/-
Note: Expression in the mutant is similar to that seen in wild type.
Specimen Label: 6P Otx2 l/-
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:1098113
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614013
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:2150159
Age: embryonic day 8.5
Image: 7K Otx2 l/l
Note: Expression in the mutant is similar to that seen in wild type.
Specimen Label: 7K Otx2 l/l
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1321252
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160589
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:2150153
Age: embryonic day 6.5
Image: 6D Otx2 l/-
Note: Expression in the mutant is similar to that seen in wild type.
Specimen Label: 6D Otx2 l/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1321239
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160589
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:2150154
Age: embryonic day 6.5
Image: 6F Otx2 l/-
Note: Expression in the mutant is similar to that seen in wild type.
Specimen Label: 6F Otx2 l/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1321259
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607311
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:2150155
Age: embryonic day 7.5
Image: 6J Otx2 l/-
Note: Expression in the mutant is similar to that seen in wild type.
Specimen Label: 6J Otx2 l/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:2149762
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614413
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:2150160
Age: embryonic day 8.5
Image: 7N Otx2 l/l
Note: Expression in mutants is very similar to that seen in wild type.
Specimen Label: 7N Otx2 l/l
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:2150047
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276211
Pattern: Regionally restricted
Stage: TS11
Assay Id: MGI:2150157
Age: embryonic day 7.5
Image: 6N Otx2 l/-
Note: Expression is axial. Expression in the mutant is similar to that seen in wild type.
Specimen Label: 6N Otx2 l/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1321239
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276211
Pattern: Regionally restricted
Stage: TS11
Assay Id: MGI:2150154
Age: embryonic day 7.5
Image: 6P Otx2 l/-
Note: Expression is axial. Expression in the mutant is similar to that seen in wild type.
Specimen Label: 6P Otx2 l/-
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:1098117
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608913
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:2150158
Age: embryonic day 8.5
Image: 7F Otx2 l/-
Note: The expression domain is expanded in mutants compared to wild type.
Specimen Label: 7F Otx2 l/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:2149762
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608913
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:2150160
Age: embryonic day 8.5
Image: 7O Otx2 l/-
Note: Expression is not seen in the anterior neuroectoderm.
Specimen Label: 7O Otx2 l/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:1321259
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608913
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:2150155
Age: embryonic day 8.5
Image: 7I Otx2 l/-
Note: The area of expression is expanded in the mutant compared to wild type.
Specimen Label: 7I Otx2 l/-
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:1321255
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608911
Pattern: Regionally restricted
Stage: TS11
Assay Id: MGI:2150156
Age: embryonic day 7.5
Image: 6L Otx2 l/-
Note: Expression is in the rostral-most area fated to become the telencephalon. Expression in the mutant is similar to that seen in wild type.
Specimen Label: 6L Otx2 l/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1098113
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608913
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:2150159
Age: embryonic day 8.5
Image: 7L Otx2 l/-
Note: Expression is present in the rostral-most neuroectoderm.
Specimen Label: 7L Otx2 l/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:1098117
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608913
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:2150158
Age: embryonic day 8.5
Image: 7E Otx2 l/l
Note: There is a modest expansion of the expression domain in the mutant compared to wild type.
Specimen Label: 7E Otx2 l/l
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1321259
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608913
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:2150155
Age: embryonic day 8.5
Image: 7H Otx2 l/l
Note: There is a modest expansion of the expression domain in the mutant compared to wild type.
Specimen Label: 7H Otx2 l/l
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:1098117
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2150158
Age: embryonic day 10.5
Image: 8F Otx2 l/-
Note: Expression is present in an expanded area in the mutant compared to wild type.
Specimen Label: 8F Otx2 l/-
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:2149762
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689417
Stage: TS17
Assay Id: MGI:2150160
Age: embryonic day 10.5
Image: 8L Otx2 l/-
Note: Lack of expression indicates the lack of forebrain.
Specimen Label: 8L Otx2 l/-
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:1321259
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:2150155
Age: embryonic day 10.5
Image: 8I Otx2 l/-
Note: Expression is present in an extended area compared to that seen in wild type.
Specimen Label: 8I Otx2 l/-
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
Probe: MGI:1098117
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2150158
Age: embryonic day 10.5
Image: 8E Otx2 l/l
Note: The expression domain is slightly expanded in the mutant compared to wild type.
Specimen Label: 8E Otx2 l/l
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:1321259
Assay Type: RNA in situ
Annotation Date: 2001-09-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:2150155
Age: embryonic day 10.5
Image: 8H Otx2 l/l
Note: The area of expression is slightly expanded in the mutant compared to wild type.
Specimen Label: 8H Otx2 l/l
Detected: true
Specimen Num: 8
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Publication
10440864 | J:56663
First Author: Hirth F
Year: 1999
Journal: Bioessays
Title: Conserved genetic programs in insect and mammalian brain development.
Volume: 21
Issue: 8
Pages: 677-84
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Publication
23154415 | J:191079
First Author: Acampora D
Year: 2013
Journal: Development
Title: Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition.
Volume: 140
Issue: 1
Pages: 43-55
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Publication
19615442 | J:153562
First Author: Acampora D
Year: 2009
Journal: Mech Dev
Title: Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm.
Volume: 126
Issue: 10
Pages: 882-97
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GXD Expression
GXD Expression
Probe: MGI:1309445
Assay Type: RNA in situ
Annotation Date: 1998-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607311
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:1309627
Age: embryonic day 7.75
Image: 3D
Note: Otx2 is present in the neuroectoderm and axial mesendoderm.
Specimen Label: 3D
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1309445
Assay Type: RNA in situ
Annotation Date: 1998-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276211
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:1309627
Age: embryonic day 7.75
Image: 3D
Note: Otx2 is present in the neuroectoderm and axial mesendoderm.
Specimen Label: 3D
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7434335
Assay Type: RNA in situ
Annotation Date: 2023-02-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:160508
Pattern: Regionally restricted
Stage: TS08
Assay Id: MGI:7434372
Age: embryonic day 6.5
Image: 5f
Note: Otx2 was significantly reduced in the distal epiblast.
Specimen Label: 5f
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6179932
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191006
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Otx2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6179932
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191006
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Otx2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6179932
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191006
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Otx2
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6179932
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191006
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Otx2
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6179932
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191006
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Otx2
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6179932
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191006
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Otx2
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6179932
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191006
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Otx2
Detected: true
Specimen Num: 7
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Publication
1353865 | J:2076
First Author: Simeone A
Year: 1992
Journal: Nature
Title: Nested expression domains of four homeobox genes in developing rostral brain.
Volume: 358
Issue: 6388
Pages: 687-90
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Publication
18728160 | -
First Author: Diaczok D
Year: 2008
Journal: J Clin Endocrinol Metab
Title: A novel dominant negative mutation of OTX2 associated with combined pituitary hormone deficiency.
Volume: 93
Issue: 11
Pages: 4351-9
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GXD Expression
GXD Expression
 
Probe: MGI:1331375
Assay Type: RNA in situ
Annotation Date: 2017-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697420
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5902921
Age: embryonic day 12.5
Note: Otx2 expression limit is coincident but not is overlapping with the Otp anterior limit.
Specimen Label: 11a
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:23226
Assay Type: RNA in situ
Annotation Date: 1998-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1606910
Pattern: Not Specified
Stage: TS10
Assay Id: MGI:1275040
Age: embryonic day 7.0-7.3
Note: Otx2 expression was present in all three germ layers at the anterior end of the embryo.
Specimen Label: not shown
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:23226
Assay Type: RNA in situ
Annotation Date: 1998-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607110
Pattern: Not Specified
Stage: TS10
Assay Id: MGI:1275040
Age: embryonic day 7.0-7.3
Note: Otx2 expression was present in all three germ layers at the anterior end of the embryo.
Specimen Label: not shown
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
Probe: MGI:1309322
Assay Type: Immunohistochemistry
Annotation Date: 1998-11-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607311
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:1309367
Age: embryonic day 7.75
Image: 3E/F
Note: Otx2 is present in the neuroectoderm and axial mesendoderm at 7.75 d.p.c.
Specimen Label: 3E/F
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:1309322
Assay Type: Immunohistochemistry
Annotation Date: 1998-11-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276211
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:1309367
Age: embryonic day 7.75
Image: 3E/F
Note: Otx2 is present in the neuroectoderm and axial mesendoderm at 7.75 d.p.c.
Specimen Label: 3E/F
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:7788141
Assay Type: RNA in situ
Annotation Date: 2024-12-17
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1666917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7788226
Age: embryonic day 10.5
Image: 4E Tbx2/3cDKO
Note: Otx2 expression was completely abolished from the ventro-lateral region in the Tbx2/3cDKO.
Specimen Label: 4E Tbx2/3cDKO
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:23226
Assay Type: RNA in situ
Annotation Date: 1998-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1606210
Pattern: Not Specified
Stage: TS10
Assay Id: MGI:1275040
Age: embryonic day 7.0-7.3
Note: Otx2 expression was present in all three germ layers at the anterior end of the embryo.
Specimen Label: not shown
Detected: true
Specimen Num: 9
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UniProt Feature
UniProt Feature
Begin: 1
Description: Homeobox protein OTX2
Type: chain
End: 289
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HT Experiment
E-GEOD-21900 | Expression profiling of the Otx2 CKO retina
Series Id: GSE21900
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Domain
IPR003022 | Otx2_TF
Type: Family
Description: Otx proteins constitute a class of vertebrate homeodomain-containingtranscription factors that have been shown to be essential for anteriorhead formation, including brain morphogenesis. They are orthologous to theproduct of the Drosophila head gap gene, orthodenticle (Otd), and appear toplay similar roles in both, since the developmental abnormalities caused bydisruption of these transcription factors in one, can be recovered bysubstitution of the factor(s) from the other. Such studies have providedstrong evidence that there exists a conserved genetic programme for insectand mammalian brain development, which presumably arose in a more primitivecommon ancestor [, ].Two vertebrate orthodenticle-related transcription factors have been indentified, Otx1 and Otx2, which have sizes of 355 and 289 residuesrespectively. They contain a bicoid-like homeodomain, which features aconserved lysine residue at position 9 of the DNA recognition helix, whichis thought to confer high-affinity binding to TAATCC/T elements on DNA [].Otd-like transcription factors have also been found in zebrafish and certain lamprey species. Mice completely lacking Otx2 (due to targeted gene disruption) die duringearly embryogenesis. Analysis reveals that they lack the neuroectodermthat is destined to become the forebrain, midbrain and rostral hindbrain.They also show major abnormalities in their body plan. Mice that haveartificially-reduced levels of Otx2 develop head abnormalities reminiscentof otocephaly [].
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GXD Expression
GXD Expression
Probe: MGI:23226
Assay Type: RNA in situ
Annotation Date: 1999-10-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611812
Pattern: Not Specified
Stage: TS12
Assay Id: MGI:1346315
Age: embryonic day 8.0
Image: Lim1-/- embryo
Note: Otx2 was expressed only in the first branchial arch, indicating that anterior neural tissue was not present.
Specimen Label: Lim1-/- embryo
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:23226
Assay Type: RNA in situ
Annotation Date: 1998-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Pattern: Regionally restricted
Stage: TS10
Assay Id: MGI:1275040
Age: embryonic day 7.0-7.3
Image: 2B
Note: Between the early- and late-streak stages, Otx2 expression became progressively restricted to the anterior half of the embryo.
Specimen Label: 2B
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:6430205
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3574228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6430451
Age: postnatal day 20
Image: 5D
Note: In the conditional mutant, the identity of ectopic cone photoreceptors was confirmed by co-localization of Otx2 and Arr3.
Specimen Label: 5D
Detected: true
Specimen Num: 12
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Publication
27292645 | J:238298
First Author: Acampora D
Year: 2016
Journal: Cell Rep
Title: Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.
Volume: 15
Issue: 12
Pages: 2651-64
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GXD Expression
GXD Expression
Probe: MGI:1289932
Assay Type: Immunohistochemistry
Annotation Date: 1998-10-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1697418
Pattern: Regionally restricted
Stage: TS18
Assay Id: MGI:1289943
Age: embryonic day 11.0
Image: 1. A
Note: Expression of Otx2 is elevated along several boundaries; the border between the dorsal and ventral thalamus, the ZLI, the alar/basal plate boundary and between the metencephalon and mesencephalon.
Specimen Label: 1. A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:1289932
Assay Type: Immunohistochemistry
Annotation Date: 1998-10-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1708418
Pattern: Regionally restricted
Stage: TS18
Assay Id: MGI:1289943
Age: embryonic day 11.0
Image: 1. A
Note: Expression of Otx2 is elevated along several boundaries; the border between the dorsal and ventral thalamus, the ZLI, the alar/basal plate boundary and between the metencephalon and mesencephalon.
Specimen Label: 1. A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:1289932
Assay Type: Immunohistochemistry
Annotation Date: 1998-10-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689618
Pattern: Regionally restricted
Stage: TS18
Assay Id: MGI:1289943
Age: embryonic day 11.0
Image: 1. A
Note: Expression of Otx2 is elevated along several boundaries; the border between the dorsal and ventral thalamus, the ZLI, the alar/basal plate boundary and between the metencephalon and mesencephalon.
Specimen Label: 1. A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:1289932
Assay Type: Immunohistochemistry
Annotation Date: 1998-10-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1707818
Pattern: Regionally restricted
Stage: TS18
Assay Id: MGI:1289943
Age: embryonic day 11.0
Image: 1. A
Note: Expression of Otx2 is elevated along several boundaries; the border between the dorsal and ventral thalamus, the ZLI, the alar/basal plate boundary and between the metencephalon and mesencephalon.
Specimen Label: 1. A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:1289932
Assay Type: Immunohistochemistry
Annotation Date: 1998-10-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1708818
Pattern: Regionally restricted
Stage: TS18
Assay Id: MGI:1289943
Age: embryonic day 11.0
Image: 1. A
Note: Expression of Otx2 is elevated along several boundaries; the border between the dorsal and ventral thalamus, the ZLI, the alar/basal plate boundary and between the metencephalon and mesencephalon.
Specimen Label: 1. A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:1289932
Assay Type: Immunohistochemistry
Annotation Date: 1998-10-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1707318
Pattern: Regionally restricted
Stage: TS18
Assay Id: MGI:1289943
Age: embryonic day 11.0
Image: 1. A
Note: Expression of Otx2 is elevated along several boundaries; the border between the dorsal and ventral thalamus, the ZLI, the alar/basal plate boundary and between the metencephalon and mesencephalon.
Specimen Label: 1. A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:1289932
Assay Type: Immunohistochemistry
Annotation Date: 1998-10-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1707118
Pattern: Regionally restricted
Stage: TS18
Assay Id: MGI:1289943
Age: embryonic day 11.0
Image: 1. A
Note: Expression of Otx2 is elevated along several boundaries; the border between the dorsal and ventral thalamus, the ZLI, the alar/basal plate boundary and between the metencephalon and mesencephalon.
Specimen Label: 1. A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6179932
Assay Type: RNA in situ
Annotation Date: 2024-07-12
Strength: Present
Sex: Male
Emaps: EMAPS:3828223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7664405
Age: embryonic day 15.5
Image: 7l
Note: A paramedian parasagittal section illustrated the Otx2 signal in the basal preisthmus, representing a quite narrow transverse and radial interstice placed in a retrorubral position.
Specimen Label: 7l
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
Probe: MGI:6179932
Assay Type: RNA in situ
Annotation Date: 2024-07-12
Strength: Present
Sex: Male
Emaps: EMAPS:3828226
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:7664405
Age: embryonic day 18.5
Image: 9b
Note: Expression was detected in the preisthmus. The dorsalmost Otx2 section illustrates dorsomedial continuity of the positive preisthmic mantle with symmetric bulges at the dorsocaudal midbrain midline.
Specimen Label: 9b
Detected: true
Specimen Num: 23
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GXD Expression
GXD Expression
Probe: MGI:6317004
Assay Type: Immunohistochemistry
Annotation Date: 2019-07-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3574225
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:6317221
Age: embryonic day 17.5
Image: 9B
Note: Strong expression was detected in the central portion of the conditional knockout retina, but decreased Otx2 labeling was noted in the distal portion of the retina in the Rx-deletion region.
Specimen Label: 9B
Detected: true
Specimen Num: 2
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Publication
9501024 | J:46377
First Author: Biben C
Year: 1998
Journal: Dev Biol
Title: Murine cerberus homologue mCer-1: a candidate anterior patterning molecule.
Volume: 194
Issue: 2
Pages: 135-51
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Publication
17107664 | J:116479
First Author: Luxardi G
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Glypicans are differentially expressed during patterning and neurogenesis of early mouse brain.
Volume: 352
Issue: 1
Pages: 55-60
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Strain
MGI:5905622 | STOCK Otx2<tm12.1Asim>/Cnrm
Attribute String: mutant stock, targeted mutation
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Publication
10068635 | J:52989
First Author: Acampora D
Year: 1999
Journal: Development
Title: Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes.
Volume: 126
Issue: 7
Pages: 1417-26
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Publication
24384227 | J:207997
 
First Author: Tripathi PP
Year: 2014
Journal: Neuroscience
Title: Increased dopaminergic innervation in the brain of conditional mutant mice overexpressing Otx2: effects on locomotor behavior and seizure susceptibility.
Volume: 261
Pages: 173-83
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HT Experiment
E-GEOD-27630 | The transcription factor Otx2 regulates choroid plexus development and function
Series Id: GSE27630
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
12764108 | J:88192
First Author: Brodski C
Year: 2003
Journal: J Neurosci
Title: Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer.
Volume: 23
Issue: 10
Pages: 4199-207
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HT Experiment
GSE129443 | Gene expression profile of Otx2 KI and Crx KO retina at P12
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Publication
20493948 | J:171333
First Author: Tilleman H
Year: 2010
Journal: Mol Cell Neurosci
Title: Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neurons.
Volume: 45
Issue: 1
Pages: 1-11
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Publication
16339193 | J:104370
First Author: Prakash N
Year: 2006
Journal: Development
Title: A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo.
Volume: 133
Issue: 1
Pages: 89-98
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Publication
16256739 | J:103272
First Author: Kimura-Yoshida C
Year: 2005
Journal: Dev Cell
Title: Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm.
Volume: 9
Issue: 5
Pages: 639-50
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Publication
11493561 | J:70745
First Author: Suda Y
Year: 2001
Journal: Development
Title: Emx2 directs the development of diencephalon in cooperation with Otx2.
Volume: 128
Issue: 13
Pages: 2433-50
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DO Term
DOID:0111806 | syndromic microphthalmia 5
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Publication
19592574 | J:152847
First Author: Prakash N
Year: 2009
Journal: Development
Title: Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain.
Volume: 136
Issue: 15
Pages: 2545-55
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Publication
34445655 | J:331152
 
First Author: Planques A
Year: 2021
Journal: Int J Mol Sci
Title: OTX2 Homeoprotein Functions in Adult Choroid Plexus.
Volume: 22
Issue: 16
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Publication
9398463 | J:44423
First Author: Makiyama Y
Year: 1997
Journal: Exp Neurol
Title: Hydrocephalus in the Otx2+/- mutant mouse.
Volume: 148
Issue: 1
Pages: 215-21
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Publication
30739114 | J:285939
First Author: Hoffmann HM
Year: 2019
Journal: Neuroendocrinology
Title: Differential CRE Expression in Lhrh-cre and GnRH-cre Alleles and the Impact on Fertility in Otx2-Flox Mice.
Volume: 108
Issue: 4
Pages: 328-342
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Publication
11114168 | J:66476
First Author: Zakin L
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos.
Volume: 97
Issue: 26
Pages: 14388-93
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Publication
15890343 | J:99788
First Author: Kimura K
Year: 2005
Journal: FEBS Lett
Title: Functional analysis of transcriptional repressor Otx3/Dmbx1.
Volume: 579
Issue: 13
Pages: 2926-32
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Protein
D3Z581
Organism: Mus musculus/domesticus
Length: 46  
Fragment?: true
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Protein
D3Z4G2
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
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Protein
D3Z7L5
Organism: Mus musculus/domesticus
Length: 63  
Fragment?: true
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Publication
25155555 | J:214806
First Author: Wang S
Year: 2014
Journal: Dev Cell
Title: A gene regulatory network controls the binary fate decision of rod and bipolar cells in the vertebrate retina.
Volume: 30
Issue: 5
Pages: 513-27
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Publication
28619944 | J:243966
First Author: Peña CJ
Year: 2017
Journal: Science
Title: Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2.
Volume: 356
Issue: 6343
Pages: 1185-1188
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HT Experiment
GSE69547 | Otx2 controls regional patterning within the MGE and regional identity of the septum [Agilent]
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Publication
28974755 | J:255446
First Author: Hou X
Year: 2017
Journal: Sci Rep
Title: Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex.
Volume: 7
Issue: 1
Pages: 12646
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Publication
36849521 | J:352438
First Author: Park JW
Year: 2023
Journal: Nat Commun
Title: Orthodenticle homeobox 2 is transported to lysosomes by nuclear budding vesicles.
Volume: 14
Issue: 1
Pages: 1111
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Publication
10498271 | J:59473
First Author: Acampora D
Year: 1999
Journal: Cereb Cortex
Title: Otx genes in corticogenesis and brain development.
Volume: 9
Issue: 6
Pages: 533-42
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Publication
11922976 | J:79632
First Author: Gimeno L
Year: 2002
Journal: Brain Res Bull
Title: Analysis of Fgf15 expression pattern in the mouse neural tube.
Volume: 57
Issue: 3-4
Pages: 297-9
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HT Experiment
E-GEOD-52006 | OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness
Series Id: GSE52006
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
10452857 | J:57266
First Author: Simpson EH
Year: 1999
Journal: Dev Biol
Title: The mouse Cer1 (Cerberus related or homologue) gene is not required for anterior pattern formation.
Volume: 213
Issue: 1
Pages: 202-6
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Publication
12915315 | J:85711
First Author: Gimeno L
Year: 2003
Journal: Gene Expr Patterns
Title: Study of Fgf15 gene expression in developing mouse brain.
Volume: 3
Issue: 4
Pages: 473-81
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